{"id":"https://openalex.org/W928630352","doi":null,"title":"Intranasal delivery of nerve growth factor to protect the central nervous system against acute cerebral infarction.","display_name":"Intranasal delivery of nerve growth factor to protect the central nervous system against acute cerebral infarction.","publication_year":2004,"publication_date":"2004-12-01","ids":{"openalex":"https://openalex.org/W928630352","mag":"928630352","pmid":"https://pubmed.ncbi.nlm.nih.gov/15669182"},"language":"en","primary_location":{"id":"pmid:15669182","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15669182","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019574232","display_name":"Hong-meiZhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128175","display_name":"Shanghai East Hospital","ror":"https://ror.org/038xmzj21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128175"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong-mei Zhao","raw_affiliation_strings":["Traumatic Center and Emergency Department, East Hospital, Shanghai 200120"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Traumatic Center and Emergency Department, East Hospital, Shanghai 200120","institution_ids":["https://openalex.org/I4210128175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079049000","display_name":"XinfengLiu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xin-feng Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013026967","display_name":"Xiao-weiMao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiao-wei Mao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5049622971","display_name":"Chun-fuChen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chun-fu Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.656,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.66628728,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"19","issue":"4","first_page":"257","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.5288000106811523,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.5288000106811523,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.1378999948501587,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.10700000077486038,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nerve-growth-factor","display_name":"nerve growth factor","score":0.9869999885559082},{"id":"https://openalex.org/keywords/intranasal-drug-delivery","display_name":"intranasal drug delivery","score":0.9089999794960022},{"id":"https://openalex.org/keywords/blood-brain-barrier-bypass","display_name":"blood-brain barrier bypass","score":0.8080000281333923},{"id":"https://openalex.org/keywords/acute-cerebral-ischemia","display_name":"acute cerebral ischemia","score":0.7590000033378601},{"id":"https://openalex.org/keywords/middle-cerebral-artery-occlusion","display_name":"middle cerebral artery occlusion","score":0.8569999933242798},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8809999823570251},{"id":"https://openalex.org/keywords/stroke-treatment","display_name":"stroke treatment","score":0.6650000214576721},{"id":"https://openalex.org/keywords/olfactory-bulb","display_name":"olfactory bulb","score":0.8849999904632568},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9860000014305115},{"id":"https://openalex.org/keywords/infarct-size","display_name":"infarct size","score":0.9629999995231628},{"id":"https://openalex.org/keywords/neurological-function","display_name":"neurological function","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C2778423431","wikidata":"https://www.wikidata.org/wiki/Q417782","display_name":"Nerve growth factor","level":3,"score":0.932816743850708},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7669909000396729},{"id":"https://openalex.org/C85663871","wikidata":"https://www.wikidata.org/wiki/Q6966562","display_name":"Nasal administration","level":2,"score":0.6516534090042114},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.6317824721336365},{"id":"https://openalex.org/C2780496858","wikidata":"https://www.wikidata.org/wiki/Q644945","display_name":"Olfactory bulb","level":3,"score":0.5769244432449341},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5403950214385986},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.5125539302825928},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.4934209883213043},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.4135719835758209},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38850292563438416},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34401893615722656},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.24742764234542847},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06582525372505188},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000281","descriptor_name":"Administration, Intranasal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009830","descriptor_name":"Olfactory Bulb","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020244","descriptor_name":"Infarction, Middle Cerebral Artery","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020244","descriptor_name":"Infarction, Middle Cerebral Artery","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020932","descriptor_name":"Nerve Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020932","descriptor_name":"Nerve Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:15669182","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15669182","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih","raw_type":"Comparative Study"},{"id":"mag:2465295486","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15669182","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null},{"id":"mag:928630352","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/86798X/200404/11885628.html","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u6742\u5fd7\uff1a\u82f1\u6587\u7248","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2381874511","https://openalex.org/W2047173091","https://openalex.org/W2019861549","https://openalex.org/W7201868461","https://openalex.org/W4233417974","https://openalex.org/W2359526083","https://openalex.org/W1971206035","https://openalex.org/W1968657094","https://openalex.org/W2037411373","https://openalex.org/W2057737598"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1,27,77],"confirmed":[2],"reliability":[3],"and":[4,16,52,115,128,176,190,224,234,256],"feasibility":[5],"of":[6,60,62,81,113,133,144,160,229,266],"intranasal":[7,46],"nerve":[8],"growth":[9],"factor":[10],"(NGF)":[11],"bypassing":[12],"the":[13,67,155,167,173,245,249],"blood-brain":[14,246],"barrier":[15],"its":[17],"potential":[18],"neuroprotective":[19,79],"effects":[20],"on":[21,83],"acute":[22],"cerebral":[23,37,85],"ischemia.":[24],"METHODS:":[25],"(1)":[26],"assay":[28],"NGF":[29,61,82,102,152,161,170,180,189,198,211,241,267],"concentrations":[30,59,171],"in":[31,66,150,172,178,187,196,260],"different":[32,63],"brain":[33,64],"regions":[34,65],"after":[35,70,111,142,227],"middle":[36],"artery":[38],"occlusion":[39],"(MCAO).":[40],"Rats":[41,88],"were":[42,72,89,125,138,182],"randomly":[43,90],"divided":[44],"into":[45],"(i.n.)":[47],"NGF,":[48,51,98],"intravenous":[49],"(i.v.)":[50],"untreated":[53],"group":[54,153,181,199,212,221],"(n":[55,103],"=":[56,104,232,236],"4).":[57],"The":[58,147,169,193],"three":[68],"groups":[69],"MCAO":[71,114,230],"measured":[73],"by":[74,166,203],"ELISA.":[75],"(2)":[76],"observe":[78],"action":[80],"focal":[84],"ischemic":[86],"damage.":[87],"assigned":[91],"to":[92],"4":[93],"groups:":[94],"i.n.":[95,97,151,179,197,207,219],"vehicle,":[96,100],"i.v.":[99,101,188],"8).":[105],"Treatment":[106],"was":[107,200],"initiated":[108],"30":[109],"minutes":[110],"onset":[112,132,143,228],"given":[116],"again":[117],"24":[118,127,223],"hours":[119,130,141,226],"later.":[120],"Three":[121],"neurologic":[122,258],"behavioral":[123],"tests":[124],"performed":[126],"48":[129,140,225],"following":[131,262],"MCAO.":[134,145,263],"Corrected":[135],"infarct":[136,194,254],"volumes":[137],"determined":[139],"RESULTS:":[146],"olfactory":[148,174],"bulb":[149,175],"obtained":[154],"highest":[156],"concentration":[157],"(3252":[158],"pg/g)":[159],"among":[162],"all":[163],"regions,":[164],"followed":[165],"hippocampus.":[168],"hippocampus":[177],"markedly":[183,201,215],"higher":[184],"than":[185],"that":[186],"control":[191],"groups.":[192],"volume":[195],"reduced":[202],"38.8%":[204],"compared":[205,217],"with":[206,218],"vehicle":[208,220],"group.":[209],"I.n.":[210],"vestibulum":[213],"function":[214,259],"improved":[216],"at":[222],"(P24h":[231],"0.02":[233],"P48h":[235],"0.04,":[237],"respectively).":[238],"CONCLUSION:":[239],"Intranasal":[240,264],"could":[242],"pass":[243],"through":[244],"barrier,":[247],"reach":[248],"central":[250],"nervous":[251],"system,":[252],"reduce":[253],"volume,":[255],"improve":[257],"rats":[261],"delivery":[265],"may":[268],"be":[269],"a":[270],"promising":[271],"treatment":[272],"for":[273],"stroke.":[274]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
