{"id":"https://openalex.org/W94914740","doi":null,"title":"Iron Acquisition by Uropathogenic Escherichia coli: ChuA and Hma Heme Receptors as Virulence Determinants and Vaccine Targets.","display_name":"Iron Acquisition by Uropathogenic Escherichia coli: ChuA and Hma Heme Receptors as Virulence Determinants and Vaccine Targets.","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W94914740","mag":"94914740"},"language":"en","primary_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/63718","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/63718","pdf_url":"https://hdl.handle.net/2027.42/63718","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/2027.42/63718","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067030381","display_name":"Erin C. Hagan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Erin C. Hagan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5067030381"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.007499999832361937,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uropathogenic-escherichia-coli","display_name":"uropathogenic Escherichia coli","score":0.9599999785423279},{"id":"https://openalex.org/keywords/iron-acquisition","display_name":"iron acquisition","score":0.9340000152587891},{"id":"https://openalex.org/keywords/heme-acquisition","display_name":"heme acquisition","score":0.7710000276565552},{"id":"https://openalex.org/keywords/chua","display_name":"chuA","score":0.8399999737739563},{"id":"https://openalex.org/keywords/hma","display_name":"HMA","score":0.7979999780654907},{"id":"https://openalex.org/keywords/tonb-dependent-receptors","display_name":"TonB-dependent receptors","score":0.9380000233650208},{"id":"https://openalex.org/keywords/siderophore-receptors","display_name":"siderophore receptors","score":0.8460000157356262},{"id":"https://openalex.org/keywords/iuta","display_name":"iutA","score":0.671999990940094},{"id":"https://openalex.org/keywords/outer-membrane-proteins","display_name":"outer membrane proteins","score":0.8399999737739563},{"id":"https://openalex.org/keywords/urinary-tract-infection","display_name":"urinary tract infection","score":0.8790000081062317},{"id":"https://openalex.org/keywords/vaccine-targets","display_name":"vaccine targets","score":0.7950000166893005},{"id":"https://openalex.org/keywords/immunoproteomics","display_name":"immunoproteomics","score":0.8489999771118164},{"id":"https://openalex.org/keywords/intranasal-immunization","display_name":"intranasal immunization","score":0.8460000157356262},{"id":"https://openalex.org/keywords/virulence-factors","display_name":"virulence factors","score":0.7829999923706055}],"concepts":[{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.7567524313926697},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.6141754984855652},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5633050203323364},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.43623054027557373},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.42711853981018066},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3619680404663086},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3586219549179077},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.32620522379875183},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23770412802696228},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18932867050170898},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11116880178451538}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/63718","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/63718","pdf_url":"https://hdl.handle.net/2027.42/63718","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.910.4649","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.910.4649","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://deepblue.lib.umich.edu/bitstream/handle/2027.42/63718/hagane_1.pdf%3Bjsessionid%3D0995A5204EFBB1CCC645A95F4734E7D5?sequence%3D1","raw_type":"text"},{"id":"mag:94914740","doi":null,"is_oa":false,"landing_page_url":"http://deepblue.lib.umich.edu/handle/2027.42/63718","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/63718","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2027.42/63718","pdf_url":"https://hdl.handle.net/2027.42/63718","source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W94914740.pdf","grobid_xml":"https://content.openalex.org/works/W94914740.grobid-xml"},"referenced_works_count":196,"referenced_works":["https://openalex.org/W163411833","https://openalex.org/W1488537544","https://openalex.org/W1538795905","https://openalex.org/W1546174188","https://openalex.org/W1548038775","https://openalex.org/W1556405345","https://openalex.org/W1566515137","https://openalex.org/W1578241902","https://openalex.org/W1593385374","https://openalex.org/W1600173007","https://openalex.org/W1619896608","https://openalex.org/W1666110846","https://openalex.org/W1792460127","https://openalex.org/W1807500802","https://openalex.org/W1849515690","https://openalex.org/W1854179685","https://openalex.org/W1869191601","https://openalex.org/W1870707005","https://openalex.org/W1872504890","https://openalex.org/W1881630408","https://openalex.org/W1890589065","https://openalex.org/W1901972977","https://openalex.org/W1906639127","https://openalex.org/W1907864415","https://openalex.org/W1913820841","https://openalex.org/W1917705354","https://openalex.org/W1963676019","https://openalex.org/W1965600386","https://openalex.org/W1965829665","https://openalex.org/W1969529960","https://openalex.org/W1972623506","https://openalex.org/W1972759891","https://openalex.org/W1972987983","https://openalex.org/W1973734543","https://openalex.org/W1974311793","https://openalex.org/W1975793951","https://openalex.org/W1980273234","https://openalex.org/W1985395817","https://openalex.org/W1992057102","https://openalex.org/W1994246342","https://openalex.org/W1999344743","https://openalex.org/W1999823179","https://openalex.org/W2000282637","https://openalex.org/W2001643087","https://openalex.org/W2001932212","https://openalex.org/W2002232188","https://openalex.org/W2004200553","https://openalex.org/W2006580038","https://openalex.org/W2009181053","https://openalex.org/W2011711317","https://openalex.org/W2015342296","https://openalex.org/W2018549431","https://openalex.org/W2019875425","https://openalex.org/W2019912196","https://openalex.org/W2021277836","https://openalex.org/W2022242615","https://openalex.org/W2022548242","https://openalex.org/W2025437109","https://openalex.org/W2026856977","https://openalex.org/W2028585341","https://openalex.org/W2029972223","https://openalex.org/W2030015794","https://openalex.org/W2031833328","https://openalex.org/W2034048814","https://openalex.org/W2035271197","https://openalex.org/W2036083275","https://openalex.org/W2036124167","https://openalex.org/W2036301066","https://openalex.org/W2037656756","https://openalex.org/W2039577100","https://openalex.org/W2039722695","https://openalex.org/W2042556618","https://openalex.org/W2043010220","https://openalex.org/W2043947029","https://openalex.org/W2052112559","https://openalex.org/W2053138162","https://openalex.org/W2056929310","https://openalex.org/W2057515702","https://openalex.org/W2059787437","https://openalex.org/W2061379882","https://openalex.org/W2062199244","https://openalex.org/W2065325129","https://openalex.org/W2070929893","https://openalex.org/W2074692187","https://openalex.org/W2075598670","https://openalex.org/W2076069260","https://openalex.org/W2077960312","https://openalex.org/W2079785911","https://openalex.org/W2082345749","https://openalex.org/W2082436823","https://openalex.org/W2084608838","https://openalex.org/W2087285822","https://openalex.org/W2091804239","https://openalex.org/W2092591554","https://openalex.org/W2094621349","https://openalex.org/W2094940364","https://openalex.org/W2096642494","https://openalex.org/W2098536639","https://openalex.org/W2100118286","https://openalex.org/W2100297933","https://openalex.org/W2103678964","https://openalex.org/W2104845311","https://openalex.org/W2104893055","https://openalex.org/W2105022650","https://openalex.org/W2107533276","https://openalex.org/W2108503897","https://openalex.org/W2109359144","https://openalex.org/W2110830984","https://openalex.org/W2110974151","https://openalex.org/W2111200149","https://openalex.org/W2111683372","https://openalex.org/W2112100803","https://openalex.org/W2112264573","https://openalex.org/W2113038756","https://openalex.org/W2115422910","https://openalex.org/W2115511385","https://openalex.org/W2116137883","https://openalex.org/W2116910915","https://openalex.org/W2118051267","https://openalex.org/W2118307978","https://openalex.org/W2119158447","https://openalex.org/W2119692320","https://openalex.org/W2120030078","https://openalex.org/W2120921897","https://openalex.org/W2121354549","https://openalex.org/W2121491059","https://openalex.org/W2121793978","https://openalex.org/W2123827367","https://openalex.org/W2124550409","https://openalex.org/W2124672930","https://openalex.org/W2124772160","https://openalex.org/W2125018422","https://openalex.org/W2125193767","https://openalex.org/W2126130975","https://openalex.org/W2126180048","https://openalex.org/W2127146104","https://openalex.org/W2127789620","https://openalex.org/W2129026971","https://openalex.org/W2129742068","https://openalex.org/W2130630244","https://openalex.org/W2131105067","https://openalex.org/W2131282911","https://openalex.org/W2131631054","https://openalex.org/W2132387397","https://openalex.org/W2133676365","https://openalex.org/W2134153749","https://openalex.org/W2134423611","https://openalex.org/W2135935394","https://openalex.org/W2137147102","https://openalex.org/W2137789272","https://openalex.org/W2139356838","https://openalex.org/W2139380457","https://openalex.org/W2141292721","https://openalex.org/W2141484353","https://openalex.org/W2141703773","https://openalex.org/W2142717815","https://openalex.org/W2143610158","https://openalex.org/W2144098483","https://openalex.org/W2144498842","https://openalex.org/W2148800629","https://openalex.org/W2149414511","https://openalex.org/W2150508126","https://openalex.org/W2151251464","https://openalex.org/W2152881784","https://openalex.org/W2153139855","https://openalex.org/W2154070326","https://openalex.org/W2154075906","https://openalex.org/W2154133823","https://openalex.org/W2155179086","https://openalex.org/W2157117327","https://openalex.org/W2158218459","https://openalex.org/W2158921730","https://openalex.org/W2159153498","https://openalex.org/W2160529598","https://openalex.org/W2160954897","https://openalex.org/W2162749433","https://openalex.org/W2163298956","https://openalex.org/W2163671891","https://openalex.org/W2163764373","https://openalex.org/W2164563191","https://openalex.org/W2164648927","https://openalex.org/W2164785842","https://openalex.org/W2165222007","https://openalex.org/W2166935715","https://openalex.org/W2166979496","https://openalex.org/W2168517557","https://openalex.org/W2168676208","https://openalex.org/W2169286099","https://openalex.org/W2169478013","https://openalex.org/W2171651950","https://openalex.org/W2172286252","https://openalex.org/W2223001592","https://openalex.org/W2339176981","https://openalex.org/W2409109169","https://openalex.org/W2462118641","https://openalex.org/W3142072044"],"related_works":["https://openalex.org/W4406865969","https://openalex.org/W2137813404","https://openalex.org/W7099064595","https://openalex.org/W2136361919","https://openalex.org/W2152359855","https://openalex.org/W2136296923","https://openalex.org/W2059801322","https://openalex.org/W2550045509","https://openalex.org/W2059111761","https://openalex.org/W2104845311"],"abstract_inverted_index":{"In":[0],"Gram":[1,264],"negative":[2,265],"bacteria,":[3],"specific":[4,55,278],"outer":[5,97,245],"membrane":[6,98,246],"receptors":[7,38,137,187,280],"facilitate":[8],"the":[9,23,47,52,109,122,135,150,170,215,221,227,241,274,283,292],"import":[10],"of":[11,26,36,54,57,112,210,223,229,243,277,285],"iron-chelating":[12],"siderophores":[13],"and":[14,117,162,188,217,251,281],"iron":[15,59,118,211,231,254,286],"from":[16,45,144,158],"host":[17,58],"organisms.":[18],"Uropathogenic":[19],"Escherichia":[20],"coli":[21],"(UPEC),":[22],"predominant":[24],"cause":[25],"uncomplicated":[27],"urinary":[28,49],"tract":[29],"infection":[30],"(UTI),":[31],"utilizes":[32],"a":[33,176,193,238],"wide":[34],"array":[35],"these":[37,113],"to":[39,64,94,167],"acquire":[40],"iron,":[41],"an":[42,88,102,207,244],"essential":[43,208],"nutrient,":[44],"within":[46,226,291],"iron-limited":[48],"tract.":[50],"However,":[51],"contributions":[53,276],"sources":[56],"remain":[60],"unknown.":[61],"Furthermore,":[62,267],"efforts":[63],"induce":[65],"protective":[66],"immunity":[67],"against":[68,149,249],"UPEC":[69,145,213,250,279],"by":[70],"targeting":[71],"known":[72,185],"virulence":[73],"determinants":[74],"have":[75],"been":[76],"largely":[77],"unsuccessful,":[78],"suggesting":[79],"that":[80,100,169,204,253],"novel":[81,271],"targets":[82,261],"are":[83],"required.":[84],"To":[85],"address":[86],"this,":[87],"immunoproteomics":[89],"approach":[90],"was":[91],"used":[92,166],"here":[93,236],"identify":[95],"23":[96],"proteins":[99],"elicited":[101],"immune":[103],"response":[104],"during":[105],"murine":[106],"UTI.":[107,159],"Among":[108],"most":[110],"prevalent":[111],"were":[114,165],"TonB-dependent":[115,177],"siderophore":[116,136],"compound":[119],"receptors,":[120],"including":[121],"putative":[123,259],"receptor":[124,152,255],"c2482":[125],"(heme":[126],"acquisition":[127,225,287],"protein,":[128],"Hma).":[129],"Intranasal":[130],"immunization":[131],"with":[132,184],"Hma":[133,173,180],"or":[134,139],"IreA":[138],"IutA":[140],"significantly":[141],"protected":[142],"mice":[143],"challenge,":[146],"while":[147],"vaccination":[148],"heme":[151,178,186,199,205,224],"ChuA":[153],"did":[154],"not":[155],"confer":[156],"protection":[157],"Additionally,":[160],"genetic":[161],"biochemical":[163],"approaches":[164],"demonstrate":[168],"vaccine":[171,248,260],"candidate":[172],"functions":[174],"as":[175],"receptor.":[179],"shares":[181],"limited":[182],"homology":[183],"our":[189],"structure-function":[190],"studies":[191],"identified":[192],"unique":[194],"residue":[195],"required":[196],"for":[197,212,220,240,288],"Hma-mediated":[198],"utilization.":[200],"We":[201],"further":[202],"establish":[203],"is":[206],"source":[209],"in":[214,262],"kidney":[216],"present":[218],"evidence":[219],"importance":[222],"context":[228],"siderophore-mediated":[230],"uptake.":[232],"The":[233],"findings":[234],"presented":[235],"provide":[237],"foundation":[239],"development":[242],"protein-based":[247],"suggest":[252],"antigens":[256],"may":[257],"represent":[258],"other":[263],"bacteria.":[266],"this":[268],"work":[269],"offers":[270],"insight":[272],"into":[273],"distinct":[275],"highlights":[282],"necessity":[284],"bacterial":[289],"survival":[290],"mammalian":[293],"host.":[294]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":2}],"updated_date":"2026-08-29T07:29:34.045763","created_date":"2016-06-24T00:00:00"}