{"id":"https://openalex.org/W90832251","doi":null,"title":"Regulation of the Apoptosome in Cancer","display_name":"Regulation of the Apoptosome in Cancer","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W90832251","mag":"90832251"},"language":"en","primary_location":{"id":"pmh:oai:CiteSeerX.psu:10.1.1.885.8228","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.885.8228","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://dukespace.lib.duke.edu/dspace/bitstream/handle/10161/5787/Kim_duke_0066D_11520.pdf%3Bjsessionid%3DC721C91450D2FDD94A4D29FACD6A69AD?sequence%3D1","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100396579","display_name":"Jiyeon Kim","orcid":"https://orcid.org/0000-0001-7509-5313","observed_orcids":["https://orcid.org/0000-0001-7509-5313"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jiyeon Kim","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7509-5313","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5100396579"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00615614,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apoptosome","display_name":"apoptosome","score":0.8579999804496765},{"id":"https://openalex.org/keywords/apoptosis-regulation","display_name":"apoptosis regulation","score":0.7329999804496765},{"id":"https://openalex.org/keywords/cytochrome-c-release","display_name":"cytochrome c release","score":0.9049999713897705},{"id":"https://openalex.org/keywords/caspase-activation","display_name":"caspase activation","score":0.8420000076293945},{"id":"https://openalex.org/keywords/rsk","display_name":"RSK","score":0.7020000219345093},{"id":"https://openalex.org/keywords/14-3-3epsilon","display_name":"14-3-3\u03b5","score":0.906000018119812},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.9829999804496765},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9869999885559082},{"id":"https://openalex.org/keywords/protein-phosphatase-5","display_name":"protein phosphatase 5","score":0.7979999780654907},{"id":"https://openalex.org/keywords/hsp90beta","display_name":"HSP90\u03b2","score":0.9279999732971191},{"id":"https://openalex.org/keywords/oncogenic-tyrosine-kinase","display_name":"oncogenic tyrosine kinase","score":0.7919999957084656},{"id":"https://openalex.org/keywords/leukemia","display_name":"leukemia","score":0.6620000004768372},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8240000009536743},{"id":"https://openalex.org/keywords/apoptosis-resistance","display_name":"apoptosis resistance","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C193349765","wikidata":"https://www.wikidata.org/wiki/Q2061363","display_name":"Apoptosome","level":5,"score":0.7019543051719666},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46822473406791687},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.3487599492073059},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2686966061592102},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07053375244140625},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.0},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.0},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:CiteSeerX.psu:10.1.1.885.8228","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.885.8228","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://dukespace.lib.duke.edu/dspace/bitstream/handle/10161/5787/Kim_duke_0066D_11520.pdf%3Bjsessionid%3DC721C91450D2FDD94A4D29FACD6A69AD?sequence%3D1","raw_type":"text"},{"id":"pmh:oai:dukespace.lib.duke.edu:10161/5787","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10161/5787","pdf_url":null,"source":{"id":"https://openalex.org/S4306400687","display_name":"DukeSpace (Duke University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I170897317","host_organization_name":"Duke University","host_organization_lineage":["https://openalex.org/I170897317"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dissertation"},{"id":"mag:90832251","doi":null,"is_oa":false,"landing_page_url":"https://dukespace.lib.duke.edu/dspace/bitstream/10161/5787/1/Kim_duke_0066D_11520.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8199999928474426,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":281,"referenced_works":["https://openalex.org/W7787382","https://openalex.org/W26566176","https://openalex.org/W165470091","https://openalex.org/W197615574","https://openalex.org/W221180449","https://openalex.org/W935855719","https://openalex.org/W1420696562","https://openalex.org/W1480948328","https://openalex.org/W1488282372","https://openalex.org/W1494965011","https://openalex.org/W1506642042","https://openalex.org/W1515506492","https://openalex.org/W1524671781","https://openalex.org/W1533153036","https://openalex.org/W1557686543","https://openalex.org/W1564236089","https://openalex.org/W1564408770","https://openalex.org/W1573146315","https://openalex.org/W1587753447","https://openalex.org/W1605728736","https://openalex.org/W1607777232","https://openalex.org/W1618299283","https://openalex.org/W1625702540","https://openalex.org/W1626908637","https://openalex.org/W1836073275","https://openalex.org/W1880638494","https://openalex.org/W1890121728","https://openalex.org/W1928548710","https://openalex.org/W1942297882","https://openalex.org/W1964209243","https://openalex.org/W1964420304","https://openalex.org/W1964483580","https://openalex.org/W1965286700","https://openalex.org/W1966687534","https://openalex.org/W1966939490","https://openalex.org/W1968505830","https://openalex.org/W1969150779","https://openalex.org/W1969855050","https://openalex.org/W1971621147","https://openalex.org/W1974075993","https://openalex.org/W1975232450","https://openalex.org/W1975320495","https://openalex.org/W1975667451","https://openalex.org/W1975857526","https://openalex.org/W1976141746","https://openalex.org/W1976312800","https://openalex.org/W1976692354","https://openalex.org/W1977258127","https://openalex.org/W1978406914","https://openalex.org/W1979039759","https://openalex.org/W1979107490","https://openalex.org/W1979895333","https://openalex.org/W1979909416","https://openalex.org/W1979977032","https://openalex.org/W1980771751","https://openalex.org/W1981259598","https://openalex.org/W1981301540","https://openalex.org/W1982144667","https://openalex.org/W1982878038","https://openalex.org/W1983721925","https://openalex.org/W1983821530","https://openalex.org/W1986819159","https://openalex.org/W1986889175","https://openalex.org/W1986889827","https://openalex.org/W1988636548","https://openalex.org/W1988728998","https://openalex.org/W1989280667","https://openalex.org/W1989357232","https://openalex.org/W1989524887","https://openalex.org/W1990011854","https://openalex.org/W1990199438","https://openalex.org/W1990283596","https://openalex.org/W1990425248","https://openalex.org/W1990801507","https://openalex.org/W1991455654","https://openalex.org/W1991865867","https://openalex.org/W1991868101","https://openalex.org/W1992435071","https://openalex.org/W1992746048","https://openalex.org/W1992902970","https://openalex.org/W1993614010","https://openalex.org/W1994637279","https://openalex.org/W1994792502","https://openalex.org/W1995496043","https://openalex.org/W1996476532","https://openalex.org/W1996743951","https://openalex.org/W1996892555","https://openalex.org/W1998571837","https://openalex.org/W2000352412","https://openalex.org/W2001010204","https://openalex.org/W2002145400","https://openalex.org/W2004980848","https://openalex.org/W2005441809","https://openalex.org/W2006917576","https://openalex.org/W2008063886","https://openalex.org/W2008079574","https://openalex.org/W2008258524","https://openalex.org/W2008369686","https://openalex.org/W2008910497","https://openalex.org/W2009165736","https://openalex.org/W2009826707","https://openalex.org/W2009966959","https://openalex.org/W2010194189","https://openalex.org/W2010243701","https://openalex.org/W2010495529","https://openalex.org/W2010547510","https://openalex.org/W2011177813","https://openalex.org/W2012051875","https://openalex.org/W2012173926","https://openalex.org/W2013052118","https://openalex.org/W2013583594","https://openalex.org/W2014447062","https://openalex.org/W2014983456","https://openalex.org/W2015871538","https://openalex.org/W2018929938","https://openalex.org/W2019431066","https://openalex.org/W2021581111","https://openalex.org/W2022285476","https://openalex.org/W2023018711","https://openalex.org/W2024306318","https://openalex.org/W2024445545","https://openalex.org/W2024923170","https://openalex.org/W2028551440","https://openalex.org/W2028803495","https://openalex.org/W2029130907","https://openalex.org/W2030546970","https://openalex.org/W2030923676","https://openalex.org/W2031469256","https://openalex.org/W2032163135","https://openalex.org/W2032164085","https://openalex.org/W2033240274","https://openalex.org/W2034862875","https://openalex.org/W2035040393","https://openalex.org/W2036180570","https://openalex.org/W2037170872","https://openalex.org/W2037422913","https://openalex.org/W2037658687","https://openalex.org/W2038248457","https://openalex.org/W2038588592","https://openalex.org/W2039597975","https://openalex.org/W2040360153","https://openalex.org/W2042100759","https://openalex.org/W2042316019","https://openalex.org/W2042409437","https://openalex.org/W2042625441","https://openalex.org/W2042830971","https://openalex.org/W2043963147","https://openalex.org/W2045563337","https://openalex.org/W2047708528","https://openalex.org/W2048168473","https://openalex.org/W2048990794","https://openalex.org/W2049202753","https://openalex.org/W2049219332","https://openalex.org/W2050054339","https://openalex.org/W2050339689","https://openalex.org/W2052788415","https://openalex.org/W2053656665","https://openalex.org/W2054192775","https://openalex.org/W2055042914","https://openalex.org/W2055203873","https://openalex.org/W2057604385","https://openalex.org/W2061541038","https://openalex.org/W2061738083","https://openalex.org/W2062014088","https://openalex.org/W2062268785","https://openalex.org/W2062289724","https://openalex.org/W2062853648","https://openalex.org/W2063526201","https://openalex.org/W2064495417","https://openalex.org/W2064698668","https://openalex.org/W2066756232","https://openalex.org/W2067534266","https://openalex.org/W2068444709","https://openalex.org/W2068753140","https://openalex.org/W2071075259","https://openalex.org/W2071909988","https://openalex.org/W2073672336","https://openalex.org/W2075809552","https://openalex.org/W2076485183","https://openalex.org/W2077697175","https://openalex.org/W2079524217","https://openalex.org/W2079948123","https://openalex.org/W2081145901","https://openalex.org/W2083560313","https://openalex.org/W2084472730","https://openalex.org/W2085601531","https://openalex.org/W2085643470","https://openalex.org/W2087128996","https://openalex.org/W2087450028","https://openalex.org/W2088238268","https://openalex.org/W2090725024","https://openalex.org/W2091501983","https://openalex.org/W2093628776","https://openalex.org/W2093833189","https://openalex.org/W2093857293","https://openalex.org/W2095346103","https://openalex.org/W2096882254","https://openalex.org/W2097347894","https://openalex.org/W2097767970","https://openalex.org/W2098536205","https://openalex.org/W2099803844","https://openalex.org/W2099941735","https://openalex.org/W2102067723","https://openalex.org/W2103072940","https://openalex.org/W2103854266","https://openalex.org/W2104588821","https://openalex.org/W2105209136","https://openalex.org/W2107789276","https://openalex.org/W2109743589","https://openalex.org/W2111305238","https://openalex.org/W2112127173","https://openalex.org/W2113280225","https://openalex.org/W2114125896","https://openalex.org/W2115772647","https://openalex.org/W2116745531","https://openalex.org/W2116764248","https://openalex.org/W2117303613","https://openalex.org/W2117394006","https://openalex.org/W2117820574","https://openalex.org/W2117998622","https://openalex.org/W2118084489","https://openalex.org/W2118161431","https://openalex.org/W2119683782","https://openalex.org/W2119800239","https://openalex.org/W2119874123","https://openalex.org/W2120490968","https://openalex.org/W2121796473","https://openalex.org/W2123513769","https://openalex.org/W2123619341","https://openalex.org/W2123671636","https://openalex.org/W2124880603","https://openalex.org/W2125751525","https://openalex.org/W2126376871","https://openalex.org/W2127450786","https://openalex.org/W2128170318","https://openalex.org/W2128483394","https://openalex.org/W2129925175","https://openalex.org/W2130135811","https://openalex.org/W2130603065","https://openalex.org/W2131627815","https://openalex.org/W2131924812","https://openalex.org/W2132411546","https://openalex.org/W2133697722","https://openalex.org/W2134919261","https://openalex.org/W2135570735","https://openalex.org/W2135603829","https://openalex.org/W2137221055","https://openalex.org/W2138892400","https://openalex.org/W2138971291","https://openalex.org/W2140787953","https://openalex.org/W2140805161","https://openalex.org/W2141267324","https://openalex.org/W2141595533","https://openalex.org/W2143067729","https://openalex.org/W2144654038","https://openalex.org/W2144701362","https://openalex.org/W2144841919","https://openalex.org/W2146226667","https://openalex.org/W2148561037","https://openalex.org/W2149967205","https://openalex.org/W2156712995","https://openalex.org/W2157761330","https://openalex.org/W2158460758","https://openalex.org/W2159582103","https://openalex.org/W2159594827","https://openalex.org/W2161583051","https://openalex.org/W2161839272","https://openalex.org/W2162653594","https://openalex.org/W2166239684","https://openalex.org/W2168182011","https://openalex.org/W2170425393","https://openalex.org/W2172196619","https://openalex.org/W2189820974","https://openalex.org/W2274981692","https://openalex.org/W2283944990","https://openalex.org/W2313180978","https://openalex.org/W2316761701","https://openalex.org/W2330398072","https://openalex.org/W2331087852","https://openalex.org/W2403474134","https://openalex.org/W2472672020"],"related_works":["https://openalex.org/W2128170318","https://openalex.org/W2101903202","https://openalex.org/W2791895358","https://openalex.org/W2035103468","https://openalex.org/W1999057673","https://openalex.org/W111319820","https://openalex.org/W2000989775","https://openalex.org/W2410565486","https://openalex.org/W6980795806","https://openalex.org/W2985896306"],"abstract_inverted_index":{"Apoptosis":[0],"is":[1,44,70,314,337],"a":[2,56,74,173,187,259,280,371,417,428],"cellular":[3,67,301],"suicide":[4],"program":[5],"that":[6,85,115,134,207,332,379,389],"can":[7,161,343],"be":[8,129,427],"initiated":[9],"by":[10,31,73,104,183,197,316,321,420],"various":[11],"genotoxic":[12],"and":[13,37,78,97,224,250,270,293,408],"cytotoxic":[14],"stimuli.":[15],"In":[16,131,306],"many":[17],"cases,":[18],"such":[19],"cell":[20,24,87,102,109,243,347,454,459,474],"damaging":[21],"agents":[22,422],"promote":[23],"death":[25,79,348,455],"through":[26,194],"the":[27,51,60,64,91,98,112,132,143,154,163,176,198,215,252,307,450,470],"intrinsic":[28],"apoptotic":[29,61,108,164,191,265,453,467],"pathway":[30],"triggering":[32],"mitochondrial":[33,149],"cytochrome":[34,42,150,179,218,256,304,465],"c":[35,43,151,219],"release":[36,152],"subsequent":[38],"caspase":[39,124,181],"activation.":[40],"Cytosolic":[41],"directly":[45],"responsible":[46,338],"for":[47,175,261,339,431],"initiating":[48],"formation":[49,122,223],"of":[50,66,119,145,148,156,178,190,209,217,231,267,283,296,356,362,441,443,452,472],"caspase-activating":[52],"apoptosome,":[53],"which":[54,342,394,421],"plays":[55],"crucial":[57],"role":[58,260],"in":[59,137,233,241,264,299,349,359,397,469],"process.":[62],"Given":[63],"importance":[65],"fate,":[68],"apoptosis":[69,146,313],"tightly":[71],"controlled":[72],"balance":[75],"between":[76],"survival":[77,88,159],"signals.":[80],"It":[81],"has":[82,126],"been":[83],"shown":[84],"activated":[86],"pathways,":[89],"including":[90],"mitogen-activated":[92],"protein":[93,333],"kinase":[94,202,319,373],"(MAPK)":[95],"cascade":[96],"PI3K/Akt":[99],"signaling,":[100,185],"enhance":[101],"viability":[103],"conferring":[105],"resistance":[106,266],"to":[107,117,128,167,211,220,248,255,303,345,369,403,412,457,476],"death.":[110],"However,":[111],"underlying":[113],"mechanism(s)":[114],"lead":[116],"inhibition":[118,177],"functional":[120],"apoptosome":[121,222,444],"(and":[123],"activation)":[125],"yet":[127],"elucidated.":[130],"studies":[133,415],"are":[135],"described":[136],"this":[138,434,462],"dissertation,":[139],"I":[140],"have":[141,205,330,377],"investigated":[142],"regulation":[144,192,285,442],"downstream":[147,226],"with":[153,273],"goal":[155],"understanding":[157],"how":[158,312,449],"signaling":[160,263,288,320,468],"alter":[162],"program,":[165],"contributing":[166],"human":[168],"malignancies.":[169],"First,":[170],"we":[171,310,376],"describe":[172],"mechanism":[174,419],"c-induced":[180,466],"activation":[182,240],"MAPK":[184,287],"identifying":[186],"novel":[188,281],"mode":[189],"exerted":[193],"Apaf-1":[195,249,291],"phosphorylation":[196,292],"90-kDa":[199],"ribosomal":[200],"S6":[201],"(Rsk).":[203],"We":[204,329],"found":[206],"recruitment":[208],"14-3-3\u03b5":[210,246],"phosphorylated":[212],"Ser268":[213],"impedes":[214],"ability":[216],"nucleate":[221],"activate":[225],"caspases.":[227],"High":[228],"endogenous":[229],"levels":[230],"Rsk":[232,239,262,275],"PC3":[234],"prostate":[235,268],"cancer":[236,458,473],"cells":[237,253,411],"or":[238],"other":[242,271],"types":[244],"promoted":[245],"binding":[247,295,402],"rendered":[251],"insensitive":[254],"c,":[257],"suggesting":[258],"cancers":[269,272],"elevated":[274],"activity.":[276],"These":[277,414],"results":[278,358],"identify":[279],"locus":[282],"apoptosomal":[284],"wherein":[286],"promotes":[289],"Rsk-catalyzed":[290],"consequent":[294],"14-3-3\u03b5,":[297],"resulting":[298],"decreased":[300],"responsiveness":[302,368,475],"c.":[305],"second":[308],"part,":[309],"examine":[311],"inhibited":[315,400],"oncogenic":[317,352],"tyrosine":[318,324,353],"using":[322],"leukemogenic":[323],"kinase-induced":[325],"leukemia":[326,350],"model":[327],"systems.":[328],"demonstrated":[331],"phosphatase":[334],"5":[335],"(PP5)":[336],"Hsp90\u03b2":[340,363,406],"hypophosphorylation,":[341],"contribute":[344],"impaired":[346],"expressing":[351],"kinases.":[354],"Loss":[355],"PP5":[357,382,401,424],"an":[360],"increase":[361],"phosphorylation,":[364],"raising":[365],"leukemic":[366,398],"cells'":[367],"imatinib,":[370],"BCR-ABL":[372],"inhibitor.":[374],"Further":[375],"discovered":[378],"acetylation":[380,391,425],"regulates":[381],"activity":[383],"on":[384,392],"Hsp90\u03b2.":[385],"Mutational":[386],"study":[387],"showed":[388],"K144":[390],"PP5,":[393],"was":[395],"diminished":[396],"conditions,":[399],"Hsp90\u03b2,":[404],"causing":[405],"hyperphosphorylation":[407],"subsequently":[409],"potentiating":[410],"apoptosis.":[413],"reveal":[416],"molecular":[418],"enhancing":[423],"may":[426],"potential":[429],"treatment":[430],"leukemias.":[432],"Collectively,":[433],"work":[435],"provides":[436],"new":[437],"insight":[438],"into":[439],"mechanisms":[440],"formation/function,":[445],"helping":[446],"us":[447],"understand":[448],"evasion":[451],"contributes":[456],"survival.":[460],"Further,":[461],"finding":[463],"implicates":[464],"context":[471],"chemotherapeutic":[477],"treatments.":[478]},"counts_by_year":[],"updated_date":"2026-08-26T07:47:46.906454","created_date":"2016-06-24T00:00:00"}
