{"id":"https://openalex.org/W93208276","doi":"https://doi.org/10.1007/978-1-59745-293-9_34","title":"TGF-\u03b2 at the Crossroads Between Inflammation, Suppression and Cancer","display_name":"TGF-\u03b2 at the Crossroads Between Inflammation, Suppression and Cancer","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W93208276","doi":"https://doi.org/10.1007/978-1-59745-293-9_34","mag":"93208276"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-59745-293-9_34","doi":"https://doi.org/10.1007/978-1-59745-293-9_34","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59745-293-9_34","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transforming Growth Factor-\u03b2 in Cancer Therapy, Volume II","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4230874111","display_name":"Transforming Growth Factor-\u03b2 in Cancer Therapy, Volume II"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044325577","display_name":"Nancy L McCartney-Francis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210088259","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy L. McCartney-Francis","raw_affiliation_strings":["Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, The National Institutes of Health, Bethesda, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, The National Institutes of Health, Bethesda, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035673687","display_name":"Sharon M. Wahl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210088259","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharon M. Wahl","raw_affiliation_strings":["Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, The National Institutes of Health, Bethesda, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, The National Institutes of Health, Bethesda, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.043383,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"553","last_page":"570"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.7910000085830688},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.9100000262260437},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7480000257492065},{"id":"https://openalex.org/keywords/tumor-immunosuppression","display_name":"tumor immunosuppression","score":0.7089999914169312},{"id":"https://openalex.org/keywords/tumor-immunology","display_name":"tumor immunology","score":0.6309999823570251},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.8119999766349792},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8939999938011169},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.8399999737739563},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.75},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6579927206039429},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6252537369728088},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.6200820803642273},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6132919788360596},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.57098788022995},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5467423796653748},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.546144425868988},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4884845018386841},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.48149240016937256},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46559938788414},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.452776700258255},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.4235679507255554},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.16954267024993896},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12830501794815063},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-59745-293-9_34","doi":"https://doi.org/10.1007/978-1-59745-293-9_34","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59745-293-9_34","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transforming Growth Factor-\u03b2 in Cancer Therapy, Volume II","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":183,"referenced_works":["https://openalex.org/W139759952","https://openalex.org/W1482134259","https://openalex.org/W1487581481","https://openalex.org/W1496904177","https://openalex.org/W1497240165","https://openalex.org/W1499151513","https://openalex.org/W1506043671","https://openalex.org/W1519521580","https://openalex.org/W1529983307","https://openalex.org/W1530044612","https://openalex.org/W1532921008","https://openalex.org/W1539837817","https://openalex.org/W1540115784","https://openalex.org/W1541589221","https://openalex.org/W1547565061","https://openalex.org/W1549555023","https://openalex.org/W1549837901","https://openalex.org/W1553444759","https://openalex.org/W1557482894","https://openalex.org/W1557620096","https://openalex.org/W1560500352","https://openalex.org/W1561940208","https://openalex.org/W1567420244","https://openalex.org/W1574615823","https://openalex.org/W1575585006","https://openalex.org/W1575754639","https://openalex.org/W1578030924","https://openalex.org/W1581327518","https://openalex.org/W1587849076","https://openalex.org/W1678303428","https://openalex.org/W1768438545","https://openalex.org/W1772839736","https://openalex.org/W1834041853","https://openalex.org/W1844475851","https://openalex.org/W1852725426","https://openalex.org/W1856738731","https://openalex.org/W1897269170","https://openalex.org/W1898102248","https://openalex.org/W1936190307","https://openalex.org/W1966689985","https://openalex.org/W1967261754","https://openalex.org/W1967351618","https://openalex.org/W1968551667","https://openalex.org/W1969683835","https://openalex.org/W1969875009","https://openalex.org/W1971846249","https://openalex.org/W1973047647","https://openalex.org/W1973515006","https://openalex.org/W1973837015","https://openalex.org/W1975324295","https://openalex.org/W1976646363","https://openalex.org/W1976809749","https://openalex.org/W1978146894","https://openalex.org/W1980401378","https://openalex.org/W1984641122","https://openalex.org/W1985157285","https://openalex.org/W1990227965","https://openalex.org/W1994738588","https://openalex.org/W1996184310","https://openalex.org/W1999227421","https://openalex.org/W1999833479","https://openalex.org/W2000213929","https://openalex.org/W2002726823","https://openalex.org/W2003907692","https://openalex.org/W2004708987","https://openalex.org/W2011243140","https://openalex.org/W2015085911","https://openalex.org/W2015780294","https://openalex.org/W2021107622","https://openalex.org/W2021603971","https://openalex.org/W2026426963","https://openalex.org/W2026545194","https://openalex.org/W2026901935","https://openalex.org/W2028422704","https://openalex.org/W2030021944","https://openalex.org/W2031300004","https://openalex.org/W2034185792","https://openalex.org/W2034339135","https://openalex.org/W2036582868","https://openalex.org/W2037416158","https://openalex.org/W2037991262","https://openalex.org/W2039347592","https://openalex.org/W2039992202","https://openalex.org/W2040074251","https://openalex.org/W2043017963","https://openalex.org/W2044069347","https://openalex.org/W2047406797","https://openalex.org/W2048270768","https://openalex.org/W2052562309","https://openalex.org/W2052596695","https://openalex.org/W2053131178","https://openalex.org/W2057626289","https://openalex.org/W2058006748","https://openalex.org/W2060028170","https://openalex.org/W2062199188","https://openalex.org/W2062779245","https://openalex.org/W2063679726","https://openalex.org/W2065495798","https://openalex.org/W2066191876","https://openalex.org/W2066825713","https://openalex.org/W2069524101","https://openalex.org/W2070614384","https://openalex.org/W2072429741","https://openalex.org/W2073241458","https://openalex.org/W2073310925","https://openalex.org/W2076067786","https://openalex.org/W2077392770","https://openalex.org/W2079517510","https://openalex.org/W2080481261","https://openalex.org/W2080860848","https://openalex.org/W2082873063","https://openalex.org/W2087019729","https://openalex.org/W2089313271","https://openalex.org/W2090133718","https://openalex.org/W2090241102","https://openalex.org/W2092377752","https://openalex.org/W2093103522","https://openalex.org/W2093608608","https://openalex.org/W2094280155","https://openalex.org/W2094663408","https://openalex.org/W2095537212","https://openalex.org/W2095605427","https://openalex.org/W2096662041","https://openalex.org/W2097811455","https://openalex.org/W2097829282","https://openalex.org/W2098394317","https://openalex.org/W2100357356","https://openalex.org/W2101230909","https://openalex.org/W2101236733","https://openalex.org/W2103180268","https://openalex.org/W2103498738","https://openalex.org/W2106255536","https://openalex.org/W2112866067","https://openalex.org/W2116554142","https://openalex.org/W2117200840","https://openalex.org/W2118202213","https://openalex.org/W2118857294","https://openalex.org/W2118916648","https://openalex.org/W2119727612","https://openalex.org/W2120010406","https://openalex.org/W2122689765","https://openalex.org/W2125690417","https://openalex.org/W2127248987","https://openalex.org/W2129435292","https://openalex.org/W2129505749","https://openalex.org/W2130133601","https://openalex.org/W2130188603","https://openalex.org/W2131261731","https://openalex.org/W2132143019","https://openalex.org/W2133449490","https://openalex.org/W2135197529","https://openalex.org/W2147389132","https://openalex.org/W2147754310","https://openalex.org/W2149142217","https://openalex.org/W2150678612","https://openalex.org/W2151181789","https://openalex.org/W2152601253","https://openalex.org/W2152978188","https://openalex.org/W2154086478","https://openalex.org/W2154122248","https://openalex.org/W2154568166","https://openalex.org/W2155779547","https://openalex.org/W2156104527","https://openalex.org/W2159454395","https://openalex.org/W2159987448","https://openalex.org/W2160740567","https://openalex.org/W2161545566","https://openalex.org/W2162819001","https://openalex.org/W2164904188","https://openalex.org/W2166311080","https://openalex.org/W2169233545","https://openalex.org/W2171909981","https://openalex.org/W2274634926","https://openalex.org/W2320937221","https://openalex.org/W2396056147","https://openalex.org/W2400882377","https://openalex.org/W2441700042","https://openalex.org/W2776663677","https://openalex.org/W4235300003","https://openalex.org/W4297022993","https://openalex.org/W4313324526","https://openalex.org/W4313333807","https://openalex.org/W4313422264"],"related_works":["https://openalex.org/W7160934189","https://openalex.org/W2937823726","https://openalex.org/W4366822295","https://openalex.org/W2807947863","https://openalex.org/W3206061095","https://openalex.org/W2055370220","https://openalex.org/W6995544653","https://openalex.org/W3119553910","https://openalex.org/W2058004680","https://openalex.org/W2152049148"],"abstract_inverted_index":{"Over":[0],"the":[1,10,18,33,47,95,111,122,129,134,138],"past":[2],"few":[3],"decades,":[4],"transforming":[5],"growth":[6],"factor-\u03b2":[7],"(TGF-\u03b2)":[8],"and":[9,28,46,63,92,107,115,118,150],"proteins":[11],"that":[12],"regulate":[13],"it":[14],"have":[15,99,108],"come":[16],"to":[17,44],"forefront":[19],"of":[20,25,30,32,49,90,94,113,124,132],"tumor":[21,55,148,156],"immunology.":[22],"The":[23],"relationship":[24],"mutations,":[26],"deletions,":[27],"amplifications":[29],"members":[31],"TGF-\u03b2":[34,50,72,78,114],"signaling":[35],"pathway,":[36],"as":[37,39,53,71],"well":[38],"reductions":[40],"in":[41],"receptor":[42,51],"expression,":[43],"malignancy":[45],"identification":[48],"polymorphisms":[52],"candidate":[54],"susceptibility":[56],"alleles":[57],"confirm":[58],"TGF-\u03b2\u2019s":[59],"influence":[60],"on":[61,86,110,121],"tumorigenesis":[62],"provide":[64],"avenues":[65],"for":[66,147,154],"potential":[67],"therapeutic":[68],"intervention.":[69],"Just":[70],"can":[73,79],"promote":[74,81],"or":[75,82],"suppress":[76,83],"tumorigenesis,":[77],"also":[80],"inflammation,":[84],"depending":[85],"cell":[87],"type,":[88],"state":[89],"differentiation/activation,":[91],"context":[93],"microenvironment.":[96],"Recent":[97],"studies":[98],"rejuvenated":[100],"early":[101],"observations":[102],"linking":[103],"inflammation":[104],"with":[105],"cancer":[106],"focused":[109],"impact":[112],"its":[116],"pro-":[117],"antiinflammatory":[119],"activities":[120],"outcome":[123],"tumor-specific":[125],"immune":[126,141],"responses.":[127],"Harnessing":[128],"suppressive":[130],"power":[131],"TGF-\u03b2,":[133],"regulatory":[135],"T-cell":[136],"counters":[137],"host":[139],"antitumor":[140],"response,":[142],"posing":[143],"a":[144,151],"major":[145],"mechanism":[146],"immunoevasion":[149],"significant":[152],"obstacle":[153],"effective":[155],"immunotherapy.":[157]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}