{"id":"https://openalex.org/W94772370","doi":null,"title":"A phase II trial of weekly paclitaxel and high-dose 5-fluorouracil plus leucovorin in patients with chemotherapy-pretreated metastatic breast cancer.","display_name":"A phase II trial of weekly paclitaxel and high-dose 5-fluorouracil plus leucovorin in patients with chemotherapy-pretreated metastatic breast cancer.","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W94772370","mag":"94772370","pmid":"https://pubmed.ncbi.nlm.nih.gov/17348454"},"language":"en","primary_location":{"id":"pmid:17348454","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17348454","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Clinical Trial, Phase II"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043008228","display_name":"Chia\u2010Chi Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131804","display_name":"National Taiwan University Hospital","ror":"https://ror.org/03nteze27","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210131804"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chia-Chi Lin","raw_affiliation_strings":["Departments of Oncology, National Taiwan University Hospital, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Oncology, National Taiwan University Hospital, Taipei, Taiwan","institution_ids":["https://openalex.org/I4210131804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017953971","display_name":"Ann\u2010Lii Cheng","orcid":"https://orcid.org/0000-0002-9152-6512","observed_orcids":["https://orcid.org/0000-0002-9152-6512"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ann-Lii Cheng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090591171","display_name":"Chih\u2010Hung Hsu","orcid":"https://orcid.org/0000-0003-0495-973X","observed_orcids":["https://orcid.org/0000-0003-0495-973X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chih-Hung Hsu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009846821","display_name":"Yen\u2010Shen Lu","orcid":"https://orcid.org/0000-0001-7461-1291","observed_orcids":["https://orcid.org/0000-0001-7461-1291"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yen-Shen Lu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074026718","display_name":"Chiun Hsu","orcid":"https://orcid.org/0000-0002-1122-0055","observed_orcids":["https://orcid.org/0000-0002-1122-0055"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chiun Hsu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070257043","display_name":"Kun\u2010Huei Yeh","orcid":"https://orcid.org/0000-0002-7306-174X","observed_orcids":["https://orcid.org/0000-0002-7306-174X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kun-Huei Yeh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055849155","display_name":"Chenyao Wu","orcid":"https://orcid.org/0000-0002-5179-5064","observed_orcids":["https://orcid.org/0000-0002-5179-5064"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chen-Yao Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027981189","display_name":"Chiun\u2010Sheng Huang","orcid":"https://orcid.org/0000-0002-6557-211X","observed_orcids":["https://orcid.org/0000-0002-6557-211X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chiun-Sheng Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Chih-Hsin Yang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chih-Hsin Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.01175519,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"27","issue":"1B","first_page":"641","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.008899999782443047,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-breast-cancer","display_name":"metastatic breast cancer","score":0.9309999942779541},{"id":"https://openalex.org/keywords/weekly-paclitaxel","display_name":"weekly paclitaxel","score":0.9980000257492065},{"id":"https://openalex.org/keywords/high-dose-5-fluorouracil","display_name":"high-dose 5-fluorouracil","score":0.9729999899864197},{"id":"https://openalex.org/keywords/leucovorin","display_name":"leucovorin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.6759999990463257},{"id":"https://openalex.org/keywords/previously-treated-patients","display_name":"previously treated patients","score":0.6620000004768372},{"id":"https://openalex.org/keywords/chemotherapy-toxicity","display_name":"chemotherapy toxicity","score":0.5239999890327454},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.902999997138977},{"id":"https://openalex.org/keywords/response-rate","display_name":"response rate","score":0.6859999895095825},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.8500000238418579}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8590892553329468},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.8064505457878113},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.7777296304702759},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.7442865967750549},{"id":"https://openalex.org/C2780456651","wikidata":"https://www.wikidata.org/wiki/Q238512","display_name":"Fluorouracil","level":3,"score":0.7200356125831604},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.703538715839386},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6724367141723633},{"id":"https://openalex.org/C2778822529","wikidata":"https://www.wikidata.org/wiki/Q1951525","display_name":"Progressive disease","level":3,"score":0.5608167052268982},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5360726714134216},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5012524127960205},{"id":"https://openalex.org/C2778850193","wikidata":"https://www.wikidata.org/wiki/Q3775974","display_name":"Febrile neutropenia","level":4,"score":0.49890613555908203},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.481473833322525},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.47284868359565735},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.45595741271972656},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.42849239706993103},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4112856686115265}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000505","descriptor_name":"Alopecia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D000740","descriptor_name":"Anemia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009325","descriptor_name":"Nausea","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009503","descriptor_name":"Neutropenia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:17348454","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17348454","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Clinical Trial, Phase II"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W60966954","https://openalex.org/W1601772287","https://openalex.org/W1820981194","https://openalex.org/W1890813079","https://openalex.org/W1941365207","https://openalex.org/W1946759281","https://openalex.org/W1946819517","https://openalex.org/W1960713055","https://openalex.org/W2015191990","https://openalex.org/W2018487470","https://openalex.org/W2041173222","https://openalex.org/W2069417424","https://openalex.org/W2074451117","https://openalex.org/W2081943423","https://openalex.org/W2089688513","https://openalex.org/W2111487955","https://openalex.org/W2115366398","https://openalex.org/W2128848742","https://openalex.org/W2131770017","https://openalex.org/W2161512963","https://openalex.org/W2189326648","https://openalex.org/W2231186601","https://openalex.org/W2269468903","https://openalex.org/W2595059771"],"related_works":["https://openalex.org/W2039617618","https://openalex.org/W2055093599","https://openalex.org/W2993839918","https://openalex.org/W2091646887","https://openalex.org/W2161512963","https://openalex.org/W2404022068","https://openalex.org/W2340302257","https://openalex.org/W1987592374","https://openalex.org/W26997875","https://openalex.org/W2405056926"],"abstract_inverted_index":{"BACKGROUND:":[0],"Weekly":[1,161],"paclitaxel":[2,27,69,92,162],"and":[3,47,135,155,169],"infusional":[4,164],"high-dose":[5],"5-fluorouracil/leucovorin":[6],"(HDFL)":[7],"are":[8],"both":[9],"effective":[10],"regimens":[11],"for":[12,64,123,173],"metastatic":[13],"breast":[14],"cancer":[15],"(MBC)":[16],"patients.":[17,88,176],"PATIENTS":[18],"AND":[19],"METHODS:":[20],"A":[21,79],"study":[22],"was":[23,70,142,149],"designed":[24],"using":[25],"weekly":[26],"90":[28],"mg/m(2)":[29,35,39],"1-hour":[30],"infusion":[31,42],"followed":[32],"by":[33],"2,000":[34],"5-fluorouracil":[36],"plus":[37,163],"300":[38],"leucovorin":[40],"24-hour":[41],"on":[43],"days":[44],"1,":[45],"8":[46],"15,":[48],"repeated":[49],"every":[50],"28":[51,87],"days,":[52,111],"in":[53,72,98],"patients":[54,120],"who":[55],"had":[56,126],"previously":[57],"received":[58],"a":[59],">":[60],"or":[61,106,117],"=1":[62],"regimen":[63,172],"MBC.":[65],"The":[66,89,139],"dose":[67],"of":[68,81,91],"adjusted":[71],"each":[73],"cycle":[74],"according":[75],"to":[76,86,94,114],"toxicity.":[77],"RESULTS:":[78],"total":[80],"182":[82],"cycles":[83,103],"were":[84,104,121],"given":[85],"doses":[90],"needed":[93],"be":[95],"reduced":[96],"only":[97],"22":[99],"(12%)":[100],"cycles.":[101],"Forty-five":[102],"skipped":[105],"delayed":[107],"more":[108],"than":[109],"7":[110],"mostly":[112],"due":[113],"neutropenia,":[115],"infection,":[116],"neurotoxicity.":[118],"Twenty-five":[119],"evaluable":[122],"response.":[124],"Four":[125],"complete":[127],"response,":[128,131],"13":[129],"partial":[130],"seven":[132,158],"stable":[133],"disease,":[134],"two":[136],"progressive":[137],"disease.":[138],"response":[140],"rate":[141],"60.7%":[143],"(95%":[144,152],"CI:":[145,153],"42.6-78.8).":[146],"Median":[147],"survival":[148,157],"18.1":[150],"months":[151],"11.4-24.9),":[154],"progression-free":[156],"months.":[159],"CONCLUSION:":[160],"HDFL":[165],"is":[166],"an":[167],"active":[168],"well":[170],"tolerated":[171],"pretreated":[174],"MBC":[175]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
