{"id":"https://openalex.org/W92563046","doi":null,"title":"Lipidomic analysis of eicosanoid dynamics in inflammation and disease","display_name":"Lipidomic analysis of eicosanoid dynamics in inflammation and disease","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W92563046","mag":"92563046"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt8c40880d","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/8c40880d","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058164865","display_name":"Matthew W. Buczynski","orcid":"https://orcid.org/0000-0001-5931-7107","observed_orcids":["https://orcid.org/0000-0001-5931-7107"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Matthew W. Buczynski","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5931-7107","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5058164865"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.4787999987602234,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.4787999987602234,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.20350000262260437,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.08969999849796295,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eicosanoids","display_name":"eicosanoids","score":0.9990000128746033},{"id":"https://openalex.org/keywords/arachidonic-acid","display_name":"arachidonic acid","score":0.8790000081062317},{"id":"https://openalex.org/keywords/eicosanoid-biosynthesis","display_name":"eicosanoid biosynthesis","score":0.9240000247955322},{"id":"https://openalex.org/keywords/lipidomics","display_name":"lipidomics","score":0.8569999933242798},{"id":"https://openalex.org/keywords/tandem-mass-spectrometry","display_name":"tandem mass spectrometry","score":0.949999988079071},{"id":"https://openalex.org/keywords/mass-spectral-library","display_name":"mass spectral library","score":0.7269999980926514},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8169999718666077},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7680000066757202},{"id":"https://openalex.org/keywords/lyme-disease","display_name":"Lyme disease","score":0.9760000109672546},{"id":"https://openalex.org/keywords/resolution-of-inflammation","display_name":"inflammation resolution","score":0.7360000014305115}],"concepts":[{"id":"https://openalex.org/C2776352991","wikidata":"https://www.wikidata.org/wiki/Q407680","display_name":"Eicosanoid","level":4,"score":0.8800340890884399},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6557817459106445},{"id":"https://openalex.org/C180899940","wikidata":"https://www.wikidata.org/wiki/Q117982","display_name":"Lipid signaling","level":3,"score":0.6193786263465881},{"id":"https://openalex.org/C2908562933","wikidata":"https://www.wikidata.org/wiki/Q407680","display_name":"Eicosanoid metabolism","level":5,"score":0.586127519607544},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5324614644050598},{"id":"https://openalex.org/C58017582","wikidata":"https://www.wikidata.org/wiki/Q6556376","display_name":"Lipidomics","level":2,"score":0.5115821957588196},{"id":"https://openalex.org/C2779943694","wikidata":"https://www.wikidata.org/wiki/Q425463","display_name":"Oxylipin","level":3,"score":0.5098673105239868},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.4734874665737152},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.45036742091178894},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4454202353954315},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44332197308540344},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.4173058271408081},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4152475595474243},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3613456189632416},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.18812596797943115},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.1578247845172882},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10349452495574951},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:escholarship.org/ark:/13030/qt8c40880d","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/8c40880d","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},{"id":"mag:92563046","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/content/qt8c40880d/qt8c40880d.pdf?t=lq4w18","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46000000834465027}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2007613321","https://openalex.org/W4389022847","https://openalex.org/W149123872","https://openalex.org/W1985459635","https://openalex.org/W2472258010","https://openalex.org/W175148800","https://openalex.org/W2070048233","https://openalex.org/W1978221234","https://openalex.org/W6939884107","https://openalex.org/W4220787662"],"abstract_inverted_index":{"Eicosanoids":[0],"begin":[1],"as":[2,129,131,142],"a":[3,37,70,82,151,179,209,226],"single":[4],"poly-unsaturated":[5],"fatty":[6],"acid,":[7],"arachidonic":[8],"acid.":[9],"Yet":[10],"from":[11,51,242],"this":[12,58,149,201],"simple":[13],"origin,":[14],"hundreds":[15],"of":[16,26,32,88,97,111,124,155,181,217,228,247],"bioactive":[17,34],"signaling":[18,52,80],"molecules":[19],"can":[20,74],"be":[21,75],"created,":[22],"often":[23],"within":[24],"minutes":[25],"receiving":[27],"an":[28,42,90],"initiation":[29],"signal.":[30],"Many":[31],"these":[33],"lipids":[35],"have":[36,61],"functional":[38],"partner":[39],"that":[40,73,172,194,236],"generates":[41],"opposing":[43],"effect":[44],"and":[45,65,101,106,127,136,146,160,214],"helps":[46],"prevent":[47],"any":[48],"one":[49],"pathway":[50],"uncontrollably":[53],"in":[54,81,99,109,186,198,230],"the":[55,95,104,122,132,137,187,205,221,238],"body.":[56],"For":[57],"reason,":[59],"we":[60,203,224],"adapted":[62],"liquid":[63],"chromatography":[64],"tandem":[66,169],"mass":[67,152,170],"spectrometry":[68,171],"into":[69,208],"lipidomic":[71,166],"platform":[72],"employed":[76],"to":[77,93,162,245],"study":[78],"eicosanoid":[79,125,183,240],"comprehensive":[83],"manner.":[84],"The":[85],"overarching":[86],"goal":[87],"such":[89],"approach":[91],"is":[92],"elucidate":[94],"role":[96],"eicosanoids":[98,157,197],"physiology":[100],"disease":[102,235],"at":[103],"cellular":[105],"organismal":[107,222],"level,":[108,223],"hopes":[110],"identifying":[112,190],"better":[113],"targets":[114],"for":[115,211],"pharmaceutical":[116],"intervention.":[117],"This":[118],"thesis":[119],"first":[120],"discusses":[121],"pathways":[123,185,193],"biosynthesis":[126],"catabolism,":[128],"well":[130],"differences":[133],"between":[134],"humans":[135],"model":[138,207,227],"organisms":[139],"commonly":[140],"used":[141,161],"research":[143],"surrogates":[144],"(mouse":[145],"rat).":[147],"Using":[148,200],"background,":[150],"spectra":[153],"library":[154],"known":[156],"was":[158],"generated":[159],"create":[163],"high-":[164],"throughput":[165],"methodology":[167],"using":[168],"facilitated":[173],"several":[174],"different":[175],"studies.":[176],"We":[177],"investigated":[178],"number":[180],"receptor-mediated":[182],"activation":[184],"macrophage":[188,206],"cell,":[189],"two":[191],"distinct":[192],"synergistically":[195],"produce":[196],"combination.":[199],"study,":[202],"turned":[204],"tool":[210],"developing":[212],"potent":[213],"selective":[215],"inhibitors":[216],"inflammatory":[218],"metalloproteins.":[219],"At":[220],"developed":[225],"inflammation":[229,248],"mice":[231],"infected":[232],"with":[233],"Lyme":[234],"integrates":[237],"major":[239],"pathways,":[241],"initial":[243],"infection":[244],"resolution":[246]},"counts_by_year":[],"updated_date":"2026-09-04T10:56:28.161419","created_date":"2016-06-24T00:00:00"}
