{"id":"https://openalex.org/W95341472","doi":null,"title":"Recombinant elastin -mimetic protein polymers as design elements for an arterial substitute","display_name":"Recombinant elastin -mimetic protein polymers as design elements for an arterial substitute","publication_year":2008,"publication_date":"2008-05-19","ids":{"openalex":"https://openalex.org/W95341472","mag":"95341472"},"language":"en","primary_location":{"id":"pmh:oai:smartech.gatech.edu:1853/29614","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1853/29614","pdf_url":null,"source":{"id":"https://openalex.org/S4377196313","display_name":"SMARTech Repository (Georgia Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130701444","host_organization_name":"Georgia Institute of Technology","host_organization_lineage":["https://openalex.org/I130701444"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036746021","display_name":"Rory E. Sallach","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rory E. Sallach","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5036746021"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11966","display_name":"Silk-based biomaterials and applications","score":0.5404999852180481,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11966","display_name":"Silk-based biomaterials and applications","score":0.5404999852180481,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.11729999631643295,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10661","display_name":"biodegradable polymer synthesis and properties","score":0.09889999777078629,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arterial-substitutes","display_name":"arterial substitutes","score":0.8169999718666077},{"id":"https://openalex.org/keywords/physical-crosslinking","display_name":"physical crosslinking","score":0.7630000114440918},{"id":"https://openalex.org/keywords/chemical-crosslinking","display_name":"chemical crosslinking","score":0.9789999723434448},{"id":"https://openalex.org/keywords/triblock-copolymers","display_name":"triblock copolymers","score":0.8199999928474426},{"id":"https://openalex.org/keywords/biocompatibility","display_name":"biocompatibility","score":0.8659999966621399},{"id":"https://openalex.org/keywords/biostability","display_name":"biostability","score":0.9929999709129333},{"id":"https://openalex.org/keywords/elastic-modulus","display_name":"elastic modulus","score":0.5820000171661377},{"id":"https://openalex.org/keywords/creep","display_name":"creep","score":0.7160000205039978},{"id":"https://openalex.org/keywords/pichia-pastoris-expression-system","display_name":"Pichia pastoris expression","score":0.7540000081062317},{"id":"https://openalex.org/keywords/synthetic-gene-design","display_name":"synthetic gene design","score":0.7289999723434448},{"id":"https://openalex.org/keywords/protein-polymers","display_name":"protein polymers","score":0.5630000233650208},{"id":"https://openalex.org/keywords/artificial-organs","display_name":"artificial organs","score":0.4860000014305115},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"tissue engineering","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C2779869378","wikidata":"https://www.wikidata.org/wiki/Q409747","display_name":"Elastin","level":2,"score":0.8209288716316223},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.7367058992385864},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.4524362087249756},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.36133328080177307},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3322966694831848},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3063172996044159},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3025345206260681},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.28630155324935913},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2549338936805725},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.1683923304080963},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15896031260490417},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06675106287002563}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:smartech.gatech.edu:1853/29614","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1853/29614","pdf_url":null,"source":{"id":"https://openalex.org/S4377196313","display_name":"SMARTech Repository (Georgia Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I130701444","host_organization_name":"Georgia Institute of Technology","host_organization_lineage":["https://openalex.org/I130701444"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},{"id":"mag:95341472","doi":null,"is_oa":false,"landing_page_url":"https://smartech.gatech.edu/bitstream/1853/29614/1/sallach_rory_e_200808_phd.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":274,"referenced_works":["https://openalex.org/W122011460","https://openalex.org/W255163611","https://openalex.org/W275809009","https://openalex.org/W654858911","https://openalex.org/W1492516812","https://openalex.org/W1493603787","https://openalex.org/W1497648332","https://openalex.org/W1504680742","https://openalex.org/W1527267444","https://openalex.org/W1574055976","https://openalex.org/W1589126534","https://openalex.org/W1653019055","https://openalex.org/W1730338528","https://openalex.org/W1851722589","https://openalex.org/W1907705325","https://openalex.org/W1938341712","https://openalex.org/W1963482768","https://openalex.org/W1964284889","https://openalex.org/W1964448580","https://openalex.org/W1964535384","https://openalex.org/W1965020882","https://openalex.org/W1965862536","https://openalex.org/W1966491512","https://openalex.org/W1966703456","https://openalex.org/W1967934018","https://openalex.org/W1968475097","https://openalex.org/W1969749903","https://openalex.org/W1970960314","https://openalex.org/W1971432294","https://openalex.org/W1971560783","https://openalex.org/W1972229031","https://openalex.org/W1972349762","https://openalex.org/W1974139015","https://openalex.org/W1974730295","https://openalex.org/W1974773289","https://openalex.org/W1974798445","https://openalex.org/W1975893603","https://openalex.org/W1976897771","https://openalex.org/W1977094429","https://openalex.org/W1977169440","https://openalex.org/W1978149697","https://openalex.org/W1978485557","https://openalex.org/W1978607268","https://openalex.org/W1979263939","https://openalex.org/W1979990749","https://openalex.org/W1980508338","https://openalex.org/W1981383297","https://openalex.org/W1982941857","https://openalex.org/W1983221400","https://openalex.org/W1984795021","https://openalex.org/W1985691489","https://openalex.org/W1985776360","https://openalex.org/W1986867983","https://openalex.org/W1988071432","https://openalex.org/W1988479634","https://openalex.org/W1988965898","https://openalex.org/W1989565245","https://openalex.org/W1989675515","https://openalex.org/W1989704675","https://openalex.org/W1990148399","https://openalex.org/W1990431921","https://openalex.org/W1991333489","https://openalex.org/W1992096208","https://openalex.org/W1992150382","https://openalex.org/W1992453786","https://openalex.org/W1993573305","https://openalex.org/W1993685207","https://openalex.org/W1993922159","https://openalex.org/W1995537221","https://openalex.org/W1997353385","https://openalex.org/W1997356166","https://openalex.org/W1997443446","https://openalex.org/W1998119923","https://openalex.org/W1998748630","https://openalex.org/W1999237160","https://openalex.org/W1999347645","https://openalex.org/W2000044234","https://openalex.org/W2000538288","https://openalex.org/W2001902689","https://openalex.org/W2001918706","https://openalex.org/W2002073250","https://openalex.org/W2002648741","https://openalex.org/W2002762837","https://openalex.org/W2002777106","https://openalex.org/W2004181539","https://openalex.org/W2004874831","https://openalex.org/W2006246299","https://openalex.org/W2006521996","https://openalex.org/W2010533043","https://openalex.org/W2010626991","https://openalex.org/W2010766679","https://openalex.org/W2011143189","https://openalex.org/W2011227657","https://openalex.org/W2011590928","https://openalex.org/W2012211970","https://openalex.org/W2012222854","https://openalex.org/W2013542000","https://openalex.org/W2017063582","https://openalex.org/W2017915061","https://openalex.org/W2018654421","https://openalex.org/W2020349323","https://openalex.org/W2020363418","https://openalex.org/W2020546847","https://openalex.org/W2024250531","https://openalex.org/W2024460904","https://openalex.org/W2024660473","https://openalex.org/W2024903088","https://openalex.org/W2025230468","https://openalex.org/W2025353869","https://openalex.org/W2026241393","https://openalex.org/W2027386500","https://openalex.org/W2027796832","https://openalex.org/W2028291660","https://openalex.org/W2028784198","https://openalex.org/W2028905758","https://openalex.org/W2029259783","https://openalex.org/W2032840493","https://openalex.org/W2033083169","https://openalex.org/W2033111947","https://openalex.org/W2034173639","https://openalex.org/W2035790993","https://openalex.org/W2036162008","https://openalex.org/W2036994807","https://openalex.org/W2037003793","https://openalex.org/W2037622626","https://openalex.org/W2037707760","https://openalex.org/W2038140325","https://openalex.org/W2038265624","https://openalex.org/W2039738579","https://openalex.org/W2040165312","https://openalex.org/W2041111618","https://openalex.org/W2041497985","https://openalex.org/W2042396680","https://openalex.org/W2042424591","https://openalex.org/W2042968613","https://openalex.org/W2043272676","https://openalex.org/W2043556712","https://openalex.org/W2043685554","https://openalex.org/W2044214176","https://openalex.org/W2044450078","https://openalex.org/W2044491735","https://openalex.org/W2047103746","https://openalex.org/W2048784971","https://openalex.org/W2051013729","https://openalex.org/W2051089689","https://openalex.org/W2051367185","https://openalex.org/W2051403769","https://openalex.org/W2051824584","https://openalex.org/W2051987578","https://openalex.org/W2052272490","https://openalex.org/W2055216189","https://openalex.org/W2055475096","https://openalex.org/W2061028796","https://openalex.org/W2061712172","https://openalex.org/W2062823777","https://openalex.org/W2063124314","https://openalex.org/W2063554961","https://openalex.org/W2065474987","https://openalex.org/W2065575328","https://openalex.org/W2065672036","https://openalex.org/W2067900905","https://openalex.org/W2068441590","https://openalex.org/W2068623317","https://openalex.org/W2070355721","https://openalex.org/W2070636326","https://openalex.org/W2070679280","https://openalex.org/W2071485286","https://openalex.org/W2072024015","https://openalex.org/W2073112834","https://openalex.org/W2073889644","https://openalex.org/W2074266529","https://openalex.org/W2075056504","https://openalex.org/W2075851866","https://openalex.org/W2076266519","https://openalex.org/W2076473259","https://openalex.org/W2077207024","https://openalex.org/W2078355519","https://openalex.org/W2080540716","https://openalex.org/W2080803003","https://openalex.org/W2081093172","https://openalex.org/W2081635117","https://openalex.org/W2082003638","https://openalex.org/W2082050649","https://openalex.org/W2083288707","https://openalex.org/W2084659355","https://openalex.org/W2085583717","https://openalex.org/W2085929270","https://openalex.org/W2086483409","https://openalex.org/W2086645341","https://openalex.org/W2087208805","https://openalex.org/W2088271410","https://openalex.org/W2088439854","https://openalex.org/W2089541965","https://openalex.org/W2090037733","https://openalex.org/W2090630682","https://openalex.org/W2090897179","https://openalex.org/W2092130438","https://openalex.org/W2092846883","https://openalex.org/W2093435685","https://openalex.org/W2094394466","https://openalex.org/W2095351662","https://openalex.org/W2095558061","https://openalex.org/W2096305478","https://openalex.org/W2097844740","https://openalex.org/W2098251659","https://openalex.org/W2100139763","https://openalex.org/W2100495061","https://openalex.org/W2102436727","https://openalex.org/W2102605158","https://openalex.org/W2102893683","https://openalex.org/W2103630920","https://openalex.org/W2107632694","https://openalex.org/W2107913200","https://openalex.org/W2110451053","https://openalex.org/W2112541717","https://openalex.org/W2115552610","https://openalex.org/W2117604223","https://openalex.org/W2118029163","https://openalex.org/W2118522871","https://openalex.org/W2118877693","https://openalex.org/W2121845178","https://openalex.org/W2122243862","https://openalex.org/W2122595781","https://openalex.org/W2123445510","https://openalex.org/W2123612769","https://openalex.org/W2124268486","https://openalex.org/W2124529820","https://openalex.org/W2124614834","https://openalex.org/W2125155349","https://openalex.org/W2127555424","https://openalex.org/W2128531352","https://openalex.org/W2131442097","https://openalex.org/W2132424786","https://openalex.org/W2132854921","https://openalex.org/W2134566626","https://openalex.org/W2138116842","https://openalex.org/W2139180337","https://openalex.org/W2139586508","https://openalex.org/W2141489905","https://openalex.org/W2142846436","https://openalex.org/W2143286808","https://openalex.org/W2143564590","https://openalex.org/W2145232299","https://openalex.org/W2146141733","https://openalex.org/W2147182021","https://openalex.org/W2153154949","https://openalex.org/W2154157809","https://openalex.org/W2154622848","https://openalex.org/W2157908104","https://openalex.org/W2159692941","https://openalex.org/W2159923852","https://openalex.org/W2159994931","https://openalex.org/W2162716973","https://openalex.org/W2163321666","https://openalex.org/W2166480389","https://openalex.org/W2170773321","https://openalex.org/W2200339783","https://openalex.org/W2204689676","https://openalex.org/W2205932377","https://openalex.org/W2219934691","https://openalex.org/W2226344144","https://openalex.org/W2281687240","https://openalex.org/W2314218184","https://openalex.org/W2315098107","https://openalex.org/W2399489210","https://openalex.org/W2400448718","https://openalex.org/W2413851556","https://openalex.org/W2416857557","https://openalex.org/W2471387511","https://openalex.org/W2480924511","https://openalex.org/W2524827732","https://openalex.org/W3025713423","https://openalex.org/W4237110541","https://openalex.org/W4300107898"],"related_works":["https://openalex.org/W2023691252","https://openalex.org/W4384154521","https://openalex.org/W2084014094","https://openalex.org/W2502512620","https://openalex.org/W2063010257","https://openalex.org/W2086982587","https://openalex.org/W2026241393","https://openalex.org/W2908933655","https://openalex.org/W30225889","https://openalex.org/W4387996358"],"abstract_inverted_index":{"Recombinant":[0],"synthesis":[1],"of":[2,16,39,50,72,112,118,136,152,159,165,190,216,260,287,293,301,310,315,329,332,338],"elastin-mimetic":[3,27,114,219],"proteins":[4,18,28,171,199],"has":[5],"been":[6,210],"employed":[7],"for":[8,134,172,238,252,257,327,346],"several":[9],"decades,":[10],"however,":[11],"long-term":[12,34,59],"biocompatibility":[13,32],"and":[14,33,81,121,145,206,297,341],"biostability":[15,35],"such":[17],"was":[19,143,231],"not":[20],"fully":[21],"defined.":[22],"We":[23,124,212],"present":[24],"virtually":[25],"crosslinked":[26,55,66,77,320],"which":[29,168],"exhibit":[30],"exceptional":[31],"over":[36,74],"a":[37,51,70,109,217,258,284,298,330],"period":[38],"at":[40,92],"least":[41],"seven":[42],"months.":[43],"This":[44],"report":[45],"is":[46,244],"the":[47,82,150,163,188,194,214,269,313],"first":[48],"evidence":[49],"non-chemically":[52],"or":[53,90,321,325,350],"ionically":[54],"system":[56,183],"that":[57,127,246],"exhibits":[58],"in":[60,175,233,263],"vivo":[61],"stability.":[62],"\\n":[63,156,277],"\\nAlthough,":[64],"physically":[65],"protein-based":[67],"materials":[68],"possess":[69],"number":[71,158,331],"advantages":[73,179],"their":[75],"chemically":[76,319],"counterparts,":[78],"physical":[79,120],"crosslinks":[80],"related":[83],"domains":[84],"so":[85],"formed":[86],"may":[87],"be":[88,250],"deformed":[89],"damaged":[91],"applied":[93],"stresses":[94],"lower":[95],"than":[96],"those":[97],"required":[98],"to":[99,196,265,273,306],"disrupt":[100],"covalent":[101],"crosslinks.":[102],"In":[103],"this":[104,181,247],"regard,":[105],"we":[106],"have":[107,125,161,209],"synthesized":[108],"new":[110],"class":[111,286],"recombinant":[113,218],"triblock":[115],"copolymer":[116],"capable":[117],"both":[119],"chemical":[122,128,153],"crosslinking.":[123],"demonstrated":[126],"crosslinking":[129,154],"provides":[130],"an":[131],"independent":[132],"mechanism":[133],"control":[135],"protein":[137,220,241,281],"mechanical":[138,302],"responses.":[139],"Specifically,":[140],"elastic":[141],"modulus":[142],"enhanced":[144],"creep":[146],"strain":[147],"reduced":[148],"through":[149],"addition":[151],"sites.":[155],"\\nA":[157],"reports":[160],"described":[162],"design":[164],"synthetic":[166,226],"genes,":[167],"encode":[169],"elastin-like":[170],"bacterial":[173],"expression":[174,182,215,261],"Escherichia":[176],"coli.":[177],"Although":[178],"with":[180],"exist,":[184],"significant":[185],"limitations":[186],"including":[187,335],"lack":[189],"eukaryotic":[191],"post-translational":[192],"systems,":[193],"tendency":[195],"sequester":[197],"mammalian":[198],"into":[200,318],"inclusion":[201],"bodies,":[202],"difficult":[203],"purification":[204],"protocols,":[205],"endotoxin":[207],"contamination":[208],"noted.":[211],"demonstrate":[213],"from":[221,304],"P.":[222],"pastoris.":[223],"A":[224,308],"novel":[225],"strategy,":[227],"monomer":[228],"library":[229],"concatamerization,":[230],"utilized":[232],"designing":[234],"non-repetitive":[235],"elastin":[236],"genes":[237,256],"highly":[239],"repetitive":[240,255],"sequences.":[242,276],"It":[243],"likely":[245],"strategy":[248],"will":[249],"useful":[251],"creating":[253],"large,":[254],"variety":[259,309],"systems":[262],"order":[264],"more":[266],"closely":[267],"approach":[268],"genetic":[270],"diversity":[271],"inherent":[272],"native":[274],"DNA":[275],"\\nAll":[278],"told,":[279],"elastin-based":[280],"polymers":[282],"are":[283],"promising":[285],"material":[288],"characterized":[289],"by":[290],"high":[291],"degree":[292],"biocompatibility,":[294],"excellent":[295],"biostability,":[296],"tunable":[299],"range":[300],"properties":[303],"plastic":[305],"elastic.":[307],"options":[311],"facilitate":[312],"processing":[314],"these":[316],"biopolymers":[317],"non-crosslinked":[322],"gels,":[323],"films,":[324],"nanofibers":[326],"any":[328],"implant":[333],"applications":[334],"structural":[336],"components":[337],"artificial":[339],"organs":[340],"engineered":[342],"living":[343],"tissues,":[344],"carriers":[345],"controlled":[347],"drug":[348],"release,":[349],"biocompatible":[351],"surface":[352],"coatings.":[353]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}