{"id":"https://openalex.org/W90653394","doi":null,"title":"[The role of AMP-activated protein kinase in regulation of skeletal muscle metabolism].","display_name":"[The role of AMP-activated protein kinase in regulation of skeletal muscle metabolism].","publication_year":2010,"publication_date":"2010-10-21","ids":{"openalex":"https://openalex.org/W90653394","mag":"90653394","pmid":"https://pubmed.ncbi.nlm.nih.gov/20966509"},"language":"pl","primary_location":{"id":"pmid:20966509","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20966509","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Postepy higieny i medycyny doswiadczalnej (Online)","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071372277","display_name":"Anna Dziewulska","orcid":"https://orcid.org/0000-0002-5322-1259","observed_orcids":["https://orcid.org/0000-0002-5322-1259"]},"institutions":[{"id":"https://openalex.org/I16778253","display_name":"Instytut Biologii Do\u015bwiadczalnej im. Marcelego Nenckiego","ror":"https://ror.org/04waf7p94","country_code":"PL","type":"facility","lineage":["https://openalex.org/I16778253","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Anna Dziewulska","raw_affiliation_strings":["Pracownia Sygna\u0142\u00f3w Kom\u00f3rkowych i Zaburze\u0144 Metabolicznych, Instytut Biologii Do\u015bwiadczalnej im. M. Nenckiego PAN, Warszawa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pracownia Sygna\u0142\u00f3w Kom\u00f3rkowych i Zaburze\u0144 Metabolicznych, Instytut Biologii Do\u015bwiadczalnej im. M. Nenckiego PAN, Warszawa","institution_ids":["https://openalex.org/I16778253","https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042611184","display_name":"Pawe\u0142 Dobrzy\u0144","orcid":"https://orcid.org/0000-0002-2433-1897","observed_orcids":["https://orcid.org/0000-0002-2433-1897"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pawe\u0142 Dobrzy\u0144","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5045710613","display_name":"Agnieszka Dobrzy\u0144","orcid":"https://orcid.org/0000-0002-6331-9460","observed_orcids":["https://orcid.org/0000-0002-6331-9460"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Agnieszka Dobrzy\u0144","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.00773838,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"64","issue":null,"first_page":"513","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.9990000128746033},{"id":"https://openalex.org/keywords/skeletal-muscle-metabolism","display_name":"skeletal muscle metabolism","score":0.9539999961853027},{"id":"https://openalex.org/keywords/glucose-uptake","display_name":"glucose uptake","score":0.8870000243186951},{"id":"https://openalex.org/keywords/insulin-independent-glucose-uptake","display_name":"insulin-independent glucose uptake","score":0.9330000281333923},{"id":"https://openalex.org/keywords/fatty-acid-oxidation","display_name":"fatty acid oxidation","score":0.7799999713897705},{"id":"https://openalex.org/keywords/glycogen-storage","display_name":"glycogen storage","score":0.9860000014305115},{"id":"https://openalex.org/keywords/metformin","display_name":"metformin","score":0.8629999756813049},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.9150000214576721},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.9710000157356262},{"id":"https://openalex.org/keywords/glucose-homeostasis","display_name":"glucose homeostasis","score":0.9660000205039978},{"id":"https://openalex.org/keywords/ampk-phosphorylation","display_name":"AMPK phosphorylation","score":0.6190000176429749},{"id":"https://openalex.org/keywords/upstream-kinases","display_name":"upstream kinases","score":0.48500001430511475}],"concepts":[{"id":"https://openalex.org/C2780124434","wikidata":"https://www.wikidata.org/wiki/Q12357464","display_name":"AMPK","level":4,"score":0.9449636936187744},{"id":"https://openalex.org/C2776780712","wikidata":"https://www.wikidata.org/wiki/Q295240","display_name":"AMP-activated protein kinase","level":5,"score":0.7274935841560364},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.6717382669448853},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.6523849964141846},{"id":"https://openalex.org/C2777866211","wikidata":"https://www.wikidata.org/wiki/Q5572349","display_name":"Glucose uptake","level":3,"score":0.611122727394104},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5019395351409912},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.46164077520370483},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4580818712711334},{"id":"https://openalex.org/C96942376","wikidata":"https://www.wikidata.org/wiki/Q21130714","display_name":"Catabolism","level":3,"score":0.4274854063987732},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3964485228061676},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38951411843299866},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3438130021095276},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.3358524739742279},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.25844806432724}],"mesh":[{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:20966509","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20966509","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Postepy higieny i medycyny doswiadczalnej (Online)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:95d92b9f51fb4998b6a911ed7d1ce1a8","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/95d92b9f51fb4998b6a911ed7d1ce1a8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Post\u0119py Higieny i Medycyny Do\u015bwiadczalnej, Vol 64, Iss 840537, Pp 513-521 (2010)","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1963568376","https://openalex.org/W4306175019","https://openalex.org/W1974550672","https://openalex.org/W1981275437","https://openalex.org/W2101305004","https://openalex.org/W2134304387","https://openalex.org/W2347761497","https://openalex.org/W2031565825","https://openalex.org/W2113053818","https://openalex.org/W2140398930"],"abstract_inverted_index":{"AMP-activated":[0],"protein":[1],"kinase":[2],"(AMPK)":[3],"is":[4,12,27,102,114,137],"a":[5,37,143],"conserved,":[6],"ubiquitously":[7],"expressed":[8],"eukaryotic":[9],"enzyme":[10],"that":[11,100,116,132,153],"activated":[13],"in":[14,24,78,85,92,169,176],"response":[15,86],"to":[16,87,146],"increasing":[17],"AMP":[18],"level.":[19],"Regulation":[20],"of":[21,40,64,107,124,127,138,167],"AMPK":[22,46,65,88,101,117,128,168],"activity":[23],"skeletal":[25,79,134],"muscle":[26,135],"coordinated":[28],"by":[29,33],"contraction":[30],"and":[31,36,42,52,61,69,73,112,141,171],"phosphorylation":[32],"upstream":[34],"kinases":[35],"growing":[38],"number":[39],"hormones":[41],"cytokines.":[43],"Once":[44],"activated,":[45],"turns":[47,53],"on":[48,163],"catabolic,":[49],"ATP-generating":[50],"pathways,":[51],"off":[54],"ATP-consuming":[55],"metabolic":[56],"processes":[57],"such":[58],"as":[59],"biosynthesis":[60],"proliferation.":[62],"Activation":[63],"promotes":[66],"glucose":[67,83,177],"uptake":[68,84],"fatty":[70],"acid":[71],"oxidation,":[72],"enhances":[74],"glycogen":[75],"storage":[76],"capacity":[77],"muscle.":[80],"Interestingly,":[81],"increased":[82],"activation":[89],"may":[90,118],"occur":[91],"an":[93,103],"insulin-independent":[94],"manner.":[95],"It":[96],"has":[97],"been":[98],"confirmed":[99],"indirect":[104],"molecular":[105,130],"target":[106],"the":[108,164],"antidiabetic":[109],"drug":[110],"metformin,":[111],"it":[113],"postulated":[115],"be":[119],"responsible":[120],"for":[121],"health":[122],"benefits":[123],"exercise.":[125],"Understanding":[126],"involving":[129],"pathways":[131],"govern":[133],"metabolism":[136],"special":[139],"interest":[140],"offers":[142],"unique":[144],"possibility":[145],"find":[147],"new":[148],"physiological":[149,165],"and/or":[150],"pharmacological":[151],"strategies":[152],"can":[154],"improve":[155],"insulin":[156],"sensitivity.":[157],"Here":[158],"we":[159],"review":[160],"present":[161],"knowledge":[162],"function":[166],"muscle,":[170],"highlight":[172],"its":[173],"potential":[174],"role":[175],"homeostasis":[178],"regulation.":[179]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
