{"id":"https://openalex.org/W9142892","doi":null,"title":"Experimental surgery in spinal cord lesions by connecting upper motoneurons directly to peripheral targets.","display_name":"Experimental surgery in spinal cord lesions by connecting upper motoneurons directly to peripheral targets.","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W9142892","mag":"9142892","pmid":"https://pubmed.ncbi.nlm.nih.gov/10975719"},"language":"en","primary_location":{"id":"pmid:10975719","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10975719","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the peripheral nervous system : JPNS","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089165668","display_name":"Giorgio A Brunelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79940851","display_name":"University of Brescia","ror":"https://ror.org/02q2d2610","country_code":"IT","type":"education","lineage":["https://openalex.org/I79940851"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G A Brunelli","raw_affiliation_strings":["Department of Orthopedics, University of Brescia Medical School, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedics, University of Brescia Medical School, Italy","institution_ids":["https://openalex.org/I79940851"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109160199","display_name":"Giovanni R. Brunelli","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G R Brunelli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.001181,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"1","issue":"2","first_page":"111","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.7275000214576721,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.7275000214576721,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.23229999840259552,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.01860000006854534,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spinal-cord-lesions","display_name":"spinal cord lesions","score":0.7879999876022339},{"id":"https://openalex.org/keywords/peripheral-nerve-grafts","display_name":"peripheral nerve grafts","score":0.7080000042915344},{"id":"https://openalex.org/keywords/sciatic-nerve","display_name":"sciatic nerve","score":0.8920000195503235},{"id":"https://openalex.org/keywords/reinnervation","display_name":"reinnervation","score":0.6069999933242798},{"id":"https://openalex.org/keywords/nonhuman-primates","display_name":"non-human primates","score":0.675000011920929},{"id":"https://openalex.org/keywords/cynomolgus-monkeys","display_name":"Macaca fascicularis","score":0.871999979019165},{"id":"https://openalex.org/keywords/functional-recovery","display_name":"functional recovery","score":0.4569999873638153},{"id":"https://openalex.org/keywords/axon-regeneration","display_name":"axon regeneration","score":0.40799999237060547}],"concepts":[{"id":"https://openalex.org/C2781149210","wikidata":"https://www.wikidata.org/wiki/Q307869","display_name":"Sciatic nerve","level":2,"score":0.7733258605003357},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.7515941858291626},{"id":"https://openalex.org/C2779649809","wikidata":"https://www.wikidata.org/wiki/Q7310406","display_name":"Reinnervation","level":2,"score":0.7460179328918457},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7177707552909851},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.5709269046783447},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.5337930917739868},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.5322118997573853},{"id":"https://openalex.org/C51738704","wikidata":"https://www.wikidata.org/wiki/Q5766112","display_name":"Hindlimb","level":2,"score":0.5221712589263916},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.5153359770774841},{"id":"https://openalex.org/C2776880756","wikidata":"https://www.wikidata.org/wiki/Q2945973","display_name":"Peripheral nerve injury","level":3,"score":0.4340716600418091},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.32776057720184326},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2744615077972412},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16150084137916565},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.07017779350280762},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004576","descriptor_name":"Electromyography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008252","descriptor_name":"Macaca fascicularis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009046","descriptor_name":"Motor Neurons","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D009416","descriptor_name":"Nerve Regeneration","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010264","descriptor_name":"Paraplegia","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D010543","descriptor_name":"Peroneal Nerve","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":true},{"descriptor_ui":"D012584","descriptor_name":"Sciatic Nerve","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012584","descriptor_name":"Sciatic Nerve","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012584","descriptor_name":"Sciatic Nerve","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D013119","descriptor_name":"Spinal Cord Injuries","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":false},{"descriptor_ui":"D019054","descriptor_name":"Evoked Potentials, Motor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10975719","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10975719","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the peripheral nervous system : JPNS","raw_type":"Journal Article"},{"id":"mag:9142892","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10975719","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W2411416577","https://openalex.org/W2336295574","https://openalex.org/W107017769","https://openalex.org/W2234214634","https://openalex.org/W2460103008","https://openalex.org/W2093406977","https://openalex.org/W2037260615","https://openalex.org/W2115227363","https://openalex.org/W89707315","https://openalex.org/W2399399526","https://openalex.org/W2289044249","https://openalex.org/W4242948373","https://openalex.org/W2130684966","https://openalex.org/W2077880545","https://openalex.org/W1951039334","https://openalex.org/W1962485221"],"related_works":["https://openalex.org/W2044774307","https://openalex.org/W2003417507","https://openalex.org/W2073595537","https://openalex.org/W2126900111","https://openalex.org/W2399285421","https://openalex.org/W2595211664","https://openalex.org/W1966158838","https://openalex.org/W2015703906","https://openalex.org/W1453484270","https://openalex.org/W2031965923"],"abstract_inverted_index":{"This":[0,148],"research":[1,149],"was":[2,27,110,119],"aimed":[3],"at":[4,72],"assessing":[5],"the":[6,22,41,45,50,54,58,73,90,116,125,136,163,182],"possibility":[7],"to":[8,171],"connect":[9],"central":[10],"motoneurons":[11,154],"with":[12,49,181],"skeletal":[13,184],"muscles":[14],"through":[15],"PNS":[16],"segments":[17],"bypassing":[18],"a":[19,62,167,173],"lesion":[20],"of":[21,39,44,53,75,135,145,158,166],"spinal":[23,46,91],"cord.":[24],"The":[25,35,64],"investigation":[26],"performed":[28],"in":[29],"20":[30],"non-human":[31],"primates":[32],"(Macaca":[33],"fascicularis).":[34],"surgical":[36],"paradigm":[37],"consisted":[38],"anastomosing":[40],"lateral":[42],"bundle":[43],"cord":[47],"directly":[48],"sciatic":[51,94],"nerve":[52,60,95,175],"right":[55],"hindlimb,":[56],"using":[57],"peroneal":[59],"as":[61,121],"graft.":[63],"animals":[65,126],"were":[66,87,127],"followed-up":[67],"clinically":[68],"for":[69,102],"18":[70],"months;":[71],"end":[74],"this":[76],"observation":[77],"period,":[78],"they":[79],"underwent":[80],"electrophysiological":[81,141],"examinations":[82],"before":[83],"being":[84],"killed.":[85],"Specimens":[86],"taken":[88],"from":[89],"cord,":[92],"graft,":[93,169],"and":[96,100,106,142,177],"potentially":[97,156],"reinnervated":[98],"muscles,":[99],"processed":[101],"routine":[103],"light":[104],"microscopy":[105],"immunohistochemistry.":[107],"Postoperative":[108],"mortality":[109],"fairly":[111],"high":[112],"(six":[113],"monkeys),":[114],"yet":[115],"overall":[117],"outcome":[118],"regarded":[120],"very":[122],"good":[123],"because":[124],"neither":[128],"restrained":[129],"nor":[130],"intensively":[131],"cared":[132],"for.":[133],"Five":[134],"surviving":[137],"monkeys":[138],"showed":[139],"clinical,":[140],"histological":[143],"evidence":[144],"successful":[146],"reinnervation.":[147],"demonstrated":[150],"that":[151],"upper":[152],"CNS":[153],"are":[155],"capable":[157],"elongating":[159],"neuritic":[160],"processes":[161],"into":[162],"endoneural":[164],"tubes":[165],"connecting":[168],"up":[170],"reaching":[172],"peripheral":[174],"(sciatic),":[176],"restoring":[178],"functional":[179],"connections":[180],"relevant":[183],"muscles.":[185]},"counts_by_year":[{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}