{"id":"https://openalex.org/W90995900","doi":null,"title":"Lysosomal Involvement in the Pathogenesis of Alzheimer's Disease","display_name":"Lysosomal Involvement in the Pathogenesis of Alzheimer's Disease","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W90995900","mag":"90995900"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:liu-73412","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-73412","pdf_url":null,"source":{"id":"https://openalex.org/S4306400838","display_name":"DiVA (Linkoping University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102134673","host_organization_name":"Link\u00f6ping University","host_organization_lineage":["https://openalex.org/I102134673"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-73412","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018786538","display_name":"Lin Ping Zheng","orcid":"https://orcid.org/0000-0001-5617-5895","observed_orcids":["https://orcid.org/0000-0001-5617-5895"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lin Zheng","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5617-5895","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5018786538"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9729999899864197},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.7749999761581421},{"id":"https://openalex.org/keywords/lysosomes","display_name":"lysosomes","score":0.9340000152587891},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9779999852180481},{"id":"https://openalex.org/keywords/hyperoxia","display_name":"hyperoxia","score":0.7749999761581421},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.8479999899864197},{"id":"https://openalex.org/keywords/macroautophagy","display_name":"macroautophagy","score":0.8809999823570251},{"id":"https://openalex.org/keywords/lysosomal-membrane-permeabilization","display_name":"lysosomal membrane permeabilization","score":0.9089999794960022},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7950000166893005},{"id":"https://openalex.org/keywords/app-processing","display_name":"APP processing","score":0.8399999737739563},{"id":"https://openalex.org/keywords/lysosomal-dysfunction","display_name":"lysosomal dysfunction","score":0.43799999356269836},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.6380000114440918},{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"endoplasmic reticulum","score":0.7400000095367432},{"id":"https://openalex.org/keywords/golgi-apparatus","display_name":"Golgi apparatus","score":0.7990000247955322},{"id":"https://openalex.org/keywords/synaptic-vesicles","display_name":"synaptic vesicles","score":0.8790000081062317}],"concepts":[{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.737341046333313},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6061050891876221},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5206981301307678},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41229283809661865},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35426878929138184},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27214640378952026},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.26087483763694763}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:liu-73412","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-73412","pdf_url":null,"source":{"id":"https://openalex.org/S4306400838","display_name":"DiVA (Linkoping University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102134673","host_organization_name":"Link\u00f6ping University","host_organization_lineage":["https://openalex.org/I102134673"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:90995900","doi":null,"is_oa":false,"landing_page_url":"http://liu.diva-portal.org/smash/get/diva2:472009/FULLTEXT01.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:liu-73412","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-73412","pdf_url":null,"source":{"id":"https://openalex.org/S4306400838","display_name":"DiVA (Linkoping University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102134673","host_organization_name":"Link\u00f6ping University","host_organization_lineage":["https://openalex.org/I102134673"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":212,"referenced_works":["https://openalex.org/W1919353","https://openalex.org/W15253933","https://openalex.org/W17230872","https://openalex.org/W77958047","https://openalex.org/W149130878","https://openalex.org/W192765840","https://openalex.org/W208592351","https://openalex.org/W312214294","https://openalex.org/W1487064198","https://openalex.org/W1502820594","https://openalex.org/W1510314685","https://openalex.org/W1526993239","https://openalex.org/W1543216066","https://openalex.org/W1551392207","https://openalex.org/W1554824558","https://openalex.org/W1566528879","https://openalex.org/W1575834956","https://openalex.org/W1582795354","https://openalex.org/W1586465707","https://openalex.org/W1602771322","https://openalex.org/W1641175229","https://openalex.org/W1645373081","https://openalex.org/W1663198600","https://openalex.org/W1671903847","https://openalex.org/W1773591497","https://openalex.org/W1885005952","https://openalex.org/W1889306845","https://openalex.org/W1900601199","https://openalex.org/W1926541489","https://openalex.org/W1964049915","https://openalex.org/W1968144312","https://openalex.org/W1968317065","https://openalex.org/W1969271586","https://openalex.org/W1970452111","https://openalex.org/W1971256323","https://openalex.org/W1972567838","https://openalex.org/W1972647829","https://openalex.org/W1974005435","https://openalex.org/W1975775468","https://openalex.org/W1975903250","https://openalex.org/W1977767269","https://openalex.org/W1978510853","https://openalex.org/W1979543098","https://openalex.org/W1979773315","https://openalex.org/W1980309511","https://openalex.org/W1980825524","https://openalex.org/W1980859319","https://openalex.org/W1980906872","https://openalex.org/W1981152641","https://openalex.org/W1981358316","https://openalex.org/W1982647833","https://openalex.org/W1982973473","https://openalex.org/W1983730442","https://openalex.org/W1983789627","https://openalex.org/W1985497242","https://openalex.org/W1986695958","https://openalex.org/W1987030209","https://openalex.org/W1987933993","https://openalex.org/W1988022242","https://openalex.org/W1989779456","https://openalex.org/W1990138203","https://openalex.org/W1990189498","https://openalex.org/W1990804638","https://openalex.org/W1996772579","https://openalex.org/W1998440070","https://openalex.org/W1998514549","https://openalex.org/W1999110283","https://openalex.org/W2000552348","https://openalex.org/W2001591494","https://openalex.org/W2004034281","https://openalex.org/W2004266143","https://openalex.org/W2006548069","https://openalex.org/W2007047564","https://openalex.org/W2007649442","https://openalex.org/W2009230396","https://openalex.org/W2009886346","https://openalex.org/W2015600776","https://openalex.org/W2016040396","https://openalex.org/W2016486229","https://openalex.org/W2016894006","https://openalex.org/W2017593971","https://openalex.org/W2017770853","https://openalex.org/W2018327323","https://openalex.org/W2018851870","https://openalex.org/W2019871046","https://openalex.org/W2020824841","https://openalex.org/W2021307208","https://openalex.org/W2022326612","https://openalex.org/W2022754327","https://openalex.org/W2022812113","https://openalex.org/W2023164919","https://openalex.org/W2027522832","https://openalex.org/W2028629349","https://openalex.org/W2029695041","https://openalex.org/W2030182984","https://openalex.org/W2030508474","https://openalex.org/W2033603289","https://openalex.org/W2034746288","https://openalex.org/W2035811144","https://openalex.org/W2036229829","https://openalex.org/W2036676765","https://openalex.org/W2041108499","https://openalex.org/W2041371648","https://openalex.org/W2043344837","https://openalex.org/W2043882563","https://openalex.org/W2045201133","https://openalex.org/W2045548994","https://openalex.org/W2047210662","https://openalex.org/W2048360633","https://openalex.org/W2048975745","https://openalex.org/W2049192526","https://openalex.org/W2050794707","https://openalex.org/W2051314670","https://openalex.org/W2052093947","https://openalex.org/W2052411122","https://openalex.org/W2052746044","https://openalex.org/W2053379890","https://openalex.org/W2056409809","https://openalex.org/W2058880763","https://openalex.org/W2060037872","https://openalex.org/W2061916198","https://openalex.org/W2063236931","https://openalex.org/W2063789588","https://openalex.org/W2064625375","https://openalex.org/W2065904500","https://openalex.org/W2066116456","https://openalex.org/W2066918975","https://openalex.org/W2067477189","https://openalex.org/W2067692987","https://openalex.org/W2068409549","https://openalex.org/W2070562519","https://openalex.org/W2072199290","https://openalex.org/W2073701988","https://openalex.org/W2074438246","https://openalex.org/W2074938894","https://openalex.org/W2075311568","https://openalex.org/W2076906481","https://openalex.org/W2077612844","https://openalex.org/W2078089123","https://openalex.org/W2079438371","https://openalex.org/W2080274663","https://openalex.org/W2082796078","https://openalex.org/W2083715632","https://openalex.org/W2087109004","https://openalex.org/W2091232863","https://openalex.org/W2091334591","https://openalex.org/W2092417963","https://openalex.org/W2093374391","https://openalex.org/W2093637710","https://openalex.org/W2094553350","https://openalex.org/W2095187475","https://openalex.org/W2096410114","https://openalex.org/W2100837269","https://openalex.org/W2103377481","https://openalex.org/W2103440561","https://openalex.org/W2104227586","https://openalex.org/W2108086395","https://openalex.org/W2108285073","https://openalex.org/W2108963923","https://openalex.org/W2112332398","https://openalex.org/W2113784071","https://openalex.org/W2113988778","https://openalex.org/W2116424646","https://openalex.org/W2116621818","https://openalex.org/W2118417727","https://openalex.org/W2122320288","https://openalex.org/W2122426758","https://openalex.org/W2123245905","https://openalex.org/W2123870698","https://openalex.org/W2126152332","https://openalex.org/W2126937565","https://openalex.org/W2128537698","https://openalex.org/W2128779293","https://openalex.org/W2129712803","https://openalex.org/W2130641115","https://openalex.org/W2132673369","https://openalex.org/W2132814291","https://openalex.org/W2133019124","https://openalex.org/W2134138119","https://openalex.org/W2134633907","https://openalex.org/W2138138136","https://openalex.org/W2142044474","https://openalex.org/W2142943752","https://openalex.org/W2143358143","https://openalex.org/W2144367399","https://openalex.org/W2146141276","https://openalex.org/W2146887271","https://openalex.org/W2149579301","https://openalex.org/W2150608922","https://openalex.org/W2150749054","https://openalex.org/W2151355155","https://openalex.org/W2152103960","https://openalex.org/W2152600551","https://openalex.org/W2157045574","https://openalex.org/W2157895955","https://openalex.org/W2158115879","https://openalex.org/W2158124942","https://openalex.org/W2159093573","https://openalex.org/W2159242834","https://openalex.org/W2159367229","https://openalex.org/W2159736446","https://openalex.org/W2163915292","https://openalex.org/W2167115031","https://openalex.org/W2168212241","https://openalex.org/W2169152986","https://openalex.org/W2169240711","https://openalex.org/W2308526053","https://openalex.org/W2315512556","https://openalex.org/W2344158212","https://openalex.org/W2792139654","https://openalex.org/W4248567869","https://openalex.org/W4295202935"],"related_works":["https://openalex.org/W2582369610","https://openalex.org/W2024905696","https://openalex.org/W2004266143","https://openalex.org/W2082377604","https://openalex.org/W2091232863","https://openalex.org/W1981964613","https://openalex.org/W1975222038","https://openalex.org/W1968643079","https://openalex.org/W4387392885","https://openalex.org/W2027522832"],"abstract_inverted_index":{"Alzheimer\u2019s":[0],"disease":[1],"(AD),":[2],"the":[3,37,57,78,91,102,105,109,120,133,139,162,171,184,193,349,377],"major":[4],"cause":[5],"of":[6,14,21,59,68,80,90,104,122,153,159,164,173,187,210,222,243,261,322,331,351,376,380],"senile":[7],"dementia,":[8],"is":[9,83,88,273],"associated":[10,274],"with":[11,36,275,327,337],"progressive":[12],"formation":[13,58],"neurofibrillary":[15],"tangles":[16],"and":[17,61,96,112,138,175,189,263,279,288,306,344,353,368,383,389],"extraneuronal":[18],"plaques":[19],"composed":[20],"amyloid":[22],"beta":[23],"peptide":[24],"(A\u03b2).":[25],"A\u03b2":[26,60,166,188,223,262,271,286,297,323,335,361],"has":[27],"been":[28,50],"also":[29],"found":[30,235],"within":[31,250],"Alzheimer":[32],"neurons":[33],"in":[34,55,77,94,101,118,142,167,178,214,246,283,293,386],"association":[35],"lysosomal":[38,110,140,194,265,365,384],"system,":[39],"an":[40,74,98],"acidic":[41,308],"vacuolar":[42],"compartment":[43],"possessing":[44],"numerous":[45],"hydrolytic":[46],"enzymes.":[47],"Lysosomes":[48],"have":[49],"shown":[51],"to":[52,64,192,226,230,304],"be":[53,391],"involved":[54,117],"both":[56,108],"its":[62,190,247],"toxicity":[63,228],"neurons.":[65],"Another":[66],"line":[67],"evidence":[69],"implicates":[70],"oxidative":[71,86,136,154,212,238,253,277,381],"stress":[72,137,155,213,239,254,278,357,382],"as":[73,207,346,348],"important":[75,99],"factor":[76],"development":[79,103],"AD.":[81,399],"It":[82,233],"reported":[84],"that":[85],"damage":[87],"one":[89],"earliest":[92],"changes":[93],"AD":[95,143,387],"plays":[97],"role":[100,163,172,379],"disease.":[106],"Although":[107],"system":[111,141,385],"reactive":[113],"oxygen":[114],"species":[115],"are":[116,125],"AD,":[119],"mechanisms":[121],"this":[123],"involvement":[124],"not":[126,302],"well":[127,347],"understood.":[128],"To":[129],"gain":[130],"insight":[131],"into":[132],"relationship":[134,191],"between":[135],"pathogenesis,":[144,388],"we":[145],"focused":[146],"our":[147,197],"study":[148],"on:":[149],"1)":[150,237],"The":[151],"effect":[152],"on":[156],"intracellular":[157,296],"distribution":[158],"A\u03b2;":[160],"2)":[161,252],"endogenous":[165,231],"oxidant-induced":[168],"apoptosis;":[169,290],"3)":[170,268],"autophagy":[174],"APP":[176],"processing":[177],"oxidant":[179],"induced":[180],"damage;":[181],"and,":[182,291],"4)":[183,292],"intraneuronal":[185],"localization":[186],"system.":[195],"In":[196],"study,":[198],"hyperoxia":[199],"(40%":[200],"versus":[201],"8%":[202],"ambient":[203],"oxygen)":[204],"was":[205,234],"used":[206,225],"a":[208,319,373,394],"model":[209],"mild":[211],"vitro,":[215],"while":[216],"transfected":[217],"cells":[218],"producing":[219],"different":[220],"amounts":[221],"were":[224],"assess":[227],"due":[229],"A\u03b2.":[232,355],"that:":[236],"induces":[240,358],"autophagic":[241],"uptake":[242],"A\u03b2,":[244],"resulting":[245,282],"partial":[248,325],"accumulation":[249,287],"lysosomes;":[251],"can":[255],"induce":[256],"neuronal":[257],"death":[258],"through":[259],"macroautophagy":[260],"consequent":[264,289],"membrane":[266,366],"permeabilization;":[267],"increased":[269,284,334],"cellular":[270,328],"production":[272],"enhanced":[276,280],"macroautophagy,":[281],"intralysosomal":[285,359],"normal":[294],"conditions,":[295],"shows":[298,324],"primarily":[299],"cytosolic":[300,354],"distribution,":[301],"related":[303],"lysosomes":[305],"other":[307],"vacuoles,":[309],"endoplasmic":[310,338],"reticulum,":[311,339],"Golgi":[312,340],"complexes,":[313,341],"synaptic":[314,342],"vesicles":[315,343],"or":[316],"mitochondria.":[317],"Only":[318],"minor":[320],"portion":[321],"colocalization":[326,336],"organelles.":[329],"Inhibition":[330],"secretion":[332],"significantly":[333],"lysosomes,":[345],"amount":[350],"mitochondrial":[352],"Oxidative":[356],"autophagy-generated":[360],"accumulation,":[362],"consequently":[363],"causing":[364],"permeabilization":[367],"apoptosis.":[369],"Our":[370],"findings":[371],"provide":[372],"possible":[374],"explanation":[375],"interactive":[378],"may":[390],"helpful":[392],"for":[393],"future":[395],"therapeutic":[396],"strategy":[397],"against":[398]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
