{"id":"https://openalex.org/W933723652","doi":"https://doi.org/10.1128/9781555816650.ch17","title":"Novel Anti-Inflammatory and Proresolution Lipid Mediators in Induction and Modulation of Phagocyte Function","display_name":"Novel Anti-Inflammatory and Proresolution Lipid Mediators in Induction and Modulation of Phagocyte Function","publication_year":2014,"publication_date":"2014-04-30","ids":{"openalex":"https://openalex.org/W933723652","doi":"https://doi.org/10.1128/9781555816650.ch17","mag":"933723652"},"language":"en","primary_location":{"id":"doi:10.1128/9781555816650.ch17","doi":"https://doi.org/10.1128/9781555816650.ch17","is_oa":false,"landing_page_url":"https://doi.org/10.1128/9781555816650.ch17","pdf_url":null,"source":{"id":"https://openalex.org/S4306462867","display_name":"ASM Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phagocyte-Pathogen Interactions","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2479887430","display_name":"Phagocyte-Pathogen Interactions"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029525374","display_name":"Charles Nicholas Serhan","orcid":"https://orcid.org/0000-0003-4627-8545","observed_orcids":["https://orcid.org/0000-0003-4627-8545"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles N. Serhan","raw_affiliation_strings":["Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine; Brigham and Women's Hospital and Harvard Medical School; Boston MA 02115"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine; Brigham and Women's Hospital and Harvard Medical School; Boston MA 02115","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064351054","display_name":"J\u00falio Aliberti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julio Aliberti","raw_affiliation_strings":["Divisions of Molecular Immunology and Pulmonary Medicine; Cincinnati Children's Hospital Medical Center; Cincinnati OH 45229"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Molecular Immunology and Pulmonary Medicine; Cincinnati Children's Hospital Medical Center; Cincinnati OH 45229","institution_ids":["https://openalex.org/I1285204247"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.10571185,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"265","last_page":"280"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/specialized-pro-resolving-mediators","display_name":"specialized pro-resolving mediators","score":0.8999999761581421},{"id":"https://openalex.org/keywords/resolvins","display_name":"resolvins","score":0.8569999933242798},{"id":"https://openalex.org/keywords/protectins","display_name":"protectins","score":0.9990000128746033},{"id":"https://openalex.org/keywords/eicosanoids","display_name":"eicosanoids","score":0.6140000224113464},{"id":"https://openalex.org/keywords/eicosapentaenoic-acid","display_name":"eicosapentaenoic acid","score":0.8320000171661377},{"id":"https://openalex.org/keywords/docosahexaenoic-acid","display_name":"docosahexaenoic acid","score":1.0},{"id":"https://openalex.org/keywords/cyclooxygenase","display_name":"cyclooxygenase","score":0.746999979019165},{"id":"https://openalex.org/keywords/lipoxygenase","display_name":"lipoxygenase","score":0.9860000014305115},{"id":"https://openalex.org/keywords/5-lipoxygenase","display_name":"5-lipoxygenase","score":0.9049999713897705},{"id":"https://openalex.org/keywords/cyclopentenone-prostaglandins","display_name":"cyclopentenone prostaglandins","score":0.7850000262260437},{"id":"https://openalex.org/keywords/prostaglandin-d2","display_name":"prostaglandin D2","score":0.8180000185966492},{"id":"https://openalex.org/keywords/lipoxins","display_name":"lipoxins","score":0.8489999771118164},{"id":"https://openalex.org/keywords/phagocytic-activity","display_name":"phagocytic activity","score":0.8100000023841858},{"id":"https://openalex.org/keywords/resolution-of-inflammation","display_name":"inflammation resolution","score":0.765999972820282},{"id":"https://openalex.org/keywords/acute-inflammation","display_name":"acute inflammation","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C180899940","wikidata":"https://www.wikidata.org/wiki/Q117982","display_name":"Lipid signaling","level":3,"score":0.8769546747207642},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7068467140197754},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5998266935348511},{"id":"https://openalex.org/C2777171753","wikidata":"https://www.wikidata.org/wiki/Q423345","display_name":"Docosahexaenoic acid","level":4,"score":0.5752466917037964},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5122236609458923},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5082692503929138},{"id":"https://openalex.org/C2777700362","wikidata":"https://www.wikidata.org/wiki/Q107647","display_name":"Phagocyte","level":3,"score":0.4944572448730469},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.48425933718681335},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4787028133869171},{"id":"https://openalex.org/C2776091944","wikidata":"https://www.wikidata.org/wiki/Q409990","display_name":"Eicosapentaenoic acid","level":4,"score":0.44135862588882446},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41103675961494446},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3778766989707947},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33215343952178955},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31470608711242676},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2559812068939209},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.14409473538398743},{"id":"https://openalex.org/C19038510","wikidata":"https://www.wikidata.org/wiki/Q2005087","display_name":"Polyunsaturated fatty acid","level":3,"score":0.08186778426170349},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1128/9781555816650.ch17","doi":"https://doi.org/10.1128/9781555816650.ch17","is_oa":false,"landing_page_url":"https://doi.org/10.1128/9781555816650.ch17","pdf_url":null,"source":{"id":"https://openalex.org/S4306462867","display_name":"ASM Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Phagocyte-Pathogen Interactions","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":95,"referenced_works":["https://openalex.org/W27647494","https://openalex.org/W205110630","https://openalex.org/W205238248","https://openalex.org/W1497700962","https://openalex.org/W1531140346","https://openalex.org/W1539392991","https://openalex.org/W1546975150","https://openalex.org/W1556346244","https://openalex.org/W1566827911","https://openalex.org/W1725748255","https://openalex.org/W1739691545","https://openalex.org/W1834117453","https://openalex.org/W1836416096","https://openalex.org/W1959056525","https://openalex.org/W1963938213","https://openalex.org/W1970599157","https://openalex.org/W1972148451","https://openalex.org/W1974066136","https://openalex.org/W1978586956","https://openalex.org/W1979004719","https://openalex.org/W1980108759","https://openalex.org/W1981748455","https://openalex.org/W1982178416","https://openalex.org/W1984554579","https://openalex.org/W1986483382","https://openalex.org/W1986734670","https://openalex.org/W1991110402","https://openalex.org/W1994825511","https://openalex.org/W1999224453","https://openalex.org/W2002127334","https://openalex.org/W2004536682","https://openalex.org/W2006888325","https://openalex.org/W2011451357","https://openalex.org/W2012967151","https://openalex.org/W2019945881","https://openalex.org/W2021608770","https://openalex.org/W2024176341","https://openalex.org/W2026470957","https://openalex.org/W2030583964","https://openalex.org/W2035557641","https://openalex.org/W2037697142","https://openalex.org/W2040551968","https://openalex.org/W2041831203","https://openalex.org/W2043981736","https://openalex.org/W2048565177","https://openalex.org/W2051778349","https://openalex.org/W2052085748","https://openalex.org/W2056108991","https://openalex.org/W2061167233","https://openalex.org/W2063590020","https://openalex.org/W2065376096","https://openalex.org/W2065803353","https://openalex.org/W2067161489","https://openalex.org/W2068167523","https://openalex.org/W2068210705","https://openalex.org/W2075545649","https://openalex.org/W2076559527","https://openalex.org/W2076989593","https://openalex.org/W2079341705","https://openalex.org/W2082649626","https://openalex.org/W2086790252","https://openalex.org/W2095435791","https://openalex.org/W2099020618","https://openalex.org/W2100726346","https://openalex.org/W2102138771","https://openalex.org/W2102189561","https://openalex.org/W2102410401","https://openalex.org/W2106067980","https://openalex.org/W2109225320","https://openalex.org/W2111790202","https://openalex.org/W2111873809","https://openalex.org/W2120111127","https://openalex.org/W2120699390","https://openalex.org/W2127130381","https://openalex.org/W2128788220","https://openalex.org/W2132182857","https://openalex.org/W2138291177","https://openalex.org/W2141040327","https://openalex.org/W2141344207","https://openalex.org/W2151168716","https://openalex.org/W2151840463","https://openalex.org/W2152145035","https://openalex.org/W2152874793","https://openalex.org/W2153454088","https://openalex.org/W2157340973","https://openalex.org/W2162382352","https://openalex.org/W2162465757","https://openalex.org/W2163134721","https://openalex.org/W2165193515","https://openalex.org/W2165433466","https://openalex.org/W2192223169","https://openalex.org/W2443199170","https://openalex.org/W3175877989","https://openalex.org/W4229694155","https://openalex.org/W4230714851"],"related_works":["https://openalex.org/W2142438877","https://openalex.org/W2127130381","https://openalex.org/W4230831256","https://openalex.org/W2107104127","https://openalex.org/W2501136065","https://openalex.org/W2064759451","https://openalex.org/W4308039179","https://openalex.org/W2123022291","https://openalex.org/W2122285204","https://openalex.org/W1986735406"],"abstract_inverted_index":{"Several":[0],"novel":[1,42],"enzymatic":[2,129],"pathways":[3,155],"were":[4,165],"recently":[5],"identified":[6],"that":[7,140,156,181,202],"are":[8,61,90,126,189],"activated":[9],"during":[10],"the":[11,41,57,80,114,123,142,158,162,176,182,212,219,224],"resolution":[12,89],"phase":[13],"and":[14,21,43,52,59,68,86,105,138,144,154,195,223],"initiated":[15],"from":[16],"precursors":[17],"eicosapentaenoic":[18],"acid":[19,23],"(EPA)":[20],"docosahexaenoic":[22],"(DHA).":[24],"The":[25,72,95,148,214],"protectin":[26],"family":[27],"name":[28],"signifies":[29],"their":[30],"formation,":[31],"potent":[32,44,62],"anti-inflammatory,":[33],"as":[34,36,135],"well":[35],"protective":[37],"actions":[38,184],"demonstrated":[39],"for":[40],"DHA-derived":[45],"10,17-docasatriene":[46],"in":[47,92,113,167,173,229],"animal":[48],"models":[49],"of":[50,65,74,82,100,116,146,185,204,221,226],"stroke":[51],"Alzheimer's":[53],"disease.":[54],"Both":[55],"families,":[56],"resolvins":[58],"protectins,":[60],"local-acting":[63],"agonists":[64],"endogenous":[66],"anti-inflammation":[67],"promote":[69],"resolution-specific":[70],"processes.":[71],"connection(s)":[73],"these":[75,217],"new":[76],"lipid":[77,187],"mediators":[78,102,160,188],"to":[79,122,131],"control":[81,225],"an":[83],"acute":[84],"inflammation":[85],"its":[87],"timely":[88],"illustrated":[91],"this":[93],"chapter.":[94],"chapter":[96],"focuses":[97],"on":[98],"biosynthesis":[99,115],"proresolving":[101],"via":[103,128],"cyclooxygenases":[104],"lipoxygenases.":[106],"COX-2":[107],"also":[108],"plays":[109],"a":[110,120],"key":[111],"role":[112],"PGD2,":[117],"which":[118,169],"is":[119,211],"precursor":[121],"cyclopentenones.":[124],"Precursors":[125],"transformed":[127],"mechanisms":[130],"bioactive":[132,159],"compounds":[133],"such":[134,198],"lipoxins,":[136],"resolvins,":[137],"protectins":[139],"regulate":[141],"duration":[143],"magnitude":[145],"inflammation.":[147],"most":[149],"likely":[150],"human":[151],"cell":[152],"types":[153],"biosynthesize":[157],"within":[161,175],"resolving":[163],"exudates":[164],"reconstructed":[166],"vitro,":[168],"involved":[170],"cell-cell":[171],"interactions":[172],"vivo":[174,230],"exudates.":[177],"Emerging":[178],"evidence":[179],"indicates":[180],"immunomodulatory":[183],"several":[186],"exploited":[190],"by":[191,206],"pathogens,":[192],"including":[193],"fungi":[194],"helminths.":[196],"In":[197],"cases,":[199],"it":[200],"seems":[201],"modulation":[203],"immunity":[205],"suppressing":[207],"host":[208],"proinflammatory":[209],"responses":[210,228],"aim.":[213],"interplay":[215],"between":[216],"mediators,":[218],"induction":[220],"5-LO,":[222],"immune":[227],"await":[231],"further":[232],"investigation.":[233]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
