{"id":"https://openalex.org/W938049417","doi":null,"title":"Rhythms of immunity.","display_name":"Rhythms of immunity.","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W938049417","mag":"938049417","pmid":"https://pubmed.ncbi.nlm.nih.gov/9597081"},"language":"en","primary_location":{"id":"pmid:9597081","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9597081","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archivum immunologiae et therapiae experimentalis","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078148926","display_name":"Barbara P\u0142ytycz","orcid":"https://orcid.org/0000-0002-3869-500X","observed_orcids":["https://orcid.org/0000-0002-3869-500X"]},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"B P\u0142ytycz","raw_affiliation_strings":["Department of Evolutionary Immunobiology, Institute of Zoology, Jagiellonian University, Cracow, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Evolutionary Immunobiology, Institute of Zoology, Jagiellonian University, Cracow, Poland","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050802336","display_name":"Rolf Seljelid","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Seljelid","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1155,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.359822,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"45","issue":"2-3","first_page":"157","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.9309999942779541},{"id":"https://openalex.org/keywords/seasonal-rhythms","display_name":"seasonal rhythms","score":0.7360000014305115},{"id":"https://openalex.org/keywords/immune-function","display_name":"immune function","score":0.7089999914169312},{"id":"https://openalex.org/keywords/diurnal-activity","display_name":"diurnal activity","score":0.6779999732971191},{"id":"https://openalex.org/keywords/nocturnal-activity","display_name":"nocturnal activity","score":0.9660000205039978},{"id":"https://openalex.org/keywords/melatonin","display_name":"melatonin","score":0.9649999737739563},{"id":"https://openalex.org/keywords/pineal-gland","display_name":"pineal gland","score":0.9440000057220459},{"id":"https://openalex.org/keywords/light-dark-cycle","display_name":"light-dark cycle","score":0.8569999933242798},{"id":"https://openalex.org/keywords/neuroendocrine-regulation","display_name":"neuroendocrine regulation","score":0.7229999899864197},{"id":"https://openalex.org/keywords/immune-parameters","display_name":"immunological parameters","score":0.3269999921321869}],"concepts":[{"id":"https://openalex.org/C2777334680","wikidata":"https://www.wikidata.org/wiki/Q1607611","display_name":"Nocturnal","level":2,"score":0.8670358657836914},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.8042241334915161},{"id":"https://openalex.org/C2779027399","wikidata":"https://www.wikidata.org/wiki/Q204170","display_name":"Darkness","level":2,"score":0.7802675366401672},{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.7741212844848633},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7155412435531616},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6935556530952454},{"id":"https://openalex.org/C2780059843","wikidata":"https://www.wikidata.org/wiki/Q198654","display_name":"Pineal gland","level":3,"score":0.5948284864425659},{"id":"https://openalex.org/C135343436","wikidata":"https://www.wikidata.org/wiki/Q170406","display_name":"Rhythm","level":2,"score":0.5943588018417358},{"id":"https://openalex.org/C2781291010","wikidata":"https://www.wikidata.org/wiki/Q178580","display_name":"Period (music)","level":2,"score":0.5522407293319702},{"id":"https://openalex.org/C55969652","wikidata":"https://www.wikidata.org/wiki/Q259028","display_name":"photoperiodism","level":2,"score":0.5391870141029358},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.4812476336956024},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.4413280487060547},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43142908811569214},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.3912180960178375},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.38962501287460327},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.178147554397583},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.08728504180908203},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08393073081970215},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001001","descriptor_name":"Anura","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003624","descriptor_name":"Darkness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008221","descriptor_name":"Lymphoid Tissue","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008550","descriptor_name":"Melatonin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010507","descriptor_name":"Periodicity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012621","descriptor_name":"Seasons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017440","descriptor_name":"Photoperiod","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018655","descriptor_name":"Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9597081","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9597081","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archivum immunologiae et therapiae experimentalis","raw_type":"Journal Article"},{"id":"mag:938049417","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9597081","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2416743103","https://openalex.org/W1499188344","https://openalex.org/W1423040791","https://openalex.org/W2963138285","https://openalex.org/W2019480869","https://openalex.org/W4231086298","https://openalex.org/W2092481580","https://openalex.org/W1974769168","https://openalex.org/W2081195453","https://openalex.org/W2988269642"],"abstract_inverted_index":{"Rhythms":[0],"of":[1,11,61,69,103,114,127,158,164,175,190,201],"daily":[2,54,197],"activity":[3,159],"are":[4,179,192],"found":[5],"in":[6,35,96],"all":[7,189],"vertebrate":[8],"species,":[9,100],"some":[10],"them":[12,191],"being":[13],"diurnal":[14,97,131],"(like":[15,20],"humans,":[16],"dogs,":[17],"pigeons),":[18],"others--nocturnal":[19],"mice,":[21],"rats":[22],"and":[23,50,55,81,98,106,172,185,188,194,198],"bats).":[24],"Some":[25],"species":[26,132],"undergo":[27],"very":[28],"pronounced":[29],"seasonal":[30,56,173,199],"changes,":[31],"as":[32],"they":[33],"hibernate":[34],"the":[36,42,59,62,67,73,84,93,101,112,115,156,165,169,176,206],"winter":[37],"or":[38],"mate":[39],"only":[40],"at":[41,124,146],"specific":[43],"seasons.":[44],"The":[45,119],"main":[46],"regulator":[47],"(a":[48],"clock":[49],"a":[51,130,139],"calendar)":[52],"for":[53,129,138],"rhythms":[57],"is":[58,77],"periodicity":[60,68],"external":[63,203],"light-darkness,":[64],"reflected":[65],"by":[66,79,205],"melatonin":[70,89],"secretion":[71],"from":[72],"pineal":[74],"gland,":[75],"which":[76,90],"inhibited":[78],"light":[80],"induced":[82],"during":[83,92,155,168],"darkness.":[85],"In":[86],"contrast":[87],"to":[88],"peaks":[91,123,133],"night":[94],"both":[95],"noctural":[99],"cyclicity":[102,174],"other":[104,183],"hormones":[105],"several":[107],"immune":[108,120,143,166,177],"parameters":[109,144],"correlates":[110],"with":[111,153,182,196],"pattern":[113],"animal":[116],"locomotor":[117],"activity-resting.":[118],"parameter":[121],"that":[122],"one":[125],"time":[126,148],"day":[128],"about":[134],"12":[135],"h":[136],"later":[137],"nocturnal":[140],"one.":[141],"Various":[142],"peak":[145],"various":[147],"points,":[149],"anticipating":[150],"an":[151,202],"encounter":[152],"pathogens":[154],"period":[157],"while":[160],"energetically":[161],"expensive":[162],"resolution":[163],"response":[167],"resting.":[170],"Daily":[171],"functions":[178],"temporally":[180],"integrated":[181],"physiologic":[184],"behavioral":[186],"processes":[187],"regulated":[193],"coordinated":[195],"changes":[200],"environment":[204],"neuroendocrine":[207],"homeostatic":[208],"system.":[209]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}