{"id":"https://openalex.org/W91969236","doi":null,"title":"Abstract 320: A Human Polymorphism of Protein Phosphatase 1 Inhibitor 1 is Associated With Attenuated Contractile Responses to Beta-adrenergic Stimulation","display_name":"Abstract 320: A Human Polymorphism of Protein Phosphatase 1 Inhibitor 1 is Associated With Attenuated Contractile Responses to Beta-adrenergic Stimulation","publication_year":2007,"publication_date":"2007-10-16","ids":{"openalex":"https://openalex.org/W91969236","mag":"91969236"},"language":"en","primary_location":{"id":"mag:91969236","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/abs/10.1161/circ.116.suppl_16.ii_46","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null},"volume":null,"type":"conference-abstract","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015127855","display_name":"Guoli Chen","orcid":"https://orcid.org/0000-0002-4426-6156","observed_orcids":["https://orcid.org/0000-0002-4426-6156"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guoli Chen","raw_affiliation_strings":["University of CIncinnati, CIncinnati, OH"],"raw_orcid":"https://orcid.org/0000-0002-4426-6156","affiliations":[{"raw_affiliation_string":"University of CIncinnati, CIncinnati, OH","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030326080","display_name":"Xiaoyang Zhou","orcid":"https://orcid.org/0009-0002-0483-2528","observed_orcids":["https://orcid.org/0009-0002-0483-2528","https://orcid.org/0009-0001-8229-182X"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoyang Zhou","raw_affiliation_strings":["University of CIncinnati, CIncinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of CIncinnati, CIncinnati, OH","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101657650","display_name":"Patricia Rodr\u00edguez","orcid":"https://orcid.org/0000-0002-5173-2653","observed_orcids":["https://orcid.org/0000-0002-5173-2653"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia Rodr\u00edguez","raw_affiliation_strings":["University of CIncinnati, CIncinnati, OH"],"raw_orcid":"https://orcid.org/0000-0002-5173-2653","affiliations":[{"raw_affiliation_string":"University of CIncinnati, CIncinnati, OH","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111536191","display_name":"Guojie Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092870","display_name":"Jiaxing University","ror":"https://ror.org/00j2a7k55","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092870"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guojie Song","raw_affiliation_strings":["Jiaxing Univ, Jiaxing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Jiaxing Univ, Jiaxing, China","institution_ids":["https://openalex.org/I4210092870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009468548","display_name":"Bryan A. Mitton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryan Mitton","raw_affiliation_strings":["University of CIncinnati, CIncinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of CIncinnati, CIncinnati, OH","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026862922","display_name":"Anand Pathak","orcid":"https://orcid.org/0000-0002-2972-2520","observed_orcids":["https://orcid.org/0000-0002-2972-2520"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anand Pathak","raw_affiliation_strings":["University of CIncinnati, CIncinnati, OH"],"raw_orcid":"https://orcid.org/0000-0002-2972-2520","affiliations":[{"raw_affiliation_string":"University of CIncinnati, CIncinnati, OH","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061759840","display_name":"Amit Zachariah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amit Zachariah","raw_affiliation_strings":["University of CIncinnati, CIncinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of CIncinnati, CIncinnati, OH","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007128842","display_name":"Guo\u2010Chang Fan","orcid":"https://orcid.org/0000-0002-0439-8277","observed_orcids":["https://orcid.org/0000-0002-0439-8277"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guo\u2010Chang Fan","raw_affiliation_strings":["University of CIncinnati, CIncinnati, OH"],"raw_orcid":"https://orcid.org/0000-0002-0439-8277","affiliations":[{"raw_affiliation_string":"University of CIncinnati, CIncinnati, OH","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108292243","display_name":"Gerald W. Dorn","orcid":"https://orcid.org/0000-0002-8995-1624","observed_orcids":["https://orcid.org/0000-0002-8995-1624"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerald W. Dorn","raw_affiliation_strings":["University of CIncinnati, CIncinnati, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of CIncinnati, CIncinnati, OH","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080329479","display_name":"Evangelia Galani Kranias","orcid":"https://orcid.org/0000-0002-4621-6179","observed_orcids":["https://orcid.org/0000-0002-4621-6179"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evangelia G. Kranias","raw_affiliation_strings":["University of CIncinnati, CIncinnati, OH"],"raw_orcid":"https://orcid.org/0000-0002-4621-6179","affiliations":[{"raw_affiliation_string":"University of CIncinnati, CIncinnati, OH","institution_ids":["https://openalex.org/I63135867"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"116","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.7437000274658203,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.7437000274658203,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.06780000030994415,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.035100001841783524,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-adrenergic-signaling","display_name":"beta-adrenergic signaling","score":0.8759999871253967},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.9739999771118164},{"id":"https://openalex.org/keywords/cardiomyocyte-contractility","display_name":"cardiomyocyte contractility","score":0.8849999904632568},{"id":"https://openalex.org/keywords/isoproterenol","display_name":"isoproterenol","score":0.8529999852180481},{"id":"https://openalex.org/keywords/phospholamban-phosphorylation","display_name":"phospholamban phosphorylation","score":0.9190000295639038},{"id":"https://openalex.org/keywords/calcium-transients","display_name":"calcium transients","score":0.7149999737739563},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.593999981880188},{"id":"https://openalex.org/keywords/black-patients","display_name":"Black patients","score":0.6399999856948853},{"id":"https://openalex.org/keywords/calcium-homeostasis","display_name":"calcium homeostasis","score":0.7559999823570251}],"concepts":[{"id":"https://openalex.org/C17137333","wikidata":"https://www.wikidata.org/wiki/Q410105","display_name":"Phospholamban","level":3,"score":0.8926609754562378},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7263571619987488},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7080081701278687},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.5636188387870789},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5222523808479309},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5088951587677002},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5033072829246521},{"id":"https://openalex.org/C2779408958","wikidata":"https://www.wikidata.org/wiki/Q7251492","display_name":"Protein phosphatase 1","level":4,"score":0.48735982179641724},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.47980836033821106},{"id":"https://openalex.org/C113217602","wikidata":"https://www.wikidata.org/wiki/Q416781","display_name":"Ryanodine receptor","level":3,"score":0.4311469793319702},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3166426420211792},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.28981727361679077},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.18392592668533325}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:91969236","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/abs/10.1161/circ.116.suppl_16.ii_46","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7900000214576721}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W141860905","https://openalex.org/W1973807036","https://openalex.org/W1920314700","https://openalex.org/W2123588949","https://openalex.org/W1972020650","https://openalex.org/W2135927881","https://openalex.org/W2131325542","https://openalex.org/W2140732346","https://openalex.org/W1978578637","https://openalex.org/W2117720689"],"abstract_inverted_index":{"Aberrant":[0],"\u03b2-adrenergic":[1,228],"signaling":[2],"associated":[3],"with":[4,113,163,174],"depressed":[5],"calcium":[6],"homeostasis":[7],"is":[8,43,60],"one":[9],"of":[10,15,33,39,83,102,150,180,189,204,244],"the":[11,30,65,99,103,144,148,164,169,178,208,217,224,242],"most":[12],"prominent":[13],"characteristics":[14],"heart":[16,94,239,245],"failure.":[17,246],"Abnormalities":[18],"in":[19,53,64,77,92,135,160,198],"protein":[20,26,40],"kinases":[21],"A":[22],"as":[23,25],"well":[24],"phosphatase":[27,41],"1":[28,42],"underlie":[29],"impaired":[31],"function":[32,240],"this":[34],"\u03b2-signaling":[35],"axis.":[36],"The":[37],"activity":[38],"regulated":[44],"by":[45,196],"an":[46,114],"endogenous":[47],"inhibitor,":[48],"inhibitor-1.":[49],"In":[50],"vitro":[51],"and":[52,207,241],"vivo":[54],"studies":[55],"have":[56],"indicated":[57],"that":[58,216],"inhibitor-1":[59],"a":[61,74],"critical":[62],"player":[63],"heart\u2019s":[66,225],"responses":[67,149,226],"to":[68,154,168,227,237],"neurohormonal":[69],"stimulation.":[70],"This":[71],"study":[72],"identified":[73],"novel":[75],"polymorphism":[76,222],"human":[78,218],"inhibitor":[79,105,118,122,220],"-1,":[80,119,123],"entailing":[81],"substitution":[82],"aspartic":[84],"acid":[85],"for":[86],"glycine":[87],"at":[88,191],"AA147":[89],"(G147D),":[90],"exclusively":[91],"black":[93],"failure":[95],"patients.":[96],"To":[97],"elucidate":[98],"functional":[100],"significance":[101],"G147D":[104,117,165,219],"-1":[106,221],"mutant,":[107],"we":[108],"infected":[109,162,200],"adult":[110],"rat":[111],"cardiomyocytes":[112,161],"adenovirus":[115],"expressing":[116],"wild":[120],"type":[121],"or":[124,140],"control":[125],"GFP.":[126],"Under":[127],"basal":[128],"conditions,":[129],"there":[130],"were":[131,157],"no":[132],"significant":[133],"differences":[134],"fractional":[136],"shortening,":[137],"contraction":[138],"rate":[139,142],"relaxation":[141],"among":[143],"three":[145],"groups.":[146,172],"However,":[147],"these":[151,175],"contractile":[152],"parameters":[153],"isoproterenol":[155],"stimulation":[156],"significantly":[158,185],"blunted":[159],"variant,":[166],"compared":[167],"other":[170],"two":[171],"Consistent":[173],"mechanical":[176],"parameters,":[177],"velocity":[179],"Ca":[181],"transient":[182],"decay":[183],"was":[184,194],"delayed.":[186],"Importantly,":[187],"phosphorylation":[188,203],"phospholamban":[190],"serine":[192],"16":[193],"decreased":[195,231],"50%":[197],"G147D-Inhibitor-1":[199],"cells,":[201],"although":[202],"troponin":[205],"I":[206],"ryanodine":[209],"receptor":[210],"remained":[211],"unaltered.":[212],"These":[213],"findings":[214],"suggest":[215],"attenuates":[223],"agonists":[229],"through":[230],"PLN":[232],"phosphorylation,":[233],"which":[234],"may":[235],"contribute":[236],"compromised":[238],"development":[243]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
