{"id":"https://openalex.org/W94861547","doi":"https://doi.org/10.1016/s0022-5223(19)36724-8","title":"Comparison of two levels of anticoagulant therapy in patients with substitute heart valves","display_name":"Comparison of two levels of anticoagulant therapy in patients with substitute heart valves","publication_year":1991,"publication_date":"1991-03-01","ids":{"openalex":"https://openalex.org/W94861547","doi":"https://doi.org/10.1016/s0022-5223(19)36724-8","mag":"94861547","pmid":"https://pubmed.ncbi.nlm.nih.gov/1999935"},"language":"en","primary_location":{"id":"doi:10.1016/s0022-5223(19)36724-8","doi":"https://doi.org/10.1016/s0022-5223(19)36724-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0022-5223(19)36724-8","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0022522319367248/pdf","source":{"id":"https://openalex.org/S127437062","display_name":"Journal of Thoracic and Cardiovascular Surgery","issn_l":"0022-5223","issn":["0022-5223","1085-8687","1097-685X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Thoracic and Cardiovascular Surgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.sciencedirect.com/science/article/pii/S0022522319367248/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111882344","display_name":"Ra\u00fal Altman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154782","display_name":"Favaloro Foundation","ror":"https://ror.org/053f3rt53","country_code":"AR","type":"facility","lineage":["https://openalex.org/I4210154782"]}],"countries":["AR"],"is_corresponding":true,"raw_author_name":"Raul Altman","raw_affiliation_strings":["Fundacion Favaloro and Centro de Estudios Medicos y Bioquimicos Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fundacion Favaloro and Centro de Estudios Medicos y Bioquimicos Buenos Aires, Argentina","institution_ids":["https://openalex.org/I4210154782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054933132","display_name":"Jorge Rouvier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154782","display_name":"Favaloro Foundation","ror":"https://ror.org/053f3rt53","country_code":"AR","type":"facility","lineage":["https://openalex.org/I4210154782"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Jorge Rouvier","raw_affiliation_strings":["Fundacion Favaloro and Centro de Estudios Medicos y Bioquimicos Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fundacion Favaloro and Centro de Estudios Medicos y Bioquimicos Buenos Aires, Argentina","institution_ids":["https://openalex.org/I4210154782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080382536","display_name":"Enrique Gurfinkel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154782","display_name":"Favaloro Foundation","ror":"https://ror.org/053f3rt53","country_code":"AR","type":"facility","lineage":["https://openalex.org/I4210154782"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Enrique Gurfinkel","raw_affiliation_strings":["Fundacion Favaloro and Centro de Estudios Medicos y Bioquimicos Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fundacion Favaloro and Centro de Estudios Medicos y Bioquimicos Buenos Aires, Argentina","institution_ids":["https://openalex.org/I4210154782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5097741898","display_name":"Oscar D\u2019Ortencio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154782","display_name":"Favaloro Foundation","ror":"https://ror.org/053f3rt53","country_code":"AR","type":"facility","lineage":["https://openalex.org/I4210154782"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Oscar D\u2019Ortencio","raw_affiliation_strings":["Fundacion Favaloro and Centro de Estudios Medicos y Bioquimicos Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fundacion Favaloro and Centro de Estudios Medicos y Bioquimicos Buenos Aires, Argentina","institution_ids":["https://openalex.org/I4210154782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5097768771","display_name":"Raul Manzanel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154782","display_name":"Favaloro Foundation","ror":"https://ror.org/053f3rt53","country_code":"AR","type":"facility","lineage":["https://openalex.org/I4210154782"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Raul Manzanel","raw_affiliation_strings":["Fundacion Favaloro and Centro de Estudios Medicos y Bioquimicos Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fundacion Favaloro and Centro de Estudios Medicos y Bioquimicos Buenos Aires, Argentina","institution_ids":["https://openalex.org/I4210154782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101717609","display_name":"Luis de la Fuente","orcid":"https://orcid.org/0000-0003-0845-4691","observed_orcids":["https://orcid.org/0000-0003-0845-4691"]},"institutions":[{"id":"https://openalex.org/I4210154782","display_name":"Favaloro Foundation","ror":"https://ror.org/053f3rt53","country_code":"AR","type":"facility","lineage":["https://openalex.org/I4210154782"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Luis de La Fuente","raw_affiliation_strings":["Fundacion Favaloro and Centro de Estudios Medicos y Bioquimicos Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fundacion Favaloro and Centro de Estudios Medicos y Bioquimicos Buenos Aires, Argentina","institution_ids":["https://openalex.org/I4210154782"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111364036","display_name":"Ren\u00e9 G. Favaloro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210154782","display_name":"Favaloro Foundation","ror":"https://ror.org/053f3rt53","country_code":"AR","type":"facility","lineage":["https://openalex.org/I4210154782"]}],"countries":["AR"],"is_corresponding":false,"raw_author_name":"Ren\u00e9 G. Favaloro","raw_affiliation_strings":["Fundacion Favaloro and Centro de Estudios Medicos y Bioquimicos Buenos Aires, Argentina"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fundacion Favaloro and Centro de Estudios Medicos y Bioquimicos Buenos Aires, Argentina","institution_ids":["https://openalex.org/I4210154782"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111882344"],"corresponding_institution_ids":["https://openalex.org/I4210154782"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":16.6177,"has_fulltext":true,"cited_by_count":227,"citation_normalized_percentile":{"value":0.99474613,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"101","issue":"3","first_page":"427","last_page":"431"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9032999873161316,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9032999873161316,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.05920000001788139,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11551","display_name":"Infective Endocarditis Diagnosis and Management","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mechanical-heart-valves","display_name":"mechanical heart valves","score":0.7300000190734863},{"id":"https://openalex.org/keywords/anticoagulation","display_name":"anticoagulation","score":0.8019999861717224},{"id":"https://openalex.org/keywords/acenocoumarol","display_name":"acenocoumarol","score":0.949999988079071},{"id":"https://openalex.org/keywords/international-normalized-ratio","display_name":"international normalized ratio","score":0.8339999914169312},{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.7940000295639038},{"id":"https://openalex.org/keywords/dipyridamole","display_name":"dipyridamole","score":0.9990000128746033},{"id":"https://openalex.org/keywords/thromboembolism","display_name":"thromboembolism","score":0.8450000286102295},{"id":"https://openalex.org/keywords/bleeding-complications","display_name":"bleeding complications","score":0.9440000057220459},{"id":"https://openalex.org/keywords/transient-ischemic-attack","display_name":"transient ischemic attack","score":0.7829999923706055},{"id":"https://openalex.org/keywords/antiplatelet-drugs","display_name":"antiplatelet agents","score":0.6800000071525574},{"id":"https://openalex.org/keywords/anticoagulation-target-range","display_name":"anticoagulation target range","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9829092621803284},{"id":"https://openalex.org/C2781344064","wikidata":"https://www.wikidata.org/wiki/Q304088","display_name":"Acenocoumarol","level":4,"score":0.9255342483520508},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.5956230163574219},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5944243669509888},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5230844020843506},{"id":"https://openalex.org/C2778205648","wikidata":"https://www.wikidata.org/wiki/Q215118","display_name":"Anticoagulant","level":2,"score":0.4845925569534302},{"id":"https://openalex.org/C2777785397","wikidata":"https://www.wikidata.org/wiki/Q492194","display_name":"Group B","level":2,"score":0.47133755683898926},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.4281073212623596},{"id":"https://openalex.org/C2776890861","wikidata":"https://www.wikidata.org/wiki/Q419374","display_name":"Dipyridamole","level":2,"score":0.41806966066360474},{"id":"https://openalex.org/C2776301958","wikidata":"https://www.wikidata.org/wiki/Q407431","display_name":"Warfarin","level":3,"score":0.382155179977417},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.37894222140312195},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29757559299468994},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000074","descriptor_name":"Acenocoumarol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000074","descriptor_name":"Acenocoumarol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004176","descriptor_name":"Dipyridamole","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004176","descriptor_name":"Dipyridamole","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006350","descriptor_name":"Heart Valve Prosthesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013923","descriptor_name":"Thromboembolism","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0022-5223(19)36724-8","doi":"https://doi.org/10.1016/s0022-5223(19)36724-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0022-5223(19)36724-8","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0022522319367248/pdf","source":{"id":"https://openalex.org/S127437062","display_name":"Journal of Thoracic and Cardiovascular Surgery","issn_l":"0022-5223","issn":["0022-5223","1085-8687","1097-685X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Thoracic and Cardiovascular Surgery","raw_type":"journal-article"},{"id":"pmid:1999935","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1999935","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of thoracic and cardiovascular surgery","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"doi:10.1016/s0022-5223(19)36724-8","doi":"https://doi.org/10.1016/s0022-5223(19)36724-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0022-5223(19)36724-8","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0022522319367248/pdf","source":{"id":"https://openalex.org/S127437062","display_name":"Journal of Thoracic and Cardiovascular Surgery","issn_l":"0022-5223","issn":["0022-5223","1085-8687","1097-685X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Thoracic and Cardiovascular Surgery","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W94861547.pdf","grobid_xml":"https://content.openalex.org/works/W94861547.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1260428","https://openalex.org/W218347484","https://openalex.org/W1978309666","https://openalex.org/W1980494982","https://openalex.org/W1981746689","https://openalex.org/W1985488791","https://openalex.org/W1992377235","https://openalex.org/W1998675994","https://openalex.org/W2002482714","https://openalex.org/W2054527133","https://openalex.org/W2056095258","https://openalex.org/W2088385715","https://openalex.org/W2166458827","https://openalex.org/W2335962144","https://openalex.org/W2339792503","https://openalex.org/W2399567456","https://openalex.org/W2399945057","https://openalex.org/W2402594068","https://openalex.org/W2403118956","https://openalex.org/W2410703904","https://openalex.org/W2412614696","https://openalex.org/W2416678671","https://openalex.org/W2460706701","https://openalex.org/W4232106734","https://openalex.org/W4248825153","https://openalex.org/W4321001343"],"related_works":["https://openalex.org/W1260428","https://openalex.org/W1981746689","https://openalex.org/W2160046684","https://openalex.org/W1980975906","https://openalex.org/W2405530054","https://openalex.org/W2035545749","https://openalex.org/W2166458827","https://openalex.org/W1999783537","https://openalex.org/W2004337162","https://openalex.org/W2091645038"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}