{"id":"https://openalex.org/W908931908","doi":"https://doi.org/10.1017/cbo9780511997778.024","title":"Fetal infections","display_name":"Fetal infections","publication_year":2012,"publication_date":"2012-12-13","ids":{"openalex":"https://openalex.org/W908931908","doi":"https://doi.org/10.1017/cbo9780511997778.024","mag":"908931908"},"language":"en","primary_location":{"id":"doi:10.1017/cbo9780511997778.024","doi":"https://doi.org/10.1017/cbo9780511997778.024","is_oa":false,"landing_page_url":"https://doi.org/10.1017/cbo9780511997778.024","pdf_url":null,"source":{"id":"https://openalex.org/S4306462995","display_name":"Cambridge University Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fetal Therapy","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2589495159","display_name":"Fetal Therapy"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040297394","display_name":"Ariane Huygens","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ariane Huygens","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5011424051","display_name":"Arnaud Marchant","orcid":"https://orcid.org/0000-0003-0578-0467","observed_orcids":["https://orcid.org/0000-0003-0578-0467"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arnaud Marchant","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09385113,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"200","last_page":"207"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.823199987411499,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.823199987411499,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.07109999656677246,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11961","display_name":"Neonatal and Maternal Infections","score":0.041999999433755875,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fetal-immune-system","display_name":"fetal immune system","score":0.8989999890327454},{"id":"https://openalex.org/keywords/congenital-infection","display_name":"congenital infection","score":0.8899999856948853},{"id":"https://openalex.org/keywords/fetal-infection","display_name":"fetal infection","score":0.6439999938011169},{"id":"https://openalex.org/keywords/immune-system-development","display_name":"immune system development","score":0.4390000104904175},{"id":"https://openalex.org/keywords/toll-like-receptors","display_name":"Toll-like receptors","score":0.9089999794960022},{"id":"https://openalex.org/keywords/pathogen-associated-molecular-patterns","display_name":"pathogen-associated molecular patterns","score":0.9909999966621399},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9459999799728394},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":1.0},{"id":"https://openalex.org/keywords/placenta","display_name":"placenta","score":0.5220000147819519},{"id":"https://openalex.org/keywords/inflammation-in-pregnancy","display_name":"inflammation in pregnancy","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.8515927791595459},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.7660834789276123},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.7331461310386658},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6520546674728394},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6143438220024109},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.4518711566925049},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.4461013972759247},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.23792624473571777},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1017/cbo9780511997778.024","doi":"https://doi.org/10.1017/cbo9780511997778.024","is_oa":false,"landing_page_url":"https://doi.org/10.1017/cbo9780511997778.024","pdf_url":null,"source":{"id":"https://openalex.org/S4306462995","display_name":"Cambridge University Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Fetal Therapy","raw_type":"book-chapter"},{"id":"pmh:oai:dipot.ulb.ac.be:2013/204913","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/204913","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/bookPart"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W82088075","https://openalex.org/W176669131","https://openalex.org/W232202339","https://openalex.org/W1546723842","https://openalex.org/W1556976811","https://openalex.org/W1612382123","https://openalex.org/W1662827845","https://openalex.org/W1698869900","https://openalex.org/W1967702267","https://openalex.org/W1972323633","https://openalex.org/W1980373370","https://openalex.org/W1982977224","https://openalex.org/W1989390989","https://openalex.org/W2005599815","https://openalex.org/W2027729283","https://openalex.org/W2042064054","https://openalex.org/W2046685467","https://openalex.org/W2052998574","https://openalex.org/W2054114006","https://openalex.org/W2064883226","https://openalex.org/W2066516753","https://openalex.org/W2071415293","https://openalex.org/W2072066004","https://openalex.org/W2079254194","https://openalex.org/W2079990158","https://openalex.org/W2084147684","https://openalex.org/W2092054292","https://openalex.org/W2102179509","https://openalex.org/W2108724347","https://openalex.org/W2108821947","https://openalex.org/W2112475246","https://openalex.org/W2115773000","https://openalex.org/W2129472676","https://openalex.org/W2142124450","https://openalex.org/W2150661666","https://openalex.org/W2155353912","https://openalex.org/W2157408286","https://openalex.org/W2159252441","https://openalex.org/W2321610162","https://openalex.org/W2332178538","https://openalex.org/W2399710040","https://openalex.org/W2904935375","https://openalex.org/W2905498577","https://openalex.org/W3021465649","https://openalex.org/W3023473549"],"related_works":["https://openalex.org/W2982083094","https://openalex.org/W2411456541","https://openalex.org/W4411420793","https://openalex.org/W4283387211","https://openalex.org/W4206827140","https://openalex.org/W2962955937","https://openalex.org/W1969675489","https://openalex.org/W4407797013","https://openalex.org/W4235615574","https://openalex.org/W2000352134"],"abstract_inverted_index":{"This":[0],"chapter":[1],"reviews":[2],"the":[3,8,19,22,87,113,117,122,129],"immune":[4,24,38,70,123],"system":[5,25,71],"and":[6,31,42,115],"describes":[7],"current":[9],"knowledge":[10],"of":[11,21,121,144],"its":[12],"development":[13],"during":[14,73],"fetal":[15,23,74,134],"life.":[16],"It":[17],"summarizes":[18],"capacity":[20],"to":[26,28,56,78,81,85,99,105,112,116,125,142],"respond":[27],"infectious":[29,83],"pathogens":[30,101,127],"focuses":[32],"on":[33],"congenital":[34],"infections.":[35],"In":[36],"tissues,":[37],"cells":[39,44],"like":[40],"macrophages":[41],"dendritic":[43],"(DCs)":[45],"express":[46],"specific":[47],"receptors,":[48],"such":[49],"as":[50],"toll-like":[51],"receptors":[52],"(TLRs),":[53],"allowing":[54],"them":[55],"recognize":[57],"molecules":[58],"called":[59],"pathogen-associated":[60],"molecular-patterns":[61],"(PAMPs)":[62],"that":[63,108,133],"are":[64,97,109],"specifically":[65],"expressed":[66],"by":[67],"pathogens.":[68],"The":[69],"develops":[72],"life":[75],"in":[76],"order":[77],"be":[79,90],"ready":[80],"control":[82,100],"microorganisms":[84],"which":[86],"infant":[88],"will":[89],"exposed":[91],"after":[92],"birth.":[93],"Immune":[94],"effector":[95,139],"functions":[96,140],"required":[98],"but":[102],"may":[103],"lead":[104],"inflammatory":[106],"responses":[107,124],"potentially":[110],"harmful":[111],"fetus":[114,130],"placenta.":[118],"Recent":[119],"studies":[120],"some":[126],"infecting":[128],"have":[131],"indicated":[132],"T":[135],"lymphocytes":[136],"can":[137],"develop":[138],"similar":[141],"those":[143],"older":[145],"children":[146],"or":[147],"adults.":[148]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2016-06-24T00:00:00"}