{"id":"https://openalex.org/W92285865","doi":null,"title":"Role of YopE and LcrH in effector translocation, HeLa cell cytotoxicity and virulence","display_name":"Role of YopE and LcrH in effector translocation, HeLa cell cytotoxicity and virulence","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W92285865","mag":"92285865"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:umu-646","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-646","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-646","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056408892","display_name":"Margareta Aili","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Margareta Aili","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5056408892"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12232","display_name":"Yersinia bacterium, plague, ectoparasites research","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12232","display_name":"Yersinia bacterium, plague, ectoparasites research","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.01590000092983246,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/yope","display_name":"YopE","score":0.7490000128746033},{"id":"https://openalex.org/keywords/yersinia-pseudotuberculosis","display_name":"Yersinia pseudotuberculosis","score":0.9559999704360962},{"id":"https://openalex.org/keywords/type-iii-secretion-system","display_name":"type III secretion system","score":0.984000027179718},{"id":"https://openalex.org/keywords/effector-translocation","display_name":"effector translocation","score":0.9649999737739563},{"id":"https://openalex.org/keywords/actin-cytoskeleton-disruption","display_name":"actin cytoskeleton disruption","score":0.8299999833106995},{"id":"https://openalex.org/keywords/gtpase-activating-protein","display_name":"GTPase-activating protein","score":0.8199999928474426},{"id":"https://openalex.org/keywords/rhoa","display_name":"RhoA","score":0.9760000109672546},{"id":"https://openalex.org/keywords/rac1","display_name":"Rac1","score":1.0},{"id":"https://openalex.org/keywords/cdc42","display_name":"Cdc42","score":0.9909999966621399},{"id":"https://openalex.org/keywords/yopd","display_name":"YopD","score":0.675000011920929},{"id":"https://openalex.org/keywords/exos","display_name":"exoS","score":0.6269999742507935},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.7559999823570251},{"id":"https://openalex.org/keywords/hela-cell-cytotoxicity","display_name":"HeLa cell cytotoxicity","score":0.7509999871253967},{"id":"https://openalex.org/keywords/virulence","display_name":"virulence","score":0.6100000143051147},{"id":"https://openalex.org/keywords/lactate-dehydrogenase-release","display_name":"lactate dehydrogenase release","score":0.6240000128746033},{"id":"https://openalex.org/keywords/molecular-chaperones","display_name":"molecular chaperones","score":0.4230000078678131}],"concepts":[{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.7810153365135193},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.7783598899841309},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.638443112373352},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.6281107664108276},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5055897235870361},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.4881635308265686},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.44529232382774353},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39994531869888306},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3236711025238037},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2777943015098572},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21396410465240479},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1548183262348175}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:umu-646","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-646","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:92285865","doi":null,"is_oa":false,"landing_page_url":"https://umu.diva-portal.org/smash/record.jsf?pid=diva2:144121","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:umu-646","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-646","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":320,"referenced_works":["https://openalex.org/W48024006","https://openalex.org/W59747172","https://openalex.org/W66405107","https://openalex.org/W76895504","https://openalex.org/W158273916","https://openalex.org/W273741018","https://openalex.org/W1217953477","https://openalex.org/W1480238212","https://openalex.org/W1481884569","https://openalex.org/W1484745993","https://openalex.org/W1489345209","https://openalex.org/W1492237429","https://openalex.org/W1497623655","https://openalex.org/W1499653737","https://openalex.org/W1506303970","https://openalex.org/W1524666565","https://openalex.org/W1536529129","https://openalex.org/W1538342062","https://openalex.org/W1547119038","https://openalex.org/W1547879048","https://openalex.org/W1559661404","https://openalex.org/W1572004815","https://openalex.org/W1574306778","https://openalex.org/W1576250823","https://openalex.org/W1581054924","https://openalex.org/W1594993349","https://openalex.org/W1596372166","https://openalex.org/W1597663953","https://openalex.org/W1601252131","https://openalex.org/W1619365252","https://openalex.org/W1627263949","https://openalex.org/W1648738332","https://openalex.org/W1696428769","https://openalex.org/W1710835694","https://openalex.org/W1732098708","https://openalex.org/W1739566110","https://openalex.org/W1740864638","https://openalex.org/W1748677834","https://openalex.org/W1761608298","https://openalex.org/W1763487877","https://openalex.org/W1765995278","https://openalex.org/W1769519545","https://openalex.org/W1781659395","https://openalex.org/W1825734539","https://openalex.org/W1836100527","https://openalex.org/W1852597482","https://openalex.org/W1855676723","https://openalex.org/W1866548929","https://openalex.org/W1866781827","https://openalex.org/W1867307019","https://openalex.org/W1871647010","https://openalex.org/W1877516869","https://openalex.org/W1878324752","https://openalex.org/W1883019490","https://openalex.org/W1883281974","https://openalex.org/W1900006748","https://openalex.org/W1900949055","https://openalex.org/W1903506151","https://openalex.org/W1905967313","https://openalex.org/W1906987105","https://openalex.org/W1907688355","https://openalex.org/W1908152925","https://openalex.org/W1910650341","https://openalex.org/W1915721517","https://openalex.org/W1916327110","https://openalex.org/W1917680451","https://openalex.org/W1918587989","https://openalex.org/W1919822336","https://openalex.org/W1923139939","https://openalex.org/W1926393524","https://openalex.org/W1932755342","https://openalex.org/W1933529630","https://openalex.org/W1952304498","https://openalex.org/W1955304727","https://openalex.org/W1957547301","https://openalex.org/W1961184371","https://openalex.org/W1961893762","https://openalex.org/W1963810218","https://openalex.org/W1964051095","https://openalex.org/W1966055091","https://openalex.org/W1966262091","https://openalex.org/W1966470621","https://openalex.org/W1967407512","https://openalex.org/W1970047013","https://openalex.org/W1971096395","https://openalex.org/W1973437785","https://openalex.org/W1973528297","https://openalex.org/W1974405307","https://openalex.org/W1976067490","https://openalex.org/W1976777703","https://openalex.org/W1978199442","https://openalex.org/W1978663808","https://openalex.org/W1979045234","https://openalex.org/W1979137588","https://openalex.org/W1980048807","https://openalex.org/W1980767305","https://openalex.org/W1980885258","https://openalex.org/W1981386683","https://openalex.org/W1982470594","https://openalex.org/W1982627832","https://openalex.org/W1982702591","https://openalex.org/W1983960596","https://openalex.org/W1984938130","https://openalex.org/W1985303828","https://openalex.org/W1985884514","https://openalex.org/W1989207275","https://openalex.org/W1989660766","https://openalex.org/W1989998819","https://openalex.org/W1991518398","https://openalex.org/W1993398538","https://openalex.org/W1995130655","https://openalex.org/W1996307860","https://openalex.org/W1997016195","https://openalex.org/W1997074046","https://openalex.org/W1997103512","https://openalex.org/W1997423062","https://openalex.org/W1999453285","https://openalex.org/W1999687660","https://openalex.org/W2000622387","https://openalex.org/W2000749271","https://openalex.org/W2002195659","https://openalex.org/W2002875716","https://openalex.org/W2004199116","https://openalex.org/W2004930574","https://openalex.org/W2005377146","https://openalex.org/W2006049439","https://openalex.org/W2006777514","https://openalex.org/W2007501057","https://openalex.org/W2007660746","https://openalex.org/W2007873809","https://openalex.org/W2008132225","https://openalex.org/W2009423065","https://openalex.org/W2010171857","https://openalex.org/W2011417491","https://openalex.org/W2011847534","https://openalex.org/W2014216245","https://openalex.org/W2014795040","https://openalex.org/W2015161749","https://openalex.org/W2015316514","https://openalex.org/W2015642465","https://openalex.org/W2015759788","https://openalex.org/W2017728221","https://openalex.org/W2019228627","https://openalex.org/W2019978236","https://openalex.org/W2020884037","https://openalex.org/W2021731644","https://openalex.org/W2023350554","https://openalex.org/W2024898230","https://openalex.org/W2024929819","https://openalex.org/W2026418105","https://openalex.org/W2027449551","https://openalex.org/W2027810531","https://openalex.org/W2027880544","https://openalex.org/W2040341504","https://openalex.org/W2040876192","https://openalex.org/W2040929701","https://openalex.org/W2042033082","https://openalex.org/W2042764428","https://openalex.org/W2043713273","https://openalex.org/W2044025320","https://openalex.org/W2044085349","https://openalex.org/W2044455015","https://openalex.org/W2044980899","https://openalex.org/W2045706313","https://openalex.org/W2047945304","https://openalex.org/W2048423383","https://openalex.org/W2049290302","https://openalex.org/W2049353983","https://openalex.org/W2050069092","https://openalex.org/W2050671760","https://openalex.org/W2052875067","https://openalex.org/W2055545486","https://openalex.org/W2056083529","https://openalex.org/W2056525859","https://openalex.org/W2056902230","https://openalex.org/W2058111213","https://openalex.org/W2058933513","https://openalex.org/W2059401988","https://openalex.org/W2060110412","https://openalex.org/W2060690139","https://openalex.org/W2065276461","https://openalex.org/W2065842276","https://openalex.org/W2068559925","https://openalex.org/W2069078564","https://openalex.org/W2070784886","https://openalex.org/W2071947177","https://openalex.org/W2073723461","https://openalex.org/W2074666027","https://openalex.org/W2075343422","https://openalex.org/W2076833953","https://openalex.org/W2078121570","https://openalex.org/W2079246138","https://openalex.org/W2079997045","https://openalex.org/W2080995701","https://openalex.org/W2081210153","https://openalex.org/W2081632528","https://openalex.org/W2082887128","https://openalex.org/W2083431737","https://openalex.org/W2083861520","https://openalex.org/W2084900570","https://openalex.org/W2085414634","https://openalex.org/W2085609763","https://openalex.org/W2089772414","https://openalex.org/W2092967278","https://openalex.org/W2093226717","https://openalex.org/W2094727098","https://openalex.org/W2095082570","https://openalex.org/W2096139180","https://openalex.org/W2096205447","https://openalex.org/W2096240776","https://openalex.org/W2096881433","https://openalex.org/W2097434827","https://openalex.org/W2097898346","https://openalex.org/W2099061568","https://openalex.org/W2099432505","https://openalex.org/W2100265489","https://openalex.org/W2101404732","https://openalex.org/W2101684624","https://openalex.org/W2101838082","https://openalex.org/W2102450220","https://openalex.org/W2102770487","https://openalex.org/W2105005583","https://openalex.org/W2105438508","https://openalex.org/W2105746559","https://openalex.org/W2105765197","https://openalex.org/W2106132559","https://openalex.org/W2108285818","https://openalex.org/W2108682888","https://openalex.org/W2109048203","https://openalex.org/W2110042103","https://openalex.org/W2111205680","https://openalex.org/W2111778006","https://openalex.org/W2112262471","https://openalex.org/W2112590900","https://openalex.org/W2114356152","https://openalex.org/W2114816974","https://openalex.org/W2115047987","https://openalex.org/W2115676034","https://openalex.org/W2115698580","https://openalex.org/W2116513121","https://openalex.org/W2117072224","https://openalex.org/W2117300091","https://openalex.org/W2117772438","https://openalex.org/W2120363115","https://openalex.org/W2122126108","https://openalex.org/W2123112413","https://openalex.org/W2123912039","https://openalex.org/W2124019620","https://openalex.org/W2125090285","https://openalex.org/W2125701320","https://openalex.org/W2126197220","https://openalex.org/W2127135538","https://openalex.org/W2128657529","https://openalex.org/W2128688376","https://openalex.org/W2129135399","https://openalex.org/W2129319176","https://openalex.org/W2130183608","https://openalex.org/W2130399739","https://openalex.org/W2130941393","https://openalex.org/W2131129488","https://openalex.org/W2131152565","https://openalex.org/W2131282088","https://openalex.org/W2132091434","https://openalex.org/W2132589339","https://openalex.org/W2132868108","https://openalex.org/W2133462374","https://openalex.org/W2134142007","https://openalex.org/W2135489149","https://openalex.org/W2135743634","https://openalex.org/W2137749186","https://openalex.org/W2138025831","https://openalex.org/W2138401175","https://openalex.org/W2139089172","https://openalex.org/W2140271440","https://openalex.org/W2140358495","https://openalex.org/W2141037335","https://openalex.org/W2144230942","https://openalex.org/W2144307831","https://openalex.org/W2144375173","https://openalex.org/W2144750575","https://openalex.org/W2144857390","https://openalex.org/W2144878722","https://openalex.org/W2144973194","https://openalex.org/W2145780271","https://openalex.org/W2145912774","https://openalex.org/W2146867704","https://openalex.org/W2147169435","https://openalex.org/W2148853770","https://openalex.org/W2149120880","https://openalex.org/W2150408547","https://openalex.org/W2150967773","https://openalex.org/W2150981003","https://openalex.org/W2151294441","https://openalex.org/W2151777569","https://openalex.org/W2152245097","https://openalex.org/W2154675618","https://openalex.org/W2154971985","https://openalex.org/W2157521154","https://openalex.org/W2157776180","https://openalex.org/W2158244329","https://openalex.org/W2158757814","https://openalex.org/W2159126686","https://openalex.org/W2160178001","https://openalex.org/W2163624666","https://openalex.org/W2163857732","https://openalex.org/W2163882588","https://openalex.org/W2165832942","https://openalex.org/W2166887645","https://openalex.org/W2168513931","https://openalex.org/W2169360565","https://openalex.org/W2169690786","https://openalex.org/W2169898067","https://openalex.org/W2170575767","https://openalex.org/W2172237013","https://openalex.org/W2184140746","https://openalex.org/W2192667510","https://openalex.org/W2234738384","https://openalex.org/W2293579233","https://openalex.org/W2303892997","https://openalex.org/W2316650677"],"related_works":["https://openalex.org/W6981063698","https://openalex.org/W2093688663","https://openalex.org/W108089381","https://openalex.org/W2587188619","https://openalex.org/W2045706313","https://openalex.org/W2148853770","https://openalex.org/W324339934","https://openalex.org/W1975831923","https://openalex.org/W1974472843","https://openalex.org/W248288457"],"abstract_inverted_index":{"In":[0,54],"order":[1],"to":[2,19,147,269],"establish":[3],"an":[4,71],"extra-cellular":[5],"infection":[6],"the":[7,57,77,106,117,154,170,181,200,207,221,226,229,240,300,331,341,358,374,387,406,417,426],"gram-negative":[8],"bacteria":[9,222],"Yersinia":[10,64,136,156,288],"pseudotuberculosis":[11],"uses":[12],"a":[13,21,133,177,210,253,279],"type":[14],"III":[15],"secretion":[16,355],"system":[17],"(T3SS)":[18],"translocate":[20],"set":[22],"of":[23,59,80,116,172,191,202,209,216,228,244,249,275,317,330,356,376,389,405],"anti-host":[24],"effectors":[25],"into":[26],"eukaryotic":[27,82,203,230,390],"cells.":[28,164,204,378],"The":[29],"toxins":[30],"disrupt":[31],"signalling":[32],"pathways":[33],"important":[34,307],"for":[35,135,213,282,308,313,414],"phagocytosis,":[36],"cytokine":[37],"production":[38],"and":[39,43,61,109,125,185,263,315,321,334,354,360,365,392,408,416],"cell":[40,231],"survival.":[41],"Secretion":[42],"translocation":[44,175,192,234,285,309,343,415],"via":[45],"this":[46,55,130,422],"T3SS":[47],"is":[48,70,131,235,267],"strictly":[49],"regulated":[50],"on":[51,293],"several":[52],"levels.":[53],"context,":[56],"function":[58,184,243,281],"YopE":[60,69,118,139,152,167,182,283,305],"LcrH":[62,325,350,418],"during":[63],"infections":[65],"has":[66,252],"been":[67],"analysed.":[68],"essential":[72],"translocated":[73,166],"effector":[74,157,174,233,342,399],"that":[75,122,158,179,223,289,299],"disrupts":[76],"actin":[78],"cytoskeleton":[79],"infected":[81,163,377],"cells,":[83],"by":[84,176],"inactivating":[85],"small":[86],"GTPases":[87,146],"through":[88],"its":[89,322],"GTPase":[90],"activating":[91],"protein":[92],"(GAP)":[93],"activity.":[94],"However,":[95,265],"cytotoxicity":[96,314],"can":[97],"be":[98,291],"uncoupled":[99],"from":[100,162,225,273,424],"in":[101,113,150,199,220,284,287,304,340,349,363,373,386],"vitro":[102,364],"GAP":[103,119,183,255],"activity":[104,120,259],"towards":[105,260],"RhoA,":[107,261],"Rac1":[108,126,262],"Cdc42":[110],"GTPases.":[111],"Furthermore,":[112],"vivo":[114],"studies":[115],"revealed":[121],"only":[123,155,402],"RhoA":[124],"are":[127,326,338,412],"targeted,":[128],"but":[129,311],"not":[132],"pre-requisite":[134],"virulence.":[137],"Hence,":[138],"must":[140],"target":[141],"one":[142],"or":[143],"more":[144],"additional":[145],"cause":[148],"disease":[149],"mice.":[151],"was":[153,306],"blocks":[159],"LDH":[160,318],"release":[161],"Moreover,":[165],"could":[168,394],"regulate":[169,421],"level":[171],"subsequent":[173],"mechanism":[178],"involved":[180,339],"another":[186],"T3S":[187,196,217,332],"component,":[188],"YopK.":[189],"Loss":[190],"control":[193,215,286],"elevated":[194],"total":[195],"gene":[197,218],"expression":[198,219],"presence":[201,388],"This":[205,237,277],"indicated":[206],"existence":[208],"regulatory":[211,328],"loop":[212],"feedback":[214],"originates":[224],"interior":[227],"after":[232],"completed.":[236],"might":[238,290],"represent":[239],"true":[241],"virulence":[242],"YopE.":[245,276],"Exoenzyme":[246],"S":[247],"(ExoS)":[248],"Pseudomonas":[250],"aeruginosa":[251],"YopE-like":[254],"domain":[256],"with":[257,336],"similar":[258],"Cdc42.":[264],"ExoS":[266],"unable":[268],"complement":[270],"hyper-translocation":[271],"resulting":[272],"loss":[274],"indicates":[278],"unique":[280],"dependent":[292],"correct":[294],"intracellular":[295],"localisation.":[296],"It":[297],"follows":[298],"Membrane":[301],"Localisation":[302],"Domain":[303],"control,":[310],"dispensable":[312],"blockage":[316],"release.":[319],"YopD":[320,361,409],"cognate":[323],"chaperone":[324,419],"negative":[327],"elements":[329],"regulon":[333],"together":[335],"YopB,":[337],"process.":[344],"Randomly":[345],"generated":[346],"point":[347],"mutants":[348,381],"specifically":[351],"effected":[352],"stability":[353],"both":[357],"YopB":[359,407],"substrates":[362,385],"prevented":[366],"their":[367],"apparent":[368],"insertion":[369],"as":[370],"translocon":[371],"pores":[372],"membranes":[375],"Yet,":[379],"these":[380],"still":[382],"produced":[383],"stable":[384],"cells":[391],"most":[393],"mediate":[395],"at":[396],"least":[397],"partial":[398],"translocation.":[400],"Thus,":[401],"minimal":[403],"amounts":[404],"translocator":[410],"proteins":[411],"needed":[413],"may":[420],"process":[423],"inside":[425],"bacteria.":[427]},"counts_by_year":[],"updated_date":"2026-08-13T07:04:57.449891","created_date":"2016-06-24T00:00:00"}