{"id":"https://openalex.org/W91468995","doi":null,"title":"Expression of mdr-1/P-glycoprotein in human neuroblastoma.","display_name":"Expression of mdr-1/P-glycoprotein in human neuroblastoma.","publication_year":1991,"publication_date":"1991-08-01","ids":{"openalex":"https://openalex.org/W91468995","mag":"91468995","pmid":"https://pubmed.ncbi.nlm.nih.gov/1678252","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886082"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1886082","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886082","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886082","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013592290","display_name":"Susan Elaine Bates","orcid":"https://orcid.org/0000-0001-6708-0330","observed_orcids":["https://orcid.org/0000-0001-6708-0330"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S E Bates","raw_affiliation_strings":["Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030346508","display_name":"Ching-Yi Shieh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Y Shieh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5059497696","display_name":"Maria Tsokos","orcid":"https://orcid.org/0000-0001-8072-1358","observed_orcids":["https://orcid.org/0000-0001-8072-1358"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Tsokos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.8357,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.92253,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"139","issue":"2","first_page":"305","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.7519999742507935,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.7519999742507935,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.23960000276565552,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mdr-1-gene","display_name":"MDR-1 gene","score":0.8899999856948853},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.9980000257492065},{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.9409999847412109},{"id":"https://openalex.org/keywords/tumor-differentiation","display_name":"tumor differentiation","score":0.7689999938011169},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.5899999737739563},{"id":"https://openalex.org/keywords/ganglioneuroma","display_name":"ganglioneuroma","score":0.7950000166893005},{"id":"https://openalex.org/keywords/ganglion-cells","display_name":"ganglion cells","score":0.828000009059906},{"id":"https://openalex.org/keywords/neoadjuvant-chemotherapy","display_name":"neoadjuvant chemotherapy","score":0.7450000047683716},{"id":"https://openalex.org/keywords/tumor-stroma","display_name":"tumor stroma","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.9208543300628662},{"id":"https://openalex.org/C2778707650","wikidata":"https://www.wikidata.org/wiki/Q412902","display_name":"P-glycoprotein","level":4,"score":0.7861136794090271},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7314937114715576},{"id":"https://openalex.org/C2779102060","wikidata":"https://www.wikidata.org/wiki/Q1124606","display_name":"Ganglioneuroma","level":4,"score":0.6290571689605713},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5920704007148743},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5413756966590881},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5182256698608398},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5013017654418945},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4803110957145691},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.4632158875465393},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4117983877658844},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4097304344177246},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.40092480182647705},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.35953718423843384},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.3035981059074402},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16032683849334717},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08313450217247009}],"mesh":[{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012260","descriptor_name":"Ribonucleases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012334","descriptor_name":"RNA, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1886082","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886082","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:1678252","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1678252","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"mag:91468995","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1678252","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1886082","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1886082","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W175263069","https://openalex.org/W1499694712","https://openalex.org/W1519177607","https://openalex.org/W1524993091","https://openalex.org/W1531911812","https://openalex.org/W1567907251","https://openalex.org/W1571215201","https://openalex.org/W1572770561","https://openalex.org/W1578072993","https://openalex.org/W1595352454","https://openalex.org/W1844481612","https://openalex.org/W1864905496","https://openalex.org/W1900543109","https://openalex.org/W1910121302","https://openalex.org/W1920335633","https://openalex.org/W1926885922","https://openalex.org/W1964470226","https://openalex.org/W1976029914","https://openalex.org/W1988993069","https://openalex.org/W2003476408","https://openalex.org/W2025603165","https://openalex.org/W2028533496","https://openalex.org/W2034031399","https://openalex.org/W2058609734","https://openalex.org/W2064428081","https://openalex.org/W2066943324","https://openalex.org/W2075749214","https://openalex.org/W2078119356","https://openalex.org/W2126786837","https://openalex.org/W2152029190","https://openalex.org/W2153712534","https://openalex.org/W2206624148","https://openalex.org/W2281804055","https://openalex.org/W2406511268","https://openalex.org/W2407870134","https://openalex.org/W2440303524"],"related_works":["https://openalex.org/W2062253506","https://openalex.org/W1984529434","https://openalex.org/W1910121302","https://openalex.org/W2356229428","https://openalex.org/W2218189347","https://openalex.org/W2354988938","https://openalex.org/W2041209857","https://openalex.org/W2063561945","https://openalex.org/W2084180399","https://openalex.org/W2018101112"],"abstract_inverted_index":{"Increased":[0],"expression":[1,35,104,138,145,153,179],"of":[2,16,36,83,95,103,108,178],"the":[3,7,47,80,121,127,140,167,175],"mdr-1":[4,37],"gene":[5,122],"encoding":[6],"drug":[8,18],"efflux":[9],"pump":[10],"P-glycoprotein":[11],"is":[12,38],"a":[13,23,50,74,133],"well-established":[14],"mediator":[15],"acquired":[17],"resistance":[19],"in":[20,29,31,40,55,57,79,139,146,163,166],"vitro,":[21],"and":[22,105,116,160],"similar":[24,51],"role":[25],"has":[26],"been":[27],"hypothesized":[28,49],"vivo":[30,56],"human":[32],"malignancy.":[33],"Because":[34],"increased":[39,154],"neuroblastoma":[41],"cell":[42],"lines":[43],"by":[44],"differentiating":[45],"agents,":[46],"authors":[48],"correlation":[52,70,75],"with":[53,71,155,174],"differentiation":[54,109,157],"neuroblastomas.":[58],"In":[59],"12":[60],"tumors":[61,173],"from":[62,182],"11":[63],"patients,":[64],"total":[65],"RNA":[66],"analysis":[67],"demonstrated":[68,144],"no":[69,136],"differentiation,":[72],"but":[73,143],"could":[76],"be":[77],"detected":[78],"cell-based":[81],"methods":[82],"analysis.":[84],"The":[85,97,171],"very":[86,130],"primitive":[87,115],"'stroma'-poor,":[88],"poorly":[89],"differentiated":[90,118],"neuroblastomas":[91],"had":[92,100,135],"low":[93],"levels":[94,102,125,177],"mdr-1/P-glycoprotein.":[96],"intermediate":[98],"grades":[99],"higher":[101],"although":[106],"heterogeneity":[107],"appeared":[110],"within":[111,126],"these":[112],"tumors,":[113,159],"both":[114],"more":[117],"cells":[119,165],"expressed":[120],"at":[123],"comparable":[124],"tumor.":[128,170],"One":[129],"well-differentiated":[131,169],"neuroblastoma,":[132],"ganglioneuroma,":[134],"detectable":[137],"neurofibrillary":[141],"material,":[142],"adjacent":[147],"large":[148],"ganglionic":[149,164],"cells.":[150],"Thus":[151],"mdr-1/P-glycoprotein":[152],"increasing":[156],"among":[158],"was":[161],"present":[162],"most":[168],"three":[172],"highest":[176],"were":[180],"obtained":[181],"patients":[183],"who":[184],"received":[185],"preoperative":[186],"chemotherapy.":[187]},"counts_by_year":[{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
