{"id":"https://openalex.org/W93647679","doi":null,"title":"The alpha2-delta protein: an auxiliary subunit of voltage-dependent calcium channels as a recognized drug target.","display_name":"The alpha2-delta protein: an auxiliary subunit of voltage-dependent calcium channels as a recognized drug target.","publication_year":2010,"publication_date":"2010-07-01","ids":{"openalex":"https://openalex.org/W93647679","mag":"93647679","pmid":"https://pubmed.ncbi.nlm.nih.gov/20571971"},"language":"en","primary_location":{"id":"pmid:20571971","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20571971","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in investigational drugs (London, England : 2000)","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Andrew J Thorpe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew J Thorpe","raw_affiliation_strings":["Pfizer Inc, US Medical Affairs, New York, NY 10017, USA. andrew.thorpe@pfizer.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Inc, US Medical Affairs, New York, NY 10017, USA. andrew.thorpe@pfizer.com","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039320169","display_name":"James Offord","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Offord","raw_affiliation_strings":["Pfizer"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer","institution_ids":["https://openalex.org/I180857899"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I180857899"],"apc_list":null,"apc_paid":null,"fwci":1.0619,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.72102613,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"11","issue":"7","first_page":"761","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha2-delta-subunit","display_name":"alpha2delta subunit","score":0.9950000047683716},{"id":"https://openalex.org/keywords/voltage-gated-calcium-channels","display_name":"voltage-gated calcium channels","score":0.8169999718666077},{"id":"https://openalex.org/keywords/auxiliary-subunits","display_name":"auxiliary subunits","score":0.722000002861023},{"id":"https://openalex.org/keywords/gabapentin","display_name":"gabapentin","score":0.968999981880188},{"id":"https://openalex.org/keywords/pregabalin","display_name":"pregabalin","score":1.0},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.574999988079071},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.9409999847412109},{"id":"https://openalex.org/keywords/antiepileptic-drugs","display_name":"antiepileptic drugs","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.7420029640197754},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.607926607131958},{"id":"https://openalex.org/C18699975","wikidata":"https://www.wikidata.org/wiki/Q14905735","display_name":"Voltage-dependent calcium channel","level":3,"score":0.5612918138504028},{"id":"https://openalex.org/C85520022","wikidata":"https://www.wikidata.org/wiki/Q15322916","display_name":"Calcium channel","level":3,"score":0.5560415387153625},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.54256671667099},{"id":"https://openalex.org/C2776608144","wikidata":"https://www.wikidata.org/wiki/Q410352","display_name":"Gabapentin","level":3,"score":0.5172491669654846},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47561532258987427},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.43585652112960815},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4345454275608063},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.39900797605514526},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36722153425216675},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.3641650080680847},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27404147386550903},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2385481297969818},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21607467532157898},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06657937169075012},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.06290721893310547},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.05030539631843567},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069583","descriptor_name":"Pregabalin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077206","descriptor_name":"Gabapentin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000588","descriptor_name":"Amines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000588","descriptor_name":"Amines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003509","descriptor_name":"Cyclohexanecarboxylic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003509","descriptor_name":"Cyclohexanecarboxylic Acids","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015220","descriptor_name":"Calcium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:20571971","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20571971","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in investigational drugs (London, England : 2000)","raw_type":"Journal Article"},{"id":"mag:93647679","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20571971","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W52522755","https://openalex.org/W1493682555","https://openalex.org/W1603937713","https://openalex.org/W1828582259","https://openalex.org/W1902878432","https://openalex.org/W1911040658","https://openalex.org/W1936115414","https://openalex.org/W1965762284","https://openalex.org/W1965775384","https://openalex.org/W1969197497","https://openalex.org/W1970581037","https://openalex.org/W1972403208","https://openalex.org/W1972890404","https://openalex.org/W1981942371","https://openalex.org/W1985662506","https://openalex.org/W1986910347","https://openalex.org/W1988452935","https://openalex.org/W1990287882","https://openalex.org/W1990438269","https://openalex.org/W1997048153","https://openalex.org/W2002546976","https://openalex.org/W2005215213","https://openalex.org/W2009965676","https://openalex.org/W2012093804","https://openalex.org/W2016027137","https://openalex.org/W2018461659","https://openalex.org/W2026905490","https://openalex.org/W2027775387","https://openalex.org/W2031004040","https://openalex.org/W2031489310","https://openalex.org/W2040312955","https://openalex.org/W2040475489","https://openalex.org/W2041578994","https://openalex.org/W2043361189","https://openalex.org/W2048497026","https://openalex.org/W2051599946","https://openalex.org/W2054694891","https://openalex.org/W2055523882","https://openalex.org/W2063170700","https://openalex.org/W2076930890","https://openalex.org/W2077059461","https://openalex.org/W2078512048","https://openalex.org/W2080477042","https://openalex.org/W2081664581","https://openalex.org/W2085295826","https://openalex.org/W2092472739","https://openalex.org/W2100323768","https://openalex.org/W2103289578","https://openalex.org/W2107046566","https://openalex.org/W2112375525","https://openalex.org/W2112520390","https://openalex.org/W2120884990","https://openalex.org/W2122304769","https://openalex.org/W2136298776","https://openalex.org/W2141989757","https://openalex.org/W2142711575","https://openalex.org/W2145694365","https://openalex.org/W2154603792","https://openalex.org/W2156263771","https://openalex.org/W2159874398","https://openalex.org/W2170481173","https://openalex.org/W2324262814","https://openalex.org/W2339279963","https://openalex.org/W2346657510","https://openalex.org/W2418007735","https://openalex.org/W4322703181"],"related_works":["https://openalex.org/W2085295826","https://openalex.org/W194134940","https://openalex.org/W2339279963","https://openalex.org/W2080477042","https://openalex.org/W2103289578","https://openalex.org/W2039937003","https://openalex.org/W2774190057","https://openalex.org/W2344222532","https://openalex.org/W4237118207","https://openalex.org/W52522755"],"abstract_inverted_index":{"Currently,":[0],"there":[1],"are":[2,14,89],"two":[3],"drugs":[4,83],"on":[5],"the":[6,24,36,52,55,61,66,80],"market,":[7],"gabapentin":[8],"(Neurontin)":[9],"and":[10,60,71],"pregabalin":[11],"(Lyrica),":[12],"that":[13,84],"proposed":[15],"to":[16,23,44,86],"exert":[17],"their":[18],"therapeutic":[19],"effect":[20],"through":[21],"binding":[22],"alpha2-delta":[25,37,56,67],"subunit":[26,38],"of":[27,54,63,65,82],"voltage-sensitive":[28],"calcium":[29],"channels.":[30],"This":[31],"activity":[32],"was":[33],"unexpected,":[34],"as":[35],"had":[39],"previously":[40],"been":[41],"considered":[42],"not":[43],"be":[45],"a":[46],"pharmacological":[47],"target.":[48],"In":[49],"this":[50,87],"review,":[51],"role":[53],"subunits":[57],"is":[58,74],"discussed":[59],"mechanism":[62,81],"action":[64],"ligands":[68],"in":[69,72],"vitro":[70],"vivo":[73],"summarized.":[75],"Finally,":[76],"new":[77],"insights":[78],"into":[79],"bind":[85],"protein":[88],"discussed.":[90]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}