{"id":"https://openalex.org/W93507367","doi":"https://doi.org/10.1096/fasebj.21.5.a132-c","title":"Enteric commensal bacteria elicit epithelial ROS and modulate signaling via repression of cullin\u2010dependent ubiquitination","display_name":"Enteric commensal bacteria elicit epithelial ROS and modulate signaling via repression of cullin\u2010dependent ubiquitination","publication_year":2007,"publication_date":"2007-04-01","ids":{"openalex":"https://openalex.org/W93507367","doi":"https://doi.org/10.1096/fasebj.21.5.a132-c","mag":"93507367"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.21.5.a132-c","doi":"https://doi.org/10.1096/fasebj.21.5.a132-c","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.5.a132-c","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030032530","display_name":"Lauren S. Collier-Hyams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren S Collier\u2010Hyams","raw_affiliation_strings":["Pathology and Laboratory Medicine, Emory University School of Medicine 615 Michael St. Atlanta GA 30322","Pathology and Laboratory Medicine, Emory University School of Medicine615 Michael St.AtlantaGA30322"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology and Laboratory Medicine, Emory University School of Medicine 615 Michael St. Atlanta GA 30322","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Pathology and Laboratory Medicine, Emory University School of Medicine615 Michael St.AtlantaGA30322","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Huixia Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huixia Wu","raw_affiliation_strings":["Pathology and Laboratory Medicine, Emory University School of Medicine 615 Michael St. Atlanta GA 30322","Pathology and Laboratory Medicine, Emory University School of Medicine615 Michael St.AtlantaGA30322"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology and Laboratory Medicine, Emory University School of Medicine 615 Michael St. Atlanta GA 30322","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Pathology and Laboratory Medicine, Emory University School of Medicine615 Michael St.AtlantaGA30322","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060538269","display_name":"Amrita Kumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amrita Kumar","raw_affiliation_strings":["Pathology and Laboratory Medicine, Emory University School of Medicine 615 Michael St. Atlanta GA 30322","Pathology and Laboratory Medicine, Emory University School of Medicine615 Michael St.AtlantaGA30322"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology and Laboratory Medicine, Emory University School of Medicine 615 Michael St. Atlanta GA 30322","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Pathology and Laboratory Medicine, Emory University School of Medicine615 Michael St.AtlantaGA30322","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078257803","display_name":"Andrew Scott Neish","orcid":"https://orcid.org/0000-0002-7090-0237","observed_orcids":["https://orcid.org/0000-0002-7090-0237"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew S Neish","raw_affiliation_strings":["Pathology and Laboratory Medicine, Emory University School of Medicine 615 Michael St. Atlanta GA 30322","Pathology and Laboratory Medicine, Emory University School of Medicine615 Michael St.AtlantaGA30322"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology and Laboratory Medicine, Emory University School of Medicine 615 Michael St. Atlanta GA 30322","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Pathology and Laboratory Medicine, Emory University School of Medicine615 Michael St.AtlantaGA30322","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I150468666"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01070961,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.8842999935150146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.8842999935150146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.02759999968111515,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.024000000208616257,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9679999947547913},{"id":"https://openalex.org/keywords/deneddylation","display_name":"deneddylation","score":0.9160000085830688},{"id":"https://openalex.org/keywords/ubc12","display_name":"Ubc12","score":0.9190000295639038},{"id":"https://openalex.org/keywords/cop9-signalosome","display_name":"COP9 signalosome","score":0.9769999980926514},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.6919999718666077},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9850000143051147},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.9409999847412109},{"id":"https://openalex.org/keywords/intestinal-epithelium","display_name":"intestinal epithelium","score":0.8289999961853027},{"id":"https://openalex.org/keywords/ubiquitin-proteasome-system","display_name":"ubiquitin-proteasome system","score":0.902999997138977},{"id":"https://openalex.org/keywords/probiotics","display_name":"probiotics","score":0.7269999980926514},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.8769999742507935}],"concepts":[{"id":"https://openalex.org/C2778567606","wikidata":"https://www.wikidata.org/wiki/Q41797435","display_name":"Cullin","level":5,"score":0.8396518230438232},{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.6913178563117981},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6710812449455261},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.664665937423706},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5195586681365967},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.4641702175140381},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.4020678997039795},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30293941497802734},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.2641332745552063},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1561092734336853},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07524105906486511},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05946844816207886},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.05139508843421936}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.21.5.a132-c","doi":"https://doi.org/10.1096/fasebj.21.5.a132-c","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.5.a132-c","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Zero hunger","score":0.7400000095367432,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G603896397","display_name":"Microbial Effects on Epithelial Ubiquitination Pathways","funder_award_id":"K01DK068105","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000293455","display_name":null,"funder_award_id":"AI064462","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2171353763","https://openalex.org/W1748794284","https://openalex.org/W2103863018","https://openalex.org/W1486376689","https://openalex.org/W2032580828","https://openalex.org/W133889051","https://openalex.org/W2006553908","https://openalex.org/W840503409","https://openalex.org/W2011086395","https://openalex.org/W2488897345"],"abstract_inverted_index":{"Enteric":[0],"commensal":[1,86,145,185],"bacteria":[2,38,65,87,186],"inhibit":[3],"ubiquitination":[4],"of":[5,16,20,28,41,45,68,75,101,109,117,126,132,155,164,173,184],"important":[6],"signaling":[7],"intermediates":[8],"such":[9],"as":[10,189],"I\u03baB":[11],"and":[12,129,134,178,199],"\u03b2\u2010catenin":[13],"via":[14],"deneddylation":[15,55],"the":[17,21,34,49,59,73,102,113,118,156,162,165,174,181],"Cullin\u20101":[18],"subunit":[19],"SCF":[22],"\u03b2\u2010TrCP":[23],"E3ubiquitin":[24],"ligase.":[25],"The":[26],"objective":[27],"these":[29,121],"studies":[30],"was":[31,193],"to":[32,169],"identify":[33],"mechanism":[35],"by":[36,58,71,84,144,195],"which":[37,94],"cause":[39,66],"loss":[40,67,125],"Cul\u20101":[42,46,69,127],"neddylation.":[43],"Neddylation":[44],"requires":[47],"Ubc12,":[48],"cellular":[50],"neddylase":[51],"E2":[52],"enzyme,":[53],"while":[54],"is":[56],"accomplished":[57],"Cop9":[60,119],"signalosome.":[61],"We":[62,79],"hypothesized":[63],"that":[64,81],"neddylation":[70,128],"modulating":[72],"activity":[74,116],"UBC12":[76],"and/or":[77],"Cop9.":[78],"report":[80],"epithelia":[82],"contacted":[83],"enteric":[85,166],"rapidly":[88],"generate":[89],"reactive":[90],"oxygen":[91],"species":[92],"(ROS),":[93],"causes":[95],"complete":[96],"but":[97],"transient":[98],"oxidative":[99],"inactivation":[100],"low":[103],"pK":[104],"a":[105,151],"catalytic":[106],"cysteine":[107],"residue":[108],"Ubc12.":[110],"Coupled":[111],"with":[112],"constitutive":[114],"deneddylase":[115],"signalosome,":[120],"events":[122],"result":[123],"in":[124],"consequent":[130],"modulation":[131],"NF\u2010\u03baB":[133],"Wnt":[135],"signaling.":[136],"Our":[137],"results":[138],"demonstrate":[139],"how":[140],"epithelial":[141],"ROS":[142],"elicited":[143],"bacterial":[146,167],"strains":[147],"can":[148],"directly":[149],"modulate":[150],"critical":[152],"control":[153],"point":[154],"ubiquitin\u2010proteasome":[157],"system.":[158],"These":[159],"observations":[160],"explain":[161,180],"ability":[163],"flora":[168],"influence":[170],"regulatory":[171],"pathways":[172],"mammalian":[175],"intestinal":[176],"epithelia,":[177],"may":[179],"beneficial":[182],"effects":[183],"(probiotics)":[187],"employed":[188],"therapeutics.":[190],"This":[191],"research":[192],"funded":[194],"NIH":[196],"grants":[197],"AI064462":[198],"DK068105.":[200]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}