{"id":"https://openalex.org/W92374912","doi":null,"title":"Cytoplasmic tails of integrin \u03b1IIb\u03b23 in the regulation of integrin activation, cell adhesion and spreading","display_name":"Cytoplasmic tails of integrin \u03b1IIb\u03b23 in the regulation of integrin activation, cell adhesion and spreading","publication_year":2014,"publication_date":"2014-03-01","ids":{"openalex":"https://openalex.org/W92374912","mag":"92374912"},"language":"en","primary_location":{"id":"pmh:oai:ecommons.usask.ca:10388/ETD-2014-03-1512","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10388/ETD-2014-03-1512","pdf_url":null,"source":{"id":"https://openalex.org/S4377196608","display_name":"University Library - University of Saskatchewan (University of Saskatchewan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32625721","host_organization_name":"University of Saskatchewan","host_organization_lineage":["https://openalex.org/I32625721"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090384690","display_name":"xinlei li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"xinlei li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5090384690"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glycoprotein-iib-iiia","display_name":"integrin \u03b1IIb\u03b23","score":0.9819999933242798},{"id":"https://openalex.org/keywords/integrin-cytoplasmic-tail","display_name":"integrin cytoplasmic tail","score":0.8939999938011169},{"id":"https://openalex.org/keywords/talin","display_name":"talin","score":0.9359999895095825},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.8199999928474426},{"id":"https://openalex.org/keywords/cell-spreading","display_name":"cell spreading","score":0.9929999709129333},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":0.7250000238418579},{"id":"https://openalex.org/keywords/focal-adhesions","display_name":"focal adhesions","score":0.9419999718666077},{"id":"https://openalex.org/keywords/stress-fibers","display_name":"stress fibers","score":0.75},{"id":"https://openalex.org/keywords/src-kinase-activation","display_name":"Src kinase activation","score":0.6389999985694885},{"id":"https://openalex.org/keywords/integrin-activation","display_name":"integrin activation","score":0.5740000009536743},{"id":"https://openalex.org/keywords/integrin-alphav","display_name":"ITGAV","score":0.7179999947547913},{"id":"https://openalex.org/keywords/vitronectin","display_name":"vitronectin","score":0.7839999794960022},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7070000171661377},{"id":"https://openalex.org/keywords/beta-tubulin","display_name":"beta-tubulin","score":0.8669999837875366},{"id":"https://openalex.org/keywords/microtubule-cytoskeleton","display_name":"microtubule cytoskeleton","score":0.8939999938011169}],"concepts":[{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.8183031678199768},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.6615279316902161},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6378160715103149},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.5486342906951904},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.5322169065475464},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47759270668029785},{"id":"https://openalex.org/C171779818","wikidata":"https://www.wikidata.org/wiki/Q3799301","display_name":"Integrin alpha M","level":3,"score":0.4151609539985657},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.342326283454895},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24768555164337158},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14484190940856934},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:ecommons.usask.ca:10388/ETD-2014-03-1512","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10388/ETD-2014-03-1512","pdf_url":null,"source":{"id":"https://openalex.org/S4377196608","display_name":"University Library - University of Saskatchewan (University of Saskatchewan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32625721","host_organization_name":"University of Saskatchewan","host_organization_lineage":["https://openalex.org/I32625721"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"thesis"},{"id":"pmh:oai:harvest.usask.ca:10388/ETD-2014-03-1512","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/10388/ETD-2014-03-1512","pdf_url":null,"source":{"id":"https://openalex.org/S7407063267","display_name":"HARVEST (University of Saskatchewan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:92374912","doi":null,"is_oa":false,"landing_page_url":"https://harvest.usask.ca/handle/10388/ETD-2014-03-1512","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.504800021648407,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":190,"referenced_works":["https://openalex.org/W133332340","https://openalex.org/W1499784952","https://openalex.org/W1500795239","https://openalex.org/W1506821897","https://openalex.org/W1520425169","https://openalex.org/W1538674240","https://openalex.org/W1544108259","https://openalex.org/W1560517624","https://openalex.org/W1576773659","https://openalex.org/W1604356365","https://openalex.org/W1634520049","https://openalex.org/W1785533687","https://openalex.org/W1925247341","https://openalex.org/W1938388466","https://openalex.org/W1964681919","https://openalex.org/W1965841931","https://openalex.org/W1967222491","https://openalex.org/W1968280019","https://openalex.org/W1968339091","https://openalex.org/W1968443620","https://openalex.org/W1969342647","https://openalex.org/W1969703616","https://openalex.org/W1970300303","https://openalex.org/W1970483666","https://openalex.org/W1970923523","https://openalex.org/W1973246806","https://openalex.org/W1974003656","https://openalex.org/W1977283446","https://openalex.org/W1977426071","https://openalex.org/W1979038578","https://openalex.org/W1979846463","https://openalex.org/W1981216393","https://openalex.org/W1981497079","https://openalex.org/W1981865792","https://openalex.org/W1982536372","https://openalex.org/W1982657123","https://openalex.org/W1982849870","https://openalex.org/W1985383811","https://openalex.org/W1989448848","https://openalex.org/W1990842021","https://openalex.org/W1990883677","https://openalex.org/W1992442297","https://openalex.org/W1993006648","https://openalex.org/W1996082981","https://openalex.org/W1996544591","https://openalex.org/W1998539678","https://openalex.org/W2002219680","https://openalex.org/W2002590458","https://openalex.org/W2003506380","https://openalex.org/W2003698382","https://openalex.org/W2007295620","https://openalex.org/W2009366489","https://openalex.org/W2011385348","https://openalex.org/W2012691080","https://openalex.org/W2013002982","https://openalex.org/W2013672653","https://openalex.org/W2014188639","https://openalex.org/W2016420227","https://openalex.org/W2017016480","https://openalex.org/W2018982114","https://openalex.org/W2020654599","https://openalex.org/W2020898985","https://openalex.org/W2022068330","https://openalex.org/W2024191052","https://openalex.org/W2025929177","https://openalex.org/W2026804025","https://openalex.org/W2028305453","https://openalex.org/W2029414348","https://openalex.org/W2029773366","https://openalex.org/W2031577669","https://openalex.org/W2032277323","https://openalex.org/W2032392940","https://openalex.org/W2033950365","https://openalex.org/W2038634187","https://openalex.org/W2038939944","https://openalex.org/W2039159306","https://openalex.org/W2039496775","https://openalex.org/W2040379229","https://openalex.org/W2041586068","https://openalex.org/W2041999765","https://openalex.org/W2043761739","https://openalex.org/W2044757857","https://openalex.org/W2044882848","https://openalex.org/W2044905529","https://openalex.org/W2046737719","https://openalex.org/W2049360086","https://openalex.org/W2049816773","https://openalex.org/W2051349758","https://openalex.org/W2051903847","https://openalex.org/W2055383230","https://openalex.org/W2055614158","https://openalex.org/W2055726511","https://openalex.org/W2056229955","https://openalex.org/W2057941607","https://openalex.org/W2058439851","https://openalex.org/W2058624823","https://openalex.org/W2058624942","https://openalex.org/W2059552745","https://openalex.org/W2065921660","https://openalex.org/W2066114323","https://openalex.org/W2066682264","https://openalex.org/W2067836657","https://openalex.org/W2068213566","https://openalex.org/W2069384743","https://openalex.org/W2069575222","https://openalex.org/W2069820450","https://openalex.org/W2070373300","https://openalex.org/W2071026717","https://openalex.org/W2071552704","https://openalex.org/W2071852938","https://openalex.org/W2072006267","https://openalex.org/W2073052622","https://openalex.org/W2076160983","https://openalex.org/W2077237370","https://openalex.org/W2079323372","https://openalex.org/W2079548558","https://openalex.org/W2079595896","https://openalex.org/W2079944376","https://openalex.org/W2080240343","https://openalex.org/W2081401313","https://openalex.org/W2084276037","https://openalex.org/W2085727695","https://openalex.org/W2088050180","https://openalex.org/W2088544660","https://openalex.org/W2089920144","https://openalex.org/W2090612456","https://openalex.org/W2091119718","https://openalex.org/W2092447350","https://openalex.org/W2093188244","https://openalex.org/W2094469836","https://openalex.org/W2096399528","https://openalex.org/W2098438673","https://openalex.org/W2100807457","https://openalex.org/W2101346022","https://openalex.org/W2101629153","https://openalex.org/W2102312968","https://openalex.org/W2104602333","https://openalex.org/W2105183595","https://openalex.org/W2105356859","https://openalex.org/W2106264965","https://openalex.org/W2108060607","https://openalex.org/W2110356362","https://openalex.org/W2114021514","https://openalex.org/W2114764485","https://openalex.org/W2114975607","https://openalex.org/W2118060829","https://openalex.org/W2119828692","https://openalex.org/W2120832308","https://openalex.org/W2121049679","https://openalex.org/W2121677065","https://openalex.org/W2121742239","https://openalex.org/W2124758818","https://openalex.org/W2125808023","https://openalex.org/W2126022125","https://openalex.org/W2126496496","https://openalex.org/W2128404955","https://openalex.org/W2130123417","https://openalex.org/W2131717149","https://openalex.org/W2133321290","https://openalex.org/W2135577930","https://openalex.org/W2136404658","https://openalex.org/W2138094116","https://openalex.org/W2138164563","https://openalex.org/W2138742704","https://openalex.org/W2138828504","https://openalex.org/W2141643986","https://openalex.org/W2142580186","https://openalex.org/W2147000598","https://openalex.org/W2148206240","https://openalex.org/W2149352954","https://openalex.org/W2150531719","https://openalex.org/W2151257470","https://openalex.org/W2154909249","https://openalex.org/W2155510991","https://openalex.org/W2157012084","https://openalex.org/W2157330541","https://openalex.org/W2160499160","https://openalex.org/W2160912589","https://openalex.org/W2162857895","https://openalex.org/W2164193456","https://openalex.org/W2164330595","https://openalex.org/W2167743648","https://openalex.org/W2167956058","https://openalex.org/W2168486446","https://openalex.org/W2169481463","https://openalex.org/W2286325638","https://openalex.org/W2395047360","https://openalex.org/W2427875153","https://openalex.org/W2442544949","https://openalex.org/W7140253188"],"related_works":["https://openalex.org/W2321006158","https://openalex.org/W2033950365","https://openalex.org/W2104602333","https://openalex.org/W4404297893","https://openalex.org/W2041999478","https://openalex.org/W2140627752","https://openalex.org/W3004308853","https://openalex.org/W2418908173","https://openalex.org/W2121040201","https://openalex.org/W1981944092"],"abstract_inverted_index":{"Integrins":[0],"are":[1],"major":[2],"adhesion":[3,25,257,331],"receptors":[4,49],"for":[5,116,163],"the":[6,14,32,35,67,96,113,125,128,154,179,184,198,202,229,280,284,303,313,317],"extracellular":[7],"matrix":[8],"(ECM).":[9],"This":[10],"thesis":[11],"focuses":[12],"on":[13,63,174],"motifs":[15,200,319],"and":[16,26,61,80,91,177,204,210,252,265,322,328],"interactions":[17],"within":[18],"integrin":[19,189,269,306,326],"cytoplasmic":[20],"tails":[21,324],"during":[22],"integrin-mediated":[23,329],"cell":[24,71,88,98,165,175,246,262,330],"spreading.":[27,72,89],"The":[28,107,191],"present":[29],"study":[30],"investigated":[31],"significance":[33],"of":[34,70,86,127,131,137,156,181,188,194,201,231,258,274,283,305,320],"skelemin-\u03b1IIb\u03b23":[36],"interaction":[37,247],"using":[38],"Chinese":[39],"Hamster":[40],"Ovary":[41],"(CHO)":[42],"cells":[43,56,94,133,234],"expressing":[44],"wild-type":[45],"or":[46],"mutant":[47,55,93],"\u03b1IIb\u03b23":[48,140,159,221],"defective":[50],"in":[51,119,121,147,302],"skelemin":[52,117,148,157],"binding.":[53,149],"Most":[54],"displayed":[57],"unimpaired":[58],"adhesive":[59],"capacity":[60],"spreading":[62,176],"immobilized":[64,236],"fibrinogen":[65,225],"at":[66],"early":[68],"stages":[69],"In":[73],"addition,":[74],"they":[75],"formed":[76],"normal":[77,164],"focal":[78],"adhesions":[79],"stress":[81],"fibers":[82],"with":[83,103,139,144,248,276],"no":[84],"indication":[85],"impaired":[87],"K716A":[90,132],"H722A":[92],"exhibited":[95],"greatest":[97],"spreading,":[99,166],"which":[100,141,316],"was":[101,142,214,288],"associated":[102,143],"enhanced":[104],"p-Src":[105],"activation.":[106],"K716":[108],"residue":[109],"appeared":[110],"to":[111,158,170,183,197,223,235,244,267],"be":[112],"most":[114],"important":[115],"binding":[118,155,180,222,230],"previous":[120],"vitro":[122],"studies.":[123],"Here,":[124],"protrusions":[126],"leading":[129],"edge":[130],"showed":[134],"strong":[135],"colocalization":[136],"talin":[138,182],"a":[145,291],"loss":[146],"These":[150,308],"data":[151],"suggest":[152],"that":[153,297],"is":[160],"not":[161],"essential":[162],"but":[167],"may":[168,300],"act":[169],"exert":[171],"contractile":[172],"forces":[173],"coordinate":[178],"membrane":[185],"proximal":[186],"region":[187],"tails.":[190],"functional":[192],"mode":[193],"peptides":[195,218,254],"corresponding":[196],"central":[199,318],"\u03b1IIb":[203,251,285,293,321],"\u03b1V":[205,253,268,323],"tail,":[206],"KRNRPPLEED":[207],"(\u03b1IIb":[208],"peptide)":[209,213],"KRVRPPQEEQ":[211],"(\u03b1V":[212],"also":[215,255],"investigated.":[216],"Both":[217],"inhibited":[219,256],"Mn2+-activated":[220],"soluble":[224],"as":[226,228,290],"well":[227],"\u03b1IIb\u03b23-expressing":[232],"CHO":[233],"fibrinogen.":[237],"Breast":[238],"cancer":[239,261],"progression":[240],"has":[241],"been":[242],"linked":[243],"tumor":[245],"ECM.":[249],"Our":[250],"two":[259],"breast":[260],"lines":[263],"(MDA-MB-435":[264],"MCF7)":[266],"ECM":[270],"ligand":[271],"vitronectin.":[272],"Replacement":[273],"RPP":[275],"AAA":[277],"significantly":[278],"attenuated":[279],"inhibitory":[281],"activity":[282],"peptide.":[286],"\u03b2-tubulin":[287],"identified":[289],"potential":[292],"peptide-binding":[294],"partner,":[295],"suggesting":[296],"microtubule":[298],"cytoskeleton":[299],"participate":[301],"regulation":[304],"functions.":[307],"results":[309],"provide":[310],"insights":[311],"into":[312],"mechanisms":[314],"by":[315],"regulate":[325],"activation":[327]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
