{"id":"https://openalex.org/W923036564","doi":null,"title":"The gender difference in effect of sevoflurane exposure on cognitive function and hippocampus neuronal apoptosis in rats.","display_name":"The gender difference in effect of sevoflurane exposure on cognitive function and hippocampus neuronal apoptosis in rats.","publication_year":2015,"publication_date":"2015-02-01","ids":{"openalex":"https://openalex.org/W923036564","mag":"923036564","pmid":"https://pubmed.ncbi.nlm.nih.gov/25753883"},"language":"en","primary_location":{"id":"pmid:25753883","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25753883","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086541310","display_name":"Hong Xie","orcid":"https://orcid.org/0000-0002-5762-6456","observed_orcids":["https://orcid.org/0000-0002-5762-6456","https://orcid.org/0000-0003-1410-6917"]},"institutions":[{"id":"https://openalex.org/I4210124971","display_name":"Second Affiliated Hospital of Soochow University","ror":"https://ror.org/02xjrkt08","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124971"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"H Xie","raw_affiliation_strings":["Department of Anesthesiology, The Second Affiliate Hospital of Soochow University, Suzhou, China. chenwangcn@yeah.net"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, The Second Affiliate Hospital of Soochow University, Suzhou, China. chenwangcn@yeah.net","institution_ids":["https://openalex.org/I4210124971"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027640322","display_name":"G-M She","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G-M She","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"C Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"L-Y Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L-Y Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"C-F Liu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C-F Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0319,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.86149044,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"19","issue":"4","first_page":"647","last_page":"57"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10867","display_name":"Intensive Care Unit Cognitive Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sevoflurane","display_name":"sevoflurane","score":0.9769999980926514},{"id":"https://openalex.org/keywords/postoperative-cognitive-dysfunction","display_name":"postoperative cognitive dysfunction","score":0.9490000009536743},{"id":"https://openalex.org/keywords/gender-differences","display_name":"gender differences","score":0.625},{"id":"https://openalex.org/keywords/hippocampal-neuronal-apoptosis","display_name":"hippocampal neuronal apoptosis","score":0.7910000085830688},{"id":"https://openalex.org/keywords/creb-phosphorylation","display_name":"CREB phosphorylation","score":0.8830000162124634},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9649999737739563},{"id":"https://openalex.org/keywords/caspase-8","display_name":"caspase-8","score":0.9010000228881836},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/anesthesia-induced-cognitive-impairment","display_name":"anesthesia-induced cognitive impairment","score":0.6890000104904175}],"concepts":[{"id":"https://openalex.org/C1629964","wikidata":"https://www.wikidata.org/wiki/Q106950729","display_name":"CREB","level":4,"score":0.9498554468154907},{"id":"https://openalex.org/C2781453256","wikidata":"https://www.wikidata.org/wiki/Q419394","display_name":"Sevoflurane","level":2,"score":0.9206688404083252},{"id":"https://openalex.org/C44752575","wikidata":"https://www.wikidata.org/wiki/Q1417562","display_name":"Morris water navigation task","level":3,"score":0.7647736072540283},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.7111668586730957},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6407256126403809},{"id":"https://openalex.org/C199172495","wikidata":"https://www.wikidata.org/wiki/Q21116771","display_name":"CREB1","level":5,"score":0.6051194667816162},{"id":"https://openalex.org/C2779085643","wikidata":"https://www.wikidata.org/wiki/Q7096029","display_name":"Open field","level":2,"score":0.5951495170593262},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49193501472473145},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4716973304748535},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4494032561779022},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.444072425365448},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.4234694540500641},{"id":"https://openalex.org/C2780043718","wikidata":"https://www.wikidata.org/wiki/Q956181","display_name":"Postoperative cognitive dysfunction","level":3,"score":0.4215376377105713},{"id":"https://openalex.org/C12519072","wikidata":"https://www.wikidata.org/wiki/Q14914370","display_name":"Caspase 3","level":4,"score":0.4141434133052826},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3384094834327698},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2701318562030792},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26146167516708374},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2437821626663208},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.19377580285072327},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.13588100671768188},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.13361677527427673},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07599270343780518}],"mesh":[{"descriptor_ui":"D000077149","descriptor_name":"Sevoflurane","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008738","descriptor_name":"Methyl Ethers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012727","descriptor_name":"Sex Characteristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018685","descriptor_name":"Anesthetics, Inhalation","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D018782","descriptor_name":"Maze Learning","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:25753883","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25753883","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European review for medical and pharmacological sciences","raw_type":"Journal Article"},{"id":"mag:923036564","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25753883","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1968876099","https://openalex.org/W2016970181","https://openalex.org/W2026974727","https://openalex.org/W2036450246","https://openalex.org/W2047283392","https://openalex.org/W2069494536","https://openalex.org/W2080009814","https://openalex.org/W2112761850","https://openalex.org/W2123328902","https://openalex.org/W2130055431","https://openalex.org/W2141824226"],"related_works":["https://openalex.org/W3032406135","https://openalex.org/W4399047143","https://openalex.org/W3205026717","https://openalex.org/W2791687433","https://openalex.org/W2746227823","https://openalex.org/W4388093834","https://openalex.org/W7096388888","https://openalex.org/W2133379170","https://openalex.org/W2272477841","https://openalex.org/W4402876848"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Anesthesia":[1],"and":[2,34,56,69,86,100,117,136,143,159,182,185,194],"surgery":[3],"can":[4,171,209],"induce":[5],"postoperative":[6],"cognitive":[7,58,155,174,201,214],"dysfunction.":[8],"Ser-133":[9],"phosphorylation":[10],"sites":[11],"of":[12,26,38,42,65,92,128],"cAMP-response":[13],"element":[14],"binding":[15],"protein":[16,133],"(CREB)":[17],"is":[18],"a":[19,24,39,48,90,151,198,211],"key":[20],"gene":[21],"that":[22,55,168],"mediate":[23],"variety":[25],"downstream":[27,67],"transcription":[28],"initiation":[29],"factors,":[30],"regulate":[31],"neuronal":[32,192],"survival":[33],"promote":[35],"the":[36,63,126,132],"expression":[37,64,184,188],"large":[40],"number":[41],"genes.":[43],"Thus,":[44],"CREB":[45,66,130],"may":[46,177],"play":[47],"role":[49],"in":[50,153,216],"this":[51,76],"impairment.":[52],"We":[53,148],"hypothesize":[54],"sevoflurane-induced":[57,154],"impairment":[59,156],"possibly":[60],"via":[61,179],"inhibiting":[62],"genes":[68],"proteins.":[70],"MATERIALS":[71],"AND":[72,163],"METHODS:":[73],"To":[74],"test":[75,99],"hypothesis,":[77],"adult":[78],"Sprague-Dawley":[79],"rats":[80,196],"were":[81,87,121,138],"subjected":[82],"to":[83,110,189],"sevoflurane":[84,119,169,208],"exposure":[85],"tested":[88],"with":[89],"series":[91],"behavioral":[93],"experiments":[94],"(open":[95],"field,":[96],"passive":[97],"avoidance":[98],"Morris":[101],"water":[102],"maze":[103],"test)":[104],"at":[105,123,140],"different":[106],"time":[107],"(1":[108],"d":[109],"95":[111],"d).":[112],"Besides,":[113],"blood":[114],"gas":[115],"changes":[116],"expiratory":[118],"concentrations":[120],"examined":[122],"2":[124],"h;":[125],"levels":[127],"phosphorylated":[129],"1,":[131],"Bcl-2,":[134],"Caspase-8":[135,187],"Caspase-3":[137],"assessed":[139],"1":[141],"week":[142],"3":[144],"months":[145],"after":[146],"anesthesia.":[147],"also":[149],"conducted":[150],"comparison":[152],"between":[157],"male":[158,195],"female":[160,204],"rats.":[161,205,217],"RESULTS":[162],"CONCLUSIONS:":[164],"Here,":[165],"we":[166],"found":[167],"anesthesia":[170],"impair":[172],"short-term":[173],"function,":[175],"which":[176],"be":[178],"down-regulating":[180],"p-CREB1":[181],"Bcl-2":[183],"up-regulating":[186],"reduce":[190],"hippocampus":[191],"apoptosis,":[193],"suffered":[197],"more":[199],"severe":[200],"dysfunction":[202,215],"than":[203],"In":[206],"addition,":[207],"produce":[210],"reversible":[212],"long-term":[213]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":8},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
