{"id":"https://openalex.org/W947889149","doi":null,"title":"Prediction in therapeutic effectiveness research: Prolonged dose titration in warfarin patients and model transportability","display_name":"Prediction in therapeutic effectiveness research: Prolonged dose titration in warfarin patients and model transportability","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W947889149","mag":"947889149"},"language":"en","primary_location":{"id":"pmh:oai:repository.upenn.edu:edissertations-3087","doi":null,"is_oa":true,"landing_page_url":"https://repository.upenn.edu/edissertations/1275","pdf_url":"https://repository.upenn.edu/edissertations/1275","source":{"id":"https://openalex.org/S4306402083","display_name":"ScholarlyCommons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Publicly Accessible Penn Dissertations","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://repository.upenn.edu/edissertations/1275","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079147453","display_name":"Brian Steven Finkelman","orcid":"https://orcid.org/0000-0002-4348-8208","observed_orcids":["https://orcid.org/0000-0002-4348-8208"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Brian S. Finkelman","raw_affiliation_strings":["#N#               * University of Pennsylvania"],"raw_orcid":"https://orcid.org/0000-0002-4348-8208","affiliations":[{"raw_affiliation_string":"#N#               * University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5079147453"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.6654999852180481,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.6654999852180481,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.049400001764297485,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14374","display_name":"Statistical Methods in Epidemiology","score":0.045899998396635056,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/warfarin","display_name":"warfarin","score":0.9850000143051147},{"id":"https://openalex.org/keywords/maintenance-dose","display_name":"maintenance dose","score":0.625},{"id":"https://openalex.org/keywords/clinical-prediction-model","display_name":"clinical prediction model","score":0.609000027179718},{"id":"https://openalex.org/keywords/model-transportability","display_name":"model portability","score":0.9850000143051147},{"id":"https://openalex.org/keywords/external-validation","display_name":"external validation","score":0.8009999990463257},{"id":"https://openalex.org/keywords/bleeding-risk","display_name":"bleeding risk","score":0.7310000061988831},{"id":"https://openalex.org/keywords/thrombotic-risk","display_name":"thrombosis risk","score":0.7599999904632568},{"id":"https://openalex.org/keywords/oral-anticoagulants","display_name":"oral anticoagulants","score":0.9430000185966492},{"id":"https://openalex.org/keywords/genetic-factors","display_name":"genetic factors","score":0.6389999985694885},{"id":"https://openalex.org/keywords/social-factors","display_name":"social factors","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C2776301958","wikidata":"https://www.wikidata.org/wiki/Q407431","display_name":"Warfarin","level":3,"score":0.8678891658782959},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45102399587631226},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3789949417114258},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.3242138922214508},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.32312101125717163},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20244503021240234},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:repository.upenn.edu:edissertations-3087","doi":null,"is_oa":true,"landing_page_url":"https://repository.upenn.edu/edissertations/1275","pdf_url":"https://repository.upenn.edu/edissertations/1275","source":{"id":"https://openalex.org/S4306402083","display_name":"ScholarlyCommons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Publicly Accessible Penn Dissertations","raw_type":"text"},{"id":"pmh:oai:repository.upenn.edu:20.500.14332/28069","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/handle/20.500.14332/28069","pdf_url":null,"source":{"id":"https://openalex.org/S4306402083","display_name":"ScholarlyCommons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"published","raw_type":"Dissertation/Thesis"},{"id":"pmh:oai:repository.upenn.edu:dissertations-12572","doi":null,"is_oa":false,"landing_page_url":"https://repository.upenn.edu/dissertations/AAI3670897","pdf_url":null,"source":{"id":"https://openalex.org/S4377196331","display_name":"Scholarly Commons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dissertations available from ProQuest","raw_type":"text"},{"id":"mag:947889149","doi":null,"is_oa":false,"landing_page_url":"http://repository.upenn.edu/cgi/viewcontent.cgi?article=12572&context=dissertations","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:repository.upenn.edu:edissertations-3087","doi":null,"is_oa":true,"landing_page_url":"https://repository.upenn.edu/edissertations/1275","pdf_url":"https://repository.upenn.edu/edissertations/1275","source":{"id":"https://openalex.org/S4306402083","display_name":"ScholarlyCommons (University of Pennsylvania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79576946","host_organization_name":"University of Pennsylvania","host_organization_lineage":["https://openalex.org/I79576946"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Publicly Accessible Penn Dissertations","raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G3315597426","display_name":"Clinical and Genetic Predictors of Unstable Warfarin Response","funder_award_id":"F30HL115992","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4392460704","display_name":"Prediction of warfarin dosing using clinical and genetic factors","funder_award_id":"R01HL066176","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5391029984","display_name":"Medical Scientist Training Program","funder_award_id":"T32GM007170","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332608","display_name":"Perelman School of Medicine, University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W947889149.pdf","grobid_xml":"https://content.openalex.org/works/W947889149.grobid-xml"},"referenced_works_count":137,"referenced_works":["https://openalex.org/W28365773","https://openalex.org/W161992551","https://openalex.org/W650692540","https://openalex.org/W1505427574","https://openalex.org/W1515782956","https://openalex.org/W1553549387","https://openalex.org/W1554944419","https://openalex.org/W1563471406","https://openalex.org/W1601994587","https://openalex.org/W1603903339","https://openalex.org/W1668836244","https://openalex.org/W1786557664","https://openalex.org/W1848239498","https://openalex.org/W1965237574","https://openalex.org/W1965934593","https://openalex.org/W1968265979","https://openalex.org/W1969423031","https://openalex.org/W1969839955","https://openalex.org/W1969966515","https://openalex.org/W1973200230","https://openalex.org/W1973774410","https://openalex.org/W1975897418","https://openalex.org/W1976156945","https://openalex.org/W1978892904","https://openalex.org/W1980009210","https://openalex.org/W1982056303","https://openalex.org/W1982245010","https://openalex.org/W1985995539","https://openalex.org/W1991257008","https://openalex.org/W1992656470","https://openalex.org/W1993614294","https://openalex.org/W1994894525","https://openalex.org/W1997523052","https://openalex.org/W1998269707","https://openalex.org/W2002852051","https://openalex.org/W2008706768","https://openalex.org/W2013375415","https://openalex.org/W2013622851","https://openalex.org/W2014606031","https://openalex.org/W2019071303","https://openalex.org/W2021767183","https://openalex.org/W2025626547","https://openalex.org/W2026150146","https://openalex.org/W2027446606","https://openalex.org/W2028148462","https://openalex.org/W2034561962","https://openalex.org/W2036960063","https://openalex.org/W2039240409","https://openalex.org/W2041047388","https://openalex.org/W2041256948","https://openalex.org/W2042161966","https://openalex.org/W2042633587","https://openalex.org/W2042776560","https://openalex.org/W2043662714","https://openalex.org/W2043674997","https://openalex.org/W2044255545","https://openalex.org/W2045030989","https://openalex.org/W2046133119","https://openalex.org/W2053806803","https://openalex.org/W2054440265","https://openalex.org/W2054617470","https://openalex.org/W2056860147","https://openalex.org/W2061273963","https://openalex.org/W2069773373","https://openalex.org/W2070808305","https://openalex.org/W2071066672","https://openalex.org/W2072221769","https://openalex.org/W2072773013","https://openalex.org/W2074183872","https://openalex.org/W2076047772","https://openalex.org/W2079054758","https://openalex.org/W2080546718","https://openalex.org/W2081422533","https://openalex.org/W2081581934","https://openalex.org/W2082378560","https://openalex.org/W2085825299","https://openalex.org/W2087046046","https://openalex.org/W2087316845","https://openalex.org/W2088641612","https://openalex.org/W2089335489","https://openalex.org/W2089463633","https://openalex.org/W2094536485","https://openalex.org/W2095783086","https://openalex.org/W2095987352","https://openalex.org/W2097263887","https://openalex.org/W2097395684","https://openalex.org/W2097854437","https://openalex.org/W2101212877","https://openalex.org/W2101384748","https://openalex.org/W2106143461","https://openalex.org/W2109325327","https://openalex.org/W2109780115","https://openalex.org/W2111341604","https://openalex.org/W2112316706","https://openalex.org/W2112940339","https://openalex.org/W2115471029","https://openalex.org/W2117658318","https://openalex.org/W2119221555","https://openalex.org/W2121514893","https://openalex.org/W2123664981","https://openalex.org/W2124575784","https://openalex.org/W2128189669","https://openalex.org/W2129574541","https://openalex.org/W2130728413","https://openalex.org/W2131371867","https://openalex.org/W2132495614","https://openalex.org/W2132727148","https://openalex.org/W2136489990","https://openalex.org/W2137422676","https://openalex.org/W2139360746","https://openalex.org/W2142822596","https://openalex.org/W2144051438","https://openalex.org/W2144988370","https://openalex.org/W2147646215","https://openalex.org/W2148814645","https://openalex.org/W2150276210","https://openalex.org/W2151936813","https://openalex.org/W2152584205","https://openalex.org/W2153134011","https://openalex.org/W2156402206","https://openalex.org/W2157839219","https://openalex.org/W2158840489","https://openalex.org/W2159767831","https://openalex.org/W2161876144","https://openalex.org/W2162508946","https://openalex.org/W2162974025","https://openalex.org/W2164327527","https://openalex.org/W2166339706","https://openalex.org/W2166504985","https://openalex.org/W2167964017","https://openalex.org/W2170077348","https://openalex.org/W2257838652","https://openalex.org/W2331432542","https://openalex.org/W2582743722","https://openalex.org/W2797563284","https://openalex.org/W2912934387","https://openalex.org/W3145760233"],"related_works":["https://openalex.org/W2501514113","https://openalex.org/W3158746622","https://openalex.org/W2752786594","https://openalex.org/W2062835237","https://openalex.org/W7009185587","https://openalex.org/W2896664477","https://openalex.org/W2050653405","https://openalex.org/W2020722309","https://openalex.org/W2382198800","https://openalex.org/W272287124"],"abstract_inverted_index":{"Therapeutic":[0],"effectiveness":[1],"research":[2],"relies":[3],"heavily":[4],"on":[5,27,163],"prediction":[6,78,126,191],"modeling,":[7],"as":[8,204],"improving":[9],"therapeutic":[10,66],"outcomes":[11],"for":[12],"individuals":[13],"often":[14],"requires":[15],"being":[16],"able":[17,151],"to":[18,24,62,112,152,158,172],"predict":[19,153],"which":[20,154],"patients":[21,40,116,155,169],"are":[22,47,156],"likely":[23,157],"do":[25],"poorly":[26],"a":[28,59,125,147,176],"given":[29],"therapy.":[30],"In":[31],"this":[32,187],"dissertation,":[33],"we":[34,69,92],"examine":[35,70],"the":[36,71,97,103,183],"specific":[37],"case":[38],"of":[39,45,51,74,76,128,186],"starting":[41,117],"warfarin":[42,164,174],"therapy,":[43],"many":[44],"whom":[46],"at":[48],"higher":[49],"risk":[50],"bleeding":[52],"and":[53,80,106,122,134,168,188],"thrombotic":[54],"events":[55],"because":[56],"they":[57],"take":[58],"long":[60],"time":[61,111],"determine":[63,102,137],"their":[64],"optimal":[65],"dose.":[67],"Additionally,":[68],"general":[72],"problem":[73,83],"transportability":[75,145],"clinical":[77,190],"models":[79,192],"whether":[81,138,171],"that":[82,199],"can":[84,142],"be":[85,194],"improved":[86],"through":[87],"sequential":[88,139,205],"model":[89,127,140,144,201,206],"updating.":[90,207],"Specifically,":[91],"conducted":[93],"three":[94],"projects":[95],"with":[96,110],"following":[98],"goals:":[99],"1)":[100],"To":[101,120,136],"social,":[104],"clinical,":[105],"genetic":[107],"factors":[108],"associated":[109],"maintenance":[113],"dose":[114,161],"in":[115,131,146],"warfarin;":[118],"2)":[119],"develop":[121],"externally":[123],"validate":[124],"prolonged":[129,160],"dose-titration":[130],"these":[132],"patients;":[133],"3)":[135],"updating":[141],"improve":[143,200],"simulation":[148],"study.":[149],"Being":[150],"experience":[159],"titration":[162],"could":[165,193],"help":[166],"clinicians":[167],"decide":[170],"use":[173],"or":[175],"less":[177],"burdensome":[178],"alternative":[179],"oral":[180],"anticoagulant.":[181],"Furthermore,":[182],"overall":[184],"utility":[185],"other":[189],"greatly":[195],"increased":[196],"by":[197],"strategies":[198],"transportability,":[202],"such":[203]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}