{"id":"https://openalex.org/W92082012","doi":"https://doi.org/10.1172/jci105800","title":"Serum opsonin, bacteria, and polymorphonuclear leukocyte interactions in subacute bacterial endocarditis","display_name":"Serum opsonin, bacteria, and polymorphonuclear leukocyte interactions in subacute bacterial endocarditis","publication_year":1968,"publication_date":"1968-05-01","ids":{"openalex":"https://openalex.org/W92082012","doi":"https://doi.org/10.1172/jci105800","mag":"92082012","pmid":"https://pubmed.ncbi.nlm.nih.gov/5645856","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/297263"},"language":"en","primary_location":{"id":"doi:10.1172/jci105800","doi":"https://doi.org/10.1172/jci105800","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci105800","pdf_url":"http://www.jci.org/articles/view/105800/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/105800/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038721170","display_name":"Ronald P. Messner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald P. Messner","raw_affiliation_strings":["From the Arthritis Unit, the Department of Medicine and the Department of Pediatrics, University of Minnesota College of Medicine, University Hospitals, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Arthritis Unit, the Department of Medicine and the Department of Pediatrics, University of Minnesota College of Medicine, University Hospitals, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109005023","display_name":"\u00der\u00f6stur Laxdal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Throstur Laxdal","raw_affiliation_strings":["From the Arthritis Unit, the Department of Medicine and the Department of Pediatrics, University of Minnesota College of Medicine, University Hospitals, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Arthritis Unit, the Department of Medicine and the Department of Pediatrics, University of Minnesota College of Medicine, University Hospitals, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114002590","display_name":"Paul G. Quie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul G. Quie","raw_affiliation_strings":["From the Arthritis Unit, the Department of Medicine and the Department of Pediatrics, University of Minnesota College of Medicine, University Hospitals, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Arthritis Unit, the Department of Medicine and the Department of Pediatrics, University of Minnesota College of Medicine, University Hospitals, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008244311","display_name":"Ralph C. Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ralph C. Williams","raw_affiliation_strings":["From the Arthritis Unit, the Department of Medicine and the Department of Pediatrics, University of Minnesota College of Medicine, University Hospitals, Minneapolis, Minnesota 55455"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Arthritis Unit, the Department of Medicine and the Department of Pediatrics, University of Minnesota College of Medicine, University Hospitals, Minneapolis, Minnesota 55455","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":12.3358,"has_fulltext":true,"cited_by_count":64,"citation_normalized_percentile":{"value":0.98563957,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"47","issue":"5","first_page":"1109","last_page":"1120"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11551","display_name":"Infective Endocarditis Diagnosis and Management","score":0.5044000148773193,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11551","display_name":"Infective Endocarditis Diagnosis and Management","score":0.5044000148773193,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.12240000069141388,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms","score":0.06700000166893005,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/subacute-bacterial-endocarditis","display_name":"subacute bacterial endocarditis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/opsonins","display_name":"opsonins","score":0.7879999876022339},{"id":"https://openalex.org/keywords/7s-immunoglobulin","display_name":"7S immunoglobulin","score":0.9229999780654907},{"id":"https://openalex.org/keywords/phagocytosis","display_name":"phagocytosis","score":0.8690000176429749},{"id":"https://openalex.org/keywords/polymorphonuclear-leukocytes","display_name":"polymorphonuclear leukocytes","score":0.9900000095367432},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.7950000166893005},{"id":"https://openalex.org/keywords/complement-system","display_name":"complement system","score":0.49799999594688416},{"id":"https://openalex.org/keywords/heat-labile-serum-factor","display_name":"heat-labile serum factor","score":0.8460000157356262},{"id":"https://openalex.org/keywords/bacterial-agglutination","display_name":"bacterial agglutination","score":0.8059999942779541},{"id":"https://openalex.org/keywords/serum-bactericidal-activity","display_name":"serum bactericidal activity","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C89372155","wikidata":"https://www.wikidata.org/wiki/Q420107","display_name":"Opsonin","level":3,"score":0.8401162028312683},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.8060575723648071},{"id":"https://openalex.org/C143508840","wikidata":"https://www.wikidata.org/wiki/Q393294","display_name":"Agglutination (biology)","level":3,"score":0.7149410843849182},{"id":"https://openalex.org/C81358767","wikidata":"https://www.wikidata.org/wiki/Q321710","display_name":"Globulin","level":2,"score":0.6495230197906494},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6423181295394897},{"id":"https://openalex.org/C2781396855","wikidata":"https://www.wikidata.org/wiki/Q2271749","display_name":"Subacute bacterial endocarditis","level":3,"score":0.5428375005722046},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5394980907440186},{"id":"https://openalex.org/C91523082","wikidata":"https://www.wikidata.org/wiki/Q420496","display_name":"Antiserum","level":3,"score":0.5271225571632385},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.508838951587677},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42541268467903137},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.41315802931785583},{"id":"https://openalex.org/C2775872228","wikidata":"https://www.wikidata.org/wiki/Q82504","display_name":"Endocarditis","level":2,"score":0.4030272960662842},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23662921786308289},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.05313876271247864},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000372","descriptor_name":"Agglutination Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000372","descriptor_name":"Agglutination Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000372","descriptor_name":"Agglutination Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003298","descriptor_name":"Coombs Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003298","descriptor_name":"Coombs Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003298","descriptor_name":"Coombs Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004698","descriptor_name":"Endocarditis, Subacute Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004698","descriptor_name":"Endocarditis, Subacute Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004698","descriptor_name":"Endocarditis, Subacute Bacterial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009895","descriptor_name":"Opsonin Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009895","descriptor_name":"Opsonin Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009895","descriptor_name":"Opsonin Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010587","descriptor_name":"Phagocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012217","descriptor_name":"Rheumatoid Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012217","descriptor_name":"Rheumatoid Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012217","descriptor_name":"Rheumatoid Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013210","descriptor_name":"Staphylococcus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013210","descriptor_name":"Staphylococcus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013210","descriptor_name":"Staphylococcus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci105800","doi":"https://doi.org/10.1172/jci105800","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci105800","pdf_url":"http://www.jci.org/articles/view/105800/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:297263","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/297263","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:5645856","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5645856","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci105800","doi":"https://doi.org/10.1172/jci105800","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci105800","pdf_url":"http://www.jci.org/articles/view/105800/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W92082012.pdf","grobid_xml":"https://content.openalex.org/works/W92082012.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W198387928","https://openalex.org/W1492645296","https://openalex.org/W1508065848","https://openalex.org/W1520385356","https://openalex.org/W1536269867","https://openalex.org/W1539836473","https://openalex.org/W1593999131","https://openalex.org/W1605790752","https://openalex.org/W1731303700","https://openalex.org/W1826727828","https://openalex.org/W1877906908","https://openalex.org/W1896809901","https://openalex.org/W1936537501","https://openalex.org/W1966480925","https://openalex.org/W1971316456","https://openalex.org/W1991022207","https://openalex.org/W1992301296","https://openalex.org/W2000728769","https://openalex.org/W2002559544","https://openalex.org/W2010261110","https://openalex.org/W2015631495","https://openalex.org/W2024950310","https://openalex.org/W2044538298","https://openalex.org/W2050079768","https://openalex.org/W2078241808","https://openalex.org/W2079580780","https://openalex.org/W2086801861","https://openalex.org/W2092417998","https://openalex.org/W2105866983","https://openalex.org/W2134240898","https://openalex.org/W2152994851","https://openalex.org/W2156664539","https://openalex.org/W2157909819","https://openalex.org/W2326823822","https://openalex.org/W2342365746","https://openalex.org/W2399799143","https://openalex.org/W2412954311","https://openalex.org/W2414157164","https://openalex.org/W4300854365","https://openalex.org/W4322152675"],"related_works":["https://openalex.org/W7100211963","https://openalex.org/W2056456405","https://openalex.org/W2399799143","https://openalex.org/W2408477571","https://openalex.org/W2396980515","https://openalex.org/W2050651526","https://openalex.org/W2417115669","https://openalex.org/W1505868169","https://openalex.org/W7099998549","https://openalex.org/W2006900792"],"abstract_inverted_index":{"The":[0,61],"effect":[1,51,63,87],"of":[2,41,64,76,88,95],"anti-gamma-globulin":[3,26,65,89],"factors":[4,27,66,90,98],"on":[5],"7S":[6,42,79],"gamma-globulin":[7,43],"opsonins":[8],"from":[9,28],"patients":[10,29],"with":[11,18,30,54,70],"subacute":[12,31],"bacterial":[13,32],"endocarditis":[14,33],"has":[15],"been":[16],"examined":[17],"a":[19],"quantitative":[20],"in":[21],"vitro":[22],"phagocytosis":[23],"system.":[24],"Human":[25],"and":[34,91],"rheumatoid":[35],"arthritis":[36],"inhibited":[37],"the":[38,85,92],"opsonic":[39],"action":[40,94],"specifically":[44],"bound":[45],"to":[46,57,73],"bacteria.":[47],"A":[48],"similar":[49],"antiopsonic":[50,62,86],"was":[52,82],"obtained":[53],"rabbit":[55],"antiserum":[56],"human":[58],"gammaG":[59],"globulin.":[60],"did":[67],"not":[68],"correlate":[69],"their":[71],"ability":[72],"potentiate":[74],"agglutination":[75],"bacteria":[77],"by":[78],"antibody.":[80],"Competition":[81],"demonstrated":[83],"between":[84],"phagocytosis-promoting":[93],"heat-labile":[96],"serum":[97],"containing":[99],"hemolytically":[100],"active":[101],"complement.":[102]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
