{"id":"https://openalex.org/W91932046","doi":null,"title":"Structural relationships between the insulin receptor and epidermal growth factor receptor families and other proteins.","display_name":"Structural relationships between the insulin receptor and epidermal growth factor receptor families and other proteins.","publication_year":2004,"publication_date":"2004-09-01","ids":{"openalex":"https://openalex.org/W91932046","mag":"91932046","pmid":"https://pubmed.ncbi.nlm.nih.gov/15503865"},"language":"en","primary_location":{"id":"pmid:15503865","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15503865","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in drug discovery & development","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103515859","display_name":"Colin W. Ward","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292875679","display_name":"Commonwealth Scientific and Industrial Research Organisation","ror":"https://ror.org/03qn8fb07","country_code":"AU","type":"government","lineage":["https://openalex.org/I1292875679","https://openalex.org/I2801453606","https://openalex.org/I4387156119"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Colin W Ward","raw_affiliation_strings":["CSIRO Health Sciences & Nutrition, Parkville, Victoria 3052, Australia. Colin.Ward@csiro.au"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CSIRO Health Sciences & Nutrition, Parkville, Victoria 3052, Australia. Colin.Ward@csiro.au","institution_ids":["https://openalex.org/I1292875679"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109887676","display_name":"Thomas Garrett","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas P J Garrett","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4703,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.8053444,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"7","issue":"5","first_page":"630","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-receptor","display_name":"insulin receptor","score":0.9909999966621399},{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":0.972000002861023},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinases","display_name":"receptor tyrosine kinase","score":0.8399999737739563},{"id":"https://openalex.org/keywords/igf-1-receptor","display_name":"IGF-1 receptor","score":0.9290000200271606},{"id":"https://openalex.org/keywords/erbb2","display_name":"ERBB2","score":0.8759999871253967},{"id":"https://openalex.org/keywords/her3","display_name":"HER3","score":0.9919999837875366},{"id":"https://openalex.org/keywords/extracellular-domain-structure","display_name":"extracellular domain structure","score":0.8140000104904175},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.640999972820282},{"id":"https://openalex.org/keywords/pertuzumab","display_name":"pertuzumab","score":0.9470000267028809},{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":0.9980000257492065},{"id":"https://openalex.org/keywords/epidermal-growth-factor","display_name":"epidermal growth factor","score":0.9570000171661377},{"id":"https://openalex.org/keywords/transforming-growth-factor-alpha","display_name":"transforming growth factor-alpha","score":0.9789999723434448},{"id":"https://openalex.org/keywords/receptor-dimerization","display_name":"receptor dimerization","score":0.8029999732971191},{"id":"https://openalex.org/keywords/anticancer-drug-design","display_name":"anticancer drug design","score":0.7039999961853027},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.4350000023841858}],"concepts":[{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.7132931351661682},{"id":"https://openalex.org/C115456853","wikidata":"https://www.wikidata.org/wiki/Q17917132","display_name":"ERBB3","level":4,"score":0.6565582752227783},{"id":"https://openalex.org/C2776362946","wikidata":"https://www.wikidata.org/wiki/Q424374","display_name":"Epidermal growth factor","level":3,"score":0.5764360427856445},{"id":"https://openalex.org/C130287650","wikidata":"https://www.wikidata.org/wiki/Q17091190","display_name":"Growth factor receptor inhibitor","level":4,"score":0.563026487827301},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5539770722389221},{"id":"https://openalex.org/C26375932","wikidata":"https://www.wikidata.org/wiki/Q118226","display_name":"Growth factor receptor","level":3,"score":0.5454195737838745},{"id":"https://openalex.org/C2779251935","wikidata":"https://www.wikidata.org/wiki/Q5385089","display_name":"ErbB","level":3,"score":0.5071768760681152},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.5027625560760498},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.5005934238433838},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.46774011850357056},{"id":"https://openalex.org/C144174609","wikidata":"https://www.wikidata.org/wiki/Q14901457","display_name":"Insulin-like growth factor 1 receptor","level":4,"score":0.45375585556030273},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44135579466819763},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4293721318244934},{"id":"https://openalex.org/C2908605954","wikidata":"https://www.wikidata.org/wiki/Q25098752","display_name":"Insulin-Like Growth Factor Receptor","level":5,"score":0.42360377311706543},{"id":"https://openalex.org/C2781164504","wikidata":"https://www.wikidata.org/wiki/Q1998021","display_name":"Pertuzumab","level":5,"score":0.41199013590812683},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.396271675825119},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.3548281490802765},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2703622579574585},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.22838297486305237},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.22087979316711426},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1836467981338501},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17622798681259155},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.1697850227355957},{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.09587657451629639},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011972","descriptor_name":"Receptor, Insulin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011972","descriptor_name":"Receptor, Insulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:15503865","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15503865","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in drug discovery & development","raw_type":"Comparative Study"},{"id":"mag:91932046","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15503865","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1999192227","https://openalex.org/W2073035303","https://openalex.org/W3017030605","https://openalex.org/W2113673212","https://openalex.org/W2001751915","https://openalex.org/W2036907315","https://openalex.org/W2393468444","https://openalex.org/W1978193152","https://openalex.org/W2053363022","https://openalex.org/W418913818"],"abstract_inverted_index":{"The":[0],"insulin":[1],"receptor":[2,8,17,39,91,109],"(IR)":[3],"and":[4,21,162,178,202],"epidermal":[5,182],"growth":[6,37,183,188],"factor":[7,38,184],"(EGFR)":[9],"families":[10,92],"are":[11,22],"closely":[12],"related":[13],"members":[14,42],"of":[15,43,53,56,70,81,85,89,102,106,136,210],"the":[16,24,34,44,51,68,79,82,86,96,99,103,113,124,127,150,203,208],"tyrosine":[18],"kinase":[19],"superfamily,":[20],"among":[23],"more":[25],"intensively":[26],"studied":[27],"proteins":[28],"in":[29,50,78,116,173,191],"biology.":[30],"Deregulated":[31],"signaling":[32],"by":[33],"type-1":[35],"insulin-like":[36],"(IGF-1R)":[40],"or":[41,147,186],"EGFR":[45,114,168,179],"family":[46,115],"has":[47,120,129],"been":[48,121],"implicated":[49],"progression":[52],"a":[54,133,166,170,192],"variety":[55],"cancers.":[57],"These":[58],"receptors":[59],"have":[60],"thus":[61],"emerged":[62],"as":[63],"validated":[64],"therapeutic":[65,212],"targets":[66],"for":[67,207],"development":[69],"antitumor":[71],"agents.":[72],"In":[73],"this":[74],"review,":[75],"recent":[76],"progress":[77,119],"elucidation":[80],"three-dimensional":[83],"structures":[84,139],"extracellular":[87,104,216],"domains":[88,105],"both":[90],"is":[93,112],"discussed.":[94],"While":[95],"IGF-1R":[97],"provided":[98],"first":[100],"description":[101],"these":[107,200],"two":[108,151],"families,":[110],"it":[111],"which":[117],"greatest":[118],"achieved.":[122],"Over":[123],"past":[125],"year,":[126],"field":[128],"progressed":[130],"from":[131],"having":[132,141],"complete":[134],"absence":[135],"X-ray":[137],"crystal":[138],"to":[140],"eight":[142],"such":[143],"structures;":[144],"ErbB-2":[145],"alone":[146],"complexed":[148],"with":[149,169,180],"monoclonal":[152],"antibodies":[153],"pertuzumab":[154],"(Genentech":[155],"Inc/Roche":[156],"Holdings":[157],"AG/Chugai":[158],"Pharmaceutical":[159],"Co":[160],"Ltd)":[161],"trastuzamab,":[163],"ErbB-3":[164],"without":[165],"ligand,":[167],"ligand":[171],"bound":[172],"an":[174],"unactivated":[175],"monomeric":[176],"conformation,":[177],"either":[181],"(EGF)":[185],"transforming":[187],"factor-alpha":[189],"(TGFalpha)":[190],"2:2":[193],"dimeric":[194],"complex.":[195],"This":[196],"review":[197],"will":[198],"discuss":[199],"developments":[201],"opportunities":[204],"they":[205],"provide":[206],"design":[209],"new":[211],"agents":[213],"targeting":[214],"their":[215],"domains.":[217]},"counts_by_year":[{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
