{"id":"https://openalex.org/W952196574","doi":null,"title":"Methodological Considerations in the Study of Leukemia among Genetically and Culturally Heterogeneous Populations","display_name":"Methodological Considerations in the Study of Leukemia among Genetically and Culturally Heterogeneous Populations","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W952196574","mag":"952196574"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt5vw8z1ms","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/5vw8z1ms","pdf_url":"https://escholarship.org/uc/item/5vw8z1ms","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://escholarship.org/uc/item/5vw8z1ms","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113604993","display_name":"Karen Bartley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Karen Bartley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5113604993"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10556","display_name":"Global Cancer Incidence and Screening","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12749","display_name":"Race, Genetics, and Society","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/3314","display_name":"Anthropology"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/childhood-acute-lymphoblastic-leukemia","display_name":"childhood acute lymphoblastic leukemia","score":0.9810000061988831},{"id":"https://openalex.org/keywords/racial-and-ethnic-disparities","display_name":"racial and ethnic disparities","score":0.8949999809265137},{"id":"https://openalex.org/keywords/genetic-ancestry","display_name":"genetic ancestry","score":0.8939999938011169},{"id":"https://openalex.org/keywords/admixed-populations","display_name":"admixed populations","score":0.9779999852180481},{"id":"https://openalex.org/keywords/hispanic-children","display_name":"Hispanic children","score":0.8180000185966492},{"id":"https://openalex.org/keywords/african-american-children","display_name":"African American children","score":0.9879999756813049},{"id":"https://openalex.org/keywords/induction-therapy-response","display_name":"induction therapy response","score":0.7260000109672546},{"id":"https://openalex.org/keywords/b-cell-precursor-acute-lymphoblastic-leukemia","display_name":"B-cell precursor acute lymphoblastic leukemia","score":0.6520000100135803},{"id":"https://openalex.org/keywords/california-cancer-registry","display_name":"California Cancer Registry","score":0.5180000066757202},{"id":"https://openalex.org/keywords/native-americans","display_name":"Native Americans","score":0.7080000042915344}],"concepts":[{"id":"https://openalex.org/C137403100","wikidata":"https://www.wikidata.org/wiki/Q41710","display_name":"Ethnic group","level":2,"score":0.7727741003036499},{"id":"https://openalex.org/C3020641676","wikidata":"https://www.wikidata.org/wiki/Q2065556","display_name":"Pacific islanders","level":3,"score":0.7322397232055664},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.6771219372749329},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.585308313369751},{"id":"https://openalex.org/C76509639","wikidata":"https://www.wikidata.org/wiki/Q918036","display_name":"Race (biology)","level":2,"score":0.5573453903198242},{"id":"https://openalex.org/C2779401946","wikidata":"https://www.wikidata.org/wiki/Q5097982","display_name":"Childhood leukemia","level":4,"score":0.4599025249481201},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.44505253434181213},{"id":"https://openalex.org/C2778527826","wikidata":"https://www.wikidata.org/wiki/Q1787017","display_name":"Cancer registry","level":3,"score":0.4124462604522705},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.3766692578792572},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.2746523916721344},{"id":"https://openalex.org/C2909962599","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic Leukemia","level":3,"score":0.15845727920532227},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.1575096845626831},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.14741498231887817},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07921344041824341},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:escholarship.org/ark:/13030/qt5vw8z1ms","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/5vw8z1ms","pdf_url":"https://escholarship.org/uc/item/5vw8z1ms","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},{"id":"pmh:qt5vw8z1ms","doi":null,"is_oa":true,"landing_page_url":"http://www.escholarship.org/uc/item/5vw8z1ms","pdf_url":"http://www.escholarship.org/uc/item/5vw8z1ms","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bartley, Karen M.(2011). Methodological Considerations in the Study of Leukemia among Genetically and Culturally Heterogeneous Populations. UC Berkeley: Epidemiology. Retrieved from: http://www.escholarship.org/uc/item/5vw8z1ms","raw_type":"dissertation"},{"id":"mag:952196574","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/content/qt5vw8z1ms/qt5vw8z1ms.pdf?t=mtfc0z","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt5vw8z1ms","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/5vw8z1ms","pdf_url":"https://escholarship.org/uc/item/5vw8z1ms","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9907000064849854,"display_name":"Good health and well-being"},{"id":"https://metadata.un.org/sdg/10","score":0.7578999996185303,"display_name":"Reduced inequalities"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W952196574.pdf","grobid_xml":"https://content.openalex.org/works/W952196574.grobid-xml"},"referenced_works_count":172,"referenced_works":["https://openalex.org/W956526754","https://openalex.org/W1496425023","https://openalex.org/W1502896531","https://openalex.org/W1592777209","https://openalex.org/W1841846581","https://openalex.org/W1933996892","https://openalex.org/W1966857245","https://openalex.org/W1969176674","https://openalex.org/W1969493942","https://openalex.org/W1972868749","https://openalex.org/W1973234860","https://openalex.org/W1975210853","https://openalex.org/W1975271432","https://openalex.org/W1976516726","https://openalex.org/W1978518916","https://openalex.org/W1981825846","https://openalex.org/W1981904066","https://openalex.org/W1982303250","https://openalex.org/W1983927959","https://openalex.org/W1984224132","https://openalex.org/W1986915561","https://openalex.org/W1988439198","https://openalex.org/W1989761811","https://openalex.org/W1990088808","https://openalex.org/W1993448054","https://openalex.org/W1993461437","https://openalex.org/W1993525466","https://openalex.org/W1994210005","https://openalex.org/W1995515413","https://openalex.org/W1996437556","https://openalex.org/W1996598661","https://openalex.org/W2000110989","https://openalex.org/W2000278097","https://openalex.org/W2001115778","https://openalex.org/W2002056626","https://openalex.org/W2002395285","https://openalex.org/W2003298782","https://openalex.org/W2005815436","https://openalex.org/W2005955602","https://openalex.org/W2006590644","https://openalex.org/W2006691249","https://openalex.org/W2009144436","https://openalex.org/W2010699409","https://openalex.org/W2013507406","https://openalex.org/W2015307768","https://openalex.org/W2016234895","https://openalex.org/W2021857549","https://openalex.org/W2023496421","https://openalex.org/W2024707024","https://openalex.org/W2025442777","https://openalex.org/W2026949116","https://openalex.org/W2027425522","https://openalex.org/W2027636656","https://openalex.org/W2028552734","https://openalex.org/W2028892759","https://openalex.org/W2030892908","https://openalex.org/W2032761460","https://openalex.org/W2033121166","https://openalex.org/W2033939714","https://openalex.org/W2033973364","https://openalex.org/W2034440918","https://openalex.org/W2035042134","https://openalex.org/W2036383379","https://openalex.org/W2043980214","https://openalex.org/W2047838004","https://openalex.org/W2047923046","https://openalex.org/W2048248559","https://openalex.org/W2049144241","https://openalex.org/W2052239170","https://openalex.org/W2053779282","https://openalex.org/W2055712935","https://openalex.org/W2057801064","https://openalex.org/W2058315001","https://openalex.org/W2058507082","https://openalex.org/W2059158241","https://openalex.org/W2059812486","https://openalex.org/W2060343635","https://openalex.org/W2060529907","https://openalex.org/W2064232302","https://openalex.org/W2064528916","https://openalex.org/W2069960324","https://openalex.org/W2070108329","https://openalex.org/W2073233720","https://openalex.org/W2079559732","https://openalex.org/W2081022290","https://openalex.org/W2081667605","https://openalex.org/W2082043949","https://openalex.org/W2082662990","https://openalex.org/W2082854754","https://openalex.org/W2083896837","https://openalex.org/W2085252646","https://openalex.org/W2085856127","https://openalex.org/W2087842087","https://openalex.org/W2089352857","https://openalex.org/W2090297069","https://openalex.org/W2090880353","https://openalex.org/W2092717929","https://openalex.org/W2093039556","https://openalex.org/W2093293314","https://openalex.org/W2093462075","https://openalex.org/W2093501462","https://openalex.org/W2093922898","https://openalex.org/W2094907095","https://openalex.org/W2096303238","https://openalex.org/W2097006164","https://openalex.org/W2097534278","https://openalex.org/W2098021587","https://openalex.org/W2098418288","https://openalex.org/W2098980155","https://openalex.org/W2099248143","https://openalex.org/W2102926234","https://openalex.org/W2103017569","https://openalex.org/W2103106395","https://openalex.org/W2106002960","https://openalex.org/W2107768525","https://openalex.org/W2109932150","https://openalex.org/W2110624042","https://openalex.org/W2110703115","https://openalex.org/W2112222722","https://openalex.org/W2114243671","https://openalex.org/W2115801316","https://openalex.org/W2116329478","https://openalex.org/W2116782829","https://openalex.org/W2116909092","https://openalex.org/W2118711846","https://openalex.org/W2118753748","https://openalex.org/W2119453878","https://openalex.org/W2120048533","https://openalex.org/W2121240873","https://openalex.org/W2121773128","https://openalex.org/W2122016376","https://openalex.org/W2123184366","https://openalex.org/W2123389407","https://openalex.org/W2127230663","https://openalex.org/W2128008223","https://openalex.org/W2130380437","https://openalex.org/W2130985810","https://openalex.org/W2131122897","https://openalex.org/W2134940265","https://openalex.org/W2136130512","https://openalex.org/W2136344906","https://openalex.org/W2137137328","https://openalex.org/W2137959028","https://openalex.org/W2138632717","https://openalex.org/W2138852053","https://openalex.org/W2141042406","https://openalex.org/W2141561295","https://openalex.org/W2143110890","https://openalex.org/W2145269787","https://openalex.org/W2145462912","https://openalex.org/W2147786371","https://openalex.org/W2148085682","https://openalex.org/W2150536115","https://openalex.org/W2150873076","https://openalex.org/W2151609100","https://openalex.org/W2153981527","https://openalex.org/W2156527932","https://openalex.org/W2158967917","https://openalex.org/W2158987779","https://openalex.org/W2159819284","https://openalex.org/W2160063114","https://openalex.org/W2162816545","https://openalex.org/W2164861020","https://openalex.org/W2165918430","https://openalex.org/W2167350702","https://openalex.org/W2168074442","https://openalex.org/W2169422376","https://openalex.org/W2170365155","https://openalex.org/W2171816696","https://openalex.org/W2185574499","https://openalex.org/W2235142990","https://openalex.org/W2401313193"],"related_works":["https://openalex.org/W2163241626","https://openalex.org/W1541521552","https://openalex.org/W7129007843","https://openalex.org/W4200468492","https://openalex.org/W4210417062","https://openalex.org/W3198278746","https://openalex.org/W6889294409","https://openalex.org/W7043324444","https://openalex.org/W4389259487","https://openalex.org/W4390726567"],"abstract_inverted_index":{"Incidence":[0],"of":[1,31,59,104,120,125,132,212,219,263,301,415,446,463,468,496,502,549,553],"childhood":[2,220],"acute":[3],"lymphoblastic":[4],"leukemia":[5],"(ALL)":[6],"differs":[7],"by":[8,296,357,419,476,534,556],"race":[9,60,127,191,557],"and":[10,14,21,41,61,67,89,128,161,175,205,273,282,304,318,321,342,344,394,473,494,512,551,558],"ethnicity,":[11,297],"with":[12,298,382,398,487],"lowest":[13],"highest":[15],"rates":[16,30],"observed":[17,81,515,545],"among":[18,37,107,130,230,278,312,327,347,380,396],"African":[19,39,87],"American":[20,40],"Latino":[22,42],"children,":[23],"respectively,":[24],"in":[25,63,69,142,190,268,461,516,528,547,563],"the":[26,77,118,133,143,195,202,207,213,217,244,260,269,299,383,413,455,507],"United":[27,214],"States.":[28,215],"Further,":[29,74],"adverse":[32],"treatment":[33,374],"outcomes":[34,475,514],"are":[35,48,485],"higher":[36,229,326,424],"both":[38,310,477],"children.":[43],"Reasons":[44],"for":[45,86,153,172,183,225,359,364,425,525],"these":[46],"disparities":[47],"unclear,":[49],"but":[50,111,168],"may":[51,98,531,560],"be":[52,532,561],"attributable":[53],"to":[54,72,80,112,139,223,233,259,275,335,373,409,412,430,440,544],"factors":[55,200,483],"such":[56,108,564],"as":[57,100,480,482,522],"misclassification":[58,185,226,264],"ethnicity":[62,129,193,358,559],"cancer":[64],"registry":[65],"records":[66],"differences":[68,82,527,546],"early":[70],"response":[71,274,334,372],"treatment.":[73],"information":[75],"regarding":[76],"genetic":[78,96,105,450,471,510,520,529,542],"contribution":[79],"is":[83],"limited,":[84],"particularly":[85],"Americans":[88,174],"Latinos.":[90],"It":[91],"has":[92],"been":[93],"suggested":[94],"that":[95,140,149,484,506,518],"ancestry":[97,451,464,472,511,521],"serve":[99],"an":[101],"alternative":[102],"measure":[103],"risk":[106,302,530],"\"admixed\"":[109],"populations,":[110],"date,":[113],"no":[114,459],"studies":[115,448,517],"have":[116],"reviewed":[117],"validity":[119],"this":[121,503],"approach.":[122],"A":[123],"comparison":[124],"self-reported":[126,478],"participants":[131,164,177,286,381],"California":[134,144],"Childhood":[135],"Leukemia":[136],"Study":[137],"(CCLS)":[138],"reported":[141],"Cancer":[145],"Registry":[146],"(CCR)":[147],"found":[148,458],"agreement":[150],"was":[151,169,187,209,227,248,325,378,422],"good":[152],"Asian":[154],"/":[155],"Pacific":[156],"Islander":[157],"(API),":[158],"Black,":[159],"Hispanic/Latino,":[160],"White":[162,267],"CCLS":[163,285],"(kappa":[165,178],">":[166],"0.7),":[167],"comparatively":[170],"poor":[171],"Native":[173],"multiracial":[176],"<0.2).":[179],"The":[180,500],"main":[181],"predictor":[182],"ethnic":[184,369],"identified":[186,453],"a":[188,444,523,540],"difference":[189],"and/or":[192],"between":[194,470,509],"child's":[196],"parents.":[197],"Other":[198],"contributing":[199],"include":[201],"father's":[203],"education":[204],"whether":[206],"mother":[208],"born":[210],"outside":[211],"Though":[216],"rate":[218],"ALL":[221,362],"prior":[222],"adjustment":[224,247],"significantly":[228],"Hispanics/Latinos":[231,431],"compared":[232,429],"non-Hispanic":[234,266,280,283,313,328,427],"whites":[235],"(risk":[236],"ratio":[237,245],"=":[238,241,252,255,316,331,387,391,402,407,433,438],"1.21":[239],"95%CI":[240,254],"1.09,":[242],"1.36),":[243],"after":[246],"even":[249],"greater":[250,379],"(RR":[251],"1.57,":[253],"1.40,":[256],"1.75)":[257],"due":[258],"prevailing":[261],"directionality":[262],"toward":[265],"CCR.":[270],"Baseline":[271],"characteristics":[272,290],"induction":[276],"therapy":[277],"Latino,":[279],"White,":[281],"non-White":[284],"were":[287,309,498],"assessed.":[288],"Clinical":[289],"at":[291,306,339,351,375],"diagnosis":[292],"did":[293,354],"not":[294,349,355],"differ":[295,356],"exception":[300],"level":[303,323],"age":[305],"diagnosis,":[307],"which":[308,324],"lower":[311,395],"Whites":[314,329,428],"(p-values":[315],"0.05":[317],"0.04,":[319],"respectively),":[320],"platelet":[322],"(p-value":[330],"0.04).":[332],"Overall":[333],"treatment,":[336],"proportion":[337],"responding":[338,350],"days":[340],"8":[341,353,377,421],"15,":[343],"blast":[345],"counts":[346],"those":[348,397],"day":[352,376,420],"pre-B":[360],"cell":[361],"or":[363,536],"any":[365],"subgroups.":[366],"For":[367],"all":[368],"groups":[370],"combined,":[371],"ETV6-RUNX1":[384],"translocation":[385],"(difference":[386,401,432],"7.6%,":[388],"95%":[389,405,436],"CI":[390,406,437],"-2.6":[392],"to17.0%),":[393],"high":[399],"hyperdiploidy":[400],"-15.0":[403],"%,":[404,435],"-27.0":[408],"-3.6%),":[410],"similar":[411],"findings":[414,501],"previous":[416],"studies.":[417,565],"Response":[418],"substantially":[423],"high-risk":[426],"25.0":[434],"-1.4":[439],"50.0":[441],"%).":[442],"Finally,":[443],"review":[445,504],"39":[447],"using":[449],"markers":[452],"through":[454],"Pubmed":[456],"database":[457],"trends":[460],"error":[462],"estimation.":[465],"Substantial":[466],"confounding":[467],"associations":[469,508],"disease":[474,513,550],"race,":[479,488],"well":[481],"associated":[486],"including":[489],"socioeconomic":[490],"status,":[491],"racial":[492],"discrimination,":[493],"place":[495],"residence,":[497],"observed.":[499],"suggest":[505],"utilize":[519],"proxy":[524],"continental":[526],"confounded":[533],"social":[535],"environmental":[537],"factors.":[538],"As":[539],"result,":[541],"contributions":[543],"incidence":[548],"frequency":[552],"health":[554],"measures":[555],"overestimated":[562]},"counts_by_year":[],"updated_date":"2026-09-01T08:31:24.195828","created_date":"2016-06-24T00:00:00"}