{"id":"https://openalex.org/W904010255","doi":null,"title":"Connecting Ca2+ Stores and Parkinson Disease","display_name":"Connecting Ca2+ Stores and Parkinson Disease","publication_year":2015,"publication_date":"2015-02-28","ids":{"openalex":"https://openalex.org/W904010255","mag":"904010255"},"language":"en","primary_location":{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1462165","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/1462165/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012911477","display_name":"Bethan S. Kilpatrick","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"BS Kilpatrick","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5012911477"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.7720000147819519},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-calcium","display_name":"endoplasmic reticulum calcium","score":0.843999981880188},{"id":"https://openalex.org/keywords/calcium-oscillations","display_name":"calcium oscillations","score":0.8370000123977661},{"id":"https://openalex.org/keywords/ip3-receptor","display_name":"IP3 receptor","score":0.9150000214576721},{"id":"https://openalex.org/keywords/rab7","display_name":"Rab7","score":0.8709999918937683},{"id":"https://openalex.org/keywords/trpml","display_name":"TRPML","score":0.8019999861717224},{"id":"https://openalex.org/keywords/naadp","display_name":"NAADP","score":0.6190000176429749},{"id":"https://openalex.org/keywords/gaucher-disease","display_name":"Gaucher disease","score":0.8600000143051147},{"id":"https://openalex.org/keywords/gba1","display_name":"GBA1","score":0.9259999990463257},{"id":"https://openalex.org/keywords/glucocerebrosidase","display_name":"glucocerebrosidase","score":0.9890000224113464},{"id":"https://openalex.org/keywords/lrrk2","display_name":"LRRK2","score":0.9480000138282776},{"id":"https://openalex.org/keywords/tpc2","display_name":"TPC2","score":0.949999988079071},{"id":"https://openalex.org/keywords/lysosomal-morphology","display_name":"lysosomal morphology","score":0.8830000162124634},{"id":"https://openalex.org/keywords/cyclic-adp-ribose","display_name":"cyclic ADP-ribose","score":0.8569999933242798},{"id":"https://openalex.org/keywords/ryanodine-receptor","display_name":"ryanodine receptor","score":0.8040000200271606}],"concepts":[{"id":"https://openalex.org/C2780216420","wikidata":"https://www.wikidata.org/wiki/Q83330","display_name":"Lysosome","level":3,"score":0.7865422964096069},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.7793442606925964},{"id":"https://openalex.org/C113217602","wikidata":"https://www.wikidata.org/wiki/Q416781","display_name":"Ryanodine receptor","level":3,"score":0.7717630863189697},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6112770438194275},{"id":"https://openalex.org/C152624196","wikidata":"https://www.wikidata.org/wiki/Q418917","display_name":"Inositol trisphosphate receptor","level":4,"score":0.5965198874473572},{"id":"https://openalex.org/C201571599","wikidata":"https://www.wikidata.org/wiki/Q5018840","display_name":"Calcium signaling","level":3,"score":0.5113003253936768},{"id":"https://openalex.org/C2780674200","wikidata":"https://www.wikidata.org/wiki/Q420038","display_name":"Glucocerebrosidase","level":3,"score":0.463307648897171},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45776844024658203},{"id":"https://openalex.org/C2778264360","wikidata":"https://www.wikidata.org/wiki/Q675010","display_name":"Lysosomal storage disease","level":3,"score":0.4242640733718872},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.412662148475647},{"id":"https://openalex.org/C163235415","wikidata":"https://www.wikidata.org/wiki/Q899814","display_name":"Second messenger system","level":3,"score":0.4111044108867645},{"id":"https://openalex.org/C2777427919","wikidata":"https://www.wikidata.org/wiki/Q407997","display_name":"Inositol","level":3,"score":0.3959365487098694},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3756659924983978},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2801753282546997},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2614750862121582},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.25912928581237793}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1462165","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/1462165/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},{"id":"mag:904010255","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/1462165/","pdf_url":null,"source":{"id":"https://openalex.org/S4306508231","display_name":"Doctoral thesis, UCL (University College London).","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":167,"referenced_works":["https://openalex.org/W126348829","https://openalex.org/W1482593432","https://openalex.org/W1485297825","https://openalex.org/W1489503277","https://openalex.org/W1495978914","https://openalex.org/W1509821238","https://openalex.org/W1510439895","https://openalex.org/W1566076711","https://openalex.org/W1574174694","https://openalex.org/W1579421676","https://openalex.org/W1591724033","https://openalex.org/W1615545200","https://openalex.org/W1782667879","https://openalex.org/W1859398825","https://openalex.org/W1953311373","https://openalex.org/W1963791094","https://openalex.org/W1965888147","https://openalex.org/W1966467373","https://openalex.org/W1968112618","https://openalex.org/W1968222832","https://openalex.org/W1969637387","https://openalex.org/W1969800514","https://openalex.org/W1970318769","https://openalex.org/W1970997423","https://openalex.org/W1972097907","https://openalex.org/W1972965665","https://openalex.org/W1973391847","https://openalex.org/W1981284599","https://openalex.org/W1982221081","https://openalex.org/W1987167495","https://openalex.org/W1987787530","https://openalex.org/W1990045885","https://openalex.org/W1990387678","https://openalex.org/W1993696187","https://openalex.org/W1995863785","https://openalex.org/W1997527771","https://openalex.org/W1997778815","https://openalex.org/W1997935934","https://openalex.org/W1998855882","https://openalex.org/W1999823721","https://openalex.org/W2000846031","https://openalex.org/W2002287591","https://openalex.org/W2002791298","https://openalex.org/W2003126320","https://openalex.org/W2003220014","https://openalex.org/W2003418906","https://openalex.org/W2003883601","https://openalex.org/W2004095661","https://openalex.org/W2005560465","https://openalex.org/W2005843441","https://openalex.org/W2007348345","https://openalex.org/W2012467728","https://openalex.org/W2012480312","https://openalex.org/W2012751980","https://openalex.org/W2013323818","https://openalex.org/W2013798123","https://openalex.org/W2014253236","https://openalex.org/W2015337645","https://openalex.org/W2018903124","https://openalex.org/W2019817056","https://openalex.org/W2022446710","https://openalex.org/W2028983576","https://openalex.org/W2029028848","https://openalex.org/W2029198171","https://openalex.org/W2030983907","https://openalex.org/W2031365272","https://openalex.org/W2031790758","https://openalex.org/W2035138229","https://openalex.org/W2035258856","https://openalex.org/W2037937489","https://openalex.org/W2038404508","https://openalex.org/W2042861001","https://openalex.org/W2044859092","https://openalex.org/W2046353863","https://openalex.org/W2049155506","https://openalex.org/W2050376414","https://openalex.org/W2050442651","https://openalex.org/W2050824263","https://openalex.org/W2052985285","https://openalex.org/W2054561574","https://openalex.org/W2054843536","https://openalex.org/W2055236806","https://openalex.org/W2055570767","https://openalex.org/W2057665893","https://openalex.org/W2057979657","https://openalex.org/W2059052368","https://openalex.org/W2062619493","https://openalex.org/W2063327869","https://openalex.org/W2065471120","https://openalex.org/W2067841051","https://openalex.org/W2068288454","https://openalex.org/W2069945478","https://openalex.org/W2071089917","https://openalex.org/W2075094914","https://openalex.org/W2076743021","https://openalex.org/W2077499130","https://openalex.org/W2077649619","https://openalex.org/W2078005095","https://openalex.org/W2079064010","https://openalex.org/W2079133058","https://openalex.org/W2079378641","https://openalex.org/W2080070582","https://openalex.org/W2080110261","https://openalex.org/W2080768598","https://openalex.org/W2081102375","https://openalex.org/W2081809860","https://openalex.org/W2082274457","https://openalex.org/W2083243127","https://openalex.org/W2087360216","https://openalex.org/W2087801016","https://openalex.org/W2088093088","https://openalex.org/W2090728253","https://openalex.org/W2091304198","https://openalex.org/W2092214148","https://openalex.org/W2092793930","https://openalex.org/W2093024075","https://openalex.org/W2093722439","https://openalex.org/W2093883442","https://openalex.org/W2099884882","https://openalex.org/W2100300726","https://openalex.org/W2100894616","https://openalex.org/W2104757714","https://openalex.org/W2108326484","https://openalex.org/W2109234448","https://openalex.org/W2109523366","https://openalex.org/W2110157421","https://openalex.org/W2110551795","https://openalex.org/W2110831253","https://openalex.org/W2111698016","https://openalex.org/W2111741341","https://openalex.org/W2113326963","https://openalex.org/W2114206069","https://openalex.org/W2118278336","https://openalex.org/W2121330845","https://openalex.org/W2122072833","https://openalex.org/W2123431154","https://openalex.org/W2124034869","https://openalex.org/W2131685088","https://openalex.org/W2133411368","https://openalex.org/W2136412900","https://openalex.org/W2138786573","https://openalex.org/W2139119152","https://openalex.org/W2139209671","https://openalex.org/W2139369185","https://openalex.org/W2139625864","https://openalex.org/W2140225001","https://openalex.org/W2142583550","https://openalex.org/W2144037754","https://openalex.org/W2148049759","https://openalex.org/W2149062606","https://openalex.org/W2150656456","https://openalex.org/W2153188271","https://openalex.org/W2155211555","https://openalex.org/W2155842024","https://openalex.org/W2157869491","https://openalex.org/W2162829549","https://openalex.org/W2163130181","https://openalex.org/W2164455918","https://openalex.org/W2165319889","https://openalex.org/W2165465283","https://openalex.org/W2165573061","https://openalex.org/W2166432730","https://openalex.org/W2168126136","https://openalex.org/W2168983594","https://openalex.org/W2169635583","https://openalex.org/W2314785865","https://openalex.org/W2492158827"],"related_works":["https://openalex.org/W2157869491","https://openalex.org/W2052047416","https://openalex.org/W7065338802","https://openalex.org/W4390445495","https://openalex.org/W2168983594","https://openalex.org/W2908776490","https://openalex.org/W2613415790","https://openalex.org/W2992655999","https://openalex.org/W3123784072","https://openalex.org/W4319459905"],"abstract_inverted_index":{"Accumulating":[0],"evidence":[1],"implicates":[2],"lysosomes":[3,35],"as":[4],"mobilisable":[5],"stores":[6,112,214,285],"of":[7,34,76,89,109,186,211,273],"Ca2+,":[8],"but":[9],"their":[10,290],"relationship":[11],"to":[12,115,169,220,268,295],"the":[13,30,77,90,103,145,149,170,238,247],"better-characterised":[14],"endoplasmic":[15],"reticulum":[16],"(ER)":[17],"Ca2+":[18,40,48,64,84,99,104,111,118,129,154,177,195,213,270,284],"store":[19],"and":[20,59,73,137,164,201,203,262,289],"significance":[21],"for":[22],"disease":[23,135,139],"remains":[24],"unclear.":[25],"Here":[26],"I":[27,126,223],"show":[28],"that":[29,54,66,123],"rapid":[31],"osmotic":[32],"permeabilisation":[33],"evokes":[36],"prolonged,":[37],"spatiotemporally":[38],"complex":[39,98],"signals":[41,49,119,196],"in":[42,131,144,158,191,199,228,237,256,279],"primary":[43],"cultured":[44],"human":[45],"fibroblasts.":[46],"These":[47,241],"comprised":[50],"an":[51,264],"initial":[52],"response":[53],"correlated":[55],"with":[56,142,166,205,233],"lysosomal":[57,110,150,194,225,274],"disruption":[58],"secondary":[60],"long-lasting":[61],"spatially":[62],"heterogeneous":[63],"oscillations":[65],"required":[67],"ER-localised":[68],"inositol":[69],"trisphosphate":[70],"receptors.":[71],"Pharmacological":[72],"molecular":[74,182],"inhibition":[75,185],"trafficking":[78],"protein":[79],"Rab7":[80],"supressed":[81],"lysosome":[82,207],"induced":[83],"oscillations.":[85],"A":[86],"synthetic":[87],"agonist,":[88],"endolysosomal":[91,248],"ion":[92,249],"channel":[93],"TRPML,":[94],"also":[95,127],"evoked":[96],"ER-dependent":[97,117],"signals.":[100],"Thus,":[101],"like":[102],"messenger":[105],"NAADP,":[106],"direct":[107],"mobilisation":[108],"is":[113],"sufficient":[114],"evoke":[116],"through":[120],"a":[121,234],"mechanism":[122],"maybe":[124],"Rab7-dependent.":[125],"identify":[128,224],"defects":[130,227,242],"fibroblasts":[132,229],"from":[133,230],"Gaucher":[134],"(GD)":[136],"Parkinson":[138],"(PD)":[140],"patients":[141,163,232],"mutations":[143],"gene":[146],"(GBA1)":[147],"encoding":[148],"enzyme":[151,190,239],"glucocerebrosidase.":[152],"ER":[153,176],"levels":[155],"were":[156,197,243],"increased":[157],"younger":[159],"(but":[160],"not":[161],"older)":[162],"associated":[165,204],"enhanced":[167],"responses":[168],"ryanodine":[171],"receptor":[172],"modulator,":[173],"cyclic":[174],"ADP-ribose.":[175],"signalling":[178],"was":[179,254],"unaffected":[180],"by":[181,215,245,263],"or":[183],"chemical":[184],"glucocerebrosidase,":[187],"implicating":[188],"mis-folded":[189],"pathology.":[192,281,297],"Conversely,":[193],"reduced":[198],"GD":[200],"PD":[202,231,280,296],"disrupted":[206],"morphology.":[208],"Therefore,":[209],"remodelling":[210],"ER-lysosomal":[212],"pathogenic":[216],"GBA1":[217],"might":[218,293],"predispose":[219],"PD.":[221,269],"Finally,":[222],"morphology":[226,275],"common":[235],"mutation":[236],"LRRK2.":[240],"reversed":[244],"silencing":[246],"channel,":[250],"TPC2.":[251],"Lysosomal":[252],"pathology":[253],"recapitulated":[255],"SH-SY5Y":[257],"cells":[258],"overexpressing":[259],"mutant":[260],"LRRK2":[261],"environmental":[265],"toxin":[266],"linked":[267],"dependent":[271],"regulation":[272],"may":[276],"thus":[277],"contribute":[278],"In":[282],"summary,":[283],"are":[286],"functionally":[287],"connected":[288],"compromised":[291],"homeostasis":[292],"connect":[294],"Abstract":[298]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}