{"id":"https://openalex.org/W9187695","doi":null,"title":"The surgical margin in soft tissue sarcoma.","display_name":"The surgical margin in soft tissue sarcoma.","publication_year":1990,"publication_date":"1990-01-01","ids":{"openalex":"https://openalex.org/W9187695","mag":"9187695","pmid":"https://pubmed.ncbi.nlm.nih.gov/2249507"},"language":"it","primary_location":{"id":"pmid:2249507","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2249507","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"La Chirurgia degli organi di movimento","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111815148","display_name":"R. S. Bell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"R S Bell","raw_affiliation_strings":["Musculoskeletal Oncology Unit, University of Toronto, Canada","Sarcoma Site Group, Princess Margaret Hospital, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Musculoskeletal Oncology Unit, University of Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Sarcoma Site Group, Princess Margaret Hospital, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037725319","display_name":"Brian O\u2019Sullivan","orcid":"https://orcid.org/0000-0001-8887-843X","observed_orcids":["https://orcid.org/0000-0001-8887-843X","https://orcid.org/0000-0002-9882-0570"]},"institutions":[{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"B O'Sullivan","raw_affiliation_strings":["Sarcoma Site Group, Princess Margaret Hospital, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sarcoma Site Group, Princess Margaret Hospital, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008075505","display_name":"Fei\u2010Fei Liu","orcid":"https://orcid.org/0000-0003-4344-6486","observed_orcids":["https://orcid.org/0000-0003-4344-6486","https://orcid.org/0000-0003-1988-8604"]},"institutions":[{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"F F Liu","raw_affiliation_strings":["Sarcoma Site Group, Princess Margaret Hospital, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sarcoma Site Group, Princess Margaret Hospital, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J Powell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"J Powell","raw_affiliation_strings":["Sarcoma Site Group, Princess Margaret Hospital, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sarcoma Site Group, Princess Margaret Hospital, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109909324","display_name":"Frederick Langer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"F Langer","raw_affiliation_strings":["Sarcoma Site Group, Princess Margaret Hospital, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sarcoma Site Group, Princess Margaret Hospital, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067944860","display_name":"Victor Fornasier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"V L Fornasier","raw_affiliation_strings":["Sarcoma Site Group, Princess Margaret Hospital, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sarcoma Site Group, Princess Margaret Hospital, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":null,"display_name":"B Cummings","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"B Cummings","raw_affiliation_strings":["Sarcoma Site Group, Princess Margaret Hospital, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sarcoma Site Group, Princess Margaret Hospital, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010983703","display_name":"Paul N. Miceli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"P N Miceli","raw_affiliation_strings":["Sarcoma Site Group, Princess Margaret Hospital, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sarcoma Site Group, Princess Margaret Hospital, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071876666","display_name":"Nigel V. Hawkins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"N Hawkins","raw_affiliation_strings":["Sarcoma Site Group, Princess Margaret Hospital, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sarcoma Site Group, Princess Margaret Hospital, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2802654988"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076988644","display_name":"Ian C. Quirt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"I Quirt","raw_affiliation_strings":["Sarcoma Site Group, Princess Margaret Hospital, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sarcoma Site Group, Princess Margaret Hospital, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I2802654988"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5416,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.6618219,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"75","issue":"1 Suppl","first_page":"126","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12278","display_name":"Vascular Tumors and Angiosarcomas","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11991","display_name":"Soft tissue tumor case studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/soft-tissue-sarcoma","display_name":"soft tissue sarcoma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/surgical-margins","display_name":"surgical margins","score":0.7649999856948853},{"id":"https://openalex.org/keywords/local-recurrence","display_name":"local recurrence","score":0.621999979019165},{"id":"https://openalex.org/keywords/adjuvant-radiotherapy","display_name":"adjuvant radiotherapy","score":0.8159999847412109},{"id":"https://openalex.org/keywords/local-excision","display_name":"local excision","score":0.8399999737739563},{"id":"https://openalex.org/keywords/tumor-size","display_name":"tumor size","score":0.9039999842643738},{"id":"https://openalex.org/keywords/systemic-recurrence","display_name":"systemic recurrence","score":0.5870000123977661},{"id":"https://openalex.org/keywords/extremity-sarcoma","display_name":"extremity sarcoma","score":0.6600000262260437},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7940000295639038}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8312090039253235},{"id":"https://openalex.org/C2778629024","wikidata":"https://www.wikidata.org/wiki/Q720020","display_name":"Soft tissue sarcoma","level":3,"score":0.7861378192901611},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.7646666765213013},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.6766067147254944},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.6606349945068359},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.6353676319122314},{"id":"https://openalex.org/C136948725","wikidata":"https://www.wikidata.org/wiki/Q1458306","display_name":"Soft tissue","level":2,"score":0.5768725275993347},{"id":"https://openalex.org/C2778913397","wikidata":"https://www.wikidata.org/wiki/Q7646216","display_name":"Surgical margin","level":3,"score":0.5603370070457458},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5165182948112488},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.508578896522522},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4803663194179535},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.47487708926200867},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4686790108680725},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3516913056373596},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.341122567653656},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3118174076080322},{"id":"https://openalex.org/C159110652","wikidata":"https://www.wikidata.org/wiki/Q17078201","display_name":"Resection","level":2,"score":0.28938090801239014},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1755855679512024}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001132","descriptor_name":"Arm","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007866","descriptor_name":"Leg","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D012983","descriptor_name":"Soft Tissue Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012983","descriptor_name":"Soft Tissue Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:2249507","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2249507","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"La Chirurgia degli organi di movimento","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8299999833106995,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1525008747","https://openalex.org/W7125941993","https://openalex.org/W3118813710","https://openalex.org/W2143371774","https://openalex.org/W2064285850","https://openalex.org/W2463248350","https://openalex.org/W2526050180","https://openalex.org/W1986008886","https://openalex.org/W2069930223","https://openalex.org/W1993867849"],"abstract_inverted_index":{"In":[0],"a":[1,16,105,108],"retrospective":[2],"review":[3,97],"of":[4,15,61,75,89,94,98,117,127,136,140,143,160,170,173],"231":[5],"patients":[6,23],"who":[7,26,36,111],"were":[8,24,32,49,80,112],"referred":[9],"to":[10,124,131],"Princess":[11],"Margaret":[12],"Hospital":[13],"because":[14],"soft-tissue":[17],"sarcoma":[18],"in":[19,114],"an":[20,95],"extremity,":[21],"100":[22],"identified":[25],"had":[27,37],"no":[28],"metastases":[29],"when":[30],"they":[31],"first":[33],"seen":[34],"and":[35,43,64,69,73,101,107,134],"been":[38],"treated":[39],"by":[40,104],"local":[41,132,153],"resection":[42,144],"adjuvant":[44],"radiation":[45,109],"therapy.":[46],"Complete":[47],"data":[48],"collected":[50],"for":[51,54,86],"each":[52],"patient":[53],"the":[55,62,92,99,115,141,146,161,167,171],"following":[56],"variables:":[57],"age;":[58],"sex;":[59],"location":[60],"tumor":[63,162],"its":[65],"size,":[66],"grade,":[67],"depth,":[68],"compartmental":[70],"status;":[71],"chemotherapy;":[72],"dose":[74],"radiation.":[76],"The":[77,158],"surgical":[78],"margins":[79],"characterized":[81],"as":[82],"positive":[83],"or":[84],"negative":[85],"histological":[87],"evidence":[88,135],"disease":[90],"on":[91],"basis":[93],"independent":[96],"pathological":[100],"operative":[102],"reports":[103],"surgeon":[106],"oncologist":[110],"experienced":[113],"management":[116],"sarcoma.":[118],"Cox":[119],"multivariate":[120],"analysis":[121],"was":[122,145,150,166],"used":[123],"determine":[125],"which":[126],"these":[128],"variables":[129],"contributed":[130],"recurrence":[133],"systemic":[137,174],"disease.":[138,175],"Adequacy":[139],"margin":[142],"only":[147],"variable":[148],"that":[149],"associated":[151],"with":[152],"relapse":[154],"(p":[155,163],"=":[156,164],"0.0004).":[157],"size":[159],"0.0008)":[165],"major":[168],"determinant":[169],"risk":[172]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}