{"id":"https://openalex.org/W91281079","doi":null,"title":"Isolation of adult pig islet. In vitro assessment and xenotransplantation.","display_name":"Isolation of adult pig islet. In vitro assessment and xenotransplantation.","publication_year":1992,"publication_date":"1992-10-01","ids":{"openalex":"https://openalex.org/W91281079","mag":"91281079","pmid":"https://pubmed.ncbi.nlm.nih.gov/1460332"},"language":"en","primary_location":{"id":"pmid:1460332","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1460332","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of pancreatology : official journal of the International Association of Pancreatology","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111544970","display_name":"K Inoue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K Inoue","raw_affiliation_strings":["First Department of Surgery, Faculty of Medicine, Kyoto University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, Faculty of Medicine, Kyoto University, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012279404","display_name":"Yuan Jun Gu","orcid":"https://orcid.org/0000-0003-1401-6233","observed_orcids":["https://orcid.org/0000-0003-1401-6233"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Gu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028568416","display_name":"S Shinohara","orcid":"https://orcid.org/0000-0001-8850-0859","observed_orcids":["https://orcid.org/0000-0001-8850-0859"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Shinohara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111618026","display_name":"Masafumi Kogire","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Kogire","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110105644","display_name":"Manabu MITSUO","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Mitsuo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"I Nakai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I Nakai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068189444","display_name":"Hiroyuki Hayashi","orcid":"https://orcid.org/0000-0002-7590-6419","observed_orcids":["https://orcid.org/0000-0002-7590-6419"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Hayashi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109980715","display_name":"K Uchida","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Uchida","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065428088","display_name":"Shunzo Maetani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Maetani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111614773","display_name":"Y. Ikada","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Ikada","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4663,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.80872183,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"12","issue":"2","first_page":"173","last_page":"80"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12654","display_name":"Xenotransplantation and immune response","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/islet-isolation","display_name":"islet isolation","score":0.949999988079071},{"id":"https://openalex.org/keywords/xenotransplantation","display_name":"xenotransplantation","score":0.9599999785423279},{"id":"https://openalex.org/keywords/islet-transplantation","display_name":"islet transplantation","score":0.6679999828338623},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.6740000247955322},{"id":"https://openalex.org/keywords/glucose-stimulated-insulin-secretion","display_name":"glucose-stimulated insulin secretion","score":0.9459999799728394},{"id":"https://openalex.org/keywords/pancreatic-islets","display_name":"pancreatic islets","score":0.6740000247955322},{"id":"https://openalex.org/keywords/porcine-pancreas","display_name":"porcine pancreas","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C2778442404","wikidata":"https://www.wikidata.org/wiki/Q55505","display_name":"Xenotransplantation","level":3,"score":0.9604869484901428},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.839124321937561},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6672372221946716},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.64149409532547},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6009167432785034},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5546808242797852},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5463184118270874},{"id":"https://openalex.org/C2779855799","wikidata":"https://www.wikidata.org/wiki/Q728309","display_name":"Pancreatic islets","level":4,"score":0.538986086845398},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5126044154167175},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.5084608793258667},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4966152310371399},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.44966283440589905},{"id":"https://openalex.org/C2778815084","wikidata":"https://www.wikidata.org/wiki/Q79803","display_name":"Guinea pig","level":2,"score":0.4272664785385132},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1988641321659088},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12795361876487732},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016381","descriptor_name":"Islets of Langerhans Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1460332","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1460332","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of pancreatology : official journal of the International Association of Pancreatology","raw_type":"Journal Article"},{"id":"mag:91281079","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1460332","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1993326517","https://openalex.org/W2009077317","https://openalex.org/W2017495914","https://openalex.org/W2029884165","https://openalex.org/W2031808487","https://openalex.org/W2032698393","https://openalex.org/W2046906171","https://openalex.org/W2049790774","https://openalex.org/W2060655209","https://openalex.org/W2062921970","https://openalex.org/W2081753635","https://openalex.org/W2095136381","https://openalex.org/W2112375754","https://openalex.org/W2148178913","https://openalex.org/W2170528653","https://openalex.org/W2256772495","https://openalex.org/W2323220576","https://openalex.org/W2409456916","https://openalex.org/W2414248883","https://openalex.org/W2424754404","https://openalex.org/W2443679176","https://openalex.org/W2473726475","https://openalex.org/W2473928111"],"related_works":["https://openalex.org/W4301934608","https://openalex.org/W7048039112","https://openalex.org/W2473928111","https://openalex.org/W1940125382","https://openalex.org/W2399086552","https://openalex.org/W7097668733","https://openalex.org/W2431919524","https://openalex.org/W2066581788","https://openalex.org/W2045315976","https://openalex.org/W2418813263"],"abstract_inverted_index":{"This":[0,146],"study":[1,77,96,147,171,175],"was":[2,72],"conducted":[3],"to":[4,14,90,102,137],"develop":[5],"an":[6,152],"isolation":[7,153],"method":[8,154],"for":[9,155],"adult":[10,85,113,156],"pig":[11,70,86,114,157],"islets":[12,43,87,115,158,163],"and":[13,50,159,166,172],"investigate":[15],"in":[16,24,88,169,173],"vivo":[17,174],"function":[18,26],"after":[19,144],"xenotransplantation":[20],"as":[21,23],"well":[22],"vitro":[25,75,94,170],"of":[27,34,46,61,109,120,151,176],"isolated":[28,49,84,106,112,162],"islets.":[29,107],"From":[30],"the":[31,35,62,117],"splenic":[32],"portion":[33],"glands":[36],"(n":[37,124],"=":[38,125],"20),":[39],"3277":[40],"+/-":[41,134,139],"645":[42],"per":[44],"gram":[45],"pancreas":[47],"were":[48],"recovered":[51],"by":[52],"a":[53,79,98,149],"five-step":[54],"dextran":[55],"discontinuous":[56],"density":[57],"gradient":[58],"method.":[59],"Purity":[60],"final":[63],"preparation":[64],"obtained":[65],"from":[66,83,105,132],"20":[67],"different":[68],"consecutive":[69],"pancreata":[71],"80-90%.":[73],"In":[74,93],"incubation":[76],"revealed":[78],"significant":[80],"insulin":[81,100],"release":[82],"response":[89,101],"glucose":[91,103,130],"stimulation.":[92],"perifusion":[95],"demonstrated":[97],"biphasic":[99],"stimulation":[104],"Xenotransplantation":[108],"approx":[110],"2000":[111],"into":[116],"portal":[118],"vein":[119],"diabetic":[121],"Wistar":[122],"rats":[123],"8)":[126],"significantly":[127],"reduced":[128],"serum":[129],"levels":[131],"431":[133],"24":[135,142],"mg/dL":[136,141],"173":[138],"18":[140],"h":[143],"transplantation.":[145],"provides":[148],"development":[150],"demonstrates":[160],"that":[161],"are":[164],"viable":[165],"functioning":[167],"both":[168],"xenotransplantation.":[177]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}