{"id":"https://openalex.org/W93143862","doi":"https://doi.org/10.1182/blood.v85.10.2967.bloodjournal85102967","title":"Hemin-induced acceleration of hemoglobin production in immature cultured erythroid cells: preferential enhancement of fetal hemoglobin","display_name":"Hemin-induced acceleration of hemoglobin production in immature cultured erythroid cells: preferential enhancement of fetal hemoglobin","publication_year":1995,"publication_date":"1995-05-15","ids":{"openalex":"https://openalex.org/W93143862","doi":"https://doi.org/10.1182/blood.v85.10.2967.bloodjournal85102967","mag":"93143862","pmid":"https://pubmed.ncbi.nlm.nih.gov/7537986"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v85.10.2967.bloodjournal85102967","doi":"https://doi.org/10.1182/blood.v85.10.2967.bloodjournal85102967","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v85.10.2967.bloodjournal85102967","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015469728","display_name":"Eitan Fibach","orcid":"https://orcid.org/0000-0002-6658-6126","observed_orcids":["https://orcid.org/0000-0002-6658-6126"]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"E Fibach","raw_affiliation_strings":["Department of Hematology, Hadassah University Hospital, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Hadassah University Hospital, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091418791","display_name":"P. Kollia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"P Kollia","raw_affiliation_strings":["Department of Hematology, Hadassah University Hospital, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Hadassah University Hospital, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047048178","display_name":"Alan N. Schechter","orcid":"https://orcid.org/0000-0002-6055-6452","observed_orcids":["https://orcid.org/0000-0002-6055-6452","https://orcid.org/0000-0002-5235-9408"]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"AN Schechter","raw_affiliation_strings":["Department of Hematology, Hadassah University Hospital, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Hadassah University Hospital, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112162882","display_name":"CT Noguchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"CT Noguchi","raw_affiliation_strings":["Department of Hematology, Hadassah University Hospital, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Hadassah University Hospital, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063483123","display_name":"GP Rodgers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799899409","display_name":"Hadassah Medical Center","ror":"https://ror.org/01cqmqj90","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799899409"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"GP Rodgers","raw_affiliation_strings":["Department of Hematology, Hadassah University Hospital, Jerusalem, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Hadassah University Hospital, Jerusalem, Israel","institution_ids":["https://openalex.org/I2799899409"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2799899409"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":2.1266,"has_fulltext":false,"cited_by_count":67,"citation_normalized_percentile":{"value":0.87231701,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"85","issue":"10","first_page":"2967","last_page":"2974"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemin","display_name":"hemin","score":0.996999979019165},{"id":"https://openalex.org/keywords/fetal-hemoglobin","display_name":"fetal hemoglobin","score":0.8330000042915344},{"id":"https://openalex.org/keywords/hemoglobin-synthesis","display_name":"hemoglobin synthesis","score":0.8510000109672546},{"id":"https://openalex.org/keywords/erythroid-cells","display_name":"erythroid cells","score":0.8169999718666077},{"id":"https://openalex.org/keywords/gamma-globin-mrna","display_name":"gamma-globin mRNA","score":0.8889999985694885},{"id":"https://openalex.org/keywords/succinylacetone","display_name":"succinylacetone","score":0.902999997138977},{"id":"https://openalex.org/keywords/hydroxyurea","display_name":"hydroxyurea","score":0.847000002861023},{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.9760000109672546},{"id":"https://openalex.org/keywords/beta-thalassemia","display_name":"beta-thalassemia","score":1.0},{"id":"https://openalex.org/keywords/erythropoietin","display_name":"erythropoietin","score":0.7979999780654907},{"id":"https://openalex.org/keywords/globin-gene-transcription","display_name":"globin gene transcription","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C2777723881","wikidata":"https://www.wikidata.org/wiki/Q107315604","display_name":"Hemin","level":4,"score":0.9686479568481445},{"id":"https://openalex.org/C2776317666","wikidata":"https://www.wikidata.org/wiki/Q2496436","display_name":"Fetal hemoglobin","level":4,"score":0.7313599586486816},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.7105404138565063},{"id":"https://openalex.org/C125996951","wikidata":"https://www.wikidata.org/wiki/Q412234","display_name":"Globin","level":3,"score":0.6442010402679443},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.6128870248794556},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.45224910974502563},{"id":"https://openalex.org/C2908652662","wikidata":"https://www.wikidata.org/wiki/Q2496436","display_name":"Hemoglobin F","level":5,"score":0.44587257504463196},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.44338834285736084},{"id":"https://openalex.org/C2777393523","wikidata":"https://www.wikidata.org/wiki/Q50008082","display_name":"Hemoglobin A","level":3,"score":0.43432164192199707},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4213411509990692},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40562233328819275},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.3404003977775574},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3372557759284973},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.16885966062545776},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08276346325874329},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005319","descriptor_name":"Fetal Hemoglobin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D005914","descriptor_name":"Globins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006427","descriptor_name":"Hemin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D006537","descriptor_name":"Heptanoates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006918","descriptor_name":"Hydroxyurea","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015672","descriptor_name":"Erythroid Precursor Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017086","descriptor_name":"beta-Thalassemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1182/blood.v85.10.2967.bloodjournal85102967","doi":"https://doi.org/10.1182/blood.v85.10.2967.bloodjournal85102967","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v85.10.2967.bloodjournal85102967","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:7537986","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7537986","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W70141885","https://openalex.org/W95258359","https://openalex.org/W137255699","https://openalex.org/W219805139","https://openalex.org/W324137543","https://openalex.org/W1488598317","https://openalex.org/W1489686269","https://openalex.org/W1516165231","https://openalex.org/W1556432187","https://openalex.org/W1932243120","https://openalex.org/W1965864854","https://openalex.org/W1980285314","https://openalex.org/W1987877328","https://openalex.org/W1988285714","https://openalex.org/W1989526140","https://openalex.org/W1994347885","https://openalex.org/W1996303124","https://openalex.org/W2003426797","https://openalex.org/W2005558408","https://openalex.org/W2014642850","https://openalex.org/W2016956820","https://openalex.org/W2024793020","https://openalex.org/W2025206980","https://openalex.org/W2025259610","https://openalex.org/W2027488554","https://openalex.org/W2028154108","https://openalex.org/W2053084472","https://openalex.org/W2056690450","https://openalex.org/W2066313956","https://openalex.org/W2066960428","https://openalex.org/W2081723155","https://openalex.org/W2081959583","https://openalex.org/W2086183275","https://openalex.org/W2091668307","https://openalex.org/W2106547142","https://openalex.org/W2156697515","https://openalex.org/W2212552301","https://openalex.org/W2264211064","https://openalex.org/W2323938126","https://openalex.org/W2341675267","https://openalex.org/W2394550922","https://openalex.org/W2402142321","https://openalex.org/W2407050949","https://openalex.org/W2407082523","https://openalex.org/W2407828400","https://openalex.org/W2410903228","https://openalex.org/W2413380280","https://openalex.org/W2415549287","https://openalex.org/W3093093377"],"related_works":["https://openalex.org/W2558138032","https://openalex.org/W2394684884","https://openalex.org/W95258359","https://openalex.org/W2124359529","https://openalex.org/W2045429053","https://openalex.org/W2031532553","https://openalex.org/W2001926054","https://openalex.org/W1996303124","https://openalex.org/W1595935720","https://openalex.org/W2407050949"],"abstract_inverted_index":{"The":[0,48],"effects":[1,128],"of":[2,32,36,56,75,99,120,147,162,202,215,223],"heme,":[3],"when":[4,168],"added":[5,26,169],"as":[6,158,160,177],"the":[7,33,37,73,112,118,138,178,203,216,221],"ferric":[8],"chloride":[9],"salt,":[10],"hemin,":[11],"on":[12,30,129],"human":[13],"erythroid":[14],"cells":[15,148,163],"grown":[16],"in":[17,45,91,170,200,210],"a":[18,64,87,96,182],"two-phase":[19],"liquid":[20],"culture":[21],"system":[22],"were":[23],"studied.":[24],"When":[25],"together":[27],"with":[28,80,86,152,172,187,192,212,226],"erythropoietin,":[29],"initiation":[31],"second":[34],"phase":[35],"culture,":[38],"hemin":[39,107,121,227],"greatly":[40],"accelerated":[41],"hemoglobin":[42],"(Hb)":[43],"accumulation":[44],"these":[46,236],"cells.":[47],"effect":[49,184,205],"was":[50,84,185],"greater":[51],"during":[52],"their":[53],"early":[54],"stages":[55],"maturation,":[57],"suggesting":[58],"that":[59,104,161,206],"heme":[60,100],"availability":[61],"is":[62],"then":[63],"rate-limiting":[65],"step":[66],"for":[67,141],"Hb":[68,77,142],"synthesis.":[69],"Hemin":[70,144],"increased":[71,145,207],"preferentially":[72],"production":[74],"fetal":[76],"(HbF)":[78],"compared":[79],"adult":[81],"Hb;":[82],"this":[83],"associated":[85],"selective":[88],"twofold":[89],"elevation":[90],"gamma-mRNA":[92],"levels.":[93],"Using":[94],"succinylacetone,":[95],"potent":[97],"inhibitor":[98],"synthesis,":[101],"we":[102],"showed":[103],"exogenously":[105],"supplied":[106],"could":[108],"be":[109,124],"incorporated":[110],"into":[111],"de":[113],"novo":[114],"formed":[115],"Hb.":[116],"Therefore,":[117],"mechanism":[119],"action":[122],"may":[123],"several":[125],"fold,":[126],"including":[127],"globin":[130],"gene":[131],"transcription":[132],"and":[133,156,219,228],"posttranslational":[134],"events,":[135],"eg,":[136],"supplying":[137],"prosthetic":[139],"group":[140],"assembly.":[143],"HbF":[146,208],"derived":[149],"from":[150,164],"patients":[151,211],"sickle":[153],"cell":[154],"anemia":[155],"beta-thalassemia":[157],"well":[159],"normal":[165],"donors.":[166],"Moreover,":[167],"combination":[171],"other":[173,229],"HbF-augmenting":[174],"agents":[175],"such":[176],"cytotoxic":[179],"drug,":[180],"hydroxyurea,":[181],"synergistic":[183],"obtained,":[186],"considerably":[188],"less":[189],"cytotoxicity":[190],"than":[191],"hydroxyurea":[193],"alone.":[194],"These":[195],"results":[196],"have":[197],"clinical":[198],"potential":[199],"light":[201],"ameliorating":[204],"has":[209],"genetic":[213],"diseases":[214],"beta-globin":[217],"chain":[218],"raise":[220],"possibility":[222],"combined":[224],"treatment":[225],"drugs":[230],"now":[231],"being":[232],"used":[233],"to":[234],"treat":[235],"diseases.":[237]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
