{"id":"https://openalex.org/W9167131","doi":"https://doi.org/10.1096/fasebj.21.6.a811","title":"Attenuation of AngII\u2010induced early cell death by MT results in a prevention of the late development of cardiomyopathy","display_name":"Attenuation of AngII\u2010induced early cell death by MT results in a prevention of the late development of cardiomyopathy","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W9167131","doi":"https://doi.org/10.1096/fasebj.21.6.a811","mag":"9167131"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.21.6.a811","doi":"https://doi.org/10.1096/fasebj.21.6.a811","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.6.a811","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001315085","display_name":"Guihua Zhou","orcid":"https://orcid.org/0009-0006-0251-7056","observed_orcids":["https://orcid.org/0009-0006-0251-7056"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guihua Zhou","raw_affiliation_strings":["Medicine University of Louisville 511 S Floyd St. Louisville KY 40202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine University of Louisville 511 S Floyd St. Louisville KY 40202","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026799694","display_name":"Yujian James Kang","orcid":"https://orcid.org/0000-0001-8449-7904","observed_orcids":["https://orcid.org/0000-0001-8449-7904","https://orcid.org/0000-0002-1478-4024","https://orcid.org/0000-0002-3067-7819"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Y Kang","raw_affiliation_strings":["Medicine University of Louisville 511 S Floyd St.MDR 533 Louisville KY 40202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine University of Louisville 511 S Floyd St.MDR 533 Louisville KY 40202","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017873319","display_name":"Lu Cai","orcid":"https://orcid.org/0000-0003-3048-1135","observed_orcids":["https://orcid.org/0000-0003-3048-1135"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lu Cai","raw_affiliation_strings":["Medicine University of Louisville 511 S Floyd St.MDR 533 Louisville KY 40202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine University of Louisville 511 S Floyd St.MDR 533 Louisville KY 40202","institution_ids":["https://openalex.org/I142740786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I142740786"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00149571,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.2815000116825104,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.2815000116825104,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.2615000009536743,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.2605000138282776,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.9819999933242798},{"id":"https://openalex.org/keywords/metallothionein","display_name":"metallothionein","score":0.996999979019165},{"id":"https://openalex.org/keywords/cardiomyopathy","display_name":"cardiomyopathy","score":0.9079999923706055},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6779999732971191},{"id":"https://openalex.org/keywords/nadph-oxidase","display_name":"NADPH oxidase","score":0.9380000233650208},{"id":"https://openalex.org/keywords/peroxynitrite","display_name":"peroxynitrite","score":0.8939999938011169},{"id":"https://openalex.org/keywords/nitrosative-damage","display_name":"nitrosative damage","score":0.8870000243186951},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.8339999914169312},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.9229999780654907},{"id":"https://openalex.org/keywords/connective-tissue-growth-factor","display_name":"connective tissue growth factor","score":0.9900000095367432},{"id":"https://openalex.org/keywords/diabetic-cardiomyopathy","display_name":"diabetic cardiomyopathy","score":0.8019999861717224},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.7360000014305115}],"concepts":[{"id":"https://openalex.org/C2778784160","wikidata":"https://www.wikidata.org/wiki/Q419130","display_name":"Peroxynitrite","level":4,"score":0.7575339674949646},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.7180019617080688},{"id":"https://openalex.org/C2777420927","wikidata":"https://www.wikidata.org/wiki/Q5038318","display_name":"Cardiac fibrosis","level":3,"score":0.6621628999710083},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6391054391860962},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6248995065689087},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6203330159187317},{"id":"https://openalex.org/C2776553924","wikidata":"https://www.wikidata.org/wiki/Q5270132","display_name":"Diabetic cardiomyopathy","level":4,"score":0.5801169872283936},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48988980054855347},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.4681304693222046},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.44553518295288086},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.4175565242767334},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.35972341895103455},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3363259434700012},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.24585866928100586},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.2081630527973175},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10277321934700012},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09135058522224426},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.21.6.a811","doi":"https://doi.org/10.1096/fasebj.21.6.a811","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.6.a811","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2025827803","https://openalex.org/W1990264182","https://openalex.org/W2029305679","https://openalex.org/W2138517493","https://openalex.org/W2437414159","https://openalex.org/W1992564227","https://openalex.org/W4205869351","https://openalex.org/W2366721609","https://openalex.org/W2158206142","https://openalex.org/W2352303544"],"abstract_inverted_index":{"Angiotensin":[0],"II":[1,47,68,75,118,161,182,218],"(Ang":[2],"II)":[3],"plays":[4],"a":[5,63,185,258],"critical":[6],"role":[7],"in":[8,79,106,122,188,203,210],"the":[9,41,54,88,107,123,131,204,261],"diabetic":[10],"cardiovascular":[11],"diseases.":[12],"We":[13],"have":[14],"demonstrated":[15],"that":[16,216],"cardiomyocytes":[17],"with":[18,62,92,159],"high":[19],"levels":[20],"of":[21,43,66,101,116,125,134,142,150,198,206,227,238,248,260],"metallothionein":[22],"(MT)":[23],"are":[24],"significantly":[25,120],"resistant":[26],"to":[27,257],"diabetes\u2010":[28],"and":[29,59,84,97,153,170,178,196,225,243],"Ang":[30,46,67,74,117,126,137,160,181,217,231,249],"II\u2010induced":[31,138,232,250],"apoptotic":[32],"cell":[33,234,252],"death":[34,235,253],"mediated":[35],"by":[36,82,192,254],"NOX":[37,102,143,223,239],"activation.":[38,144],"To":[39,145],"investigate":[40],"effects":[42,115],"MT":[44,56,135,229,255],"on":[45,136],"\u2013":[48],"induced":[49],"cardiac":[50,55,172,189,220,233],"injury,":[51],"we":[52],"administrated":[53],"transgenic":[57],"(MT\u2010TG)":[58],"WT":[60,154,207],"mice":[61,155],"single":[64],"injection":[65],"at":[69,162,176],"1":[70],"mg/kg":[71,164],"body":[72,165],"weight.":[73],"caused":[76,184],"an":[77,93,98],"increase":[78,187],"apoptosis,":[80],"examined":[81],"TUNEL":[83],"Western":[85],"blot":[86],"for":[87,167],"caspase\u20103":[89],"activation":[90,224],"along":[91],"increased":[94,99,193],"3\u2010NT":[95],"formation":[96,242],"expression":[100],"isoform":[103],"p47":[104],"phox":[105],"membrane":[108],"proteins":[109],"7h":[110],"after":[111],"treatment.":[112],"All":[113],"these":[114],"were":[119,156,174],"prevented":[121],"heart":[124,205],"II\u2010treated":[127],"MT\u2010TG":[128,152,211],"mice,":[129],"indicating":[130],"protective":[132],"effect":[133,149],"apoptosis":[139,221],"via":[140],"suppression":[141,237],"further":[146],"evaluate":[147],"antiapoptotic":[148],"MT,":[151],"chronically":[157],"infused":[158],"0.5":[163],"weight":[166],"two":[168],"weeks":[169],"then":[171],"tissues":[173],"collected":[175],"3":[177],"6":[179],"months.":[180],"treatment":[183],"significant":[186],"fibrosis,":[190],"shown":[191],"collagen":[194],"content":[195],"up\u2010regulation":[197],"connective":[199],"tissue":[200],"growth":[201],"factor":[202],"but":[208],"not":[209],"mice.":[212],"These":[213],"results":[214],"suggest":[215],"induces":[219],"through":[222,236],"generation":[226],"peroxynitrite.":[228],"prevents":[230],"activation,":[240],"peroxynitrite":[241],"nitrosative":[244],"damage.":[245],"The":[246],"protection":[247],"early":[251],"leads":[256],"prevention":[259],"late":[262],"cardiomyopathy.":[263]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
