{"id":"https://openalex.org/W926029167","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.868.3","title":"Visualizing the Process of Metastatic Intravasation in vivo","display_name":"Visualizing the Process of Metastatic Intravasation in vivo","publication_year":2015,"publication_date":"2015-04-01","ids":{"openalex":"https://openalex.org/W926029167","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.868.3","mag":"926029167"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.29.1_supplement.868.3","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.868.3","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.29.1_supplement.868.3","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061164275","display_name":"Caleb Michael Bailey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43943889","display_name":"Brigham Young University - Idaho","ror":"https://ror.org/05j7qk258","country_code":"US","type":"education","lineage":["https://openalex.org/I43943889"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caleb Bailey","raw_affiliation_strings":["BiologyBrigham Young University IdahoRexburgIDUnited States","1Biology Brigham Young University Idaho Rexburg ID United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BiologyBrigham Young University IdahoRexburgIDUnited States","institution_ids":["https://openalex.org/I43943889"]},{"raw_affiliation_string":"1Biology Brigham Young University Idaho Rexburg ID United States","institution_ids":["https://openalex.org/I43943889"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021609999","display_name":"Paul M. Kulesa","orcid":"https://orcid.org/0000-0001-6354-9904","observed_orcids":["https://orcid.org/0000-0001-6354-9904"]},"institutions":[{"id":"https://openalex.org/I114131015","display_name":"Stowers Institute for Medical Research","ror":"https://ror.org/04bgfm609","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I114131015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Kulesa","raw_affiliation_strings":["Imaging / Kulesa Laboratory Stowers Institute for Medical ResearchKansas CityMOUnited States","2Imaging / Kulesa Laboratory Stowers Institute for Medical Research Kansas City MO United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging / Kulesa Laboratory Stowers Institute for Medical ResearchKansas CityMOUnited States","institution_ids":["https://openalex.org/I114131015"]},{"raw_affiliation_string":"2Imaging / Kulesa Laboratory Stowers Institute for Medical Research Kansas City MO United States","institution_ids":["https://openalex.org/I114131015"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01598115,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.8511000275611877,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.8511000275611877,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.03189999982714653,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.022099999710917473,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chorioallantoic-membrane-assay","display_name":"chorioallantoic membrane assay","score":0.968999981880188},{"id":"https://openalex.org/keywords/time-lapse-microscopy","display_name":"time-lapse microscopy","score":0.800000011920929},{"id":"https://openalex.org/keywords/tumor-cell-endothelial-cell-interaction","display_name":"tumor cell-endothelial cell interaction","score":0.8880000114440918},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8259999752044678},{"id":"https://openalex.org/keywords/cell-surface-receptors","display_name":"cell surface receptors","score":0.6669999957084656},{"id":"https://openalex.org/keywords/in-vivo-imaging","display_name":"in vivo imaging","score":0.5019999742507935},{"id":"https://openalex.org/keywords/chick-embryo","display_name":"chick embryo","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C2778050619","wikidata":"https://www.wikidata.org/wiki/Q6058567","display_name":"Intravasation","level":4,"score":0.9888372421264648},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6686115264892578},{"id":"https://openalex.org/C15526883","wikidata":"https://www.wikidata.org/wiki/Q6657126","display_name":"Live cell imaging","level":3,"score":0.5739172101020813},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5677955150604248},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4333212077617645},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.41654354333877563},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41156303882598877},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3597772717475891},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35711461305618286},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3350667357444763},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2676694393157959},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2100485861301422},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10296997427940369},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.29.1_supplement.868.3","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.868.3","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.29.1_supplement.868.3","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307514","display_name":"American Association of Anatomists","ror":"https://ror.org/04v1psm68"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2093972561","https://openalex.org/W183848026","https://openalex.org/W2087496074","https://openalex.org/W1517411325","https://openalex.org/W2516001534","https://openalex.org/W1972332991","https://openalex.org/W2099662382","https://openalex.org/W2154721147","https://openalex.org/W4409440515","https://openalex.org/W2331350355"],"abstract_inverted_index":{"Metastasis":[0],"highlights":[1],"a":[2,67,83,91,124,216],"complex,":[3],"dynamic":[4,68],"relationship":[5],"between":[6,157],"the":[7,30,40,48,57,73,131,137,155,175,196,220],"tumor":[8,160,202],"and":[9,94,145,162,198],"its":[10],"microenvironment.":[11],"Signals":[12],"that":[13,128],"regulate":[14],"or":[15],"inhibit":[16],"metastatic":[17,31,49,208],"behaviors":[18],"have":[19,173],"been":[20,96],"slow":[21],"to":[22,25,55,90,117,153,181,226],"discover":[23],"due":[24],"challenges":[26,104],"associated":[27,105],"with":[28,106],"studying":[29],"process":[32,58],"in":[33,47,61,86,98,168,179],"vivo.":[34,169],"Previous":[35],"work":[36],"provided":[37],"data":[38],"suggesting":[39],"involvement":[41],"of":[42,51,59,133,136,147,200,207,223],"specific":[43],"cell":[44,204],"surface":[45],"receptors":[46],"step":[50],"intravasation.":[52,209],"In":[53,170],"order":[54,180],"visualize":[56],"intravasation":[60],"real-time,":[62],"we":[63,122,172],"worked":[64],"toward":[65],"developing":[66],"imaging":[69,110],"platform":[70,191],"based":[71],"on":[72],"chorioallantoic":[74],"membrane":[75],"(CAM)":[76],"assay.":[77],"The":[78],"embryonic":[79],"chick":[80],"CAM":[81,113,126,164,177],"provides":[82],"highly":[84],"vascular":[85],"vivo":[87],"substrate":[88],"similar":[89],"human":[92],"microenvironment":[93],"has":[95],"employed":[97],"metastasis":[99],"assays":[100],"previously.":[101],"However,":[102],"inherent":[103],"high":[107],"resolution":[108],"time-lapse":[109,184],"using":[111,186],"established":[112],"platforms":[114],"necessitated":[115],"adaptations":[116,150],"current":[118],"protocols.":[119],"As":[120],"such,":[121],"developed":[123],"shell-less":[125,176],"technique":[127],"could":[129],"dampen":[130],"effects":[132],"spontaneous":[134],"movements":[135],"embryo":[138],"proper,":[139],"which":[140],"greatly":[141],"affect":[142],"microscopic":[143],"focus":[144],"field":[146],"view.":[148],"These":[149],"allowed":[151],"us":[152],"image":[154],"interactions":[156,205],"fluorescent":[158],"labeled":[159],"cells":[161],"unlabeled":[163],"tissue":[165],"over":[166],"time":[167],"conclusion,":[171],"adaptated":[174],"assay":[178],"optimize":[182],"for":[183,195],"microscopy":[185],"any":[187],"upright":[188],"microscope.":[189],"This":[190,210],"will":[192],"now":[193],"allow":[194],"visualization":[197],"interrogation":[199],"complex":[201],"cell-endothelial":[203],"characteristic":[206],"research":[211],"was":[212],"kindly":[213],"funded":[214],"by":[215],"postdoctoral":[217],"fellowship":[218],"from":[219],"American":[221],"Association":[222],"Anatomists":[224],"awarded":[225],"CMB.":[227]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}