{"id":"https://openalex.org/W95260653","doi":null,"title":"Insights into Toxin Binding to Tubulin as a Potential Trigger in Parkinson's Disease Using Molecular Modeling","display_name":"Insights into Toxin Binding to Tubulin as a Potential Trigger in Parkinson's Disease Using Molecular Modeling","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W95260653","mag":"95260653"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt3g84f468","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/3g84f468","pdf_url":"https://escholarship.org/uc/item/3g84f468","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://escholarship.org/uc/item/3g84f468","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041169518","display_name":"Debbie Joy Hlava","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Debbie Joy Hlava","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5041169518"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.04580000042915344,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.984000027179718},{"id":"https://openalex.org/keywords/tubulin","display_name":"tubulin","score":0.6460000276565552},{"id":"https://openalex.org/keywords/microtubule-disruption","display_name":"microtubule disruption","score":0.9340000152587891},{"id":"https://openalex.org/keywords/toxin-binding","display_name":"toxin binding","score":0.703000009059906},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.828000009059906},{"id":"https://openalex.org/keywords/dopamine-oxidation","display_name":"dopamine oxidation","score":0.9100000262260437},{"id":"https://openalex.org/keywords/alpha-synuclein-aggregation","display_name":"alpha-synuclein aggregation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/rotenone","display_name":"rotenone","score":0.777999997138977},{"id":"https://openalex.org/keywords/mptp","display_name":"MPTP","score":0.8889999985694885},{"id":"https://openalex.org/keywords/toluene","display_name":"toluene","score":0.859000027179718},{"id":"https://openalex.org/keywords/saccharin","display_name":"saccharin","score":0.9430000185966492},{"id":"https://openalex.org/keywords/aspartame","display_name":"aspartame","score":0.996999979019165},{"id":"https://openalex.org/keywords/colchicine","display_name":"colchicine","score":0.8450000286102295},{"id":"https://openalex.org/keywords/tubulin-polymerization-inhibitors","display_name":"tubulin polymerization inhibitors","score":0.7879999876022339},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.8109999895095825},{"id":"https://openalex.org/keywords/sublingual-absorption","display_name":"sublingual absorption","score":0.9369999766349792},{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":0.9610000252723694},{"id":"https://openalex.org/keywords/geldanamycin","display_name":"geldanamycin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C84425145","wikidata":"https://www.wikidata.org/wiki/Q422492","display_name":"Tubulin","level":3,"score":0.7058650255203247},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.6673341989517212},{"id":"https://openalex.org/C2778389096","wikidata":"https://www.wikidata.org/wiki/Q412388","display_name":"Rotenone","level":3,"score":0.6111793518066406},{"id":"https://openalex.org/C2776636253","wikidata":"https://www.wikidata.org/wiki/Q326224","display_name":"Colchicine","level":2,"score":0.6090612411499023},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5733149647712708},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.5248565673828125},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5033182501792908},{"id":"https://openalex.org/C2781449126","wikidata":"https://www.wikidata.org/wiki/Q288591","display_name":"Alpha-synuclein","level":4,"score":0.4466540515422821},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4276329278945923},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.4183810353279114},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3890019655227661},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3482922315597534},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3470503091812134},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3330264389514923},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.209163635969162},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1635763943195343},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1524195373058319},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08050128817558289},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:escholarship.org/ark:/13030/qt3g84f468","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/3g84f468","pdf_url":"https://escholarship.org/uc/item/3g84f468","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},{"id":"pmh:oai:pqdtoai.proquest.com:1532500","doi":null,"is_oa":false,"landing_page_url":"http://pqdtopen.proquest.com/#viewpdf?dispub=1532500","pdf_url":"http://pqdtopen.proquest.com/#viewpdf?dispub=1532500","source":{"id":"https://openalex.org/S7407064308","display_name":"ProQuest Demo Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},{"id":"mag:95260653","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/content/qt3g84f468/qt3g84f468.pdf?t=mi5l5a","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt3g84f468","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/3g84f468","pdf_url":"https://escholarship.org/uc/item/3g84f468","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W95260653.pdf","grobid_xml":"https://content.openalex.org/works/W95260653.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W1628531043","https://openalex.org/W1659912652","https://openalex.org/W1854322606","https://openalex.org/W1964614233","https://openalex.org/W1968507507","https://openalex.org/W1969800514","https://openalex.org/W1970411347","https://openalex.org/W1971109610","https://openalex.org/W1971513938","https://openalex.org/W1971971409","https://openalex.org/W1973190490","https://openalex.org/W1974270379","https://openalex.org/W1976285635","https://openalex.org/W1976570448","https://openalex.org/W1976892175","https://openalex.org/W1977002760","https://openalex.org/W1978782233","https://openalex.org/W1979265620","https://openalex.org/W1979958665","https://openalex.org/W1982368211","https://openalex.org/W1983907770","https://openalex.org/W1991357897","https://openalex.org/W1992390260","https://openalex.org/W1997145609","https://openalex.org/W1998925734","https://openalex.org/W1999094083","https://openalex.org/W2001720051","https://openalex.org/W2002559713","https://openalex.org/W2008447052","https://openalex.org/W2008517160","https://openalex.org/W2008904589","https://openalex.org/W2011006339","https://openalex.org/W2015005644","https://openalex.org/W2016092552","https://openalex.org/W2016849688","https://openalex.org/W2017314199","https://openalex.org/W2025102246","https://openalex.org/W2026237079","https://openalex.org/W2042062646","https://openalex.org/W2042157082","https://openalex.org/W2045062740","https://openalex.org/W2047382426","https://openalex.org/W2052098570","https://openalex.org/W2052907531","https://openalex.org/W2059124139","https://openalex.org/W2059202612","https://openalex.org/W2062603557","https://openalex.org/W2075107244","https://openalex.org/W2076691349","https://openalex.org/W2080886752","https://openalex.org/W2082372926","https://openalex.org/W2086174102","https://openalex.org/W2090996511","https://openalex.org/W2093855538","https://openalex.org/W2094342029","https://openalex.org/W2103148772","https://openalex.org/W2103553318","https://openalex.org/W2104233676","https://openalex.org/W2111016992","https://openalex.org/W2114413959","https://openalex.org/W2118864481","https://openalex.org/W2122439340","https://openalex.org/W2126516300","https://openalex.org/W2130479394","https://openalex.org/W2132629607","https://openalex.org/W2134967712","https://openalex.org/W2145864424","https://openalex.org/W2147828801","https://openalex.org/W2150406132","https://openalex.org/W2152394246","https://openalex.org/W2154761807","https://openalex.org/W2161062388","https://openalex.org/W2165300068","https://openalex.org/W2167557753","https://openalex.org/W2171938266","https://openalex.org/W2188264700","https://openalex.org/W2320462286","https://openalex.org/W2416200338","https://openalex.org/W2461170331","https://openalex.org/W2506868041"],"related_works":["https://openalex.org/W2114413959","https://openalex.org/W7097769411","https://openalex.org/W2060071458","https://openalex.org/W4313453322","https://openalex.org/W4322587982","https://openalex.org/W4297062289","https://openalex.org/W2094552119","https://openalex.org/W2118219252","https://openalex.org/W2111130857","https://openalex.org/W2753803833"],"abstract_inverted_index":{"Despite":[0],"years":[1],"of":[2,11,56,71,74,80,84,163,186,195,203,302,304,312,327],"research,":[3],"little":[4],"is":[5,34,53],"known":[6,207,283],"about":[7],"the":[8,54,155,160,164,183,218,222,247,260,270,332],"specific":[9],"cause":[10],"Parkinson's":[12],"disease":[13],"(PD),":[14],"though":[15],"genetic":[16],"and":[17,39,82,91,105,120,122,132,140,142,147,170,189,197,220,249,286,290,309,318],"environmental":[18],"factors":[19,40,96],"have":[20,44,59,88,255,321],"been":[21,46,256],"implicated.":[22],"Evidence":[23],"suggests":[24],"that":[25,172,229,235,250,264,334],"microtubule":[26,50,67,103],"disruption":[27,68,104],"may":[28,100,274,336],"be":[29,276,337],"involved;":[30],"however":[31],"this":[32,57],"mechanism":[33],"not":[35,45,268],"yet":[36],"fully":[37],"elucidated,":[38],"implicated":[41,97],"in":[42,98],"PD":[43,64,99,335,349],"conclusively":[47],"related":[48],"to":[49,102,125,201,210,216,226,245,258,267,282,329,343],"function.":[51],"This":[52],"framework":[55],"thesis.We":[58],"expanded":[60],"on":[61,167,182,205],"a":[62,324,348],"suggested":[63],"cascade":[65],"involving":[66],"triggering":[69,347],"oxidization":[70],"dopamine,":[72],"production":[73],"reactive":[75,106],"oxygen":[76,107],"species":[77,108],"(ROS),":[78],"aggregation":[79,303,315],"alpha-synuclein,":[81],"death":[83],"neuronal":[85],"cells.":[86],"We":[87,110,149,262,279,320],"provided":[89,323],"computational":[90],"relational":[92],"evidence":[93,328],"demonstrating":[94],"how":[95],"relate":[101],"(ROS).":[109],"selected":[111],"6":[112],"potentially":[113,156,174,237,275],"PD-related":[114,157,175,238],"compounds:":[115],"rotenone,":[116],"MPTP/MPP+,":[117],"toluene,":[118],"saccharin,":[119],"aspartame,":[121,265],"compared":[123,280],"them":[124],"4":[126],"tubulin":[127,165,168,340],"inhibitors:":[128],"colchicine,":[129],"vinblastine,":[130],"soblidotin,":[131],"taxol;":[133],"identifying":[134],"~62%":[135],"chemical":[136],"similarity":[137,144],"between":[138,145],"rotenone":[139],"colchicine":[141,184],"~78%":[143],"aspartame":[146,190,281],"soblidotin.":[148],"performed":[150],"molecular":[151,291,298],"docking":[152,299],"calculations":[153],"for":[154,243],"compounds":[158,204,213,239],"at":[159],"binding":[161,180,193],"sites":[162],"inhibitors":[166],"dimers":[169],"found":[171],"all":[173,236,251],"molecules":[176],"demonstrated":[177,191,296],"lowest":[178],"(strongest)":[179],"affinities":[181,194,202],"site":[185],"tubulin.":[187],"Rotenone":[188],"significant":[192],"10.7":[196],"-8.7":[198],"kcal/mole,":[199],"comparable":[200,288],"their":[206],"receptors":[208],"(-15.0":[209],"-9.2":[211],"kcal/mole).As":[212],"would":[214],"need":[215],"enter":[217,259,269],"bloodstream":[219,271],"cross":[221,246],"blood-brain":[223],"barrier":[224],"(BBB)":[225],"enact":[227],"damage":[228],"could":[230],"trigger":[231],"PD,":[232],"we":[233,295],"illustrated":[234],"evaluated":[240],"meet":[241],"criteria":[242],"potential":[244],"BBB,":[248],"but":[252],"one":[253],"(aspartame)":[254],"proven":[257],"bloodstream.":[261],"hypothesized":[263],"believed":[266],"after":[272],"digestion,":[273],"absorbed":[277],"sublingually.":[278],"sublingual":[284],"drugs":[285],"noted":[287],"logP":[289],"weight":[292],"values.":[293],"Lastly,":[294],"via":[297],"probable":[300,310],"methods":[301],"alpha":[305],"synuclein":[306],"(\u00e1-syn)":[307],"fibrils":[308],"mechanisms":[311],"two":[313],"\u00e1-syn":[314],"inhibitors,":[316],"curcumin":[317],"geldanamycin.":[319],"thus":[322],"collective":[325],"body":[326],"help":[330],"substantiate":[331],"hypothesis":[333],"triggered":[338],"by":[339],"inhibition":[341],"leading":[342],"excessive":[344],"ROS":[345],"production,":[346],"cascade.":[350]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
