{"id":"https://openalex.org/W9251540","doi":"https://doi.org/10.18553/jmcp.2014.20.4.376","title":"Simultaneous Use of Amiodarone Influences Warfarin Maintenance Dose but Is Not Associated with Adverse Events","display_name":"Simultaneous Use of Amiodarone Influences Warfarin Maintenance Dose but Is Not Associated with Adverse Events","publication_year":2014,"publication_date":"2014-04-01","ids":{"openalex":"https://openalex.org/W9251540","doi":"https://doi.org/10.18553/jmcp.2014.20.4.376","mag":"9251540","pmid":"https://pubmed.ncbi.nlm.nih.gov/24684642","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/10438264"},"language":"en","primary_location":{"id":"doi:10.18553/jmcp.2014.20.4.376","doi":"https://doi.org/10.18553/jmcp.2014.20.4.376","is_oa":false,"landing_page_url":"https://doi.org/10.18553/jmcp.2014.20.4.376","pdf_url":null,"source":{"id":"https://openalex.org/S40961437","display_name":"Journal of Managed Care Pharmacy","issn_l":"1083-4087","issn":["1083-4087","1944-706X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4363609268","host_organization_name":"Academy of Managed Care Pharmacy","host_organization_lineage":["https://openalex.org/P4363609268"],"host_organization_lineage_names":["Academy of Managed Care Pharmacy"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Managed Care Pharmacy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10438264/pdf/jmcp.2014.20.4.376.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111583855","display_name":"Paulo Caleb J\u00fanior Lima Santos","orcid":"https://orcid.org/0000-0002-8100-2264","observed_orcids":["https://orcid.org/0000-0002-8100-2264"]},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Paulo Caleb Junior Lima Santos","raw_affiliation_strings":["University of S\u00e3o Paulo Medical School, Av. Dr. Eneas de Carvalho Aguiar, 44 Cerqueira Cesar - S\u00e3o Paulo - SP, Brazil, CEP 05403-000. alexandre.pereira@incor.usp.br; pacaleb@usp.br","University of S\u00e3o Paulo Medical School, Av. Dr. Eneas de Carvalho Aguiar, 44 Cerqueira Cesar - S\u00e3o Paulo - SP, Brazil, CEP 05403-000. alexandre.pereira@incor.usp.br"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of S\u00e3o Paulo Medical School, Av. Dr. Eneas de Carvalho Aguiar, 44 Cerqueira Cesar - S\u00e3o Paulo - SP, Brazil, CEP 05403-000. alexandre.pereira@incor.usp.br; pacaleb@usp.br","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"University of S\u00e3o Paulo Medical School, Av. Dr. Eneas de Carvalho Aguiar, 44 Cerqueira Cesar - S\u00e3o Paulo - SP, Brazil, CEP 05403-000. alexandre.pereira@incor.usp.br","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112378778","display_name":"Renata Alonso Gadi Soares","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Renata Alonso Gadi Soares","raw_affiliation_strings":["pacaleb@usp.br"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"pacaleb@usp.br","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065794128","display_name":"C\u00e9lia Maria C\u00e1ssaro Strunz","orcid":"https://orcid.org/0000-0002-9766-1184","observed_orcids":["https://orcid.org/0000-0002-9766-1184"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Celia Maria Cassaro Strunz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103281155","display_name":"Max Grinberg","orcid":"https://orcid.org/0000-0001-6439-5222","observed_orcids":["https://orcid.org/0000-0001-6439-5222"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Max Grinberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104245618","display_name":"Jo\u00e3o Ferreira","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jo\u00e3o Fernando M. Ferreira","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031062489","display_name":"Lu\u00edz Antonio Machado C\u00e9sar","orcid":"https://orcid.org/0000-0003-4436-1791","observed_orcids":["https://orcid.org/0000-0003-4436-1791"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luiz Ant\u00f4nio Machado Cesar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087881782","display_name":"Maur\u00edcio Scanavacca","orcid":"https://orcid.org/0000-0001-7327-2275","observed_orcids":["https://orcid.org/0000-0001-7327-2275"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maur\u00edcio Scanavacca","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088604083","display_name":"Jos\u00e9 Eduardo Krieger","orcid":"https://orcid.org/0000-0001-5464-1792","observed_orcids":["https://orcid.org/0000-0001-5464-1792"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jose Eduardo Krieger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5032544285","display_name":"Alexandre C. Pereira","orcid":"https://orcid.org/0000-0002-7782-5540","observed_orcids":["https://orcid.org/0000-0002-7782-5540"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexandre Costa Pereira","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3234,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.74082708,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"20","issue":"4","first_page":"376","last_page":"381"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8070999979972839,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.8070999979972839,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.17880000174045563,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amiodarone","display_name":"amiodarone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/warfarin","display_name":"warfarin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.8679999709129333},{"id":"https://openalex.org/keywords/anticoagulation","display_name":"anticoagulation","score":0.7940000295639038},{"id":"https://openalex.org/keywords/international-normalized-ratio","display_name":"international normalized ratio","score":0.5249999761581421},{"id":"https://openalex.org/keywords/bleeding-events","display_name":"bleeding events","score":0.5950000286102295},{"id":"https://openalex.org/keywords/cyp2c9-polymorphism","display_name":"CYP2C9 polymorphism","score":0.8889999985694885},{"id":"https://openalex.org/keywords/vkorc1-polymorphism","display_name":"VKORC1 polymorphism","score":0.9169999957084656},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.6690000295639038},{"id":"https://openalex.org/keywords/oral-anticoagulants","display_name":"oral anticoagulants","score":0.8069999814033508}],"concepts":[{"id":"https://openalex.org/C2778094803","wikidata":"https://www.wikidata.org/wiki/Q410061","display_name":"Amiodarone","level":3,"score":0.9415310621261597},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9050920009613037},{"id":"https://openalex.org/C2776301958","wikidata":"https://www.wikidata.org/wiki/Q407431","display_name":"Warfarin","level":3,"score":0.8853559494018555},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.7267510890960693},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.6003732681274414},{"id":"https://openalex.org/C3946865","wikidata":"https://www.wikidata.org/wiki/Q5014962","display_name":"CYP2C9","level":4,"score":0.589163601398468},{"id":"https://openalex.org/C27924281","wikidata":"https://www.wikidata.org/wiki/Q17126475","display_name":"Maintenance dose","level":2,"score":0.5774906873703003},{"id":"https://openalex.org/C2776318485","wikidata":"https://www.wikidata.org/wiki/Q18045930","display_name":"VKORC1","level":5,"score":0.543498158454895},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5223206877708435},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.5027508735656738},{"id":"https://openalex.org/C2780434524","wikidata":"https://www.wikidata.org/wiki/Q1144385","display_name":"Prothrombin time","level":2,"score":0.481361448764801},{"id":"https://openalex.org/C35294091","wikidata":"https://www.wikidata.org/wiki/Q6663385","display_name":"Loading dose","level":2,"score":0.4400922954082489},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.395781934261322},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3227337896823883},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.0},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000638","descriptor_name":"Amiodarone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000638","descriptor_name":"Amiodarone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000638","descriptor_name":"Amiodarone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000889","descriptor_name":"Anti-Arrhythmia Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000889","descriptor_name":"Anti-Arrhythmia Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000889","descriptor_name":"Anti-Arrhythmia Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011517","descriptor_name":"Prothrombin Time","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014859","descriptor_name":"Warfarin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014859","descriptor_name":"Warfarin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014859","descriptor_name":"Warfarin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019934","descriptor_name":"International Normalized Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064417","descriptor_name":"Vitamin K Epoxide Reductases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D065729","descriptor_name":"Cytochrome P-450 CYP2C9","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.18553/jmcp.2014.20.4.376","doi":"https://doi.org/10.18553/jmcp.2014.20.4.376","is_oa":false,"landing_page_url":"https://doi.org/10.18553/jmcp.2014.20.4.376","pdf_url":null,"source":{"id":"https://openalex.org/S40961437","display_name":"Journal of Managed Care Pharmacy","issn_l":"1083-4087","issn":["1083-4087","1944-706X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4363609268","host_organization_name":"Academy of Managed Care Pharmacy","host_organization_lineage":["https://openalex.org/P4363609268"],"host_organization_lineage_names":["Academy of Managed Care Pharmacy"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Managed Care Pharmacy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:10438264","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10438264","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10438264/pdf/jmcp.2014.20.4.376.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Manag Care Pharm","raw_type":"Text"},{"id":"pmid:24684642","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24684642","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of managed care & specialty pharmacy","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:10438264","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10438264","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10438264/pdf/jmcp.2014.20.4.376.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Manag Care Pharm","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320323339","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748"},{"id":"https://openalex.org/F4320323916","display_name":"Minist\u00e9rio da Sa\u00fade","ror":"https://ror.org/02y7p0749"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W9251540.pdf","grobid_xml":"https://content.openalex.org/works/W9251540.grobid-xml"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W42957898","https://openalex.org/W1586488555","https://openalex.org/W1804077004","https://openalex.org/W1974342860","https://openalex.org/W2006640042","https://openalex.org/W2018733578","https://openalex.org/W2043674997","https://openalex.org/W2047097854","https://openalex.org/W2066490209","https://openalex.org/W2075780529","https://openalex.org/W2087823856","https://openalex.org/W2118094114","https://openalex.org/W2130053080","https://openalex.org/W2131181128","https://openalex.org/W2137422676","https://openalex.org/W2163274594","https://openalex.org/W2164327527","https://openalex.org/W2165775954"],"related_works":["https://openalex.org/W2075780529","https://openalex.org/W1983041769","https://openalex.org/W4229609582","https://openalex.org/W2111636108","https://openalex.org/W2034114474","https://openalex.org/W2806658790","https://openalex.org/W197096525","https://openalex.org/W2006056499","https://openalex.org/W1982528980","https://openalex.org/W4378191260"],"abstract_inverted_index":{"BACKGROUND:":[0],"Drug":[1],"interaction":[2],"studies":[3,14],"selecting":[4],"patients":[5,109,120,143],"in":[6,38,108],"a":[7,20,43],"real-life":[8],"setting":[9],"are":[10,17],"scarce,":[11],"and":[12,35,53,74,90,93],"most":[13],"to":[15],"date":[16],"characterized":[18],"by":[19,59],"small":[21],"sample":[22],"size.":[23],"OBJECTIVE:":[24],"To":[25],"evaluate":[26],"the":[27,60,65,82,97,162,173],"effect":[28,169],"of":[29,71,175,184],"amiodarone":[30,89,112,130,146,179,185],"on":[31,172],"warfarin":[32,91,102,187],"maintenance":[33,103,188],"dose":[34,104,134],"adverse":[36,195],"events":[37],"an":[39],"anticoagulation":[40],"cohort":[41],"from":[42],"tertiary":[44],"cardiovascular":[45],"service.":[46],"METHODS:":[47],"This":[48],"study":[49],"recruited":[50],"866":[51,83],"patients,":[52,84],"oral":[54],"anticoagulant":[55],"therapy":[56],"was":[57,78,105,158,170],"monitored":[58],"prothrombin":[61],"time":[62],"expressed":[63],"as":[64],"international":[66],"normalized":[67],"ratio":[68],"(INR).":[69],"Genotyping":[70],"CYP2C9*2,":[72],"CYP2C9*3,":[73],"VKORC1":[75],"3673":[76],"polymorphisms":[77],"performed.":[79],"RESULTS:":[80],"Of":[81],"111":[85],"(12.8%)":[86],"were":[87],"taking":[88,129],"simultaneously,":[92],"514":[94],"(59.4%)":[95],"reached":[96],"therapeutic":[98],"target":[99],"dose.":[100],"The":[101],"significantly":[106],"lower":[107],"simultaneously":[110],"using":[111,145],"(23.8":[113],"\u00b1":[114,122,137,148],"11.3":[115],"mg/wk)":[116],"compared":[117,141],"with":[118,142,178,194],"other":[119],"(29.5":[121],"14.3":[123],"mg/wk;":[124],"P":[125,152],"<":[126],"0.001).":[127,154],"Patients":[128],"had":[131],"higher":[132],"INR/current":[133],"ratios":[135],"(0.83":[136],"0.04":[138],"per":[139,150],"mg)":[140],"not":[144,159,192],"(0.71":[147],"0.02":[149],"mg,":[151],"=":[153,165],"Adverse":[155],"event":[156],"frequency":[157],"different":[160],"between":[161],"groups":[163],"(P":[164],"0.40).":[166],"No":[167],"genotype":[168],"noted":[171],"odds":[174],"bleeding":[176],"associated":[177,193],"use.":[180],"CONCLUSIONS:":[181],"Simultaneous":[182],"use":[183],"influences":[186],"dose,":[189],"but":[190],"is":[191],"events.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}