{"id":"https://openalex.org/W91362472","doi":null,"title":"EFFECTS OF INTRANASALLY ADMINISTERED DNSP-11 ON THE CENTRAL DOPAMINE SYSTEM OF NORMAL AND PARKINSONIAN FISCHER 344 RATS","display_name":"EFFECTS OF INTRANASALLY ADMINISTERED DNSP-11 ON THE CENTRAL DOPAMINE SYSTEM OF NORMAL AND PARKINSONIAN FISCHER 344 RATS","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W91362472","mag":"91362472"},"language":"en","primary_location":{"id":"pmh:oai:uknowledge.uky.edu:neurobio_etds-1004","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/neurobio_etds/5","pdf_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1004&context=neurobio_etds","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations--Neuroscience","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1004&context=neurobio_etds","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091629221","display_name":"James H. Sonne","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"James H. Sonne","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5091629221"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1978,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.54426622,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intranasal-drug-delivery","display_name":"intranasal drug delivery","score":0.843999981880188},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9620000123977661},{"id":"https://openalex.org/keywords/dopaminergic-neuroprotection","display_name":"dopaminergic neuroprotection","score":0.8100000023841858},{"id":"https://openalex.org/keywords/6-ohda-lesion","display_name":"6-hydroxydopamine lesion","score":0.9039999842643738},{"id":"https://openalex.org/keywords/substantia-nigra","display_name":"substantia nigra","score":0.9919999837875366},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.8899999856948853},{"id":"https://openalex.org/keywords/tyrosine-hydroxylase","display_name":"tyrosine hydroxylase","score":0.9710000157356262},{"id":"https://openalex.org/keywords/dopamine-turnover","display_name":"dopamine turnover","score":0.9539999961853027},{"id":"https://openalex.org/keywords/glial-cell-line-derived-neurotrophic-factor","display_name":"glial cell line-derived neurotrophic factor","score":0.7039999961853027},{"id":"https://openalex.org/keywords/neuropeptide-y","display_name":"neuropeptide Y","score":0.47999998927116394},{"id":"https://openalex.org/keywords/apomorphine-rotation","display_name":"apomorphine rotation","score":0.6710000038146973},{"id":"https://openalex.org/keywords/fischer-344-rats","display_name":"F344 rats","score":0.8130000233650208}],"concepts":[{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.6566208600997925},{"id":"https://openalex.org/C85663871","wikidata":"https://www.wikidata.org/wiki/Q6966562","display_name":"Nasal administration","level":2,"score":0.5612932443618774},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4913870394229889},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3933415412902832},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34855616092681885},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.340249240398407}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:uknowledge.uky.edu:neurobio_etds-1004","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/neurobio_etds/5","pdf_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1004&context=neurobio_etds","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations--Neuroscience","raw_type":"text"},{"id":"mag:91362472","doi":null,"is_oa":false,"landing_page_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1004&context=neurobio_etds","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:uknowledge.uky.edu:neurobio_etds-1004","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/neurobio_etds/5","pdf_url":"https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1004&context=neurobio_etds","source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Theses and Dissertations--Neuroscience","raw_type":"text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W91362472.pdf","grobid_xml":"https://content.openalex.org/works/W91362472.grobid-xml"},"referenced_works_count":211,"referenced_works":["https://openalex.org/W8404831","https://openalex.org/W9942042","https://openalex.org/W47087854","https://openalex.org/W102297612","https://openalex.org/W144517712","https://openalex.org/W156099876","https://openalex.org/W175006040","https://openalex.org/W220741418","https://openalex.org/W320516346","https://openalex.org/W1513720278","https://openalex.org/W1527671059","https://openalex.org/W1527910050","https://openalex.org/W1554148270","https://openalex.org/W1561072761","https://openalex.org/W1563874445","https://openalex.org/W1580441010","https://openalex.org/W1586959905","https://openalex.org/W1605452004","https://openalex.org/W1609269723","https://openalex.org/W1629697287","https://openalex.org/W1663827195","https://openalex.org/W1830728982","https://openalex.org/W1856608655","https://openalex.org/W1877873625","https://openalex.org/W1900535849","https://openalex.org/W1902058987","https://openalex.org/W1963495653","https://openalex.org/W1964888317","https://openalex.org/W1965289808","https://openalex.org/W1965575645","https://openalex.org/W1967127565","https://openalex.org/W1967262708","https://openalex.org/W1968292591","https://openalex.org/W1969199506","https://openalex.org/W1969349734","https://openalex.org/W1970614181","https://openalex.org/W1971258758","https://openalex.org/W1971389338","https://openalex.org/W1973278285","https://openalex.org/W1974229522","https://openalex.org/W1976923417","https://openalex.org/W1977263921","https://openalex.org/W1977527392","https://openalex.org/W1978922826","https://openalex.org/W1979466796","https://openalex.org/W1979960910","https://openalex.org/W1981605166","https://openalex.org/W1983249366","https://openalex.org/W1983875035","https://openalex.org/W1985347187","https://openalex.org/W1986737100","https://openalex.org/W1991208841","https://openalex.org/W1992784996","https://openalex.org/W1993650510","https://openalex.org/W1993902481","https://openalex.org/W1995554605","https://openalex.org/W1996001296","https://openalex.org/W1997043987","https://openalex.org/W1997631088","https://openalex.org/W1997655814","https://openalex.org/W1998382665","https://openalex.org/W1998668979","https://openalex.org/W2000359896","https://openalex.org/W2000437545","https://openalex.org/W2000631088","https://openalex.org/W2001408101","https://openalex.org/W2001525797","https://openalex.org/W2001957064","https://openalex.org/W2002851005","https://openalex.org/W2003943670","https://openalex.org/W2005782006","https://openalex.org/W2006067437","https://openalex.org/W2008827303","https://openalex.org/W2008922216","https://openalex.org/W2011629756","https://openalex.org/W2011805483","https://openalex.org/W2012014320","https://openalex.org/W2014798765","https://openalex.org/W2015328983","https://openalex.org/W2017665309","https://openalex.org/W2018340655","https://openalex.org/W2019695510","https://openalex.org/W2020333978","https://openalex.org/W2020531776","https://openalex.org/W2021408577","https://openalex.org/W2024173595","https://openalex.org/W2028268940","https://openalex.org/W2030187260","https://openalex.org/W2031345305","https://openalex.org/W2032057262","https://openalex.org/W2032554568","https://openalex.org/W2033156698","https://openalex.org/W2033832481","https://openalex.org/W2039717023","https://openalex.org/W2040742427","https://openalex.org/W2042162774","https://openalex.org/W2044137812","https://openalex.org/W2044682044","https://openalex.org/W2045461387","https://openalex.org/W2045683532","https://openalex.org/W2046589157","https://openalex.org/W2046628195","https://openalex.org/W2046690778","https://openalex.org/W2047159816","https://openalex.org/W2047963679","https://openalex.org/W2050865611","https://openalex.org/W2052980020","https://openalex.org/W2053467442","https://openalex.org/W2053944183","https://openalex.org/W2054307806","https://openalex.org/W2054810445","https://openalex.org/W2056184820","https://openalex.org/W2056837063","https://openalex.org/W2056892696","https://openalex.org/W2057337103","https://openalex.org/W2057374599","https://openalex.org/W2057679038","https://openalex.org/W2060187394","https://openalex.org/W2063030523","https://openalex.org/W2063915040","https://openalex.org/W2065189628","https://openalex.org/W2065217421","https://openalex.org/W2065541320","https://openalex.org/W2066113689","https://openalex.org/W2067456724","https://openalex.org/W2067555638","https://openalex.org/W2067590452","https://openalex.org/W2072692763","https://openalex.org/W2073449985","https://openalex.org/W2073986062","https://openalex.org/W2075167352","https://openalex.org/W2075640934","https://openalex.org/W2076754896","https://openalex.org/W2077379644","https://openalex.org/W2077455609","https://openalex.org/W2077584190","https://openalex.org/W2077756131","https://openalex.org/W2079201339","https://openalex.org/W2082559815","https://openalex.org/W2083337622","https://openalex.org/W2084775411","https://openalex.org/W2085518524","https://openalex.org/W2086172007","https://openalex.org/W2086357928","https://openalex.org/W2087644918","https://openalex.org/W2088364327","https://openalex.org/W2088891222","https://openalex.org/W2089289079","https://openalex.org/W2089791510","https://openalex.org/W2091930637","https://openalex.org/W2092814867","https://openalex.org/W2093177172","https://openalex.org/W2093271285","https://openalex.org/W2093762987","https://openalex.org/W2094453116","https://openalex.org/W2095309118","https://openalex.org/W2095455694","https://openalex.org/W2098905466","https://openalex.org/W2099652807","https://openalex.org/W2101099825","https://openalex.org/W2103276585","https://openalex.org/W2103899142","https://openalex.org/W2105047187","https://openalex.org/W2105696266","https://openalex.org/W2107496222","https://openalex.org/W2109582513","https://openalex.org/W2112765817","https://openalex.org/W2114179943","https://openalex.org/W2114431468","https://openalex.org/W2118428015","https://openalex.org/W2118690897","https://openalex.org/W2120812632","https://openalex.org/W2122946342","https://openalex.org/W2123988283","https://openalex.org/W2125541186","https://openalex.org/W2131357423","https://openalex.org/W2133383948","https://openalex.org/W2134886133","https://openalex.org/W2135589155","https://openalex.org/W2136388422","https://openalex.org/W2136570995","https://openalex.org/W2140532385","https://openalex.org/W2144787755","https://openalex.org/W2145568285","https://openalex.org/W2145954079","https://openalex.org/W2148348616","https://openalex.org/W2148897945","https://openalex.org/W2149013651","https://openalex.org/W2149207985","https://openalex.org/W2151789398","https://openalex.org/W2153284686","https://openalex.org/W2154745705","https://openalex.org/W2155175950","https://openalex.org/W2160627539","https://openalex.org/W2161325655","https://openalex.org/W2161704465","https://openalex.org/W2163815564","https://openalex.org/W2165194242","https://openalex.org/W2166215147","https://openalex.org/W2167753843","https://openalex.org/W2171325190","https://openalex.org/W2240282854","https://openalex.org/W2256615984","https://openalex.org/W2331087951","https://openalex.org/W2397538863","https://openalex.org/W2426971157","https://openalex.org/W2461508939","https://openalex.org/W2474292363","https://openalex.org/W2901733309","https://openalex.org/W3021613071","https://openalex.org/W4406057327"],"related_works":["https://openalex.org/W266690365","https://openalex.org/W7095455782","https://openalex.org/W2065541320","https://openalex.org/W1965978398","https://openalex.org/W1609269723","https://openalex.org/W1965256752","https://openalex.org/W2280653124","https://openalex.org/W2795034106","https://openalex.org/W3022411757","https://openalex.org/W175253070"],"abstract_inverted_index":{"Due":[0],"to":[1,9,19,63,81,132,206,241],"the":[2,10,46,68,96,119,128,144,180,186,201,211,231,245,254,263,266,271,289,301,305,311,316,321,335],"blood-brain":[3],"barrier,":[4],"delivery":[5],"of":[6,42,56,61,70,95,109,143,183,188,233,262,282,303,346],"many":[7],"drugs":[8],"brain":[11,250,283],"has":[12],"required":[13],"intracranial":[14],"surgery":[15],"which":[16],"is":[17,276],"prone":[18],"complication.":[20],"Here":[21],"we":[22],"show":[23],"that":[24,149,164,171],"Dopamine":[25],"Neuron":[26],"Stimulating":[27],"Peptide":[28],"11":[29,292],"(DNSP-11),":[30],"following":[31],"non-invasive":[32],"intranasal":[33,151,332],"administration,":[34],"protects":[35],"dopaminergic":[36,114],"neurons":[37],"from":[38,185,200,210,280,340],"a":[39,89,140,195,329,341],"lesion":[40,94,343],"model":[41,345],"Parkinson\u2019s":[43,347],"disease":[44],"in":[45,53,67,118,127,244,253,270,300,310],"rat.":[47],"A":[48],"significant":[49],"and":[50,122,217],"dose-dependent":[51],"increase":[52],"an":[54],"index":[55],"dopamine":[57],"turnover":[58],"(the":[59],"ratio":[60],"DOPAC":[62],"dopamine)":[64],"was":[65,190,204,239],"observed":[66,269,319],"striatum":[69,129],"normal":[71],"young":[72],"adult":[73],"Fischer":[74],"344":[75],"rats":[76],"by":[77,192],"whole-tissue":[78],"neurochemistry":[79],"compared":[80,131],"vehicle":[82,137,167],"administered":[83,104],"controls.":[84],"Among":[85],"animals":[86,133,148,163],"challenged":[87],"with":[88,102,136,162,194,224,251,265,288],"moderate,":[90],"unilateral":[91],"6-hydroxy-dopamine":[92],"(6-OHDA)":[93],"substantia":[97,120,255],"nigra,":[98,256],"those":[99],"treated":[100,134],"repeatedly":[101],"intranasally":[103,135],"DNSP-11":[105,145,152,184,202,295,322,336],"exhibited":[106],"greater":[107,123,175],"numbers":[108],"tyrosine":[110],"hydroxylase":[111],"(TH)":[112],"positive":[113],"neuronal":[115],"cell":[116],"bodies":[117],"nigra":[121],"TH+":[124],"fiber":[125],"density":[126],"when":[130],"only":[138,166,306],"or":[139,168],"scrambled":[141,169],"version":[142],"sequence.":[146,296],"Lesioned":[147],"received":[150,165],"treatment":[153],"did":[154,172],"not":[155,277,286,314],"exhibit":[156,173],"abnormal,":[157],"apomorphine-induced":[158],"rotation":[159,176],"behavior,":[160],"contrasted":[161],"peptide":[170,337],"significantly":[174],"behavior.":[177],"In":[178],"addition,":[179],"endogenous":[181],"expression":[182],"pro-region":[187],"GDNF":[189,213,225,235,275],"investigated":[191],"immunohistochemistry":[193],"custom,":[196],"polyclonal":[197],"antibody.":[198],"Signal":[199],"antibody":[203],"found":[205,240],"be":[207,242],"differentially":[208],"localized":[209],"mature":[212],"protein":[214],"both":[215],"spatially":[216],"temporally.":[218],"While":[219],"DNSP-11-like":[220,237],"immunoreactivity":[221,226],"extensively":[222],"colocalizes":[223],"at":[227],"post-natal":[228],"day":[229,232],"10,":[230],"maximal":[234],"expression,":[236],"signal":[238,252,268],"present":[243,309],"3":[246],"month":[247],"old":[248],"rat":[249,294,344],"ventral":[257],"thalamic":[258],"nucleus,":[259],"dentate":[260],"gyrus":[261],"hippocampus,":[264],"strongest":[267],"locus":[272],"ceruleus":[273],"where":[274],"expressed.":[278],"Results":[279],"immunoprecipitation":[281],"homogenate":[284],"were":[285],"consistent":[287],"synthetic,":[290],"amidated":[291],"amino-acid":[293],"However,":[297],"binding":[298],"patterns":[299,318],"literature":[302],"NPY,":[304],"homologous":[307],"sequence":[308],"CNS,":[312],"do":[313],"recapitulate":[315],"immunoreactive":[317],"for":[320,328,338],"signal.":[323],"This":[324],"study":[325],"provides":[326],"evidence":[327],"potential":[330],"easy-to-administer":[331],"therapeutic":[333],"using":[334],"protection":[339],"6-OHDA":[342],"disease.":[348]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
