{"id":"https://openalex.org/W953367686","doi":null,"title":"Diagnostic and prognostic studies in Hodgkin's lymphoma with special reference to the elderly","display_name":"Diagnostic and prognostic studies in Hodgkin's lymphoma with special reference to the elderly","publication_year":2002,"publication_date":"2002-11-08","ids":{"openalex":"https://openalex.org/W953367686","mag":"953367686"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26924146","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Diagnostic_and_prognostic_studies_in_Hodgkin_s_lymphoma_with_special_reference_to_the_elderly/26924146","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082004555","display_name":"Ola Landgren","orcid":"https://orcid.org/0000-0001-6485-4839","observed_orcids":["https://orcid.org/0000-0001-6485-4839"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ola Landgren","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6485-4839","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5082004555"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hodgkin-lymphoma","display_name":"Hodgkin's disease","score":0.9810000061988831},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.9779999852180481},{"id":"https://openalex.org/keywords/fine-needle-aspiration-cytology","display_name":"fine needle aspiration cytology","score":0.9900000095367432},{"id":"https://openalex.org/keywords/immunocytochemistry","display_name":"immunocytochemistry","score":0.8370000123977661},{"id":"https://openalex.org/keywords/bone-scintigraphy","display_name":"bone scintigraphy","score":0.9729999899864197},{"id":"https://openalex.org/keywords/bone-involvement","display_name":"bone involvement","score":0.8149999976158142},{"id":"https://openalex.org/keywords/bone-pain","display_name":"bone pain","score":0.7070000171661377},{"id":"https://openalex.org/keywords/treatment-response-assessment","display_name":"treatment response assessment","score":0.8399999737739563},{"id":"https://openalex.org/keywords/pneumococcal-vaccination","display_name":"pneumococcal vaccination","score":0.9139999747276306},{"id":"https://openalex.org/keywords/splenectomy","display_name":"splenectomy","score":0.6430000066757202},{"id":"https://openalex.org/keywords/autoimmune-hemolytic-anemia","display_name":"autoimmune hemolytic anemia","score":0.8849999904632568},{"id":"https://openalex.org/keywords/immune-thrombocytopenic-purpura","display_name":"idiopathic thrombocytopenic purpura","score":0.9900000095367432},{"id":"https://openalex.org/keywords/splenic-rupture","display_name":"splenic rupture","score":0.6940000057220459},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C2992779791","wikidata":"https://www.wikidata.org/wiki/Q209369","display_name":"Hodgkin lymphoma","level":3,"score":0.6626640558242798},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5490135550498962},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.5197145938873291},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44255533814430237},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4393778145313263},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32501256465911865}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/26924146","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Diagnostic_and_prognostic_studies_in_Hodgkin_s_lymphoma_with_special_reference_to_the_elderly/26924146","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/42927","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10616/42927","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:953367686","doi":null,"is_oa":false,"landing_page_url":"http://publications.ki.se/xmlui/handle/10616/42927","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2063839690","https://openalex.org/W2109439511","https://openalex.org/W4401430122","https://openalex.org/W7072340215","https://openalex.org/W2035088271","https://openalex.org/W1256583456","https://openalex.org/W2443131907","https://openalex.org/W1993313216","https://openalex.org/W2111690396","https://openalex.org/W2084309157"],"abstract_inverted_index":{"The":[0,49,68,118,247,367],"introduction":[1],"of":[2,35,60,71,80,109,183,211,224,235,250,286,294,391,400,428,462,465,499,501,510,523,537,568,579,600,607,693,750],"modem":[3],"staging":[4],"procedures,":[5],"and":[6,11,19,90,104,131,136,155,162,177,222,231,347,371,393,402,512,572,577,691,718],"developments":[7],"in":[8,22,63,84,122,137,180,219,254,312,336,374,385,411,413,438,473,485,496,532,574,603,652,683,695,720,758],"both":[9,153],"radiotherapy":[10,274],"chemotherapy":[12,429,443,694],"have":[13],"significantly":[14],"contributed":[15],"to":[16,44,76,301,307,310,360,382,422,446,505,517,645,658,689,697,748],"improved":[17,483],"response":[18,309,329,644],"survival":[20,450,719],"rates":[21,373],"Hodgkin's":[23],"lymphoma":[24,220,682],"(HL)":[25],"during":[26],"the":[27,64,72,85,113,147,158,169,181,186,208,277,295,375,389,497,575,604,684,754],"last":[28],"decades.":[29],"However,":[30],"still":[31],"a":[32,110,126,203,263,283,303,319,327,408,423,435,493],"substantial":[33],"proportion":[34],"patients":[36,196,257,313,338,401,609,722],"succumb":[37],"from":[38,112],"tumour":[39],"progression":[40],"and/or":[41,47],"complications":[42],"related":[43],"diagnostic":[45],"procedures":[46],"treatment.":[48],"presently":[50],"identified":[51],"risk":[52,195],"factor":[53],"profiles":[54],"do":[55],"not":[56,480],"allow":[57,243],"accurate":[58,176],"tailoring":[59],"treatment,":[61],"especially":[62],"elderly":[65,414,474,487,685,721],"patient":[66,270,440],"population.":[67,441],"overriding":[69],"goal":[70],"present":[73],"study":[74,641],"was":[75,134,258,262,282,330,479,491],"improve":[77],"clinical":[78,142,154,171,248,605],"management":[79],"HL":[81,256,340,376,417,475,488],"patients,":[82],"particularly":[83],"elderly.":[86],"Individuals":[87],"with":[88,314,339,434,482,503,610,648,655,686,723],"lymphadenopathy":[89],"accessible":[91],"lymph":[92,115],"nodes":[93],"(n=103)":[94],"were":[95,120,144,150,378],"prospectively":[96],"studied":[97],"first":[98],"by":[99,106,191,364,520,753],"fine-needle":[100,569],"aspiration":[101,570],"cytology":[102,571],"(FNAC)":[103],"then":[105],"histological":[107],"examination":[108],"biopsy":[111],"same":[114],"node":[116],"site.":[117],"diagnoses":[119,133],"concordant":[121],"74%.":[123],"In":[124,193],"10%":[125],"major":[127],"discordance":[128],"between":[129,160],"FNAC":[130,161,173,197,212],"histopathologic":[132],"found":[135,331],"16%":[138],"minor":[139],"discordances":[140],"without":[141],"impact":[143,167],"recorded.":[145],"Since":[146],"treatment":[148,311,471],"decisions":[149],"based":[151,275],"on":[152,168,276,318,332,642],"FNAC/histopathology":[156],"data":[157],"discrepancies":[159],"histopathology":[163,573],"had":[164],"only":[165],"limited":[166,601],"overall":[170],"strategy.":[172],"is":[174,189,407,431,459,599],"an":[175,486],"safe":[178],"method":[179,306],"diagnosis":[182,188,215,576],"lymphomas":[184],"when":[185],"cytologic":[187],"corroborated":[190],"immunocytochemistry.":[192],"certain":[194,217,244],"may":[198,746],"well":[199,353,468],"be":[200,302,452,530],"used":[201],"as":[202,352,354,380,398,467,469],"single":[204],"method.":[205],"Concerns":[206],"about":[207],"increasing":[209],"use":[210],"for":[213,227],"primary":[214],"include":[216],"shortcomings":[218],"classification":[221,578],"loss":[223],"archival":[225],"tissue":[226],"complementary":[228],"analyses,":[229],"reclassification":[230],"research":[232],"purposes.":[233],"Freezing":[234],"cytospin":[236],"material":[237],"or":[238],"cell":[239],"pellets":[240],"may,":[241],"however,":[242],"future":[245],"analyses.":[246],"value":[249,390,602],"routine":[251],"bone":[252,315,597],"scintigraphy":[253,300,598],"untreated":[255,608],"limited.":[259],"Bone":[260,280],"involvement":[261],"rare":[264],"finding":[265],"(7/183;":[266],"4%).":[267],"Only":[268],"one":[269],"received":[271],"additional":[272],"local":[273],"scintigraphic":[278],"findings.":[279],"pain":[281],"good":[284],"predictor":[285],"osseous":[287],"involvement.":[288,316],"Performed":[289],"follow-up":[290],"scintigraphies":[291],"showed":[292],"regression":[293],"initially":[296],"observed":[297,368],"abnormalities":[298],"suggesting":[299,525],"cost-effective":[304],"alternative":[305,470],"assess":[308],"Based":[317],"vaccination":[320,334],"algorithm":[321],"including":[322],"repeated":[323,646],"23-valent":[324],"pneumococcal":[325,649],"vaccinations,":[326],"significant":[328,494],"three":[333],"occasions":[335],"splenectomized":[337,653],"(n=208),":[341],"autoimmune":[342],"hemolytic":[343],"anemia":[344],"(n=":[345],"15),":[346],"immune":[348],"thrombocytopenic":[349],"purpura":[350],"(n=60)":[351],"individuals":[355,654],"who":[356],"underwent":[357],"splenectomy":[358],"due":[359],"splenic":[361],"rupture":[362],"caused":[363],"trauma":[365],"(n=28).":[366],"case":[369],"morbidity":[370],"fatality":[372],"cohort":[377],"lower":[379],"compared":[381],"those":[383],"reported":[384],"most":[386],"studies":[387],"supporting":[388],"revaccination":[392],"other":[394],"preventive":[395],"measures":[396],"such":[397],"education":[399],"health":[403],"care":[404],"professionals.":[405],"There":[406,458],"great":[409,460],"heterogeneity":[410],"outcome":[412,484,751],"(>60":[415],"years)":[416],"patients.":[418,476],"Many":[419],"factors":[420],"contribute":[421],"decreased":[424],"relative":[425],"dose":[426],"intensity":[427,692],"which":[430],"strongly":[432],"associated":[433,481],"dismal":[436],"prognosis":[437,466],"this":[439],"ABVD-based":[442],"appears":[444],"superior":[445],"MOPP":[447],"variants.":[448],"Long-term":[449],"can":[451],"achieved":[453,519,752],"even":[454],"following":[455],"minimal":[456],"chemotherapy.":[457],"lack":[461],"apt":[463],"predictors":[464,522],"modalities":[472],"Parental":[477,716],"longevity":[478,717],"cohort.":[489],"Neither":[490],"there":[492],"difference":[495],"distribution":[498],"causes":[500],"death":[502],"reference":[504,657,688],"parental":[506],"lifespan.":[507],"Serum":[508],"levels":[509],"IL-10":[511],"sCD30":[513],"added":[514],"prognostic":[515],"information":[516],"that":[518,526],"conventional":[521],"prognosis,":[524],"these":[527],"markers":[528,745],"should":[529],"validated":[531],"large":[533],"prospective":[534,566,640],"trials.":[535],"List":[536],"scientific":[538],"papers":[539],"I.":[540],"Landgren":[541,583,619,663,701,737],"O,":[542,584,620,664,702,738],"Porwit":[543,673],"macDonald":[544],"A,":[545,555,631,675,712,740],"Tani":[546],"E,":[547,561,708],"Czader":[548],"M,":[549,622,627,635],"Grimfors":[550,591,636,676,735],"G,":[551,592,677,736],"Skoog":[552],"L,":[553],"Ost":[554],"Wedelin":[556,671],"C,":[557,666,672],"Axdorph":[558,585,632,667,709,731],"U,":[559,586,633,668,710,732],"Svedmyr":[560],"Bjorkholm":[562,593,678,713,741],"M":[563,594,679,714,742],"(2002).":[564,638,680,715],"A":[565,639],"comparison":[567],"lymphomas.":[580],"[Submitted]":[581,699],"II.":[582],"Jacobsson":[587],"H,":[588,625],"Johansson":[589],"B,":[590,629,670],"(2000).":[595,743],"Routine":[596],"assessment":[606],"Hodgkins":[611,659,681,724,759],"disease.":[612,760],"Med":[613],"Oncol.":[614,762],"17(3):":[615],"174-8.":[616],"https://pubmed.ncbi.nlm.nih.gov/10962526":[617],"III.":[618],"Bkorkholm":[621],"Bossen":[623],"Konradsen":[624],"Soderquist":[626],"Nilsson":[628,669],"Gustavsson":[630],"Kalin":[634],"G":[637],"antibody":[643],"vaccinations":[647],"capsular":[650],"polysacharide":[651],"special":[656,687],"lymphoma.":[660,725],"[Manuscript]":[661],"IV.":[662],"Algernon":[665],"MacDonald":[674],"type":[690],"relation":[696],"prognosis.":[698],"V.":[700],"Askling":[703],"J,":[704,734],"Dickman":[705],"PW,":[706],"Osby":[707],"Ekbom":[711],"Haematologica.":[726],"87(6):":[727],"595-601.":[728],"https://pubmed.ncbi.nlm.nih.gov/12031915":[729],"VI.":[730],"Sjoberg":[733],"Porwit-MacDonald":[739],"Biological":[744],"add":[747],"prediction":[749],"International":[755],"Prognostic":[756],"Score":[757],"Ann":[761],"11(11):":[763],"1405-11.":[764],"https://pubmed.ncbi.nlm.nih.gov/11142480":[765]},"counts_by_year":[],"updated_date":"2026-09-11T09:22:31.653822","created_date":"2016-06-24T00:00:00"}
