{"id":"https://openalex.org/W90587980","doi":"https://doi.org/10.1023/a:1014568904957","title":"Bioreactor production of camptothecin by hairy root cultures of Ophiorrhiza pumila","display_name":"Bioreactor production of camptothecin by hairy root cultures of Ophiorrhiza pumila","publication_year":2002,"publication_date":"2002-03-01","ids":{"openalex":"https://openalex.org/W90587980","doi":"https://doi.org/10.1023/a:1014568904957","mag":"90587980"},"language":"en","primary_location":{"id":"doi:10.1023/a:1014568904957","doi":"https://doi.org/10.1023/a:1014568904957","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1014568904957","pdf_url":null,"source":{"id":"https://openalex.org/S113993733","display_name":"Biotechnology Letters","issn_l":"0141-5492","issn":["0141-5492","1573-6776"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019850682","display_name":"Hiroshi Sudo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Sudo","raw_affiliation_strings":["Department of Molecular Biology and Biotechnology and Department of Molecular Structure and Biological Function, Graduate school of Pharmaceutical Sciences, Chiba University, Yayoi-cho 1-33, Inage-ku, Chiba, 263-8522, Japan","Department of Molecular Biology and Biotechnology and Department of Molecular Structure and Biological Function, Graduate school of Pharmaceutical Sciences, Chiba University, Inage-ku, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology and Department of Molecular Structure and Biological Function, Graduate school of Pharmaceutical Sciences, Chiba University, Yayoi-cho 1-33, Inage-ku, Chiba, 263-8522, Japan","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology and Department of Molecular Structure and Biological Function, Graduate school of Pharmaceutical Sciences, Chiba University, Inage-ku, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101434972","display_name":"Takashi Yamakawa","orcid":"https://orcid.org/0000-0002-9528-9198","observed_orcids":["https://orcid.org/0000-0002-9528-9198"]},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Yamakawa","raw_affiliation_strings":["Department of Global Agricultural Sciences, The University of Tokyo, Yayoi 1-chome, Bunkyo-ku, Tokyo, 113-8657, Japan","Department of Global Agricultural Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Global Agricultural Sciences, The University of Tokyo, Yayoi 1-chome, Bunkyo-ku, Tokyo, 113-8657, Japan","institution_ids":["https://openalex.org/I74801974"]},{"raw_affiliation_string":"Department of Global Agricultural Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055464615","display_name":"Mami Yamazaki","orcid":"https://orcid.org/0000-0001-6157-5287","observed_orcids":["https://orcid.org/0000-0001-6157-5287"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mami Yamazaki","raw_affiliation_strings":["Department of Molecular Biology and Biotechnology and Department of Molecular Structure and Biological Function, Graduate school of Pharmaceutical Sciences, Chiba University, Yayoi-cho 1-33, Inage-ku, Chiba, 263-8522, Japan","Department of Molecular Biology and Biotechnology and Department of Molecular Structure and Biological Function, Graduate school of Pharmaceutical Sciences, Chiba University, Inage-ku, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology and Department of Molecular Structure and Biological Function, Graduate school of Pharmaceutical Sciences, Chiba University, Yayoi-cho 1-33, Inage-ku, Chiba, 263-8522, Japan","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology and Department of Molecular Structure and Biological Function, Graduate school of Pharmaceutical Sciences, Chiba University, Inage-ku, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111785969","display_name":"Norio Aimi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Norio Aimi","raw_affiliation_strings":["Department of Molecular Structure and Biological Function, Graduate school of Pharmaceutical Sciences, Chiba University, Yayoi-cho 1-33, Inage-ku, Chiba, 263-8522, Japan","Department of Molecular Structure and Biological Function, Graduate school of Pharmaceutical Sciences, Chiba University, Inage-ku, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Structure and Biological Function, Graduate school of Pharmaceutical Sciences, Chiba University, Yayoi-cho 1-33, Inage-ku, Chiba, 263-8522, Japan","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Department of Molecular Structure and Biological Function, Graduate school of Pharmaceutical Sciences, Chiba University, Inage-ku, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052696406","display_name":"Kazuki Saito","orcid":"https://orcid.org/0000-0001-6310-5342","observed_orcids":["https://orcid.org/0000-0001-6310-5342","https://orcid.org/0000-0003-1117-7648","https://orcid.org/0009-0005-5571-884X","https://orcid.org/0000-0001-8590-9800"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kazuki Saito","raw_affiliation_strings":["Department of Molecular Biology and Biotechnology and Department of Molecular Structure and Biological Function, Graduate school of Pharmaceutical Sciences, Chiba University, Yayoi-cho 1-33, Inage-ku, Chiba, 263-8522, Japan","Department of Molecular Biology and Biotechnology and Department of Molecular Structure and Biological Function, Graduate school of Pharmaceutical Sciences, Chiba University, Inage-ku, Chiba, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology and Department of Molecular Structure and Biological Function, Graduate school of Pharmaceutical Sciences, Chiba University, Yayoi-cho 1-33, Inage-ku, Chiba, 263-8522, Japan","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Department of Molecular Biology and Biotechnology and Department of Molecular Structure and Biological Function, Graduate school of Pharmaceutical Sciences, Chiba University, Inage-ku, Chiba, Japan","institution_ids":["https://openalex.org/I159385669"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5052696406"],"corresponding_institution_ids":["https://openalex.org/I159385669"],"apc_list":{"value":3890,"currency":"USD","value_usd":3890},"apc_paid":null,"fwci":4.4159,"has_fulltext":false,"cited_by_count":95,"citation_normalized_percentile":{"value":0.9370509,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"24","issue":"5","first_page":"359","last_page":"363"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10240","display_name":"Plant tissue culture and regeneration","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10240","display_name":"Plant tissue culture and regeneration","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12856","display_name":"Transgenic Plants and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/camptothecin","display_name":"camptothecin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/ophiorrhiza-pumila","display_name":"Ophiorrhiza pumila","score":0.9829999804496765},{"id":"https://openalex.org/keywords/hairy-root-culture","display_name":"hairy root culture","score":0.9350000023841858},{"id":"https://openalex.org/keywords/bioreactor-culture","display_name":"bioreactor cultivation","score":0.7910000085830688},{"id":"https://openalex.org/keywords/agrobacterium-rhizogenes","display_name":"Agrobacterium rhizogenes","score":0.9810000061988831},{"id":"https://openalex.org/keywords/quinoline-alkaloids","display_name":"quinoline alkaloids","score":0.8479999899864197},{"id":"https://openalex.org/keywords/secondary-metabolite-production","display_name":"secondary metabolite production","score":0.7670000195503235}],"concepts":[{"id":"https://openalex.org/C2779682216","wikidata":"https://www.wikidata.org/wiki/Q419964","display_name":"Camptothecin","level":2,"score":0.9496328830718994},{"id":"https://openalex.org/C168170006","wikidata":"https://www.wikidata.org/wiki/Q864699","display_name":"Bioreactor","level":2,"score":0.7758012413978577},{"id":"https://openalex.org/C2779656422","wikidata":"https://www.wikidata.org/wiki/Q2700446","display_name":"Agrobacterium","level":4,"score":0.6930980086326599},{"id":"https://openalex.org/C2777667214","wikidata":"https://www.wikidata.org/wiki/Q70702","display_name":"Alkaloid","level":2,"score":0.6915388107299805},{"id":"https://openalex.org/C2776309666","wikidata":"https://www.wikidata.org/wiki/Q408384","display_name":"Quinoline","level":2,"score":0.6505184173583984},{"id":"https://openalex.org/C157428477","wikidata":"https://www.wikidata.org/wiki/Q5639642","display_name":"Hairy root culture","level":5,"score":0.579432487487793},{"id":"https://openalex.org/C90703135","wikidata":"https://www.wikidata.org/wiki/Q3287622","display_name":"Tissue culture","level":3,"score":0.4550614356994629},{"id":"https://openalex.org/C9549007","wikidata":"https://www.wikidata.org/wiki/Q1072909","display_name":"Callus","level":2,"score":0.4375317394733429},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43116265535354614},{"id":"https://openalex.org/C27881333","wikidata":"https://www.wikidata.org/wiki/Q864895","display_name":"Biotransformation","level":3,"score":0.4261193871498108},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.422049343585968},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.4150926470756531},{"id":"https://openalex.org/C204241405","wikidata":"https://www.wikidata.org/wiki/Q461499","display_name":"Transformation (genetics)","level":3,"score":0.2025027871131897},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17491286993026733},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.16275912523269653},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.14218956232070923},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07880237698554993},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1023/a:1014568904957","doi":"https://doi.org/10.1023/a:1014568904957","is_oa":false,"landing_page_url":"https://doi.org/10.1023/a:1014568904957","pdf_url":null,"source":{"id":"https://openalex.org/S113993733","display_name":"Biotechnology Letters","issn_l":"0141-5492","issn":["0141-5492","1573-6776"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biotechnology Letters","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4043000042438507,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W25389467","https://openalex.org/W1571410963","https://openalex.org/W1971048504","https://openalex.org/W1971523530","https://openalex.org/W2007369532","https://openalex.org/W2014198144","https://openalex.org/W2018185888","https://openalex.org/W2019590605","https://openalex.org/W2034609461","https://openalex.org/W2044704327","https://openalex.org/W2053989646","https://openalex.org/W2058029076","https://openalex.org/W2073682960","https://openalex.org/W2077545872","https://openalex.org/W2141647694","https://openalex.org/W2399911079","https://openalex.org/W6603617293"],"related_works":["https://openalex.org/W2073682960","https://openalex.org/W7054858584","https://openalex.org/W2391332638","https://openalex.org/W2077935447","https://openalex.org/W2264825877","https://openalex.org/W2440277430","https://openalex.org/W131654959","https://openalex.org/W2354400015","https://openalex.org/W2781507379","https://openalex.org/W2607750499"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
