{"id":"https://openalex.org/W9396432","doi":null,"title":"Muscle actin genes: a first step towards computational classification of tissue specific promoters.","display_name":"Muscle actin genes: a first step towards computational classification of tissue specific promoters.","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W9396432","mag":"9396432","pmid":"https://pubmed.ncbi.nlm.nih.gov/11471240"},"language":"en","primary_location":{"id":"pmid:11471240","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11471240","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In silico biology","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070297842","display_name":"Kornelie Frech","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Frech","raw_affiliation_strings":["GSF-National Research Center for Environment and Health, Institute of Mammalian Genetics, Ingolst\u00e4dter Landstrasse 1, D-85764 Neuherberg, Germany. frech@gsf.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GSF-National Research Center for Environment and Health, Institute of Mammalian Genetics, Ingolst\u00e4dter Landstrasse 1, D-85764 Neuherberg, Germany. frech@gsf.de","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016433934","display_name":"Kerstin Quandt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Quandt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5003191047","display_name":"Thomas Werner","orcid":"https://orcid.org/0000-0002-8865-365X","observed_orcids":["https://orcid.org/0000-0002-8865-365X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Werner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7433,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.83967445,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":"1","first_page":"29","last_page":"38"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tissue-specific-promoters","display_name":"tissue-specific promoters","score":0.9769999980926514},{"id":"https://openalex.org/keywords/promoter-classification","display_name":"promoter classification","score":0.7239999771118164},{"id":"https://openalex.org/keywords/transcription-factor-binding-sites","display_name":"transcription factor binding sites","score":0.7929999828338623},{"id":"https://openalex.org/keywords/muscle-specific-gene-expression","display_name":"muscle-specific gene expression","score":0.7910000085830688},{"id":"https://openalex.org/keywords/enhancers","display_name":"enhancers","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.8137082457542419},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.6560521125793457},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5812975168228149},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5455467700958252},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5358572602272034},{"id":"https://openalex.org/C54985914","wikidata":"https://www.wikidata.org/wiki/Q1295754","display_name":"Consensus sequence","level":4,"score":0.5117973685264587},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.5115910172462463},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4483180046081543},{"id":"https://openalex.org/C21592294","wikidata":"https://www.wikidata.org/wiki/Q3238407","display_name":"Regulatory sequence","level":4,"score":0.44072335958480835},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39723193645477295},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3620504140853882},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.14757078886032104},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:11471240","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11471240","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"In silico biology","raw_type":"Journal Article"},{"id":"mag:9396432","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11471240","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W1485987033","https://openalex.org/W1970175473","https://openalex.org/W1970361463","https://openalex.org/W1970964138","https://openalex.org/W1970991888","https://openalex.org/W1973469298","https://openalex.org/W1975224552","https://openalex.org/W1976709012","https://openalex.org/W1979103216","https://openalex.org/W1987123427","https://openalex.org/W1987779126","https://openalex.org/W1990166821","https://openalex.org/W1990977693","https://openalex.org/W1991271139","https://openalex.org/W1993257446","https://openalex.org/W1995479866","https://openalex.org/W1998075825","https://openalex.org/W1999802857","https://openalex.org/W1999966058","https://openalex.org/W2001488949","https://openalex.org/W2001785106","https://openalex.org/W2003233163","https://openalex.org/W2007375934","https://openalex.org/W2012533449","https://openalex.org/W2014461783","https://openalex.org/W2026501903","https://openalex.org/W2029162380","https://openalex.org/W2035277145","https://openalex.org/W2037366548","https://openalex.org/W2044928209","https://openalex.org/W2052286096","https://openalex.org/W2060440102","https://openalex.org/W2064879068","https://openalex.org/W2071596356","https://openalex.org/W2075435641","https://openalex.org/W2077164491","https://openalex.org/W2079988105","https://openalex.org/W2083193728","https://openalex.org/W2086997247","https://openalex.org/W2088245792","https://openalex.org/W2090138161","https://openalex.org/W2091686071","https://openalex.org/W2102950226","https://openalex.org/W2104235495","https://openalex.org/W2108601665","https://openalex.org/W2119899834","https://openalex.org/W2124025352","https://openalex.org/W2132348994","https://openalex.org/W2133778193","https://openalex.org/W2140551486","https://openalex.org/W2141867979","https://openalex.org/W2143729412","https://openalex.org/W2149754027","https://openalex.org/W2151238743","https://openalex.org/W2169351355","https://openalex.org/W2313326603","https://openalex.org/W2321708739"],"related_works":["https://openalex.org/W4406623080","https://openalex.org/W2164129281","https://openalex.org/W2061123083","https://openalex.org/W2142186549","https://openalex.org/W2158712722","https://openalex.org/W2522207564","https://openalex.org/W2068135787","https://openalex.org/W2146202528","https://openalex.org/W2418041278","https://openalex.org/W2030397504"],"abstract_inverted_index":{"Tissue-specific":[0],"gene":[1,28],"expression":[2,29],"is":[3],"governed":[4],"by":[5,15],"enhancer":[6],"and":[7,139],"promoter":[8,59,116,167],"sequences":[9,99],"determining":[10],"the":[11,37,119,154,163],"specificity":[12],"most":[13],"probably":[14],"their":[16],"internal":[17],"organization":[18],"of":[19,26,32,44,75,89,121,157,165],"transcription":[20],"factor":[21],"binding":[22],"sites.":[23],"In":[24],"case":[25],"muscle-specific":[27],"excellent":[30],"compilations":[31],"sequence":[33,70],"regions":[34,78],"responsible":[35],"for":[36,106,145],"tissue-specificity":[38],"are":[39,55],"available.":[40],"We":[41,61,92,148],"took":[42],"advantage":[43],"such":[45,90],"a":[46,63,69,101,113],"compilation":[47],"in":[48,81],"order":[49],"to":[50,73,85,95,111,132,142],"elucidate":[51],"organizational":[52],"features":[53],"that":[54,97],"directly":[56],"correlated":[57],"with":[58,130],"specificity.":[60],"chose":[62],"systematic":[64],"approach":[65,159],"solely":[66],"based":[67],"on":[68],"collection":[71],"known":[72,123],"consist":[74],"specific":[76,115,138],"regulatory":[77],"which":[79,107],"can":[80],"principle":[82],"be":[83,143],"applied":[84],"every":[86],"precompiled":[87],"set":[88],"sequences.":[91,125],"were":[93],"able":[94],"show":[96],"these":[98],"contained":[100],"detectable":[102],"subgroup":[103],"(actin":[104],"promoters)":[105],"it":[108],"was":[109,128],"possible":[110],"construct":[112],"highly":[114],"model":[117,127],"recognizing":[118],"majority":[120],"all":[122],"actin":[124],"The":[126],"robust":[129],"respect":[131],"different":[133],"training":[134],"sets,":[135],"almost":[136],"100%":[137],"sensitive":[140],"enough":[141],"suitable":[144],"database":[146],"searches.":[147],"believe":[149],"this":[150],"pilot":[151],"study":[152],"demonstrates":[153],"general":[155],"applicability":[156],"our":[158],"as":[160,162],"well":[161],"concept":[164],"modular":[166],"organization.":[168]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
