{"id":"https://openalex.org/W94420933","doi":null,"title":"Interactions between ibuprofen and antihypertensive drugs: incidence and clinical relevance in dental practice.","display_name":"Interactions between ibuprofen and antihypertensive drugs: incidence and clinical relevance in dental practice.","publication_year":2008,"publication_date":"2008-11-01","ids":{"openalex":"https://openalex.org/W94420933","mag":"94420933","pmid":"https://pubmed.ncbi.nlm.nih.gov/18978713"},"language":"en","primary_location":{"id":"pmid:18978713","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18978713","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina oral, patologia oral y cirugia bucal","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10550/63642","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027887799","display_name":"C\u00e9sar Salort-Llorca","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C\u00e9sar Salort-Llorca","raw_affiliation_strings":["Mutua de Terrassa Hospital, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mutua de Terrassa Hospital, Barcelona, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105894229","display_name":"Mar\u00eda Paz M\u00ednguez Serra","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mar\u00eda Paz M\u00ednguez-Serra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5018145823","display_name":"Francisco Javier Silvestre Donat","orcid":"https://orcid.org/0000-0001-7858-7735","observed_orcids":["https://orcid.org/0000-0001-7858-7735"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francisco Javier Silvestre-Donat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2355,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.6260203,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"13","issue":"11","first_page":"E717","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.6836000084877014,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.6836000084877014,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.18690000474452972,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.03020000085234642,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ibuprofen","display_name":"ibuprofen","score":1.0},{"id":"https://openalex.org/keywords/antihypertensive-drugs","display_name":"antihypertensive drugs","score":0.9089999794960022},{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.9350000023841858},{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.8360000252723694},{"id":"https://openalex.org/keywords/alpha-blockers","display_name":"alpha-blockers","score":0.9819999933242798},{"id":"https://openalex.org/keywords/diuretics","display_name":"diuretics","score":0.9890000224113464},{"id":"https://openalex.org/keywords/ace-inhibitors","display_name":"ACE inhibitors","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cyclooxygenase-inhibition","display_name":"cyclooxygenase inhibition","score":0.9890000224113464},{"id":"https://openalex.org/keywords/prostaglandins","display_name":"prostaglandins","score":0.8190000057220459},{"id":"https://openalex.org/keywords/elevated-blood-pressure","display_name":"elevated blood pressure","score":0.7519999742507935},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.8539999723434448},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.9210000038146973},{"id":"https://openalex.org/keywords/dental-practice","display_name":"dental practice","score":0.7480000257492065}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8344253301620483},{"id":"https://openalex.org/C2779944601","wikidata":"https://www.wikidata.org/wiki/Q186969","display_name":"Ibuprofen","level":2,"score":0.7930317521095276},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.7066840529441833},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.573346734046936},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.518240213394165},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.49829626083374023},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.44733676314353943},{"id":"https://openalex.org/C27016395","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Angiotensin-converting enzyme","level":3,"score":0.412047415971756},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3930933177471161},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.34942370653152466},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.13462471961975098},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.07842373847961426},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007052","descriptor_name":"Ibuprofen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018712","descriptor_name":"Analgesics, Non-Narcotic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019242","descriptor_name":"Oral Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:18978713","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18978713","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicina oral, patologia oral y cirugia bucal","raw_type":"Journal Article"},{"id":"pmh:oai:roderic.uv.es:10550/63642","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10550/63642","pdf_url":"http://hdl.handle.net/10550/63642","source":{"id":"https://openalex.org/S4306400245","display_name":"Repository of Digital Objects for Teaching Research and Culture (University of Valencia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I16097986","host_organization_name":"Universitat de Val\u00e8ncia","host_organization_lineage":["https://openalex.org/I16097986"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"mag:94420933","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18978713","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:roderic.uv.es:10550/63642","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10550/63642","pdf_url":"http://hdl.handle.net/10550/63642","source":{"id":"https://openalex.org/S4306400245","display_name":"Repository of Digital Objects for Teaching Research and Culture (University of Valencia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I16097986","host_organization_name":"Universitat de Val\u00e8ncia","host_organization_lineage":["https://openalex.org/I16097986"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W94420933.pdf","grobid_xml":"https://content.openalex.org/works/W94420933.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W18166154","https://openalex.org/W93561101","https://openalex.org/W190401824","https://openalex.org/W1973757442","https://openalex.org/W1978060305","https://openalex.org/W1978809227","https://openalex.org/W1983370454","https://openalex.org/W1992728863","https://openalex.org/W2001845419","https://openalex.org/W2009112268","https://openalex.org/W2011555946","https://openalex.org/W2023666105","https://openalex.org/W2030123119","https://openalex.org/W2044106370","https://openalex.org/W2062335942","https://openalex.org/W2073613120","https://openalex.org/W2113504627","https://openalex.org/W2117584029","https://openalex.org/W2120216360","https://openalex.org/W2293695308","https://openalex.org/W2404262463","https://openalex.org/W2410466230","https://openalex.org/W2412512894","https://openalex.org/W2414362260","https://openalex.org/W2417694934","https://openalex.org/W2436402378"],"related_works":["https://openalex.org/W115840060","https://openalex.org/W2023550218","https://openalex.org/W1973757442","https://openalex.org/W2808845167","https://openalex.org/W2027051281","https://openalex.org/W2294307268","https://openalex.org/W2088217785","https://openalex.org/W1555183507","https://openalex.org/W2009112268","https://openalex.org/W7211249054"],"abstract_inverted_index":{"It":[0,109],"has":[1,110],"been":[2,111],"well":[3],"documented":[4],"in":[5,86,102,119,122,150],"the":[6,39,44,60,79,84,114,151],"literature":[7],"that":[8,52,113],"ibuprofen":[9,35],"interacts":[10],"with":[11,72,124,129],"different":[12],"groups":[13],"of":[14,32,34,38,46,62,70,116],"antihypertensive":[15,28],"drugs":[16,74,132],"(beta-adrenergic":[17],"blockers,":[18,20],"alpha-adrenergic":[19],"diuretics":[21],"and":[22,49,57,64,105,142],"angiotensin-converting":[23],"enzyme":[24,40],"inhibitors),":[25],"reducing":[26],"their":[27],"activity.":[29],"The":[30],"mechanism":[31],"action":[33],"involves":[36],"inhibition":[37],"cyclooxygenase,":[41],"thereby":[42],"inhibiting":[43],"synthesis":[45],"inflammatory":[47],"prostaglandins":[48,51],"vasodilatory":[50],"increase":[53],"renal":[54],"blood":[55,87,107],"flow":[56],"thus":[58],"favor":[59],"excretion":[61],"water":[63],"sodium.":[65],"More":[66],"than":[67],"five":[68],"days":[69],"treatment":[71,128],"both":[73,103],"are":[75,93],"normally":[76],"required":[77],"for":[78],"interaction":[80,92],"to":[81,127,139,147],"manifest.":[82],"Although":[83],"changes":[85,118],"pressure":[88,121],"resulting":[89],"from":[90],"this":[91],"typically":[94],"small,":[95],"some":[96],"patients":[97,123],"can":[98],"experience":[99],"substantial":[100],"elevations":[101],"systolic":[104,120],"diastolic":[106],"pressure.":[108],"estimated":[112],"avoidance":[115],"minor":[117],"osteoarthritis":[125],"subjected":[126],"nonsteroidal":[130],"antiinflammatory":[131],"would":[133],"avoid":[134],"over":[135,143],"30,000":[136],"deaths":[137,145],"due":[138,146],"myocardial":[140],"infarction,":[141],"2000":[144],"coronary":[148],"disease,":[149],"United":[152],"States":[153],"alone.":[154]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}