{"id":"https://openalex.org/W91294951","doi":null,"title":"Protein kinase C is involved in cyclic adenosine monophosphate formation due to PGF2 alpha desensitization in bovine iris sphincter.","display_name":"Protein kinase C is involved in cyclic adenosine monophosphate formation due to PGF2 alpha desensitization in bovine iris sphincter.","publication_year":1993,"publication_date":"1993-05-01","ids":{"openalex":"https://openalex.org/W91294951","mag":"91294951","pmid":"https://pubmed.ncbi.nlm.nih.gov/8387977"},"language":"en","primary_location":{"id":"pmid:8387977","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8387977","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058551426","display_name":"Souvenir D. Tachado","orcid":"https://orcid.org/0000-0002-8368-6102","observed_orcids":["https://orcid.org/0000-0002-8368-6102"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S D Tachado","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta 30912-2100"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta 30912-2100","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100692579","display_name":"Yawen Zhang","orcid":"https://orcid.org/0000-0001-9613-4721","observed_orcids":["https://orcid.org/0000-0001-9613-4721"]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y Zhang","raw_affiliation_strings":["*Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta 30912-2100"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta 30912-2100","institution_ids":["https://openalex.org/I25041050"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113469803","display_name":"Ata A. Abdel\u2010Latif","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25041050","display_name":"Augusta University","ror":"https://ror.org/012mef835","country_code":"US","type":"education","lineage":["https://openalex.org/I25041050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A A Abdel-Latif","raw_affiliation_strings":["*Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta 30912-2100"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"*Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta 30912-2100","institution_ids":["https://openalex.org/I25041050"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I25041050"],"apc_list":null,"apc_paid":null,"fwci":0.3267,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.45002175,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"34","issue":"6","first_page":"2023","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.6230000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.6230000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.3118000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.046799998730421066,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.996999979019165},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.8529999852180481},{"id":"https://openalex.org/keywords/prostaglandin-f2alpha","display_name":"prostaglandin F2alpha","score":0.8240000009536743},{"id":"https://openalex.org/keywords/receptor-desensitization","display_name":"receptor desensitization","score":0.9200000166893005},{"id":"https://openalex.org/keywords/iris-sphincter-muscle","display_name":"iris sphincter","score":0.8220000267028809},{"id":"https://openalex.org/keywords/adenylyl-cyclase-activation","display_name":"adenylate cyclase activation","score":0.9070000052452087},{"id":"https://openalex.org/keywords/inositol-1-4-5-trisphosphate","display_name":"inositol 1,4,5-trisphosphate","score":0.9900000095367432},{"id":"https://openalex.org/keywords/phorbol-12-13-dibutyrate","display_name":"phorbol 12,13-dibutyrate","score":0.9290000200271606},{"id":"https://openalex.org/keywords/staurosporine","display_name":"staurosporine","score":0.9919999837875366},{"id":"https://openalex.org/keywords/camp-phosphodiesterase","display_name":"cAMP phosphodiesterase","score":0.7720000147819519},{"id":"https://openalex.org/keywords/smooth-muscle-contraction","display_name":"smooth muscle contraction","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.8031154870986938},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6086217761039734},{"id":"https://openalex.org/C2776668983","wikidata":"https://www.wikidata.org/wiki/Q210041","display_name":"Cyclic adenosine monophosphate","level":3,"score":0.602372944355011},{"id":"https://openalex.org/C2780043322","wikidata":"https://www.wikidata.org/wiki/Q2705359","display_name":"Phorbol","level":4,"score":0.5981398224830627},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5963151454925537},{"id":"https://openalex.org/C2779084600","wikidata":"https://www.wikidata.org/wiki/Q5957181","display_name":"Staurosporine","level":4,"score":0.5851006507873535},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49487799406051636},{"id":"https://openalex.org/C180526460","wikidata":"https://www.wikidata.org/wiki/Q356240","display_name":"Adenylate kinase","level":3,"score":0.4791135787963867},{"id":"https://openalex.org/C163235415","wikidata":"https://www.wikidata.org/wiki/Q899814","display_name":"Second messenger system","level":3,"score":0.4733704924583435},{"id":"https://openalex.org/C92759361","wikidata":"https://www.wikidata.org/wiki/Q5891436","display_name":"Homologous desensitization","level":4,"score":0.46654486656188965},{"id":"https://openalex.org/C2780069284","wikidata":"https://www.wikidata.org/wiki/Q5198121","display_name":"Cyclase","level":3,"score":0.4474951922893524},{"id":"https://openalex.org/C2778618036","wikidata":"https://www.wikidata.org/wiki/Q2878809","display_name":"Inositol phosphate","level":4,"score":0.42214494943618774},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.41773557662963867},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.41354215145111084},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3906722068786621},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3502277731895447},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.3191035985946655},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.25983333587646484},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23228973150253296},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.20399540662765503},{"id":"https://openalex.org/C2777427919","wikidata":"https://www.wikidata.org/wiki/Q407997","display_name":"Inositol","level":3,"score":0.1824915111064911},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08627122640609741}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002852","descriptor_name":"Chromatography, Ion Exchange","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007498","descriptor_name":"Iris","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D007498","descriptor_name":"Iris","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010703","descriptor_name":"Phorbol Esters","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011982","descriptor_name":"Receptors, Prostaglandin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015237","descriptor_name":"Dinoprost","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015544","descriptor_name":"Inositol 1,4,5-Trisphosphate","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D019311","descriptor_name":"Staurosporine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:8387977","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8387977","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"mag:91294951","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8387977","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2952964345","display_name":"LIPID AND PROTEIN PO4 TURNOVER IN IRIS OF THE EYE","funder_award_id":"R37EY004171","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G7516293457","display_name":"GLYCEROLIPIDS AND PROSTAGLANDIN BIOSYNTHESIS","funder_award_id":"R01EY004387","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W109509756","https://openalex.org/W631486094","https://openalex.org/W883704299","https://openalex.org/W1536585049","https://openalex.org/W1589866689","https://openalex.org/W1976100975","https://openalex.org/W1978053452","https://openalex.org/W1980854090","https://openalex.org/W2003436933","https://openalex.org/W2017733935","https://openalex.org/W2029181329","https://openalex.org/W2029690467","https://openalex.org/W2031233656","https://openalex.org/W2049675026","https://openalex.org/W2062499314","https://openalex.org/W2075880457","https://openalex.org/W2087936575","https://openalex.org/W2152311269","https://openalex.org/W2257013954","https://openalex.org/W2291594199","https://openalex.org/W2472184801"],"related_works":["https://openalex.org/W1978053452","https://openalex.org/W2029181329","https://openalex.org/W2339010627","https://openalex.org/W7100484329","https://openalex.org/W2034083303","https://openalex.org/W1982114808","https://openalex.org/W2038144617","https://openalex.org/W2472184801","https://openalex.org/W1994873358","https://openalex.org/W2415554920"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"examine":[2],"the":[3,6,31,40,92,104,110,125,165,228,244,272,280,288,292,310,354,357,371,377,381,398,411],"mechanisms":[4],"underlying":[5],"effects":[7,59,262],"of":[8,30,60,106,112,124,194,208,215,227,243,263,271,277,295,307,317,366,376,386,389,400],"PGF2":[9,26,49,61,239,247,264,281,337,349,401],"alpha":[10,27,50,62,115,248,265,338,350,402],"receptor":[11,28,355,383],"desensitization":[12,29,111,266,339,351],"on":[13,67],"agonist-induced":[14],"second":[15,413],"messenger":[16,414],"formation":[17,77,137,188,254],"and":[18,63,72,80,88,109,147,162,218,255,259,320,333,359,362,384,416],"contraction":[19],"in":[20,42,78,103,138,189,199,236,284,309,324,341,392],"bovine":[21,32,94,311],"iris":[22,33,95,312],"sphincter.":[23],"METHODS:":[24],"Short-term":[25],"sphincter":[34,245,313],"was":[35],"carried":[36],"out":[37],"by":[38,85,119,160,202,269],"incubating":[39],"tissue":[41,126,229,273],"Krebs-Ringer":[43],"bicarbonate":[44],"buffer":[45],"containing":[46],"25":[47],"microM":[48],"for":[51,249],"45":[52,250],"min":[53,251],"at":[54],"37":[55],"degrees":[56],"C.":[57],"The":[58,169,197,261,327],"other":[64],"pharmacologic":[65],"agents":[66],"inositol":[68],"1,4,5-triphosphate":[69],"(IP3)":[70],"production":[71,235,258,332],"cyclic":[73],"adenosine":[74],"monophosphate":[75],"(cAMP)":[76],"desensitized":[79,289],"nondesensitized":[81],"tissues":[82],"were":[83,267],"monitored":[84],"anion-exchange":[86],"chromatography":[87],"radioimmunoassay.":[89],"RESULTS:":[90],"In":[91,287],"isolated":[93],"sphincter,":[96],"protein":[97],"kinase":[98],"C":[99],"(PKC)":[100],"is":[101,220],"involved":[102],"activation":[105,385],"adenylate":[107,209,318,342,367],"cyclase":[108,319,343,368],"prostaglandin":[113],"F2":[114],"receptor-mediated":[116],"responses":[117],"supported":[118],"these":[120],"findings.":[121],"(A)":[122,305],"Exposure":[123],"to":[127,131,238,315,321],"phorbol":[128,172,185,203,231],"12,13-dibutyrate,":[129],"used":[130],"activate":[132],"PKC,":[133,296,387],"enhanced":[134,393],"basal":[135],"cAMP":[136,158,167,187,200,216,253,285,325,328,394],"a":[139,180,190],"dose":[140],"(EC50":[141],"=":[142,150],"8.8":[143],"x":[144],"10(-8)":[145],"M)":[146],"time":[148],"(t1/2":[149],"7.5":[151],"min)":[152],"dependent":[153],"manner.":[154],"Phorbol":[155],"12,13-dibutyrate":[156,204,232],"increased":[157,252],"levels":[159,201],"twofold":[161],"it":[163,219],"potentiated":[164],"isoproterenol-induced":[166],"formation.":[168,286,326],"biologically":[170],"inactive":[171],"ester,":[173],"4":[174],"alpha-phorbol":[175],"had":[176],"no":[177],"effect.":[178],"Staurosporine,":[179],"potent":[181],"PKC":[182,278,308],"inhibitor,":[183],"inhibited":[184,233],"12,13-dibutyrate-induced":[186],"dose-dependent":[191],"manner":[192],"(IC50":[193],"0.25":[195],"microM).":[196],"increase":[198,283,323],"results":[205,340],"from":[206,213,299,356,380],"stimulation":[207,316,365],"cyclase,":[210],"rather":[211],"than":[212],"inhibition":[214],"phosphodiesterase,":[217],"not":[221],"mediated":[222,345],"through":[223,346,370],"Ca2+":[224],"mobilization.":[225],"Pretreatment":[226],"with":[230,246,274],"IP3":[234,257,331],"response":[237],"alpha.":[240],"(B)":[241,336],"Desensitization":[242],"attenuated":[256],"contraction.":[260,335],"reversed":[268],"pretreatment":[270],"staurosporine.":[275],"Down-regulation":[276],"prevented":[279],"alpha-stimulated":[282],"tissue,":[290],"diacylglycerol,":[291],"endogenous":[293],"activator":[294],"may":[297,396],"arise":[298],"phosphatidylcholine,":[300],"via":[301],"phospholipase":[302],"D.":[303],"CONCLUSIONS:":[304],"Activation":[306],"leads":[314],"an":[322],"formed":[329],"inhibits":[330],"muscle":[334],"activation,":[344],"PKC.":[347],"(C)":[348],"could":[352],"uncouple":[353],"Gq":[358],"Gi":[360],"proteins":[361,379],"enhance":[363],"PG":[364,382],"activity":[369],"Gs":[372],"protein.":[373],"(D)":[374],"Uncoupling":[375],"G":[378],"both":[388],"which":[390],"result":[391],"formation,":[395],"underlie":[397],"mechanism":[399],"desensitization.":[403],"(E)":[404],"These":[405],"observations":[406],"demonstrate":[407],"\"cross":[408],"talk\"":[409],"between":[410],"two":[412],"systems":[415],"their":[417],"physiologic":[418],"consequences.":[419]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
