{"id":"https://openalex.org/W950591772","doi":null,"title":"Wnt5a \u4fee\u9970\u7684bMSCs \u5bf9\u767d\u8840\u75c5\u5c0f\u9f20\u9020\u8840\u53ca\u767d\u8840\u75c5\u7ec6\u80de\u751f\u957f\u7684\u5f71\u54cd","display_name":"Wnt5a \u4fee\u9970\u7684bMSCs \u5bf9\u767d\u8840\u75c5\u5c0f\u9f20\u9020\u8840\u53ca\u767d\u8840\u75c5\u7ec6\u80de\u751f\u957f\u7684\u5f71\u54cd","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W950591772","mag":"950591772"},"language":"zh","primary_location":{"id":"mag:950591772","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/90003X/201114/38689407.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306542213","display_name":"\u4e2d\u56fd\u80bf\u7624\u4e34\u5e8a","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u56fd\u80bf\u7624\u4e34\u5e8a","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024173582","display_name":"\u6c88\u4e9a\u8389","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u6c88\u4e9a\u8389","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021462888","display_name":"\u5f90\u9149\u534e","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u5f90\u9149\u534e","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5078321980","display_name":"\u987e\u6653\u8273","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u987e\u6653\u8273","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.05489609,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"38","issue":"14","first_page":"811","last_page":"816"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.7250999808311462,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.7250999808311462,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.2386000007390976,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.01850000023841858,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wnt5a","display_name":"Wnt5a","score":0.9980000257492065},{"id":"https://openalex.org/keywords/bone-marrow-mesenchymal-stem-cells","display_name":"bone marrow mesenchymal stem cells","score":0.9900000095367432},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9900000095367432},{"id":"https://openalex.org/keywords/genetically-modified-stem-cells","display_name":"gene-modified stem cells","score":0.7689999938011169},{"id":"https://openalex.org/keywords/hematopoiesis","display_name":"hematopoiesis","score":0.859000027179718},{"id":"https://openalex.org/keywords/leukemia-cell-growth-inhibition","display_name":"leukemia cell growth inhibition","score":0.8679999709129333},{"id":"https://openalex.org/keywords/scid-mouse-model","display_name":"SCID mouse model","score":0.7210000157356262},{"id":"https://openalex.org/keywords/hl-60-cells","display_name":"HL-60 cells","score":0.6809999942779541},{"id":"https://openalex.org/keywords/cfu-mix","display_name":"CFU-Mix","score":0.722000002861023},{"id":"https://openalex.org/keywords/cd33","display_name":"CD33","score":0.578000009059906},{"id":"https://openalex.org/keywords/transfection-efficiency","display_name":"transfection efficiency","score":0.4560000002384186},{"id":"https://openalex.org/keywords/adoptive-immunotherapy","display_name":"adoptive immunotherapy","score":0.46799999475479126}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4242384433746338}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:950591772","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/90003X/201114/38689407.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306542213","display_name":"\u4e2d\u56fd\u80bf\u7624\u4e34\u5e8a","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u56fd\u80bf\u7624\u4e34\u5e8a","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2391303810","https://openalex.org/W2106377435","https://openalex.org/W909166757","https://openalex.org/W3213805606","https://openalex.org/W842271228","https://openalex.org/W2747921809","https://openalex.org/W2317830195","https://openalex.org/W2583694029","https://openalex.org/W2354826229","https://openalex.org/W4380423299"],"abstract_inverted_index":{"\u76ee\u7684\uff1a\u63a2\u8ba8Wnt5a\u57fa\u56e0\u4fee\u9970\u7684\u9aa8\u9ad3\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08bMSCs\uff09\u5bf9\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u5c0f\u9f20\u4f53\u5185\u9020\u8840\u548c\u767d\u8840\u75c5\u7ec6\u80de\u751f\u957f\u7684\u5f71\u54cd.\u65b9\u6cd5\uff1a\u5916\u5468\u8840\u745e\u6c0f\u67d3\u8272\u3001\u9aa8\u9ad3\u6d41\u5f0f\u7ec6\u80de\u4eea\u9274\u5b9a\u79fb\u690d\u6027HL60\u4eba\u767d\u8840\u75c5\u91cd\u5ea6\u8054\u5408\u514d\u75ab\u7f3a\u9677\uff08SCID\uff09\u5c0f\u9f20\u6a21\u578b.\u9020\u6a21\u6210\u529f\u7684SCID\u5c0f\u9f20,\u968f\u673a\u5206\u4e3a\u5b9e\u9a8c\u7ec4\uff08A\u7ec4\uff1aAd5-Wnt5a-bMSCs\uff0b\u6a21\u578b\u5c0f\u9f20\uff09;\u5bf9\u7167\u7ec4\uff08B\u7ec4\uff1aAd5-GFP-bMSC\uff0b\u6a21\u578b\u5c0f\u9f20;C\u7ec4\uff1abMSC\uff0b\u6a21\u578b\u5c0f\u9f20;D\u7ec4\uff1a\u6a21\u578b\u5c0f\u9f20\uff09.RT-PCR\u68c0\u6d4b\u5916\u6e90\u6027Wnt5a\u57fa\u56e0\u7ecf\u9aa8\u9ad3\u8154\u79fb\u690d\u5165\u767d\u8840\u75c5\u5c0f\u9f20\u6a21\u578b\u540e\u7684\u5b9a\u690d\u60c5\u51b5.\u9aa8\u9ad3MSC\u53caCFU-Mix\u57f9\u517b\u3001\u6d41\u5f0f\u7ec6\u80de\u4eea\u3001\u7ec4\u7ec7\u7ec6\u80de\u5316\u5b66\u53ca\u7ec4\u7ec7\u75c5\u7406\u68c0\u6d4b\u767d\u8840\u75c5\u5c0f\u9f20\u79fb\u690d\u524d\u540e\u5404\u7ec4\u5916\u5468\u8840\u3001\u9aa8\u9ad3\u3001\u809d\u3001\u813e\u3001\u80be\u4e2d\u7684\u767d\u8840\u75c5\u7ec6\u80de\u4ee5\u53ca\u9aa8\u9ad3\u9020\u8840\u7684\u53d8\u5316.\u7ed3\u679c\uff1a\u6210\u529f\u5efa\u7acb\u6025\u6027\u9ad3\u6027\u767d\u8840\u75c5\u6a21\u578b;\u5916\u6e90\u6027Wnt5a\u57fa\u56e0\u8f6c\u67d3\u4ebabMSCs,\u8f6c\u67d3\u7387\u8fbe37.38%.\u5916\u6e90\u6027Wnt5a\u57fa\u56e0\u6210\u529f\u5b9a\u690d\u4e8e\u53d7\u4f53\u9aa8\u9ad3\u4e2d.Wnt5a\u57fa\u56e0\u4fee\u9970bMSCs\u79fb\u690d\u540e,\u4e0e\u5bf9\u7167\u7ec4\u6bd4\u8f83,\u5b9e\u9a8c\u7ec4SCID\u5c0f\u9f20\u751f\u5b58\u7387\u660e\u663e\u63d0\u9ad8,\u5dee\u5f02\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\uff08P\uff1c0.05\uff09;\u5916\u5468\u8840\u6709\u6838\u7ec6\u80de\u53ca\u7624\u7ec6\u80de\u8ba1\u6570\u660e\u663e\u964d\u4f4e,\u5dee\u5f02\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\uff08P\uff1c0.05\uff09;CFU-Mix\u548cMSC\u96c6\u843d\u751f\u957f\u6062\u590d\u8f83\u5feb,\u96c6\u843d\u6570\u660e\u663e\u589e\u591a,\u5dee\u5f02\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\uff08P\uff1c0.05\uff09;\u5c0f\u9f20\u9aa8\u9ad3\u3001\u80ba\u3001\u809d\u3001\u813e\u3001\u80beCD33\u9633\u6027\u7387\u660e\u663e\u964d\u4f4e,\u5dee\u5f02\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\uff08P\uff1c0.05\uff09.\u7ed3\u8bba\uff1aWnt5a\u57fa\u56e0\u4fee\u9970\u7684bMSCs\u5728\u4f53\u5185\u80fd\u6709\u6548\u5730\u6291\u5236\u767d\u8840\u75c5\u7ec6\u80de\u751f\u957f,\u652f\u6301\u9aa8\u9ad3\u9020\u8840.":[0]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}