{"id":"https://openalex.org/W94387486","doi":null,"title":"In the absence of dietary surveillance, chitosan does not reduce plasma lipids or obesity in hypercholesterolaemic obese Asian subjects.","display_name":"In the absence of dietary surveillance, chitosan does not reduce plasma lipids or obesity in hypercholesterolaemic obese Asian subjects.","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W94387486","mag":"94387486","pmid":"https://pubmed.ncbi.nlm.nih.gov/11361230"},"language":"en","primary_location":{"id":"pmid:11361230","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11361230","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Singapore medical journal","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109534180","display_name":"Su-Chin Ho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2251586001","display_name":"Singapore General Hospital","ror":"https://ror.org/036j6sg82","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I2251586001"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"S C Ho","raw_affiliation_strings":["Department of Endocrinology, Singapore General Hospital, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Singapore General Hospital, Singapore","institution_ids":["https://openalex.org/I2251586001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049068947","display_name":"E Shyong Tai","orcid":"https://orcid.org/0000-0003-2929-8966","observed_orcids":["https://orcid.org/0000-0003-2929-8966"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E S Tai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112169857","display_name":"Peter Eng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P H Eng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103392004","display_name":"Chang Tan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C E Tan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5109302403","display_name":"Alex C.K. Fok","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A C Fok","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7488,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.83500212,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"42","issue":"1","first_page":"6","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.5351999998092651,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.5351999998092651,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13828","display_name":"Natural Products and Biological Research","score":0.21529999375343323,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.11479999870061874,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chitosan","display_name":"chitosan","score":0.9860000014305115},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.8700000047683716},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.996999979019165},{"id":"https://openalex.org/keywords/dietary-monitoring","display_name":"dietary monitoring","score":0.6460000276565552},{"id":"https://openalex.org/keywords/plasma-lipids","display_name":"plasma lipids","score":0.6830000281333923},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.8489999771118164},{"id":"https://openalex.org/keywords/body-weight","display_name":"body weight","score":0.6610000133514404},{"id":"https://openalex.org/keywords/body-composition","display_name":"body composition","score":0.8659999966621399},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.8370000123977661},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.6650000214576721},{"id":"https://openalex.org/keywords/weight-loss-supplements","display_name":"weight loss supplements","score":0.5270000100135803}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9218428134918213},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7907661199569702},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.7242285013198853},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6528165936470032},{"id":"https://openalex.org/C61427482","wikidata":"https://www.wikidata.org/wiki/Q6656244","display_name":"Anthropometry","level":2,"score":0.6261944770812988},{"id":"https://openalex.org/C2778270857","wikidata":"https://www.wikidata.org/wiki/Q2723972","display_name":"Lipid profile","level":3,"score":0.5938600301742554},{"id":"https://openalex.org/C2776193436","wikidata":"https://www.wikidata.org/wiki/Q236232","display_name":"Waist","level":3,"score":0.5766807198524475},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5731154680252075},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5711841583251953},{"id":"https://openalex.org/C139572402","wikidata":"https://www.wikidata.org/wiki/Q4927820","display_name":"Blood lipids","level":3,"score":0.5653704404830933},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.530326783657074},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.45495668053627014},{"id":"https://openalex.org/C2780586474","wikidata":"https://www.wikidata.org/wiki/Q332428","display_name":"Overweight","level":3,"score":0.4349900186061859},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.3976905345916748},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002686","descriptor_name":"Chitin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002686","descriptor_name":"Chitin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D002686","descriptor_name":"Chitin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006937","descriptor_name":"Hypercholesterolemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006937","descriptor_name":"Hypercholesterolemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008019","descriptor_name":"Life Style","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008076","descriptor_name":"Cholesterol, HDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D048271","descriptor_name":"Chitosan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11361230","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11361230","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Singapore medical journal","raw_type":"Clinical Trial"},{"id":"mag:94387486","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11361230","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1978237331","https://openalex.org/W2008304298","https://openalex.org/W2015265314","https://openalex.org/W2025970938","https://openalex.org/W2069563757","https://openalex.org/W2076544995","https://openalex.org/W2101320446","https://openalex.org/W2102267027","https://openalex.org/W2109555667","https://openalex.org/W2146951052","https://openalex.org/W2149350538","https://openalex.org/W2332884880"],"related_works":["https://openalex.org/W7095446164","https://openalex.org/W7095268672","https://openalex.org/W4300695719","https://openalex.org/W4417485600","https://openalex.org/W2783045696","https://openalex.org/W2025566560","https://openalex.org/W98273598","https://openalex.org/W2112037245","https://openalex.org/W2015114734","https://openalex.org/W2370428295"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"investigate":[2],"the":[3,68,134,169,188,194,212],"effects":[4,200],"of":[5,38,133,183,201,208,214],"Absorbitol":[6,173,202,217],"on":[7,95,141,179],"body":[8,11,110,114,226],"weight,":[9,224],"anthropometry,":[10,225],"composition,":[12,227],"blood":[13,118,228],"pressures":[14],"and":[15,52,57,122,130,153,158,191],"lipid":[16,231],"profiles":[17],"in":[18,50,55,76,168,172,187,193,223],"obese,":[19],"hypercholesterolaemic":[20,58],"subjects":[21,66,175],"without":[22],"dietary":[23,102,215],"restriction.":[24],"DESIGN:":[25],"A":[26],"randomised,":[27],"double":[28],"blind.":[29],"Placebo-controlled":[30],"study.":[31,69,135],"SUBJECTS:":[32],"Normal":[33],"volunteers":[34],"with":[35,181],"no":[36,101,165],"history":[37],"chronic":[39],"illnesses":[40],"(n=88)":[41],"who":[42],"were":[43,83,125,140,148,203],"obese":[44],"(body":[45],"fat":[46],"percentage":[47],">":[48,53,61],"20%":[49],"males":[51],"30%":[54],"females)":[56],"(total":[59],"cholesterol":[60],"5.20":[62],"mmol/L).":[63],"Sixty-eight":[64],"(72.3%)":[65],"completed":[67],"INTERVENTION:":[70],"After":[71],"a":[72,87],"4":[73,78],"week":[74,132],"run":[75],"phase,":[77],"placebo/Absorbitol":[79],"(250":[80],"mg)":[81],"capsules":[82],"prescribed":[84],"3":[85],"times":[86],"day":[88],"before":[89],"meals.":[90],"Subjects":[91],"received":[92],"written":[93],"information":[94],"healthy":[96],"lifestyle":[97],"but":[98],"there":[99],"was":[100,164],"restriction":[103],"or":[104,230],"monitoring.":[105],"MAIN":[106],"OUTCOME":[107],"MEASURES:":[108],"Weight,":[109],"mass":[111],"index,":[112],"lean":[113],"mass,":[115],"waist,":[116],"hip,":[117],"pressure,":[119],"fasting":[120],"lipids":[121],"insulin":[123],"levels":[124],"taken":[126],"at":[127],"baseline,":[128],"4th":[129],"16th":[131],"STATISTICAL":[136],"ANALYSIS":[137],"PERFORMED:":[138],"Analyses":[139],"an":[142],"intention-to-treat":[143],"basis.":[144],"Comparisons":[145],"between":[146],"groups":[147],"made":[149],"using":[150],"Student's":[151],"t":[152],"Mann-Whitney":[154],"tests":[155],"for":[156],"parametric":[157],"non-parametric":[159],"data":[160],"respectively.":[161],"RESULTS:":[162],"There":[163],"significant":[166],"change":[167],"measured":[170],"parameters":[171],"treated":[174],"compared":[176],"to":[177,206],"those":[178],"placebo,":[180],"exception":[182],"HDL-cholesterol":[184],"which":[185],"increased":[186],"absorbitol":[189],"group":[190,196],"decreased":[192],"placebo":[195],"(p=0.048).":[197],"The":[198],"side":[199],"also":[204],"comparable":[205],"that":[207],"placebo.":[209],"CONCLUSIONS:":[210],"In":[211],"absence":[213],"surveillance,":[216],"does":[218],"not":[219],"bring":[220],"about":[221],"improvement":[222],"pressure":[229],"profile.":[232]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}