{"id":"https://openalex.org/W94837478","doi":null,"title":"Laboratory diagnosis of multiple pituitary hormone deficiencies: issues with testing of the growth and thyroid axes.","display_name":"Laboratory diagnosis of multiple pituitary hormone deficiencies: issues with testing of the growth and thyroid axes.","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W94837478","mag":"94837478","pmid":"https://pubmed.ncbi.nlm.nih.gov/19337184"},"language":"en","primary_location":{"id":"pmid:19337184","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19337184","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric endocrinology reviews : PER","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112095093","display_name":"Jon M. Nakamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74614422","display_name":"Quest Diagnostics (United States)","ror":"https://ror.org/010g9bb70","country_code":"US","type":"company","lineage":["https://openalex.org/I74614422"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jon Nakamoto","raw_affiliation_strings":["Managing Director, Quest Diagnostics Nichols Institute, San Juan Capistrano, CA 92675, USA. jon.m.nakamoto@questdiagnostics.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Managing Director, Quest Diagnostics Nichols Institute, San Juan Capistrano, CA 92675, USA. jon.m.nakamoto@questdiagnostics.com","institution_ids":["https://openalex.org/I74614422"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5112095093"],"corresponding_institution_ids":["https://openalex.org/I74614422"],"apc_list":null,"apc_paid":null,"fwci":0.5932,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.70541556,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"6 Suppl 2","issue":null,"first_page":"291","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.011300000362098217,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-pituitary-hormone-deficiency","display_name":"multiple pituitary hormone deficiency","score":0.9879999756813049},{"id":"https://openalex.org/keywords/hypopituitarism","display_name":"hypopituitarism","score":0.9929999709129333},{"id":"https://openalex.org/keywords/growth-hormone-deficiency","display_name":"growth hormone deficiency","score":0.984000027179718},{"id":"https://openalex.org/keywords/thyroid-disease","display_name":"thyroid dysfunction","score":0.5609999895095825},{"id":"https://openalex.org/keywords/hypothyroidism","display_name":"hypothyroidism","score":0.8569999933242798},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9660000205039978},{"id":"https://openalex.org/keywords/free-thyroxine","display_name":"free thyroxine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/assay-harmonization","display_name":"assay harmonization","score":0.8180000185966492},{"id":"https://openalex.org/keywords/diagnostic-cut-off-values","display_name":"diagnostic thresholds","score":0.953000009059906},{"id":"https://openalex.org/keywords/laboratory-diagnosis","display_name":"laboratory diagnosis","score":0.43299999833106995}],"concepts":[{"id":"https://openalex.org/C2778491484","wikidata":"https://www.wikidata.org/wiki/Q922411","display_name":"Hypopituitarism","level":2,"score":0.8573093414306641},{"id":"https://openalex.org/C2779952775","wikidata":"https://www.wikidata.org/wiki/Q369262","display_name":"Growth hormone deficiency","level":4,"score":0.7812073230743408},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.6770156025886536},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5987547039985657},{"id":"https://openalex.org/C40993552","wikidata":"https://www.wikidata.org/wiki/Q514654","display_name":"Gold standard (test)","level":2,"score":0.5165706872940063},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.49636322259902954},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.4330636262893677},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3522784113883972},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3508028984069824},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3253490924835205}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007018","descriptor_name":"Hypopituitarism","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007018","descriptor_name":"Hypopituitarism","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010907","descriptor_name":"Pituitary Hormones","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true}],"locations_count":1,"locations":[{"id":"pmid:19337184","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19337184","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric endocrinology reviews : PER","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2046690020","https://openalex.org/W4405816688","https://openalex.org/W4238171994","https://openalex.org/W1981319054","https://openalex.org/W1988732638","https://openalex.org/W2295595978","https://openalex.org/W2412154441","https://openalex.org/W2043347430","https://openalex.org/W3006760588","https://openalex.org/W2053018886"],"abstract_inverted_index":{"Clinical":[0],"manifestations":[1,61],"of":[2,11,20,38,57,62,69,82,100,108,122],"hypopituitarism":[3],"are":[4,67,97,127,132,138],"variable":[5],"and":[6,34,53,116,124,146],"depend":[7],"on":[8],"the":[9,21,45,49,58,70,79,98,106,120],"severity":[10],"hormone":[12,31,65,148],"deficiency,":[13,66],"creating":[14],"a":[15,27,36,74],"diagnostic":[16,46,95,142],"challenge":[17],"for":[18,51,84,144],"diagnosis":[19,121],"non-classical":[22],"patient":[23],"who":[24],"may":[25],"have":[26],"less":[28],"severe":[29],"growth":[30,52,114],"(GH)":[32],"deficiency":[33,126],"only":[35],"suggestion":[37],"possible":[39],"hypothyroidism.":[40],"Laboratory":[41],"tests":[42,50,110],"contribute":[43],"to":[44,105,140],"process,":[47],"but":[48],"thyroid":[54,125,147],"dysfunction,":[55],"two":[56],"most":[59,71],"common":[60],"multiple":[63],"pituitary":[64],"some":[68],"problematic":[72],"from":[73],"methodological":[75],"perspective.":[76],"Patients":[77],"in":[78,119],"\"grey":[80],"zone\"":[81],"diagnosis,":[83],"whom":[85],"there":[86],"is":[87],"no":[88],"distinct":[89],"dividing":[90],"line":[91],"or":[92],"gold":[93],"standard":[94],"test,":[96],"focus":[99],"this":[101],"article.":[102],"Issues":[103],"relating":[104],"use":[107],"laboratory":[109],"involving":[111],"GH,":[112],"insulin-like":[113],"factor-I,":[115],"free":[117],"thyroxine":[118],"GH":[123,145],"reviewed.":[128],"Assay":[129],"harmonization":[130],"initiatives":[131],"required":[133],"before":[134],"clinical":[135],"research":[136],"studies":[137],"performed":[139],"establish":[141],"thresholds":[143],"deficiencies.":[149]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}