{"id":"https://openalex.org/W92275619","doi":null,"title":"Effect of mushroom polysaccharides and olive phenolic compounds on human carcinoma cells","display_name":"Effect of mushroom polysaccharides and olive phenolic compounds on human carcinoma cells","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W92275619","mag":"92275619"},"language":"en","primary_location":{"id":"pmh:oai:repositorio.ulisboa.pt:10451/7703","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10451/7703","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10451/7703","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Diana Martinho","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Diana Martinho","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11085","display_name":"Fungal Biology and Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11085","display_name":"Fungal Biology and Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13130","display_name":"Biological and pharmacological studies of plants","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14135","display_name":"Cancer and biochemical research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mushroom-polysaccharides","display_name":"mushroom polysaccharides","score":0.9990000128746033},{"id":"https://openalex.org/keywords/olive-phenolic-compounds","display_name":"olive phenolic compounds","score":0.9860000014305115},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8019999861717224},{"id":"https://openalex.org/keywords/human-carcinoma-cells","display_name":"human carcinoma cells","score":0.671999990940094},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5590000152587891},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.6959999799728394},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.5109999775886536},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.5410000085830688},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.3440000116825104},{"id":"https://openalex.org/keywords/complementary-cancer-therapy","display_name":"complementary cancer therapy","score":0.5889999866485596},{"id":"https://openalex.org/keywords/natural-products","display_name":"natural products","score":0.31200000643730164},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.5230000019073486},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.31200000643730164},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.39100000262260437},{"id":"https://openalex.org/keywords/cell-morphology","display_name":"cell morphology","score":0.3409999907016754}],"concepts":[{"id":"https://openalex.org/C2776474821","wikidata":"https://www.wikidata.org/wiki/Q83093","display_name":"Mushroom","level":2,"score":0.894636332988739},{"id":"https://openalex.org/C100817775","wikidata":"https://www.wikidata.org/wiki/Q134219","display_name":"Polysaccharide","level":2,"score":0.7257370948791504},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.48237863183021545},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46906447410583496},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.37651389837265015},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.34770798683166504},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31338363885879517},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29585039615631104},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1620185673236847}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repositorio.ulisboa.pt:10451/7703","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10451/7703","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},{"id":"mag:92275619","doi":null,"is_oa":false,"landing_page_url":"https://repositorio.ul.pt/bitstream/10451/7703/1/ulfc099177_tm_diana_martinho.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:repositorio.ulisboa.pt:10451/7703","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10451/7703","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W118828521","https://openalex.org/W612360463","https://openalex.org/W848896762","https://openalex.org/W1968834637","https://openalex.org/W1972165536","https://openalex.org/W1974648086","https://openalex.org/W1974932792","https://openalex.org/W1978206619","https://openalex.org/W1982195663","https://openalex.org/W2002132951","https://openalex.org/W2014988363","https://openalex.org/W2017150008","https://openalex.org/W2020824472","https://openalex.org/W2022510326","https://openalex.org/W2027850869","https://openalex.org/W2042921173","https://openalex.org/W2046771719","https://openalex.org/W2047793611","https://openalex.org/W2057844020","https://openalex.org/W2064906725","https://openalex.org/W2065626182","https://openalex.org/W2066505604","https://openalex.org/W2072639113","https://openalex.org/W2078032276","https://openalex.org/W2080432546","https://openalex.org/W2080499714","https://openalex.org/W2081587998","https://openalex.org/W2084115847","https://openalex.org/W2087071948","https://openalex.org/W2091609445","https://openalex.org/W2102386727","https://openalex.org/W2119931687","https://openalex.org/W2128635872","https://openalex.org/W2130821112","https://openalex.org/W2144911172","https://openalex.org/W2147810177","https://openalex.org/W2158764247","https://openalex.org/W2953028997"],"related_works":["https://openalex.org/W2248164981","https://openalex.org/W7132322027","https://openalex.org/W3202957441","https://openalex.org/W948894638","https://openalex.org/W1181759332","https://openalex.org/W2289738136","https://openalex.org/W2083732339","https://openalex.org/W2004307973","https://openalex.org/W7036437336","https://openalex.org/W2235227867"],"abstract_inverted_index":{"Hoje":[0],"em":[1,192,367,408,457],"dia,":[2],"devido":[3],"ao":[4,41,151,345,428,507,530,589,608,628],"prolongamento":[5],"da":[6,103,131,133,142,204,305,398,516,548,591,630,735],"esperan\u00e7a":[7],"m\u00e9dia":[8],"de":[9,36,45,98,100,111,167,197,216,220,252,256,280,370,376,389,434,470,484,501,532,539,552,561,584,596,606,653,661,668,671,678,687,705,732,749,759,763,771],"vida,":[10],"bem":[11,566],"como":[12,64,95,297,303,372,475,567,593,795],"o":[13,22,153,250,450,476,649,664],"aumento":[14,397],"das":[15,26,83,238,518,614,699,777],"agress\u00f5es":[16],"sofridas":[17],"pelo":[18],"meio":[19,595],"ambiente":[20],"envolvente,":[21],"cancro":[23,136,477,607,629],"\u00e9":[24,513],"uma":[25,514,755],"doen\u00e7as":[27,471,569],"mais":[28,182,202,538,572,615],"proeminentes":[29],"no":[30,149,270,505],"seculo":[31],"XXI.":[32],"Neoplasmas,":[33],"conjuntos":[34],"anormais":[35],"c\u00e9lulas":[37,78,411,679,778],"cromossomicamente":[38],"mutadas,":[39],"levam":[40],"crescimento":[42,677],"relativamente":[43],"aut\u00f3nomo":[44],"tecido":[46],"danificado.":[47],"As":[48,77,761],"causas":[49],"destas":[50],"muta\u00e7\u00f5es":[51],"variam":[52],"entre":[53,722],"internas":[54],"-":[55,60,63,301,308],"condi\u00e7\u00f5es":[56,790],"imunit\u00e1rias,":[57],"hormonais,":[58],"heritabilidade":[59],"ou":[61,69],"externas":[62],"tabagismo,":[65],"exposi\u00e7\u00e3o":[66],"a":[67,96,109,264,287,337,559,702,730,792],"radia\u00e7\u00e3o":[68],"agentes":[70,176],"qu\u00edmicos":[71],"infecciosos":[72],"(Zaidman":[73,115],"et":[74,116,120,138,185,283,350,382,414,479,521,543,575,579,601,638,642],"al.,":[75,117,186,284,351,383,415,522,544,576,580,602,639,643],"2005).":[76],"neopl\u00e1sicas":[79],"caracterizam-se":[80],"pela":[81],"perda":[82],"suas":[84,231,239],"fun\u00e7\u00f5es":[85,244],"especializadas":[86],"e":[87,108,207,278,309,315,378,403,461,473,635,691,694,717,744],"ganham":[88],"por":[89,135,213,360,765],"sua":[90,418,766,793],"vez":[91],"caracter\u00edsticas":[92],"biol\u00f3gicas":[93],"tais":[94],"produ\u00e7\u00e3o":[97],"sinais":[99],"crescimento,":[101],"inibi\u00e7\u00e3o":[102,405,675],"apoptose,":[104],"elevado":[105],"potencial":[106,774],"replicativo":[107],"capacidade":[110,756],"invadir":[112],"tecidos":[113,127],"circundantes":[114],"2005;":[118],"Zong":[119],"al.,,":[121,139],"2012).":[122,140,285,581],"A":[123,323,509,582,604],"esta":[124],"metastiza\u00e7\u00e3o":[125],"dos":[126,144,160,169,347,430,496,651,666],"est\u00e1":[128],"associada":[129],"90%":[130],"responsabilidade":[132],"morte":[134],"(Zong":[137,282],"Apesar":[141],"efici\u00eancia":[143],"f\u00e1rmacos":[145],"gerados":[146],"at\u00e9":[147],"hoje":[148,344],"combate":[150,506,597],"cancro,":[152],"seu":[154,441],"efeito":[155],"t\u00f3xico":[156],"causa":[157],"na":[158,165,236,261,273,482,674],"maioria":[159,419],"casos":[161],"um":[162,327,446,494,594,740,773],"decr\u00e9scimo":[163],"acentuado":[164],"qualidade":[166],"vida":[168],"doentes.":[170],"Assim,":[171,481],"torna-se":[172],"importante":[173],"descobrir":[174],"novos":[175],"anti":[177,319,331,775],"cancerigenos":[178],"com":[179,329,410,524,619,663],"efeitos":[180,365,497,652,667],"t\u00f3xicos":[181,487],"baixos":[183],"(Cao":[184,349],"2010)":[187],"que":[188,223,291,339,422,488,498,527,729,745,783],"possam":[189,503],"ser":[190],"utilizados":[191],"terapias":[193,799],"complementares.":[194],"Vir\u00e1mo-nos":[195],"ent\u00e3o":[196],"novo":[198],"para":[199,468,558,791],"as":[200,499,550,751,789],"tradi\u00e7\u00f5es":[201],"antigas":[203],"medicina":[205,288],"Chinesa":[206],"Mediterr\u00e2nea.":[208],"Polissac\u00e1ridos":[209],"s\u00e3o":[210],"biopol\u00edmeros":[211],"constitu\u00eddos":[212],"v\u00e1rias":[214],"unidades":[215,232],"monossac\u00e1ridos":[217],"ligados":[218],"atrav\u00e9s":[219],"liga\u00e7\u00f5es":[221],"glicosid\u00edcas,":[222],"podem":[224,786],"apresentar":[225],"diferentes":[226],"conforma\u00e7\u00f5es,":[227],"n\u00e3o":[228,486],"s\u00f3":[229],"nas":[230,316],"constituintes,":[233],"mas":[234],"tamb\u00e9m":[235,444,493,769],"conforma\u00e7\u00e3o":[237],"liga\u00e7\u00f5es,":[240],"atribuindo-lhes":[241],"assim":[242],"diversas":[243,697],"biol\u00f3gicas.":[245],"Estes":[246],"est\u00e3o":[247],"presentes":[248,788],"desde":[249,536],"armazenamento":[251],"energia":[253],"(amido),":[254],"forma\u00e7\u00e3o":[255],"componentes":[257],"estruturais":[258],"(celulose),":[259],"participantes":[260],"comunica\u00e7\u00e3o":[262],"c\u00e9lula":[263],"c\u00e9lula,":[265],"possuindo":[266,310],"ainda":[267,587],"pap\u00e9is":[268],"importantes":[269],"sistema":[271],"imunit\u00e1rio,":[272],"fertiliza\u00e7\u00e3o,":[274],"desenvolvimento,":[275],"agrega\u00e7\u00e3o":[276],"plaquet\u00e1ria":[277],"preven\u00e7\u00e3o":[279,469,560],"patog\u00e9neses":[281],"Desde":[286],"ancestral":[289],"chinesa":[290],"os":[292,420,723,746],"cogumelos":[293,421,460],"t\u00eam":[294,362,465,555],"sido":[295,341,466,556,613],"reportados":[296],"tendo":[298],"propriedades":[299,311,330,490],"imunomoduladoras":[300],"actuando":[302],"modificadores":[304],"resposta":[306,399],"biol\u00f3gica":[307],"antivirais,":[312],"antimicrobiais,":[313],"circulat\u00f3rias":[314],"ultimas":[317],"d\u00e9cadas":[318],"cancerigenas.":[320],"(Wasser,":[321,438],"2010).":[322,352],"descoberta":[324],"do":[325,355,401,570,610,622,632,676],"Lentinian,":[326],"polissac\u00e1rido":[328],"cancer\u00edgenas,":[332],"despoletou":[333],"nos":[334,626],"anos":[335,541],"60":[336],"pesquisa":[338],"tem":[340,612],"dedicada":[342],"ate":[343],"campo":[346],"polissac\u00e1ridos":[348,358,424,734,748],"Ao":[353,546],"longo":[354,531,547,590,609],"tempo,":[356],"diversos":[357],"produzidos":[359],"cogumelos,":[361,662],"demonstrado":[363],"largos":[364],"inibidores":[366],"v\u00e1rios":[368,685],"tipos":[369],"tumores":[371],"Sarcoma":[373,380],"180,":[374],"carcinoma":[375,706,709,712,715,719],"Lewis":[377],"Yoshida":[379],"(Zhang":[381,413],"2007).":[384,416],"Existem":[385],"tr\u00eas":[386],"mecanismos":[387],"propostos":[388],"actua\u00e7\u00e3o":[390],"destes":[391],"polissac\u00e1ridos:":[392],"(1)":[393],"actividade":[394],"preventiva,":[395],"(2)":[396],"imunit\u00e1ria":[400],"hospedeiro":[402],"(3)":[404],"directa":[406],"quando":[407,617,625],"contacto":[409],"cancer\u00edgenas":[412],"Na":[417],"possuem":[423],"biologicamente":[425],"activos":[426],"pertencem":[427],"grupo":[429],"basidiomicetes":[431],"contendo":[432],"cerca":[433],"700":[435],"esp\u00e9cies":[436,655,700],"descritas":[437],"2002).":[439],"O":[440],"poder":[442],"antioxidante":[443],"desempenha":[445],"papel":[447],"fundamental":[448],"contra":[449],"desenvolvimento":[451],"cancer\u00edgeno.":[452],"Anti":[453],"oxidantes":[454],"naturais":[455],"encontrados":[456],"fruta,":[458],"vegetais,":[459],"outros":[462],"recursos":[463],"alimentares":[464],"investigados":[467],"coron\u00e1rias":[472],"outras":[474,568,620,658],"(Kozarski":[478],"al.,2012).":[480],"procura":[483],"compostos":[485,692,785],"possu\u00edssem":[489],"anticancer\u00edgenas":[491,800],"investigou-se":[492],"pouco":[495],"folhas":[500,525,551,762],"oliveira":[502,510,585,764],"ter":[504],"cancro.":[508],"(Olea":[511],"europaea)":[512],"\u00e1rvore":[515],"fam\u00edlia":[517],"Oleaceae,":[519],"(Zaid":[520],"2012)":[523,644],"alongadas,":[526],"se":[528],"encontra":[529],"toda":[533],"regi\u00e3o":[534],"Mediterr\u00e2nea":[535],"h\u00e1":[537],"7000":[540],"(Lalas":[542],"2011).":[545],"hist\u00f3ria":[549,592],"Olea":[553],"europaea":[554],"exploradas":[557],"hipertens\u00e3o,":[562],"carcinog\u00e9nese,":[563],"diabetes,":[564],"arteroesclerose":[565],"foro":[571],"comum":[573],"(Bouallagui":[574,637],"2011;":[577,640],"Zaid":[578,641],"folha":[583],"foi":[586],"utilizada":[588],"\u00e1":[598],"mal\u00e1ria":[599],"(Lee":[600],"2009)":[603],"incid\u00eancia":[605],"mediterr\u00e2neo":[611],"baixas":[616],"comparada":[618],"partes":[621],"mundo,":[623],"principalmente":[624],"referimos":[627],"mama,":[631],"endom\u00e9trio,":[633],"pr\u00f3stata":[634],"leucemia.":[636],"Assim":[645],"reunimos":[646],"neste":[647],"trabalho,":[648],"estudo":[650,665],"algumas":[654,669],"conhecidas":[656],"(e":[657],"menos":[659],"conhecidas)":[660],"variedades":[670],"oliveiras":[672],"nacionais,":[673],"tumorais.":[680],"Para":[681],"isso,":[682],"foram":[683,695,768],"efectuados":[684],"doseamentos":[686],"polissac\u00e1ridos,":[688],"prote\u00ednas,":[689],"a\u00e7ucares":[690],"fen\u00f3licos":[693],"aplicadas":[696],"amostras":[698],"amostradas":[701,753],"quatro":[703],"linhas":[704],"humano:":[707],"HeLa,":[708],"cervical,":[710],"A549":[711],"pulmonar;":[713],"A431":[714],"epiderm\u00f3ide":[716],"OE21":[718],"es\u00f3fagofaringeal.":[720],"De":[721],"variados":[724],"resultados":[725],"obtidos,":[726],"pudemos":[727],"concluir":[728],"aplica\u00e7\u00e3o":[731,794],"extra":[733],"estirpe":[736],"Ganoderma":[737],"carnosum":[738],"revelou":[739],"alto":[741],"teor":[742],"inibit\u00f3rio,":[743],"intra":[747],"todas":[750],"estirpes":[752],"mostraram":[754],"antioxidativa":[757],"acima":[758],"50%.":[760],"vez,":[767],"capazes":[770],"mostrar":[772],"proliferativo":[776],"tumorais":[779],"bastante":[780],"satisfat\u00f3rio.":[781],"Acreditamos":[782],"nestes":[784],"estar":[787],"terapia":[796],"complementar":[797],"\u00e0s":[798],"existentes.":[801]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}