{"id":"https://openalex.org/W92308392","doi":null,"title":"Tumorigenic activity of rho genes from Aplysia californica.","display_name":"Tumorigenic activity of rho genes from Aplysia californica.","publication_year":1993,"publication_date":"1993-05-01","ids":{"openalex":"https://openalex.org/W92308392","mag":"92308392","pmid":"https://pubmed.ncbi.nlm.nih.gov/8479750"},"language":"en","primary_location":{"id":"pmid:8479750","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8479750","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028089976","display_name":"Rosario Perona","orcid":"https://orcid.org/0000-0002-2973-5153","observed_orcids":["https://orcid.org/0000-0002-2973-5153"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"R Perona","raw_affiliation_strings":["Instituto de Investigaciones Biom\u00e9dicas, CSIC, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones Biom\u00e9dicas, CSIC, Madrid, Spain","institution_ids":["https://openalex.org/I134820265"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064572623","display_name":"Pilar Esteve","orcid":"https://orcid.org/0000-0002-7519-8918","observed_orcids":["https://orcid.org/0000-0002-7519-8918"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P Esteve","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025178599","display_name":"Benilde Jim\u00e9nez","orcid":"https://orcid.org/0000-0002-1806-6636","observed_orcids":["https://orcid.org/0000-0002-1806-6636"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Jim\u00e9nez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084061501","display_name":"Rafael P. Ballestero","orcid":"https://orcid.org/0000-0001-8251-2875","observed_orcids":["https://orcid.org/0000-0001-8251-2875"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R P Ballestero","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088341849","display_name":"Santiago Ram\u00f3n y Cajal","orcid":"https://orcid.org/0000-0002-3867-1390","observed_orcids":["https://orcid.org/0000-0002-3867-1390"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Ram\u00f3n y Cajal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5040208664","display_name":"Juan Carlos Lacal","orcid":"https://orcid.org/0000-0002-1908-2777","observed_orcids":["https://orcid.org/0000-0002-1908-2777"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J C Lacal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.396,"has_fulltext":false,"cited_by_count":105,"citation_normalized_percentile":{"value":0.89848634,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"8","issue":"5","first_page":"1285","last_page":"92"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rho-proteins","display_name":"Rho proteins","score":0.7300000190734863},{"id":"https://openalex.org/keywords/aplysia-californica","display_name":"Aplysia californica","score":0.9539999961853027},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.9380000233650208},{"id":"https://openalex.org/keywords/ras-gtpase","display_name":"Ras GTPase","score":0.6439999938011169},{"id":"https://openalex.org/keywords/anchorage-independent-growth","display_name":"anchorage-independent growth","score":0.8489999771118164},{"id":"https://openalex.org/keywords/fibrosarcoma","display_name":"fibrosarcoma","score":0.9589999914169312},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.7910000085830688},{"id":"https://openalex.org/keywords/fibroblast-proliferation","display_name":"fibroblast proliferation","score":0.875},{"id":"https://openalex.org/keywords/gtpase-superfamily","display_name":"GTPase superfamily","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9385908842086792},{"id":"https://openalex.org/C2781335528","wikidata":"https://www.wikidata.org/wiki/Q24781762","display_name":"Ras superfamily","level":4,"score":0.8544653654098511},{"id":"https://openalex.org/C207332259","wikidata":"https://www.wikidata.org/wiki/Q769143","display_name":"GTPase","level":2,"score":0.7252419590950012},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6889185905456543},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5939639806747437},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5866907238960266},{"id":"https://openalex.org/C156728348","wikidata":"https://www.wikidata.org/wiki/Q416778","display_name":"Rab","level":3,"score":0.5689371824264526},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.51799476146698},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4784429371356964},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.41111502051353455},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39755484461784363},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3523597717285156},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12886229157447815},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07663208246231079},{"id":"https://openalex.org/C118716","wikidata":"https://www.wikidata.org/wiki/Q5514725","display_name":"GTP'","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001048","descriptor_name":"Aplysia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001790","descriptor_name":"Blood Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016475","descriptor_name":"3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020558","descriptor_name":"GTP Phosphohydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020558","descriptor_name":"GTP Phosphohydrolases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020743","descriptor_name":"rhoB GTP-Binding Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8479750","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8479750","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"},{"id":"mag:92308392","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8479750","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W154708182","https://openalex.org/W2320359800","https://openalex.org/W2308783294","https://openalex.org/W2115638428","https://openalex.org/W2043186432","https://openalex.org/W2084832908","https://openalex.org/W7097195582","https://openalex.org/W33386556","https://openalex.org/W2035643930","https://openalex.org/W172019621"],"abstract_inverted_index":{"rho":[0,66,99,169],"genes":[1,89,170],"have":[2,60,176],"been":[3],"found":[4,90],"in":[5,20,49,91,179,184],"both":[6],"lower":[7],"and":[8,46,77,93,106,147,150,174],"higher":[9],"eucaryotes.":[10],"They":[11],"code":[12],"for":[13],"proteins":[14,38,47,67],"of":[15,27,33,56,65,87,97,182],"21":[16],"kDa,":[17],"highly":[18],"conserved":[19],"evolution,":[21],"which":[22],"belong":[23],"to":[24,82,103,123,142],"the":[25,31,54,62,75,83,129,180],"superfamily":[26,35],"ras":[28,88],"GTPases.":[29],"Among":[30],"members":[32],"this":[34],"there":[36],"are":[37],"with":[39,145],"a":[40,78,177],"regulatory":[41],"function,":[42],"such":[43,52],"as":[44,53,71,172],"ras,":[45],"involved":[48],"vesicular":[50],"trafficking,":[51],"family":[55],"rab":[57],"proteins.":[58],"We":[59],"investigated":[61],"putative":[63],"role":[64,178],"from":[68,118],"Aplysia":[69],"californica":[70],"transforming":[72],"GTPases":[73],"utilizing":[74],"wild-type":[76],"Val-14":[79],"mutant,":[80],"equivalent":[81],"oncogenic":[84],"Val-12":[85],"mutation":[86],"animal":[92],"human":[94],"tumors.":[95],"Over-expression":[96],"either":[98,119],"gene":[100,120],"was":[101],"sufficient":[102],"confer":[104],"anchorage-":[105],"serum-independent":[107],"growth.":[108],"Moreover,":[109],"when":[110],"introduced":[111],"into":[112],"nude":[113],"mice,":[114],"selected":[115],"clones":[116],"generated":[117,139],"were":[121,132,157],"able":[122],"induce":[124],"tumors,":[125],"although":[126],"those":[127],"carrying":[128],"mutated":[130],"version":[131],"more":[133],"efficient.":[134],"Pathological":[135],"analysis":[136],"indicated":[137],"that":[138,165],"tumors":[140,156],"corresponded":[141],"well-differentiated":[143],"fibrosarcomas":[144],"distinct":[146],"intersecting":[148],"bundles":[149],"spindle":[151],"cells.":[152,186],"By":[153],"contrast,":[154],"ras-induced":[155],"poorly":[158],"differentiated":[159],"fibrosarcomas.":[160],"Thus,":[161],"our":[162],"results":[163],"indicate":[164],"under":[166],"appropriate":[167],"conditions":[168],"function":[171],"oncogenes":[173],"may":[175],"regulation":[181],"proliferation":[183],"fibroblast":[185]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
