{"id":"https://openalex.org/W95350028","doi":"https://doi.org/10.1093/ajcp/111.5.676","title":"Usefulness of Certain Red Blood Cell Indices in Diagnosing and Differentiating Thalassemia Trait From Iron-Deficiency Anemia","display_name":"Usefulness of Certain Red Blood Cell Indices in Diagnosing and Differentiating Thalassemia Trait From Iron-Deficiency Anemia","publication_year":1999,"publication_date":"1999-05-01","ids":{"openalex":"https://openalex.org/W95350028","doi":"https://doi.org/10.1093/ajcp/111.5.676","mag":"95350028","pmid":"https://pubmed.ncbi.nlm.nih.gov/10230359"},"language":"en","primary_location":{"id":"doi:10.1093/ajcp/111.5.676","doi":"https://doi.org/10.1093/ajcp/111.5.676","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ajcp/111.5.676","pdf_url":null,"source":{"id":"https://openalex.org/S15871148","display_name":"American Journal of Clinical Pathology","issn_l":"0002-9173","issn":["0002-9173","1943-7722"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Clinical Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059477170","display_name":"Mohamed M. Eldibany","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122734","display_name":"Advocate Illinois Masonic Medical Center","ror":"https://ror.org/036vtmj33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210088488","https://openalex.org/I4210122734"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohamed M. Eldibany","raw_affiliation_strings":["Department of Pathology, Illinois Masonic Medical Center, Chicago 60657-5193, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Illinois Masonic Medical Center, Chicago 60657-5193, USA","institution_ids":["https://openalex.org/I4210122734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005784848","display_name":"Kameel F. Totonchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122734","display_name":"Advocate Illinois Masonic Medical Center","ror":"https://ror.org/036vtmj33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210088488","https://openalex.org/I4210122734"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kameel F. Totonchi","raw_affiliation_strings":["Department of Pathology, Illinois Masonic Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Illinois Masonic Medical Center","institution_ids":["https://openalex.org/I4210122734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061608634","display_name":"Ninos J. Joseph","orcid":"https://orcid.org/0000-0001-7579-5889","observed_orcids":["https://orcid.org/0000-0001-7579-5889"]},"institutions":[{"id":"https://openalex.org/I4210122734","display_name":"Advocate Illinois Masonic Medical Center","ror":"https://ror.org/036vtmj33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210088488","https://openalex.org/I4210122734"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ninos J. Joseph","raw_affiliation_strings":["Department of Anesthesiology, Illinois Masonic Medical Center, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Illinois Masonic Medical Center, Chicago, IL","institution_ids":["https://openalex.org/I4210122734"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072702450","display_name":"Douglas P. Rhone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas Rhone","raw_affiliation_strings":["Department of Pathology, University of Illinois at Chicago, College of Medicine, Chicago, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Illinois at Chicago, College of Medicine, Chicago, IL","institution_ids":["https://openalex.org/I39422238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4660,"currency":"USD","value_usd":4660},"apc_paid":null,"fwci":1.2452,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.78301887,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"111","issue":"5","first_page":"676","last_page":"682"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thalassemia-trait","display_name":"thalassemia trait","score":0.9629999995231628},{"id":"https://openalex.org/keywords/iron-deficiency-anemia","display_name":"iron deficiency anemia","score":0.953000009059906},{"id":"https://openalex.org/keywords/red-blood-cell-indices","display_name":"red blood cell indices","score":0.8870000243186951},{"id":"https://openalex.org/keywords/microcytic-anemia","display_name":"microcytic anemia","score":0.9110000133514404},{"id":"https://openalex.org/keywords/alpha-thalassemia","display_name":"alpha-thalassemia","score":0.9210000038146973},{"id":"https://openalex.org/keywords/beta-thalassemia","display_name":"beta-thalassemia","score":1.0},{"id":"https://openalex.org/keywords/mean-corpuscular-hemoglobin","display_name":"mean corpuscular hemoglobin","score":0.8650000095367432},{"id":"https://openalex.org/keywords/mean-corpuscular-volume","display_name":"mean corpuscular volume","score":0.9890000224113464},{"id":"https://openalex.org/keywords/red-blood-cell-distribution-width","display_name":"red cell distribution width","score":0.8410000205039978},{"id":"https://openalex.org/keywords/complete-blood-count","display_name":"complete blood count","score":0.5690000057220459},{"id":"https://openalex.org/keywords/differential-diagnosis","display_name":"differential diagnosis","score":0.7580000162124634},{"id":"https://openalex.org/keywords/discriminant-analysis","display_name":"discriminant analysis","score":0.824999988079071}],"concepts":[{"id":"https://openalex.org/C2781058662","wikidata":"https://www.wikidata.org/wiki/Q1358504","display_name":"Mean corpuscular volume","level":3,"score":0.8352465629577637},{"id":"https://openalex.org/C2775897519","wikidata":"https://www.wikidata.org/wiki/Q1273048","display_name":"Mean corpuscular hemoglobin concentration","level":4,"score":0.7615110874176025},{"id":"https://openalex.org/C2777799968","wikidata":"https://www.wikidata.org/wiki/Q185137","display_name":"Thalassemia","level":2,"score":0.7201918363571167},{"id":"https://openalex.org/C2780554921","wikidata":"https://www.wikidata.org/wiki/Q1940759","display_name":"Mean corpuscular hemoglobin","level":4,"score":0.6455845832824707},{"id":"https://openalex.org/C78529466","wikidata":"https://www.wikidata.org/wiki/Q1363819","display_name":"Red blood cell distribution width","level":2,"score":0.557672381401062},{"id":"https://openalex.org/C69738355","wikidata":"https://www.wikidata.org/wiki/Q1228929","display_name":"Linear discriminant analysis","level":2,"score":0.5502656698226929},{"id":"https://openalex.org/C2776732101","wikidata":"https://www.wikidata.org/wiki/Q954674","display_name":"Iron-deficiency anemia","level":3,"score":0.4790424108505249},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4380667209625244},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43243739008903503},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.42154788970947266},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4082638621330261},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.39575207233428955},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3844970166683197},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.212059885263443}],"mesh":[{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004906","descriptor_name":"Erythrocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004909","descriptor_name":"Erythrocyte Indices","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005069","descriptor_name":"Evaluation Studies as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013789","descriptor_name":"Thalassemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013789","descriptor_name":"Thalassemia","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016002","descriptor_name":"Discriminant Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018798","descriptor_name":"Anemia, Iron-Deficiency","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018798","descriptor_name":"Anemia, Iron-Deficiency","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/ajcp/111.5.676","doi":"https://doi.org/10.1093/ajcp/111.5.676","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ajcp/111.5.676","pdf_url":null,"source":{"id":"https://openalex.org/S15871148","display_name":"American Journal of Clinical Pathology","issn_l":"0002-9173","issn":["0002-9173","1943-7722"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Clinical Pathology","raw_type":"journal-article"},{"id":"pmid:10230359","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10230359","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of clinical pathology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1984518619","https://openalex.org/W2105229522","https://openalex.org/W3140463733","https://openalex.org/W2007076414","https://openalex.org/W2101841779","https://openalex.org/W2018896287","https://openalex.org/W2070524896","https://openalex.org/W2917839200","https://openalex.org/W3024753169","https://openalex.org/W2288228663"],"abstract_inverted_index":{"Iron-deficiency":[0],"anemia":[1,64],"and":[2,43,62,86,113,127,179],"thalassemia":[3],"are":[4],"among":[5],"the":[6,33,100,132,139,145],"most":[7],"common":[8],"microcytic":[9],"anemias.":[10],"Differentiating":[11],"these":[12],"anemias":[13],"by":[14],"means":[15],"of":[16,70,135,144,155,164,186],"hemogrant":[17],"indices":[18,96,136],"is":[19],"imprecise.":[20],"Powerful":[21],"statistical":[22],"computer":[23],"programming":[24],"now":[25],"enables":[26],"sensitive":[27],"discriminant":[28,92,106,149,166],"analyses":[29],"to":[30,46],"aid":[31],"in":[32,152],"diagnosis.":[34],"Laboratory":[35],"results":[36,71],"from":[37],"383":[38],"adults":[39],"were":[40],"examined":[41],"retrospectively":[42],"grouped":[44],"according":[45],"their":[47],"original":[48],"diagnoses:":[49],"normal":[50],"(n":[51,55,59,65],"=":[52,56,60,66],"78);":[53],"beta-thalassemia":[54],"134);":[57],"alpha-thalassemia":[58],"106);":[61],"iron-deficiency":[63,180],"65).":[67],"Statistical":[68],"analysis":[69,93,117],"evaluated":[72],"only":[73],"RBC":[74,76,87,122,128],"indices:":[75],"count,":[77,123],"hemoglobin":[78],"level,":[79],"mean":[80,83,119,124],"corpuscular":[81,84,120,125],"volume,":[82,126],"hemoglobin,":[85,121],"distribution":[88,129],"width.":[89],"Stepwise":[90],"multivariate":[91],"determined":[94],"those":[95],"that":[97,161],"best":[98,133],"differentiated":[99],"4":[101,140],"groups.":[102],"The":[103,157],"Fisher":[104,147],"linear":[105,148,165],"function":[107,150],"for":[108,137],"each":[109],"group":[110],"was":[111],"calculated":[112,146],"tested":[114],"casewise.":[115],"Discriminant":[116],"identified":[118],"width":[130],"as":[131],"set":[134,163],"differentiating":[138],"diagnoses.":[141],"Casewise":[142],"testing":[143],"resulted":[151],"mean-weighted":[153],"sensitivity":[154],"80.4%.":[156],"present":[158],"study":[159],"demonstrates":[160],"a":[162,183],"functions":[167],"based":[168],"on":[169],"routine":[170],"hemogram":[171],"data":[172],"can":[173],"effectively":[174],"differentiate":[175],"between":[176],"alpha-thalassemia,":[177],"beta-thalassemia,":[178],"anemia,":[181],"with":[182],"high":[184],"degree":[185],"accuracy.":[187]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
