{"id":"https://openalex.org/W90516274","doi":"https://doi.org/10.1096/fasebj.21.6.a1317-c","title":"Ethanol inhibits gastric acid secretion in rats through increased AMP\u2010K activity","display_name":"Ethanol inhibits gastric acid secretion in rats through increased AMP\u2010K activity","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W90516274","doi":"https://doi.org/10.1096/fasebj.21.6.a1317-c","mag":"90516274"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.21.6.a1317-c","doi":"https://doi.org/10.1096/fasebj.21.6.a1317-c","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.6.a1317-c","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004434507","display_name":"Stefanie Corradini","orcid":"https://orcid.org/0000-0001-8709-7252","observed_orcids":["https://orcid.org/0000-0001-8709-7252"]},"institutions":[{"id":"https://openalex.org/I27945538","display_name":"Paracelsus Medical University","ror":"https://ror.org/03z3mg085","country_code":"AT","type":"education","lineage":["https://openalex.org/I27945538"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["AT","US"],"is_corresponding":false,"raw_author_name":"Stefanie Corradini","raw_affiliation_strings":["Department of Surgery & Department of Cellular and Molecular PhysiologyYale UniversitySchool of Medicine310 Cedar streetNew HavenCT06520","Institute of Physiology and Pathophysiology, Paracelsus Private Medical University, Strubergasse 21, Salzburg, 5020 Austria","Department of Surgery & Department of Cellular and Molecular Physiology, Yale University, School of Medicine, 310 Cedar street, New Haven, CT, 06520"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery & Department of Cellular and Molecular PhysiologyYale UniversitySchool of Medicine310 Cedar streetNew HavenCT06520","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Institute of Physiology and Pathophysiology, Paracelsus Private Medical University, Strubergasse 21, Salzburg, 5020 Austria","institution_ids":["https://openalex.org/I27945538"]},{"raw_affiliation_string":"Department of Surgery & Department of Cellular and Molecular Physiology, Yale University, School of Medicine, 310 Cedar street, New Haven, CT, 06520","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004840502","display_name":"Sascha Kopic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27945538","display_name":"Paracelsus Medical University","ror":"https://ror.org/03z3mg085","country_code":"AT","type":"education","lineage":["https://openalex.org/I27945538"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["AT","US"],"is_corresponding":false,"raw_author_name":"Sascha Kopic","raw_affiliation_strings":["Department of Surgery & Department of Cellular and Molecular PhysiologyYale UniversitySchool of Medicine310 Cedar streetNew HavenCT06520","Institute of Physiology and Pathophysiology, Paracelsus Private Medical University, Strubergasse 21, Salzburg, 5020 Austria","Department of Surgery & Department of Cellular and Molecular Physiology, Yale University, School of Medicine, 310 Cedar street, New Haven, CT, 06520"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery & Department of Cellular and Molecular PhysiologyYale UniversitySchool of Medicine310 Cedar streetNew HavenCT06520","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Institute of Physiology and Pathophysiology, Paracelsus Private Medical University, Strubergasse 21, Salzburg, 5020 Austria","institution_ids":["https://openalex.org/I27945538"]},{"raw_affiliation_string":"Department of Surgery & Department of Cellular and Molecular Physiology, Yale University, School of Medicine, 310 Cedar street, New Haven, CT, 06520","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025390295","display_name":"Markus Ritter","orcid":"https://orcid.org/0000-0001-7346-7750","observed_orcids":["https://orcid.org/0000-0001-7346-7750"]},"institutions":[{"id":"https://openalex.org/I27945538","display_name":"Paracelsus Medical University","ror":"https://ror.org/03z3mg085","country_code":"AT","type":"education","lineage":["https://openalex.org/I27945538"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Markus Ritter","raw_affiliation_strings":["Institute of Physiology and Pathophysiology, Paracelsus Private Medical University, Strubergasse 21, Salzburg, 5020 Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Physiology and Pathophysiology, Paracelsus Private Medical University, Strubergasse 21, Salzburg, 5020 Austria","institution_ids":["https://openalex.org/I27945538"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065040724","display_name":"John Peter Geibel","orcid":"https://orcid.org/0000-0003-1147-7501","observed_orcids":["https://orcid.org/0000-0003-1147-7501"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Geibel","raw_affiliation_strings":["Department of Surgery & Department of Cellular and Molecular PhysiologyYale UniversitySchool of Medicine310 Cedar streetNew HavenCT06520","Department of Surgery & Department of Cellular and Molecular Physiology, Yale University, School of Medicine, 310 Cedar street, New Haven, CT, 06520"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery & Department of Cellular and Molecular PhysiologyYale UniversitySchool of Medicine310 Cedar streetNew HavenCT06520","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Surgery & Department of Cellular and Molecular Physiology, Yale University, School of Medicine, 310 Cedar street, New Haven, CT, 06520","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0104647,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.4165000021457672,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.4165000021457672,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.1906999945640564,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects","score":0.1387999951839447,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ethanol","display_name":"ethanol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gastric-acid-secretion","display_name":"gastric acid secretion","score":0.9950000047683716},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.8970000147819519},{"id":"https://openalex.org/keywords/ampk-activation","display_name":"AMPK activation","score":0.5220000147819519},{"id":"https://openalex.org/keywords/compound-c","display_name":"compound C","score":0.7129999995231628},{"id":"https://openalex.org/keywords/parietal-cells","display_name":"parietal cells","score":0.8730000257492065},{"id":"https://openalex.org/keywords/carbachol","display_name":"carbachol","score":0.7620000243186951},{"id":"https://openalex.org/keywords/histamine","display_name":"histamine","score":0.996999979019165},{"id":"https://openalex.org/keywords/alkalinization","display_name":"alkalization","score":0.6859999895095825},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.460999995470047},{"id":"https://openalex.org/keywords/low-dose-ethanol","display_name":"low-dose ethanol","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C2780161494","wikidata":"https://www.wikidata.org/wiki/Q3510429","display_name":"Secretagogue","level":3,"score":0.9741631150245667},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.695863664150238},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.6412913799285889},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.6385289430618286},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.6093897819519043},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.556342601776123},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5493651032447815},{"id":"https://openalex.org/C2777504413","wikidata":"https://www.wikidata.org/wiki/Q846270","display_name":"Gastric acid","level":3,"score":0.5306963324546814},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34325680136680603},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22298088669776917},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06016191840171814}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.21.6.a1317-c","doi":"https://doi.org/10.1096/fasebj.21.6.a1317-c","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.6.a1317-c","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2072654859","https://openalex.org/W2065974210","https://openalex.org/W2431554407","https://openalex.org/W1564191357","https://openalex.org/W2072717587","https://openalex.org/W2031560298","https://openalex.org/W1885740345","https://openalex.org/W2007541893","https://openalex.org/W221859105","https://openalex.org/W2062153480"],"abstract_inverted_index":{"We":[0,152],"have":[1],"previously":[2],"shown":[3],"that":[4,154],"short-term":[5],"(15\u201320":[6],"min)":[7],"low":[8,155],"dose":[9,156],"(1\u20132%)":[10],"ethanol":[11,27,95,114,147,157,192],"exposure":[12,179],"inhibits":[13,158],"secretagogue-induced":[14,135,149],"acid":[15,136,150,160],"secretion.":[16,137,151],"In":[17,90,110],"the":[18,23,49,102,130,143,165,181,201],"present":[19],"study":[20],"we":[21],"investigate":[22],"potential":[24],"interactions":[25],"of":[26,34,40,84,93,104,129,139,146,164],"with":[28,48,119],"AMP-Kinase":[29],"(AMP-K),":[30],"a":[31,38,79,111,188],"potent":[32],"modulator":[33],"energy-dependent":[35],"processes":[36],"in":[37,117,168],"variety":[39],"cells.":[41,172],"Individual":[42],"rat":[43,169],"gastric":[44,170],"glands":[45,69],"were":[46,59,70,86],"incubated":[47],"pH-sensitive":[50],"dye":[51],"BCECF.":[52],"The":[53],"secretagogues":[54,108],"carbachol":[55],"or":[56],"histamine":[57],"(200\u03bcM)":[58],"added":[60,97,116],"during":[61],"dye-loading":[62],"and":[63,78,101,193],"to":[64,73,98,107,126,180],"all":[65,99],"solutions.":[66],"Following":[67],"loading,":[68],"subsequently":[71],"exposed":[72],"an":[74,123],"NH4Cl":[75],"prepulse":[76],"(20mM)":[77],"0mM":[80],"Na+":[81],"solution.":[82],"Rates":[83],"alkalinization":[85,105],"calculated":[87],"as":[88],"dpHi/dT.":[89],"one":[91],"series":[92,113],"experiments":[94],"was":[96,115,198],"solutions":[100],"rate":[103],"compared":[106],"alone.":[109],"separate":[112],"combination":[118],"compound":[120,140,184],"C":[121,141],"(20\u03bcM)":[122],"AMP-K":[124,166,182,194],"inhibitor":[125,183],"prevent":[127],"activation":[128,163],"AMP-K.":[131],"Ethanol":[132],"significantly":[133],"suppressed":[134],"Addition":[138],"reversed":[142,177],"inhibitory":[144],"effects":[145],"on":[148],"demonstrate":[153],"secretagogue-dependent":[159],"secretion":[161],"by":[162,178,200],"pathway":[167],"parietal":[171],"This":[173,196],"inhibition":[174],"can":[175],"be":[176],"C,":[185],"further":[186],"suggesting":[187],"strong":[189],"link":[190],"between":[191],"activation.":[195],"work":[197],"supported":[199],"Ohse":[202],"Fund.":[203]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}