{"id":"https://openalex.org/W92258932","doi":null,"title":"An immunohistological approach to persistent lymphadenopathy and its relevance to AIDS.","display_name":"An immunohistological approach to persistent lymphadenopathy and its relevance to AIDS.","publication_year":1985,"publication_date":"1985-02-01","ids":{"openalex":"https://openalex.org/W92258932","mag":"92258932","pmid":"https://pubmed.ncbi.nlm.nih.gov/3884195","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1577142"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1577142","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1577142","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1577142","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045532145","display_name":"George Janossy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Janossy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110304503","display_name":"A J Pinching","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A J Pinching","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112097995","display_name":"Margarita Bofill","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Bofill","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001221271","display_name":"J Weber","orcid":"https://orcid.org/0000-0003-3561-809X","observed_orcids":["https://orcid.org/0000-0003-3561-809X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Weber","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103174306","display_name":"J. McLaughlin","orcid":"https://orcid.org/0000-0003-4511-6202","observed_orcids":["https://orcid.org/0000-0003-4511-6202"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J E McLaughlin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M Ornstein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Ornstein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034975405","display_name":"Kamal Ivory","orcid":"https://orcid.org/0000-0002-7372-7564","observed_orcids":["https://orcid.org/0000-0002-7372-7564"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Ivory","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112423231","display_name":"J R Harris","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J R Harris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111485813","display_name":"M Favrot","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Favrot","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5072158593","display_name":"David MacDonald-Burns","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D C Macdonald-Burns","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.6075,"has_fulltext":false,"cited_by_count":103,"citation_normalized_percentile":{"value":0.93376319,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"59","issue":"2","first_page":"257","last_page":"66"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13314","display_name":"Lymphadenopathy Diagnosis and Analysis","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/persistent-generalized-lymphadenopathy","display_name":"persistent generalized lymphadenopathy","score":0.9639999866485596},{"id":"https://openalex.org/keywords/aids","display_name":"AIDS","score":0.8920000195503235},{"id":"https://openalex.org/keywords/dendritic-reticulum-cells","display_name":"dendritic reticulum cells","score":0.9179999828338623},{"id":"https://openalex.org/keywords/follicular-hyperplasia","display_name":"follicular hyperplasia","score":0.8460000157356262},{"id":"https://openalex.org/keywords/paracortical-hyperplasia","display_name":"paracortical hyperplasia","score":0.8840000033378601},{"id":"https://openalex.org/keywords/plasma-cell-infiltration","display_name":"plasma cell infiltration","score":0.7990000247955322},{"id":"https://openalex.org/keywords/kaposi-sarcoma","display_name":"Kaposi's sarcoma","score":0.8899999856948853},{"id":"https://openalex.org/keywords/t-lymphopenia","display_name":"T lymphopenia","score":0.5839999914169312},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.5630000233650208},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.6060000061988831},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.6899999976158142}],"concepts":[{"id":"https://openalex.org/C96926380","wikidata":"https://www.wikidata.org/wiki/Q1737968","display_name":"Germinal center","level":4,"score":0.8830049633979797},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6066370606422424},{"id":"https://openalex.org/C2776396001","wikidata":"https://www.wikidata.org/wiki/Q250694","display_name":"Plasma cell","level":3,"score":0.5927259922027588},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5688497424125671},{"id":"https://openalex.org/C2778372705","wikidata":"https://www.wikidata.org/wiki/Q5532491","display_name":"Generalized lymphadenopathy","level":3,"score":0.5410380363464355},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.5285778641700745},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.4724605083465576},{"id":"https://openalex.org/C3753494","wikidata":"https://www.wikidata.org/wiki/Q2631550","display_name":"Follicular dendritic cells","level":5,"score":0.46083101630210876},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4365460276603699},{"id":"https://openalex.org/C2908591792","wikidata":"https://www.wikidata.org/wiki/Q16999269","display_name":"Follicular hyperplasia","level":3,"score":0.4211370348930359},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.41446205973625183},{"id":"https://openalex.org/C2777562237","wikidata":"https://www.wikidata.org/wiki/Q835051","display_name":"Hyperplasia","level":2,"score":0.4095376133918762},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3940729796886444},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.3554530143737793},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.34726816415786743},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.2757578492164612},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.14035624265670776},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.13596069812774658},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007958","descriptor_name":"Leukocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008206","descriptor_name":"Lymphatic Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008206","descriptor_name":"Lymphatic Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012514","descriptor_name":"Sarcoma, Kaposi","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1577142","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1577142","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},{"id":"pmid:3884195","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3884195","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental immunology","raw_type":"Journal Article"},{"id":"mag:92258932","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3884195","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1577142","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1577142","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Exp Immunol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W146864211","https://openalex.org/W1525047978","https://openalex.org/W1529201377","https://openalex.org/W1966625144","https://openalex.org/W1977691157","https://openalex.org/W1991670386","https://openalex.org/W2014880976","https://openalex.org/W2043015697","https://openalex.org/W2046690158","https://openalex.org/W2048610332","https://openalex.org/W2057388929","https://openalex.org/W2058311915","https://openalex.org/W2074081823","https://openalex.org/W2088055135","https://openalex.org/W2088740626","https://openalex.org/W2091187316","https://openalex.org/W2117400957","https://openalex.org/W2164563724","https://openalex.org/W2319153630","https://openalex.org/W2325624902","https://openalex.org/W2334860476","https://openalex.org/W2338572106","https://openalex.org/W2410336712","https://openalex.org/W2411848786","https://openalex.org/W2416325770","https://openalex.org/W2441156880","https://openalex.org/W2986476073","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2330583641","https://openalex.org/W1546417235","https://openalex.org/W2324969646","https://openalex.org/W333356916","https://openalex.org/W2416104935","https://openalex.org/W1964651547","https://openalex.org/W2984919205","https://openalex.org/W1653936274","https://openalex.org/W191218928","https://openalex.org/W2046872863"],"abstract_inverted_index":{"Recent":[0],"evidence":[1],"has":[2],"shown":[3],"that":[4,160],"not":[5,152,192],"only":[6,82],"AIDS":[7,32],"but":[8,197],"also":[9],"the":[10,62,96,112,119,143,149,157,169,208],"majority":[11],"of":[12,61,95,114,140,145,171,183,210,214],"'unexplained'":[13],"persistent,":[14],"generalized":[15],"lymphadenopathy":[16],"(PGL)":[17],"are":[18],"related":[19],"to":[20,31,57,123,132,207],"HTLV-III/LAV":[21],"infections.":[22],"The":[23],"early":[24,108],"detection":[25],"how":[26],"these":[27],"changes":[28],"may":[29,110,163,205],"proceed":[30],"then":[33],"become":[34],"a":[35],"prime":[36],"interest.":[37],"Eleven":[38],"patients":[39,218],"with":[40,103,134,188,219],"PGL":[41],"(10":[42],"homosexual":[43],"males":[44],"and":[45,66,72,84,121,212],"one":[46],"heterosexual":[47],"haemophiliac)":[48],"have":[49],"been":[50],"studied":[51],"by":[52],"immunohistology":[53],"using":[54],"monoclonal":[55],"antibodies":[56],"dendritic":[58,97],"reticulum":[59,98],"cells":[60,71,117,147,162],"germinal":[63,176,194],"centre,":[64],"T":[65],"B":[67,116],"lymphocyte":[68],"subsets,":[69],"plasma":[70,201],"factor":[73],"VIII,":[74],"as":[75,129,153,155],"an":[76,125,179],"endothelial":[77],"marker.":[78],"In":[79,137,174],"six":[80],"cases":[81,93,142],"follicular":[83],"paracortical":[85],"hyperplasia":[86],"was":[87,101,151],"detected,":[88],"while":[89],"in":[90,148,156,166,217],"five":[91],"other":[92],"destruction":[94,109,196],"cell":[99,202],"network":[100],"seen":[102],"this":[104],"sensitive":[105],"method.":[106],"This":[107],"explain":[111],"release":[113],"activated":[115],"into":[118],"circulation":[120],"prove":[122],"be":[124],"ominous":[126],"prognostic":[127],"sign,":[128],"it":[130],"appears":[131],"correlate":[133],"'prodromal'":[135],"symptoms.":[136],"four":[138],"out":[139],"11":[141],"depletion":[144],"T4+":[146,161],"paracortex":[150],"severe":[154],"blood,":[158],"indicating":[159],"preferentially":[164],"settle":[165],"tissues":[167],"at":[168],"time":[170],"T4":[172],"lymphopenia.":[173],"addition,":[175],"centres":[177],"contained":[178],"additional":[180],"patchy":[181],"infiltration":[182],"T8+":[184],"cells.":[185],"A":[186],"patient":[187],"Kaposi's":[189],"sarcoma":[190],"did":[191,198],"show":[193],"centre":[195],"reveal":[199],"extensive":[200],"infiltrates.":[203],"Immunohistology":[204],"contribute":[206],"definition":[209],"prognosis":[211],"analysis":[213],"disease":[215],"progression":[216],"PGL.":[220]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}