{"id":"https://openalex.org/W9423534","doi":null,"title":"Prenatal detection of inherited disorders.","display_name":"Prenatal detection of inherited disorders.","publication_year":1981,"publication_date":"1981-03-01","ids":{"openalex":"https://openalex.org/W9423534","mag":"9423534","pmid":"https://pubmed.ncbi.nlm.nih.gov/7205985","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2609809"},"language":"en","primary_location":{"id":"pmid:7205985","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7205985","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the National Medical Association","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2609809/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103175786","display_name":"Chandradhar Dwivedi","orcid":"https://orcid.org/0000-0003-3478-8660","observed_orcids":["https://orcid.org/0000-0003-3478-8660"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"C Dwivedi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5103175786"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00068388,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"73","issue":"3","first_page":"223","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prenatal-diagnosis","display_name":"prenatal diagnosis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/transabdominal-amniocentesis","display_name":"transabdominal amniocentesis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/amniotic-fluid-cell-culture","display_name":"amniotic fluid culture","score":0.7910000085830688},{"id":"https://openalex.org/keywords/metabolic-disorders","display_name":"metabolic disorders","score":0.6779999732971191},{"id":"https://openalex.org/keywords/monogenic-diseases","display_name":"monogenic disorders","score":0.859000027179718},{"id":"https://openalex.org/keywords/complex-diseases","display_name":"complex diseases","score":0.8820000290870667},{"id":"https://openalex.org/keywords/neural-tube-defects","display_name":"neural tube defects","score":0.9990000128746033},{"id":"https://openalex.org/keywords/alpha-fetoprotein","display_name":"alpha-fetoprotein","score":0.9240000247955322},{"id":"https://openalex.org/keywords/genetic-disorders","display_name":"genetic disorders","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C2777966818","wikidata":"https://www.wikidata.org/wiki/Q473768","display_name":"Amniocentesis","level":5,"score":0.970537543296814},{"id":"https://openalex.org/C2778258057","wikidata":"https://www.wikidata.org/wiki/Q1136569","display_name":"Prenatal diagnosis","level":4,"score":0.8745742440223694},{"id":"https://openalex.org/C2778194526","wikidata":"https://www.wikidata.org/wiki/Q901674","display_name":"Amniotic fluid","level":4,"score":0.8438897132873535},{"id":"https://openalex.org/C2780594696","wikidata":"https://www.wikidata.org/wiki/Q1127402","display_name":"Neural tube","level":3,"score":0.7307530641555786},{"id":"https://openalex.org/C201614185","wikidata":"https://www.wikidata.org/wiki/Q396833","display_name":"In utero","level":4,"score":0.6990114450454712},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6702017784118652},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.5615902543067932},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.5522489547729492},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.5206702947616577},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.4722021520137787},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17382043600082397},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13918131589889526},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.06828466057777405}],"mesh":[{"descriptor_ui":"D000649","descriptor_name":"Amniocentesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005808","descriptor_name":"Genes, Recessive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011296","descriptor_name":"Prenatal Diagnosis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D025063","descriptor_name":"Chromosome Disorders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030342","descriptor_name":"Genetic Diseases, Inborn","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D030342","descriptor_name":"Genetic Diseases, Inborn","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:7205985","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7205985","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the National Medical Association","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2609809","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2609809/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Natl Med Assoc","raw_type":"Text"},{"id":"mag:9423534","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7205985","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2609809","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2609809/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Natl Med Assoc","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W190774674","https://openalex.org/W240180853","https://openalex.org/W1502633111","https://openalex.org/W1561780468","https://openalex.org/W1607087104","https://openalex.org/W1867269609","https://openalex.org/W1970837350","https://openalex.org/W1980876896","https://openalex.org/W1997184345","https://openalex.org/W2025783865","https://openalex.org/W2028860086","https://openalex.org/W2044933365","https://openalex.org/W2048485889","https://openalex.org/W2076743789","https://openalex.org/W2078769264","https://openalex.org/W2166538243","https://openalex.org/W2166804143","https://openalex.org/W2243336020","https://openalex.org/W2397930073","https://openalex.org/W2408063584","https://openalex.org/W2411023543","https://openalex.org/W2411350694","https://openalex.org/W2411635982","https://openalex.org/W2415099067","https://openalex.org/W4233587738"],"related_works":["https://openalex.org/W2139047144","https://openalex.org/W2122746588","https://openalex.org/W2414221393","https://openalex.org/W87970685","https://openalex.org/W2444085460","https://openalex.org/W2244009798","https://openalex.org/W2413456167","https://openalex.org/W3198141076","https://openalex.org/W2394665141","https://openalex.org/W2046466598"],"abstract_inverted_index":{"The":[0,23],"following":[1],"is":[2,13],"a":[3,54],"review":[4],"of":[5,8,25,35,41,71,77,85],"current":[6],"concepts":[7],"prenatal":[9,21,69],"detection.":[10],"Transabdominal":[11],"amniocentesis":[12,86],"recognized":[14],"to":[15,20,53,59],"be":[16],"an":[17],"integral":[18],"adjunct":[19],"care.":[22],"analysis":[24],"cultured":[26],"amniotic":[27,81],"fluid":[28],"cells":[29],"collected":[30],"at":[31],"about":[32],"16":[33],"weeks":[34],"gestation":[36],"provides":[37],"in":[38,80],"utero":[39],"diagnosis":[40,70],"nearly":[42],"all":[43],"chromosomal":[44],"aberration":[45],"syndromes,":[46],"several":[47],"metabolic":[48],"disorders":[49],"which":[50],"are":[51,87],"due":[52,58],"specific":[55],"enzymic":[56],"deficiency":[57],"single":[60],"gene":[61],"disorders,":[62,66],"and":[63],"some":[64],"multifactorial":[65],"such":[67],"as":[68],"neural":[72],"tube":[73],"defects":[74],"by":[75],"estimation":[76],"alphafeto":[78],"protein":[79],"fluid.":[82],"Various":[83],"aspects":[84],"discussed.":[88]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}