{"id":"https://openalex.org/W94379055","doi":"https://doi.org/10.22203/ecm.v022a25","title":"A review of decellularized stem cell matrix: a novel cell expansion system for cartilage tissue engineering","display_name":"A review of decellularized stem cell matrix: a novel cell expansion system for cartilage tissue engineering","publication_year":2011,"publication_date":"2011-11-24","ids":{"openalex":"https://openalex.org/W94379055","doi":"https://doi.org/10.22203/ecm.v022a25","mag":"94379055","pmid":"https://pubmed.ncbi.nlm.nih.gov/22116651"},"language":"en","primary_location":{"id":"doi:10.22203/ecm.v022a25","doi":"https://doi.org/10.22203/ecm.v022a25","is_oa":true,"landing_page_url":"https://doi.org/10.22203/ecm.v022a25","pdf_url":null,"source":{"id":"https://openalex.org/S4210216592","display_name":"European Cells and Materials","issn_l":"1473-2262","issn":["1473-2262"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Cells and Materials","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.22203/ecm.v022a25","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062679781","display_name":"Ming Pei","orcid":"https://orcid.org/0000-0001-5710-3578","observed_orcids":["https://orcid.org/0000-0001-5710-3578"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Pei","raw_affiliation_strings":["Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, One Medical Center Drive, P.O.Box 9196, Morgantown, WV 26506-9196, USA. mpei@ hsc.wvu.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, One Medical Center Drive, P.O.Box 9196, Morgantown, WV 26506-9196, USA. mpei@ hsc.wvu.edu","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018680724","display_name":"Jingting Li","orcid":"https://orcid.org/0000-0002-3576-0320","observed_orcids":["https://orcid.org/0000-0002-3576-0320","https://orcid.org/0009-0005-5217-0997"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JT Li","raw_affiliation_strings":["Division of Exercise Physiology, West Virginia University, Morgantown, WV, USA","Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Exercise Physiology, West Virginia University, Morgantown, WV, USA","institution_ids":["https://openalex.org/I12097938"]},{"raw_affiliation_string":"Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV, USA","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009276331","display_name":"Mark S. Shoukry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Shoukry","raw_affiliation_strings":["Mechanical and Aerospace Engineering, West Virginia University, Morgantown, WV, USA","Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mechanical and Aerospace Engineering, West Virginia University, Morgantown, WV, USA","institution_ids":["https://openalex.org/I12097938"]},{"raw_affiliation_string":"Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV, USA","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016728897","display_name":"Yanshuang Zhang","orcid":"https://orcid.org/0009-0009-0935-1759","observed_orcids":["https://orcid.org/0009-0009-0935-1759"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y Zhang","raw_affiliation_strings":["Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV, USA","institution_ids":["https://openalex.org/I12097938"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I12097938"],"apc_list":{"value":1000,"currency":"USD","value_usd":1000},"apc_paid":{"value":1000,"currency":"USD","value_usd":1000},"fwci":7.5182,"has_fulltext":false,"cited_by_count":109,"citation_normalized_percentile":{"value":0.97314278,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"22","issue":null,"first_page":"333","last_page":"343"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cartilage-tissue-engineering","display_name":"cartilage tissue engineering","score":0.9729999899864197},{"id":"https://openalex.org/keywords/cartilage-regeneration","display_name":"cartilage regeneration","score":0.8029999732971191},{"id":"https://openalex.org/keywords/cell-expansion","display_name":"cell expansion","score":0.7919999957084656},{"id":"https://openalex.org/keywords/chondrocytes","display_name":"chondrocytes","score":0.8389999866485596},{"id":"https://openalex.org/keywords/adult-stem-cells","display_name":"adult stem cells","score":0.9879999756813049},{"id":"https://openalex.org/keywords/replicative-senescence","display_name":"replicative senescence","score":0.9589999914169312},{"id":"https://openalex.org/keywords/stem-cell-niche","display_name":"stem cell niche","score":0.8479999899864197},{"id":"https://openalex.org/keywords/chondrogenic-differentiation","display_name":"chondrogenic differentiation","score":0.8149999976158142},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7760000228881836},{"id":"https://openalex.org/keywords/cell-transplantation","display_name":"cell transplantation","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C190672674","wikidata":"https://www.wikidata.org/wiki/Q3866591","display_name":"Decellularization","level":3,"score":0.957685112953186},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.6778647899627686},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5861608386039734},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.5801820158958435},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.5346234440803528},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.457109272480011},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4318673014640808},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4280669093132019},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4098033308982849},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3497229218482971},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2886333167552948},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.23540520668029785},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2169630229473114},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.19049036502838135},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.08331584930419922},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05027797818183899}],"mesh":[{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D014182","descriptor_name":"Transplantation, Autologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020219","descriptor_name":"Chondrogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053687","descriptor_name":"Adult Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053687","descriptor_name":"Adult Stem Cells","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D055153","descriptor_name":"Stem Cell Niche","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.22203/ecm.v022a25","doi":"https://doi.org/10.22203/ecm.v022a25","is_oa":true,"landing_page_url":"https://doi.org/10.22203/ecm.v022a25","pdf_url":null,"source":{"id":"https://openalex.org/S4210216592","display_name":"European Cells and Materials","issn_l":"1473-2262","issn":["1473-2262"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Cells and Materials","raw_type":"journal-article"},{"id":"pmid:22116651","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22116651","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European cells & materials","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:7db9c4c6b76d408b83c0dad01cf72652","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7db9c4c6b76d408b83c0dad01cf72652","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European Cells & Materials, Vol 22, Pp 333-343 (2011)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.22203/ecm.v022a25","doi":"https://doi.org/10.22203/ecm.v022a25","is_oa":true,"landing_page_url":"https://doi.org/10.22203/ecm.v022a25","pdf_url":null,"source":{"id":"https://openalex.org/S4210216592","display_name":"European Cells and Materials","issn_l":"1473-2262","issn":["1473-2262"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Cells and Materials","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306775","display_name":"Musculoskeletal Transplant Foundation","ror":"https://ror.org/011398447"},{"id":"https://openalex.org/F4320311274","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24"},{"id":"https://openalex.org/F4320320914","display_name":"AO Foundation","ror":"https://ror.org/04v7vb598"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":128,"referenced_works":["https://openalex.org/W151805421","https://openalex.org/W286759358","https://openalex.org/W1505671001","https://openalex.org/W1576773659","https://openalex.org/W1763024686","https://openalex.org/W1795940530","https://openalex.org/W1816956112","https://openalex.org/W1861988602","https://openalex.org/W1907686361","https://openalex.org/W1947391889","https://openalex.org/W1964812787","https://openalex.org/W1966260349","https://openalex.org/W1967462133","https://openalex.org/W1968222609","https://openalex.org/W1968671910","https://openalex.org/W1969660907","https://openalex.org/W1969929382","https://openalex.org/W1970199527","https://openalex.org/W1970924670","https://openalex.org/W1972812055","https://openalex.org/W1973089587","https://openalex.org/W1973994630","https://openalex.org/W1974614332","https://openalex.org/W1976636905","https://openalex.org/W1980359589","https://openalex.org/W1981049421","https://openalex.org/W1982337820","https://openalex.org/W1983001876","https://openalex.org/W1983438215","https://openalex.org/W1986480691","https://openalex.org/W1987543170","https://openalex.org/W1987746848","https://openalex.org/W1988432563","https://openalex.org/W1990574061","https://openalex.org/W1995122819","https://openalex.org/W1996087228","https://openalex.org/W1997660384","https://openalex.org/W1999837753","https://openalex.org/W2002412801","https://openalex.org/W2003873431","https://openalex.org/W2005111784","https://openalex.org/W2011562199","https://openalex.org/W2011653215","https://openalex.org/W2014107261","https://openalex.org/W2014187819","https://openalex.org/W2014280822","https://openalex.org/W2015495840","https://openalex.org/W2017509374","https://openalex.org/W2020453105","https://openalex.org/W2020682158","https://openalex.org/W2022231651","https://openalex.org/W2026632078","https://openalex.org/W2031569048","https://openalex.org/W2037048003","https://openalex.org/W2037483649","https://openalex.org/W2039184273","https://openalex.org/W2040075920","https://openalex.org/W2041522326","https://openalex.org/W2043814008","https://openalex.org/W2046986640","https://openalex.org/W2050440015","https://openalex.org/W2052786158","https://openalex.org/W2054635074","https://openalex.org/W2055873350","https://openalex.org/W2058096164","https://openalex.org/W2058184498","https://openalex.org/W2058500387","https://openalex.org/W2059035317","https://openalex.org/W2060600990","https://openalex.org/W2063753069","https://openalex.org/W2065289282","https://openalex.org/W2066668792","https://openalex.org/W2067716147","https://openalex.org/W2068092779","https://openalex.org/W2068137014","https://openalex.org/W2072079099","https://openalex.org/W2074541678","https://openalex.org/W2074800593","https://openalex.org/W2076318547","https://openalex.org/W2077309660","https://openalex.org/W2081992432","https://openalex.org/W2083312275","https://openalex.org/W2083838222","https://openalex.org/W2084680820","https://openalex.org/W2084849128","https://openalex.org/W2088012334","https://openalex.org/W2088473349","https://openalex.org/W2090854725","https://openalex.org/W2093720544","https://openalex.org/W2101471690","https://openalex.org/W2104551938","https://openalex.org/W2105565758","https://openalex.org/W2107988515","https://openalex.org/W2108725095","https://openalex.org/W2114257111","https://openalex.org/W2115023398","https://openalex.org/W2115785626","https://openalex.org/W2120097273","https://openalex.org/W2122764374","https://openalex.org/W2125527918","https://openalex.org/W2127219942","https://openalex.org/W2130933340","https://openalex.org/W2131444686","https://openalex.org/W2133527571","https://openalex.org/W2133669494","https://openalex.org/W2133877095","https://openalex.org/W2134208433","https://openalex.org/W2134257943","https://openalex.org/W2137089064","https://openalex.org/W2137134545","https://openalex.org/W2138007542","https://openalex.org/W2139867678","https://openalex.org/W2141075109","https://openalex.org/W2142579731","https://openalex.org/W2143000352","https://openalex.org/W2148501741","https://openalex.org/W2148625728","https://openalex.org/W2150102283","https://openalex.org/W2160698607","https://openalex.org/W2160912589","https://openalex.org/W2162084700","https://openalex.org/W2166841062","https://openalex.org/W2169755701","https://openalex.org/W2315061138","https://openalex.org/W4229780853","https://openalex.org/W4237306139","https://openalex.org/W4285719527","https://openalex.org/W4320996308"],"related_works":["https://openalex.org/W2315061138","https://openalex.org/W2610119907","https://openalex.org/W2327261690","https://openalex.org/W2523440768","https://openalex.org/W2048737850","https://openalex.org/W8781833","https://openalex.org/W2520895385","https://openalex.org/W2996422900","https://openalex.org/W2089472303","https://openalex.org/W4310019407"],"abstract_inverted_index":{"Cell-based":[0],"therapy":[1],"is":[2,70,79,207],"a":[3,35,80,145],"promising":[4],"biological":[5],"approach":[6,243],"for":[7,23,39,83,108,132,163,190],"the":[8,15,65,73,122,232],"treatment":[9],"of":[10,18,67,124,221,231],"cartilage":[11,20,40,84,164],"defects.":[12],"Due":[13],"to":[14,30,33,49,157,216,244],"small":[16],"size":[17,105],"autologous":[19],"samples":[21],"available":[22],"cell":[24,37,68,75,96,104,109,118,130,133,148,180,224],"transplantation":[25,110],"in":[26,95,113,116,127,175,177,205,209,236,247],"patients,":[27],"cells":[28,47,162,200],"need":[29],"be":[31,245],"expanded":[32,56,103],"yield":[34,158],"sufficient":[36],"number":[38],"repair.":[41],"However,":[42],"chondrocytes":[43],"and":[44,87,106,135,139,160,167,182,201,226,235],"adult":[45,198],"stem":[46,117,129,147,179,199],"tend":[48],"become":[50],"replicatively":[51],"senescent":[52],"once":[53],"they":[54],"are":[55,99,213],"on":[57,184,188,196,223],"conventional":[58],"plastic":[59],"flasks.":[60],"Many":[61],"studies":[62],"demonstrate":[63],"that":[64,144],"loss":[66],"properties":[69],"concomitant":[71],"with":[72],"decreased":[74],"proliferation":[76,225],"capacity.":[77],"This":[78,169],"significant":[81],"challenge":[82],"tissue":[85,165],"engineering":[86,166],"regeneration.":[88,168],"Despite":[89],"much":[90],"progress":[91],"having":[92],"been":[93],"made":[94],"expansion,":[97],"there":[98],"still":[100,208],"concerns":[101],"over":[102],"quality":[107],"applications.":[111],"Recently,":[112],"vivo":[114,178,237],"investigations":[115,230],"niches":[119],"have":[120],"suggested":[121],"importance":[123],"developing":[125],"an":[126,154,176],"vitro":[128],"microenvironment":[131],"expansion":[134,155],"tissue-specific":[136],"differentiation.":[137],"Our":[138],"other":[140],"investigators'":[141],"work":[142,187],"indicates":[143],"decellularized":[146],"matrix":[149],"(DSCM)":[150],"may":[151],"provide":[152],"such":[153],"system":[156],"large-quantity":[159],"high-quality":[161],"review":[170],"briefly":[171],"introduces":[172],"key":[173],"parameters":[174],"niche":[181],"focuses":[183],"our":[185],"recent":[186],"DSCM":[189,206,222],"its":[191,210],"rejuvenating":[192],"or":[193],"reprograming":[194],"effect":[195],"various":[197],"chondrocytes.":[202],"Since":[203],"research":[204],"infancy,":[211],"we":[212],"only":[214],"able":[215],"discuss":[217],"some":[218],"potential":[219],"mechanisms":[220],"chondrogenic":[227],"potential.":[228],"Further":[229],"underlying":[233],"mechanism":[234],"regeneration":[238],"capacity":[239],"will":[240],"allow":[241],"this":[242],"used":[246],"clinics.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":10}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
