{"id":"https://openalex.org/W93605349","doi":null,"title":"Impaired physical function, loss of muscle mass and assessment of biomechanical properties in critical ill patients.","display_name":"Impaired physical function, loss of muscle mass and assessment of biomechanical properties in critical ill patients.","publication_year":2012,"publication_date":"2012-11-01","ids":{"openalex":"https://openalex.org/W93605349","mag":"93605349","pmid":"https://pubmed.ncbi.nlm.nih.gov/23171753"},"language":"en","primary_location":{"id":"pmid:23171753","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23171753","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Danish medical journal","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102072228","display_name":"Jesper Br\u00f8ndum Poulsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802567020","display_name":"Copenhagen University Hospital","ror":"https://ror.org/05bpbnx46","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Jesper Br\u00f8ndum Poulsen","raw_affiliation_strings":["Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. jpoulsen@dadlnet.dk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. jpoulsen@dadlnet.dk","institution_ids":["https://openalex.org/I2802567020","https://openalex.org/I2802709434"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5102072228"],"corresponding_institution_ids":["https://openalex.org/I2802567020","https://openalex.org/I2802709434"],"apc_list":null,"apc_paid":null,"fwci":0.2876,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.64750405,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"59","issue":"11","first_page":"B4544","last_page":"B4544"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10867","display_name":"Intensive Care Unit Cognitive Disorders","score":0.9185000061988831,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10867","display_name":"Intensive Care Unit Cognitive Disorders","score":0.9185000061988831,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10858","display_name":"Clinical Nutrition and Gastroenterology","score":0.02419999986886978,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.023099999874830246,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/critical-illness","display_name":"critical illness","score":0.7639999985694885},{"id":"https://openalex.org/keywords/intensive-care-unit-survivors","display_name":"intensive care unit survivors","score":0.6809999942779541},{"id":"https://openalex.org/keywords/muscle-weakness","display_name":"muscle weakness","score":0.6190000176429749},{"id":"https://openalex.org/keywords/muscle-atrophy","display_name":"muscle atrophy","score":0.9079999923706055},{"id":"https://openalex.org/keywords/muscle-loss","display_name":"muscle mass loss","score":0.7229999899864197},{"id":"https://openalex.org/keywords/physical-functioning","display_name":"physical function","score":0.8880000114440918},{"id":"https://openalex.org/keywords/catabolism","display_name":"catabolism","score":0.7390000224113464},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9620000123977661},{"id":"https://openalex.org/keywords/inactivity","display_name":"inactivity","score":0.7649999856948853},{"id":"https://openalex.org/keywords/intensive-care-unit","display_name":"intensive care unit","score":0.628000020980835}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.879325270652771},{"id":"https://openalex.org/C2779764123","wikidata":"https://www.wikidata.org/wiki/Q7972881","display_name":"Wasting","level":2,"score":0.7878152132034302},{"id":"https://openalex.org/C2776418732","wikidata":"https://www.wikidata.org/wiki/Q270421","display_name":"Muscle weakness","level":2,"score":0.6369320154190063},{"id":"https://openalex.org/C2776376669","wikidata":"https://www.wikidata.org/wiki/Q5094647","display_name":"Intensive care unit","level":2,"score":0.6349101066589355},{"id":"https://openalex.org/C2776263037","wikidata":"https://www.wikidata.org/wiki/Q1557686","display_name":"Muscle atrophy","level":3,"score":0.6297357082366943},{"id":"https://openalex.org/C2776214593","wikidata":"https://www.wikidata.org/wiki/Q1787939","display_name":"Sarcopenia","level":2,"score":0.6017745733261108},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.5623095631599426},{"id":"https://openalex.org/C2780247198","wikidata":"https://www.wikidata.org/wiki/Q633403","display_name":"Weakness","level":2,"score":0.5124309659004211},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5023026466369629},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.4295569658279419},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.38529878854751587},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21059852838516235},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.13636648654937744}],"mesh":[{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003422","descriptor_name":"Critical Care","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004599","descriptor_name":"Electric Stimulation Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007103","descriptor_name":"Immobilization","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007362","descriptor_name":"Intensive Care Units","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D008660","descriptor_name":"Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009133","descriptor_name":"Muscular Atrophy","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009133","descriptor_name":"Muscular Atrophy","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D009133","descriptor_name":"Muscular Atrophy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009133","descriptor_name":"Muscular Atrophy","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D010809","descriptor_name":"Physical Fitness","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011315","descriptor_name":"Preventive Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016638","descriptor_name":"Critical Illness","qualifier_ui":"Q000534","qualifier_name":"rehabilitation","is_major_topic":true},{"descriptor_ui":"D017063","descriptor_name":"Outcome Assessment, Health Care","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017741","descriptor_name":"Survivors","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D053580","descriptor_name":"Muscle Strength","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061345","descriptor_name":"Early Medical Intervention","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:23171753","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23171753","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Danish medical journal","raw_type":"Journal Article"},{"id":"mag:93605349","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23171753","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":182,"referenced_works":["https://openalex.org/W832664","https://openalex.org/W64057920","https://openalex.org/W134753650","https://openalex.org/W171242146","https://openalex.org/W1505512693","https://openalex.org/W1530294052","https://openalex.org/W1552699877","https://openalex.org/W1556150576","https://openalex.org/W1556303558","https://openalex.org/W1563749042","https://openalex.org/W1845511895","https://openalex.org/W1848702238","https://openalex.org/W1873658666","https://openalex.org/W1924434992","https://openalex.org/W1926115347","https://openalex.org/W1930882462","https://openalex.org/W1945431751","https://openalex.org/W1964493140","https://openalex.org/W1965928998","https://openalex.org/W1967542427","https://openalex.org/W1967687886","https://openalex.org/W1968577785","https://openalex.org/W1975706961","https://openalex.org/W1975825830","https://openalex.org/W1976580928","https://openalex.org/W1977724043","https://openalex.org/W1979609987","https://openalex.org/W1979954100","https://openalex.org/W1982138498","https://openalex.org/W1983438735","https://openalex.org/W1987647235","https://openalex.org/W1988515588","https://openalex.org/W1989771979","https://openalex.org/W1990258338","https://openalex.org/W1991627457","https://openalex.org/W1992073689","https://openalex.org/W1992118938","https://openalex.org/W1993397663","https://openalex.org/W1994860823","https://openalex.org/W1995813754","https://openalex.org/W1996060602","https://openalex.org/W1996093404","https://openalex.org/W1996574322","https://openalex.org/W1997961280","https://openalex.org/W1999164035","https://openalex.org/W2001318507","https://openalex.org/W2003427382","https://openalex.org/W2003522977","https://openalex.org/W2004295774","https://openalex.org/W2006071856","https://openalex.org/W2008215444","https://openalex.org/W2008814391","https://openalex.org/W2011494742","https://openalex.org/W2011865490","https://openalex.org/W2013062326","https://openalex.org/W2015325491","https://openalex.org/W2017359398","https://openalex.org/W2020230229","https://openalex.org/W2023922133","https://openalex.org/W2024303025","https://openalex.org/W2030038103","https://openalex.org/W2030963910","https://openalex.org/W2031974456","https://openalex.org/W2032116377","https://openalex.org/W2035416139","https://openalex.org/W2037260615","https://openalex.org/W2037377025","https://openalex.org/W2037467650","https://openalex.org/W2038032492","https://openalex.org/W2038459645","https://openalex.org/W2040076964","https://openalex.org/W2040670798","https://openalex.org/W2041107146","https://openalex.org/W2045577106","https://openalex.org/W2045799753","https://openalex.org/W2048750727","https://openalex.org/W2050253272","https://openalex.org/W2050841366","https://openalex.org/W2051151561","https://openalex.org/W2051775246","https://openalex.org/W2053627700","https://openalex.org/W2053768799","https://openalex.org/W2055499007","https://openalex.org/W2060886633","https://openalex.org/W2062538521","https://openalex.org/W2062717409","https://openalex.org/W2063403408","https://openalex.org/W2063407488","https://openalex.org/W2065567800","https://openalex.org/W2066712893","https://openalex.org/W2066827200","https://openalex.org/W2068555870","https://openalex.org/W2070030360","https://openalex.org/W2073173204","https://openalex.org/W2073344687","https://openalex.org/W2073615795","https://openalex.org/W2076916612","https://openalex.org/W2078775423","https://openalex.org/W2079797922","https://openalex.org/W2083688004","https://openalex.org/W2087308665","https://openalex.org/W2087526580","https://openalex.org/W2090230778","https://openalex.org/W2090939818","https://openalex.org/W2093081515","https://openalex.org/W2093440134","https://openalex.org/W2096329726","https://openalex.org/W2097419280","https://openalex.org/W2098068896","https://openalex.org/W2098094335","https://openalex.org/W2100042510","https://openalex.org/W2100464618","https://openalex.org/W2100952762","https://openalex.org/W2103303901","https://openalex.org/W2103403570","https://openalex.org/W2103943037","https://openalex.org/W2104904325","https://openalex.org/W2107034110","https://openalex.org/W2107156652","https://openalex.org/W2107254995","https://openalex.org/W2107257285","https://openalex.org/W2107387209","https://openalex.org/W2108413402","https://openalex.org/W2108700902","https://openalex.org/W2109005423","https://openalex.org/W2111861407","https://openalex.org/W2112196811","https://openalex.org/W2114151775","https://openalex.org/W2114208099","https://openalex.org/W2115227363","https://openalex.org/W2116440960","https://openalex.org/W2116650230","https://openalex.org/W2117093670","https://openalex.org/W2119279345","https://openalex.org/W2122638153","https://openalex.org/W2124817377","https://openalex.org/W2125051264","https://openalex.org/W2127920599","https://openalex.org/W2129562049","https://openalex.org/W2132607881","https://openalex.org/W2133596412","https://openalex.org/W2133762721","https://openalex.org/W2134822922","https://openalex.org/W2136185750","https://openalex.org/W2137904740","https://openalex.org/W2139656274","https://openalex.org/W2140928457","https://openalex.org/W2141011481","https://openalex.org/W2141156437","https://openalex.org/W2141403362","https://openalex.org/W2141500947","https://openalex.org/W2141901467","https://openalex.org/W2143539577","https://openalex.org/W2146984342","https://openalex.org/W2147257117","https://openalex.org/W2149189574","https://openalex.org/W2149927687","https://openalex.org/W2151451374","https://openalex.org/W2151552361","https://openalex.org/W2154379123","https://openalex.org/W2156207350","https://openalex.org/W2158333360","https://openalex.org/W2160691650","https://openalex.org/W2161114756","https://openalex.org/W2161349877","https://openalex.org/W2164335545","https://openalex.org/W2167565177","https://openalex.org/W2170347681","https://openalex.org/W2170686215","https://openalex.org/W2171010597","https://openalex.org/W2171508974","https://openalex.org/W2181494902","https://openalex.org/W2205573324","https://openalex.org/W2208931577","https://openalex.org/W2229259429","https://openalex.org/W2277270809","https://openalex.org/W2322707526","https://openalex.org/W2325918023","https://openalex.org/W2330163665","https://openalex.org/W2398059519","https://openalex.org/W2418532320","https://openalex.org/W3143060430"],"related_works":["https://openalex.org/W1510438347","https://openalex.org/W4401451566","https://openalex.org/W2321066301","https://openalex.org/W2969834722","https://openalex.org/W2970065331","https://openalex.org/W4411369110","https://openalex.org/W2625623380","https://openalex.org/W2326471898","https://openalex.org/W2134292643","https://openalex.org/W2351505105"],"abstract_inverted_index":{"Intensive":[0],"care":[1],"unit":[2],"(ICU)":[3],"admission":[4],"is":[5,25,49,124],"associated":[6],"with":[7],"muscle":[8,35,61,91,99,144],"weakness":[9],"and":[10,55,131,137,146],"ICU":[11,47,74,107,135,160],"survivors":[12],"report":[13],"sustained":[14],"limitation":[15],"of":[16,60,73,90,98,120,128,156],"physical":[17,129,157],"capacity":[18],"for":[19,33,101,152],"years":[20],"after":[21],"discharge.":[22],"Limited":[23],"information":[24],"available":[26],"on":[27],"the":[28,42,70,84,94,102,121,147,153],"underlying":[29,148],"biomechanical":[30,132,149],"properties":[31,133],"responsible":[32,151],"this":[34,79],"function":[36,130,158],"impairment.":[37],"A":[38],"plausible":[39],"contributor":[40],"to":[41,53,58,87,125,138],"accentuated":[43],"catabolic":[44],"drive":[45],"in":[46,69,106,134,159],"patients":[48,136],"a":[50],"synergistic":[51],"response":[52],"inflammation":[54],"inactivity":[56],"leading":[57],"loss":[59,89],"mass.":[62,92],"As":[63],"these":[64],"entities":[65],"are":[66],"predominantly":[67],"present":[68,122],"early":[71],"phase":[72],"stay,":[75],"interventions":[76],"employed":[77],"during":[78],"time":[80],"frame":[81],"may":[82],"exhibit":[83],"greatest":[85],"potential":[86],"counteract":[88],"Despite":[93],"obvious":[95],"clinical":[96],"significance":[97],"atrophy":[100],"functional":[103],"impairment":[104,155],"observed":[105],"survivors,":[108],"no":[109],"preventive":[110],"therapies":[111],"have":[112],"been":[113],"identified":[114],"as":[115],"yet.":[116],"The":[117],"overall":[118],"aim":[119],"dissertation":[123],"characterize":[126],"aspects":[127],"provide":[139],"new":[140],"insights":[141],"into":[142],"ICU-induced":[143],"wasting":[145],"mechanisms":[150],"residual":[154],"survivors.":[161]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
